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Cyclometalated Ir( iii ) complexes as targeted theranostic anticancer therapeutics: combining HDAC inhibition with photodynamic therapy

https://doi.org/10.1039/c4cc05215c
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/anie.201000682openalex-snapshot
Iridium Complex with Antiangiogenic Properties
inferredcites →https://doi.org/10.1002/anie.201107333openalex-snapshot
[(Cp‐R)M(CO)3] (M=Re or 99mTc) Arylsulfonamide, Arylsulfamide, and Arylsulfamate Conjugates for Selective Targeting of Human Carbonic Anhydrase IX
inferredcites →https://doi.org/10.1002/anie.201307505openalex-snapshot
De Novo Generation of Singlet Oxygen and Ammine Ligands by Photoactivation of a Platinum Anticancer Complex
inferredcites →https://doi.org/10.1002/anie.201311161openalex-snapshot
The Potent Oxidant Anticancer Activity of Organoiridium Catalysts
inferredcites →https://doi.org/10.1002/anie.201400533openalex-snapshot
Visible‐Light‐Induced Annihilation of Tumor Cells with Platinum–Porphyrin Conjugates
inferredcites →https://doi.org/10.1002/chem.201300814openalex-snapshot
Histone‐Deacetylase‐Targeted Fluorescent Ruthenium(II) Polypyridyl Complexes as Potent Anticancer Agents
inferredcites →https://doi.org/10.1002/cmdc.201300060openalex-snapshot
Rhenium Complexes with Visible‐Light‐Induced Anticancer Activity
inferredcites →https://doi.org/10.1016/j.biomaterials.2013.06.028openalex-snapshot
Mitochondria-targeting cyclometalated iridium(III)–PEG complexes with tunable photodynamic activity
inferredcites →https://doi.org/10.1016/j.ccr.2013.01.034openalex-snapshot
Bioactive iridium and rhodium complexes as therapeutic agents
inferredcites →https://doi.org/10.1021/cr900300popenalex-snapshot
Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization
inferredcites →https://doi.org/10.1021/ja00099a026openalex-snapshot
Tetranuclear Bimetallic Complexes of Ruthenium, Osmium, Rhodium, and Iridium. Synthesis, Absorption Spectra, Luminescence, and Electrochemical Properties
inferredcites →https://doi.org/10.1021/ja1112996openalex-snapshot
Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors
inferredcites →https://doi.org/10.1021/ja204997copenalex-snapshot
Phosphorescent Sensor for Robust Quantification of Copper(II) Ion
inferredcites →https://doi.org/10.1021/ja3009677openalex-snapshot
Strained Ruthenium Complexes Are Potent Light-Activated Anticancer Agents
inferredcites →https://doi.org/10.1021/ja401350xopenalex-snapshot
Gemcitabine–Coumarin–Biotin Conjugates: A Target Specific Theranostic Anticancer Prodrug
inferredcites →https://doi.org/10.1021/ja4045604openalex-snapshot
Cellular Toxicity Induced by the Photorelease of a Caged Bioactive Molecule: Design of a Potential Dual-Action Ru(II) Complex
inferredcites →https://doi.org/10.1021/ja408426zopenalex-snapshot
Exploitation of Long-Lived 3IL Excited States for Metal–Organic Photodynamic Therapy: Verification in a Metastatic Melanoma Model
inferredcites →https://doi.org/10.1021/ml100295vopenalex-snapshot
Synthesis and Biological Evaluation of JAHAs: Ferrocene-Based Histone Deacetylase Inhibitors
inferredcites →https://doi.org/10.1021/ol102562kopenalex-snapshot
Tuning Photosensitized Singlet Oxygen Generation Efficiency of Novel Aza-BODIPY Dyes
inferredcites →https://doi.org/10.1038/nbt1272openalex-snapshot
Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug
inferredcites →https://doi.org/10.1038/nrc1071openalex-snapshot
Photodynamic therapy for cancer
inferredcites →https://doi.org/10.1038/nrc1779openalex-snapshot
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
inferredcites →https://doi.org/10.1038/onc.2008.297openalex-snapshot
Caspases in apoptosis and beyond
inferredcites →https://doi.org/10.1038/onc.2011.384openalex-snapshot
Molecular mechanisms of cisplatin resistance
inferredcites →https://doi.org/10.1039/b108586gopenalex-snapshot
The role of apoptosis in response to photodynamic therapy: what, where, why, and how
inferredcites →https://doi.org/10.1039/c1cc15378aopenalex-snapshot
Dual anticancer activity in a single compound: visible-light-induced apoptosis by an antiangiogenic iridium complex
inferredcites →https://doi.org/10.1039/c1md00203aopenalex-snapshot
Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors
inferredcites →https://doi.org/10.1039/c2cc36907aopenalex-snapshot
Cyclometalated iridium( iii ) polypyridine dibenzocyclooctyne complexes as the first phosphorescent bioorthogonal probes
inferredcites →https://doi.org/10.1039/c2cs35171dopenalex-snapshot
Photofunctional triplet excited states of cyclometalated Ir(iii) complexes: beyond electroluminescence
