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Design and synthesis of screening libraries based on the muurolane natural product scaffold

https://doi.org/10.1039/c2ob00029f
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Synthesis of Natural Product Inspired Compound Collections
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Identification of Protein Fold Topology Shared between Different Folds Inhibited by Natural Products
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Synthesis and spectroscopic characterisation of a combinatorial library based on the fungal natural product 3‐chloro‐4‐hydroxyphenylacetamide
inferredcites →https://doi.org/10.1002/ptr.1716openalex-snapshot
Antibacterial activity of essential oils from Australian native plants
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Nature: a vital source of leads for anticancer drug development
inferredcites →https://doi.org/10.1007/s11224-010-9654-2openalex-snapshot
Merging structural biology with chemical biology: Structural Chemistry at Eskitis
inferredcites →https://doi.org/10.1016/0001-706x(93)90083-nopenalex-snapshot
A comparison of three methods of estimating EC50 in studies of drug resistance of malaria parasites
inferredcites →https://doi.org/10.1016/0040-4039(96)01350-0openalex-snapshot
Combinatorial chemistry and natural products. Teicoplanin aglycone as a molecular scaffold for solid phase synthesis of combinatorial libraries
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Combinatorial modification of natural products: Preparation of unencoded and encoded libraries of Rauwolfia alkaloids
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Natural products in drug discovery
inferredcites →https://doi.org/10.1016/j.phytochem.2010.12.011openalex-snapshot
Chemical composition and cytotoxicity of oils and eremophilanes derived from various parts of Eremophila mitchellii Benth. (Myoporaceae)
inferredcites →https://doi.org/10.1016/s0020-7519(00)00043-6openalex-snapshot
Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents
inferredcites →https://doi.org/10.1016/s0040-4020(01)85139-5openalex-snapshot
A new stereochemical class of bicyclic sesquiterpenes from eremophila virgata W.V. Fitzg. (Myoporaceae)
inferredcites →https://doi.org/10.1016/s0040-4020(99)00809-1openalex-snapshot
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methyl-morpholinium chloride: an efficient condensing agent leading to the formation of amides and esters
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The condensation reaction between isocyanates and carboxylic acids. A practical synthesis of substituted amides and anilides.
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
inferredcites →https://doi.org/10.1021/bi700190popenalex-snapshot
Actinorhodin Biosynthesis: Structural Requirements for Post-PKS Tailoring Intermediates Revealed by Functional Analysis of ActVI-ORF1 Reductase
inferredcites →https://doi.org/10.1021/ci0200467openalex-snapshot
Property Distributions: Differences between Drugs, Natural Products, and Molecules from Combinatorial Chemistry
inferredcites →https://doi.org/10.1021/ci700286xopenalex-snapshot
Natural Product-likeness Score and Its Application for Prioritization of Compound Libraries
inferredcites →https://doi.org/10.1021/cr800188vopenalex-snapshot
Advances in Solution- and Solid-Phase Synthesis toward the Generation of Natural Product-like Libraries
inferredcites →https://doi.org/10.1021/cr900019jopenalex-snapshot
Impact of Natural Products on Developing New Anti-Cancer Agents
inferredcites →https://doi.org/10.1021/ja907193bopenalex-snapshot
Total Synthesis of Chloropeptin II (Complestatin) and Chloropeptin I
inferredcites →https://doi.org/10.1021/jf801311hopenalex-snapshot
Synthesis, Crystal Structure, and Insecticidal Activity of Novel N-Alkyloxyoxalyl Derivatives of 2-Arylpyrrole
inferredcites →https://doi.org/10.1021/jm0704090openalex-snapshot
Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery?