inferredcites →https://doi.org/10.1039/c3dt51817eopenalex-snapshot
Towards cancer cell-specific phototoxic organometallic rhenium( i ) complexes
inferredcites →https://doi.org/10.1039/c3dt51917aopenalex-snapshot
Efficient new constructs against triple negative breast cancer cells: synthesis and preliminary biological study of ferrocifen–SAHA hybrids and related species
inferredcites →https://doi.org/10.1039/c3sc53550aopenalex-snapshot
Photo-induced uncaging of a specific Re( i ) organometallic complex in living cells
inferredcites →https://doi.org/10.1074/jbc.273.50.33533openalex-snapshot
Importance of Poly(ADP-ribose) Polymerase and Its Cleavage in Apoptosis
inferredcites →https://doi.org/10.1101/cshperspect.a018713openalex-snapshot
Erasers of Histone Acetylation: The Histone Deacetylase Enzymes
inferredcites →https://doi.org/10.1128/mcb.00413-08openalex-snapshot
Histone Deacetylase Inhibitors Modify Pancreatic Cell Fate Determination and Amplify Endocrine Progenitors
inferredcites →https://doi.org/10.1146/annurev-genet-102108-134850openalex-snapshot
The Role of Mitochondria in Apoptosis
inferredcites →https://doi.org/10.1186/1476-4598-8-93openalex-snapshot
EM011 activates a survivin-dependent apoptotic program in human non-small cell lung cancer cells
inferredcites →https://doi.org/10.3322/caac.20114openalex-snapshot
Photodynamic therapy of cancer: An update

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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A Meso-Protonated Iridium(Iii) Α-Octabutoxyphthalocyanine for Enhanced Near-Infrared Driven the Generation of Singlet Oxygen and Photothermal Property
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Cyclometalated Ruthenium(II) Anthraquinone Complexes Exhibit Strong Anticancer Activity in Hypoxic Tumor Cells
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Mono‐ and Dinuclear Phosphorescent Rhenium(I) Complexes: Impact of Subcellular Localization on Anticancer Mechanisms
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Metal Complexes for Two‐Photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two‐Photon Photosensitization of Cancer Cells under Near‐IR Light
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Valproic Acid‐Functionalized Cyclometalated Iridium(III) Complexes as Mitochondria‐Targeting Anticancer Agents
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Current Context of Designing Phototheranostic Cyclometalated Iridium (III) Complexes to Open a New Avenue in Cancer Therapy
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Anticancer RuII and RhIII Piano‐Stool Complexes that are Histone Deacetylase Inhibitors
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Cyclometalated IrIII Complexes as Mitochondria‐Targeted Photodynamic Anticancer Agents
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Nanocomposite‐Based Photodynamic Therapy Strategies for Deep Tumor Treatment
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Progress and Challenges in Tumor Ferroptosis Treatment Strategies: A Comprehensive Review of Metal Complexes and Nanomedicine
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Inhibition of histone deacetylases, topoisomerases and epidermal growth factor receptor by metal-based anticancer agents: Design & synthetic strategies and their medicinal attributes
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Cyclometalated iridium(III) luminescent complexes in therapy and phototherapy
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Transition metal complexes as photosensitisers in one- and two-photon photodynamic therapy
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Dual function luminescent transition metal complexes for cancer theranostics: The combination of diagnosis and therapy
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Perspectives of molecular and nanostructured systems with d- and f-block metals in photogeneration of reactive oxygen species for medical strategies
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Recent advances of iridium(III) metallophosphors for health-related applications
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Recent advances on organelle specific Ru(II)/Ir(III)/Re(I) based complexes for photodynamic therapy
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Targeting emerging cancer hallmarks by transition metal complexes: Epigenetic reprogramming and epitherapies. Part II
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Phosphorogenic dipyrrinato-iridium(III) complexes as photosensitizers for photodynamic therapy
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Strong in vitro and vivo cytotoxicity of novel organoplatinum(II) complexes with quinoline-coumarin derivatives
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Novel dual-mode antitumor chlorin-based derivatives as potent photosensitizers and histone deacetylase inhibitors for photodynamic therapy and chemotherapy
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Iridium(III) complexes as novel theranostic small molecules for medical diagnostics, precise imaging at a single cell level and targeted anticancer therapy
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Drive to organoruthenium and organoiridium complexes from organoplatinum: Next-generation anticancer metallotherapeutics
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Identification of two mitochondrial-targeting cyclometalated iridium(III) complexes as potent anti-glioma stem cells agents
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Visible light-controlled carbon monoxide delivery combined with the inhibitory activity of histone deacetylases from a manganese complex for an enhanced antitumor therapy
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Cyclometalated iridium(III) complexes as mitochondria-targeted anticancer and antibacterial agents to induce both autophagy and apoptosis
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NIR light-controlled mitochondria-targeted delivery of carbon monoxide combined with histone deacetylase inhibition for synergistic anticancer therapy
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Rational design of mitochondria targeted thiabendazole-based Ir(III) biscyclometalated complexes for a multimodal photodynamic therapy of cancer
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Heteronuclear Ru(II)-Re(I) complexes as potential photodynamic anticancer agents with anti-metastatic and anti-angiogenic activities
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Advances in the design of organometallic anticancer complexes
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Mixed Ru(II)–Ir(III) Complexes as Photoactive Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4
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Mitochondria Localized Anticancer Iridium(III) Prodrugs for Targeted Delivery of Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors and Cytotoxic Iridium(III) Complex
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Photochemical Properties of Red-Emitting Tris(cyclometalated) Iridium(III) Complexes Having Basic and Nitro Groups and Application to pH Sensing and Photoinduced Cell Death
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Design and Synthesis of Heteroleptic Cyclometalated Iridium(III) Complexes Containing Quinoline-Type Ligands that Exhibit Dual Phosphorescence
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Anticancer Activity of Iridium(III) Complexes Based on a Pyrazole-Appended Quinoline-Based BODIPY
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Photophysical and Photobiological Properties of Dinuclear Iridium(III) Bis-tridentate Complexes
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Construction of 5-Fluorouracil and Gallium Corrole Conjugates for Enhanced Photodynamic Therapy
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Pojamide: An HDAC3-Selective Ferrocene Analogue with Remarkably Enhanced Redox-Triggered Ferrocenium Activity in Cells
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Graphene Oxide Decorated with Ru(II)–Polyethylene Glycol Complex for Lysosome-Targeted Imaging and Photodynamic/Photothermal Therapy
inferred← citeshttps://doi.org/10.1021/acsami.7b01735openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acsomega.0c03180openalex-snapshot
A Translational Study of a Silicon Phthalocyanine Substituted with a Histone Deacetylase Inhibitor for Photodynamic Therapy
inferred← citeshttps://doi.org/10.1021/acsomega.3c04867openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/ic502378zopenalex-snapshot
A Luminescent Poly(amidoamine)–Iridium Complex as a New Singlet-Oxygen Sensitizer for Photodynamic Therapy
inferred← citeshttps://doi.org/10.1038/srep38954openalex-snapshot
Ester-Modified Cyclometalated Iridium(III) Complexes as Mitochondria-Targeting Anticancer Agents
inferred← citeshttps://doi.org/10.1039/9781788016452-00031openalex-snapshot
Ruthenium, Osmium and Iridium in the Fight Against Cancer
inferred← citeshttps://doi.org/10.1039/c5cc02354hopenalex-snapshot
A phosphorescent rhenium( i ) histone deacetylase inhibitor: mitochondrial targeting and paraptosis induction
inferred← citeshttps://doi.org/10.1039/c5dt04275eopenalex-snapshot