inferredcites →https://doi.org/10.1021/jm801514wopenalex-snapshot
Novel Chemical Space Exploration via Natural Products
inferredcites →https://doi.org/10.1021/jo00869a026openalex-snapshot
Palladium-catalyzed vinyl substitution reactions. II. Synthesis of aryl substituted allylic alcohols, aldehydes, and ketones from aryl halides and unsaturated alcohols
inferredcites →https://doi.org/10.1021/jo701873topenalex-snapshot
Synthesis of Analogues of (E)-1-Hydroxy-2-methylbut-2-enyl 4-Diphosphate, an Isoprenoid Precursor and Human γδ T Cell Activator
inferredcites →https://doi.org/10.1021/mp0700209openalex-snapshot
The Rule of Five Revisited: Applying Log D in Place of Log P in Drug-Likeness Filters
inferredcites →https://doi.org/10.1021/np068054vopenalex-snapshot
Natural Products as Sources of New Drugs over the Last 25 Years
inferredcites →https://doi.org/10.1021/np2003676openalex-snapshot
Mitchellenes A–E, Cyclic Sesquiterpenes from the Australian Plant Eremophila mitchellii
inferredcites →https://doi.org/10.1021/np200687vopenalex-snapshot
Drug-like Properties: Guiding Principles for the Design of Natural Product Libraries
inferredcites →https://doi.org/10.1021/ol027116fopenalex-snapshot
Extensively Stereodiversified Scaffolds for Use in Diversity-Oriented Library Synthesis
inferredcites →https://doi.org/10.1021/ol9900055openalex-snapshot
Cycloaddition Reactions of Trimethylenemethane Radical Cation Generated from Methylenecyclopropanone Thioacetal
inferredcites →https://doi.org/10.1021/om950574qopenalex-snapshot
(Alkoxyalkyl)boronic Ester Intermediates for Asymmetric Synthesis
inferredcites →https://doi.org/10.1023/b:conc.0000025465.76505.33openalex-snapshot
Synthesis of New Estrone Derivatives Using Excess Oxalyl Chloride
inferredcites →https://doi.org/10.1038/nchembio.180openalex-snapshot
Quantifying biogenic bias in screening libraries
inferredcites →https://doi.org/10.1039/b715668popenalex-snapshot
Scaffold diversity of natural products: inspiration for combinatorial library design
inferredcites →https://doi.org/10.1039/c1np00026hopenalex-snapshot
Similar interactions of natural products with biosynthetic enzymes and therapeutic targets could explain why nature produces such a large proportion of existing drugs
inferredcites →https://doi.org/10.1039/c1ob05299copenalex-snapshot
Synthesis of novel molecular probes inspired by harringtonolide
inferredcites →https://doi.org/10.1071/ch01123openalex-snapshot
The Synthesis of a Combinatorial Library Using a Tambjamine Natural Product Template
inferredcites →https://doi.org/10.1093/jnci/82.13.1107openalex-snapshot
New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening
inferredcites →https://doi.org/10.1126/science.1168243openalex-snapshot
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
inferredcites →https://doi.org/10.1351/pac200880050979openalex-snapshot
Palladium-catalyzed selective activation of allyl alcohols as allyl cations, allyl anions, and zwitterionic trimethylenemethanes
inferredcites →https://doi.org/10.2174/157340908786786010openalex-snapshot
Visualization of the Chemical Space in Drug Discovery
inferredcites →https://doi.org/10.4155/fmc.09.113openalex-snapshot
Natural Product Scaffolds as Leads to Drugs

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Copper porphyrin‐catalyzed C(sp2)—O bond construction via coupling phenols with formamides
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Design, synthesis and spectroscopic characterisation of a focused library based on the polyandrocarpamine natural product scaffold
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In vitro biocompatibility and proliferative effects of polar and non-polar extracts of cucurbita ficifolia on human mesenchymal stem cells
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Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold
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The design, synthesis, and anti-inflammatory evaluation of a drug-like library based on the natural product valerenic acid
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Synthesis of antimalarial amide analogues based on the plant serrulatane diterpenoid 3,7,8-trihydroxyserrulat-14-en-19-oic acid
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Combinatorial Chemistry Online
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Natural products as lead structures: chemical transformations to create lead-like libraries
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Anti Mtb Medicinal Plants Database (AMMPDB): A curated database of Indian anti-tubercular medicinal plants
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Pyridocoumarin, aristolactam and aporphine alkaloids from the Australian rainforest plant Goniothalamus australis
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Antibacterial serrulatane diterpenes from the Australian native plant Eremophila microtheca
inferred← citeshttps://doi.org/10.1016/j.tetlet.2013.07.058openalex-snapshot
The discovery, synthesis and antimalarial evaluation of natural product-based polyamine alkaloids
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c00121openalex-snapshot
Synthesis of a Unique Psammaplysin F Library and Functional Evaluation in Prostate Cancer Cells by Multiparametric Quantitative Single Cell Imaging
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Using a Bioactive Eremophila -Derived Serrulatane Scaffold to Generate a Unique Carbamate Library for Anti-infective Evaluations
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.6b00950openalex-snapshot
Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2
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Revision of the Phytochemistry of Eremophila sturtii and E. mitchellii
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Identification of Gibberellic Acid Derivatives That Deregulate Cholesterol Metabolism in Prostate Cancer Cells
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Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca
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Biomimetic Synthesis of Mitchellenes B–H from the Abundant Biological Precursor 14-Hydroxy-6,12-muuroloadien-15-oic Acid
inferred← citeshttps://doi.org/10.1021/np500856uopenalex-snapshot
Design and Synthesis of a Screening Library Using the Natural Product Scaffold 3-Chloro-4-hydroxyphenylacetic Acid
inferred← citeshttps://doi.org/10.1039/c4md00310aopenalex-snapshot
Non-classical β-carbonic anhydrase inhibitors-towards novel anti-mycobacterials
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Domino intramolecular Diels–Alder reactions to construct a 6/6/5/5 fused tetracyclic framework
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A systematic approach to prioritize drug targets using machine learning, a molecular descriptor-based classification model, and high-throughput screening of plant derived molecules: a case study in oral cancer
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The use of isolated natural products as scaffolds for the generation of chemically diverse screening libraries for drug discovery
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Potassium Channels: Structures, Diseases, and Modulators
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Natural Product Polyamines That Inhibit Human Carbonic Anhydrases
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SerpentinaDB: a database of plant-derived molecules of Rauvolfia serpentina
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Prospecting for Novel Plant-Derived Molecules of Rauvolfia serpentina as Inhibitors of Aldose Reductase, a Potent Drug Target for Diabetes and Its Complications
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