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inferred← citeshttps://doi.org/10.1039/c5sc01955aopenalex-snapshot
Cyclometalated iridium( iii ) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents
inferred← citeshttps://doi.org/10.1039/c5tb01501dopenalex-snapshot
Selenadiazole derivatives as theranostic agents for simultaneous cancer chemo-/radiotherapy by targeting thioredoxin reductase
inferred← citeshttps://doi.org/10.1039/c5tb02555aopenalex-snapshot
Near-infrared triggered generation of reactive oxygen species from upconverting nanoparticles decorated with an organoiridium complex
inferred← citeshttps://doi.org/10.1039/c6dt00601aopenalex-snapshot
Coumarin-appended phosphorescent cyclometalated iridium( iii ) complexes as mitochondria-targeted theranostic anticancer agents
inferred← citeshttps://doi.org/10.1039/c6dt02416eopenalex-snapshot
Increasing the triplet lifetime and extending the ground-state absorption of biscyclometalated Ir( iii ) complexes for reverse saturable absorption and photodynamic therapy applications
inferred← citeshttps://doi.org/10.1039/c6sc02901aopenalex-snapshot
Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium( iii ) complexes
inferred← citeshttps://doi.org/10.1039/c7cs00195aopenalex-snapshot
The development of anticancer ruthenium( ii ) complexes: from single molecule compounds to nanomaterials
inferred← citeshttps://doi.org/10.1039/c7dt00913eopenalex-snapshot
Near-infrared-emitting heteroleptic cationic iridium complexes derived from 2,3-diphenylbenzo[g]quinoxaline as in vitro theranostic photodynamic therapy agents
inferred← citeshttps://doi.org/10.1039/c7dt01043eopenalex-snapshot
Fluorinated cyclometalated iridium( iii ) complexes as mitochondria-targeted theranostic anticancer agents
inferred← citeshttps://doi.org/10.1039/c7dt01091eopenalex-snapshot
The discovery of half-sandwich iridium complexes containing lidocaine and (pyren-1-yl)ethynyl derivatives of phenylcyanamide ligands for photodynamic therapy
inferred← citeshttps://doi.org/10.1039/c7dt02273eopenalex-snapshot
Mixed-ligand iridium( iii ) complexes as photodynamic anticancer agents
inferred← citeshttps://doi.org/10.1039/c7dt02477kopenalex-snapshot
Iridium( iii ) complexes with five-membered heterocyclic ligands for combined photodynamic therapy and photoactivated chemotherapy
inferred← citeshttps://doi.org/10.1039/c7nj02224gopenalex-snapshot
Preparation of metalated azine complexes of iridium( iii )
inferred← citeshttps://doi.org/10.1039/c7nr05349eopenalex-snapshot
Ruthenium complex-modified carbon nanodots for lysosome-targeted one- and two-photon imaging and photodynamic therapy
inferred← citeshttps://doi.org/10.1039/c8cc09396bopenalex-snapshot
A smart perylene derived photosensitizer for lysosome-targeted and self-assessed photodynamic therapy
inferred← citeshttps://doi.org/10.1039/c8dt00783gopenalex-snapshot
Cyclometalated iridium( iii ) complexes induce mitochondria-derived paraptotic cell death and inhibit tumor growth in vivo
inferred← citeshttps://doi.org/10.1039/c8ra00265gopenalex-snapshot
Pyridazine-bridged cationic diiridium complexes as potential dual-mode bioimaging probes
inferred← citeshttps://doi.org/10.1039/c9dt04594eopenalex-snapshot
Complexes of oxoplatin with rhein and ferulic acid ligands as platinum( iv ) prodrugs with high anti-tumor activity
inferred← citeshttps://doi.org/10.1039/c9sc00696fopenalex-snapshot
Cyclometalated iridium–BODIPY ratiometric O 2 sensors
inferred← citeshttps://doi.org/10.1039/d0cc00524jopenalex-snapshot
Imaging and therapeutic applications of Zn( ii )-cryptolepine–curcumin molecular probes in cell apoptosis detection and photodynamic therapy
inferred← citeshttps://doi.org/10.1039/d0cs00173bopenalex-snapshot
Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application
inferred← citeshttps://doi.org/10.1039/d0dt00180eopenalex-snapshot
Cyclometalated iridium( iii ) complexes for mitochondria-targeted combined chemo-photodynamic therapy
inferred← citeshttps://doi.org/10.1039/d0mt00060dopenalex-snapshot
Mitochondria-targeted artesunate conjugated cyclometalated iridium( iii ) complexes as potent anti-HepG2 hepatocellular carcinoma agents
inferred← citeshttps://doi.org/10.1039/d1ra05404jopenalex-snapshot
Evaluation of histone deacetylase inhibitor substituted zinc and indium phthalocyanines for chemo- and photodynamic therapy
inferred← citeshttps://doi.org/10.1039/d2dt00719copenalex-snapshot
Novel heterobimetallic Ir( iii )–Re( i ) complexes: design, synthesis and antitumor mechanism investigation
inferred← citeshttps://doi.org/10.1039/d2dt01765bopenalex-snapshot
8-Hydroxyquinoline-modified ruthenium( ii ) polypyridyl complexes for JMJD inhibition and photodynamic antitumor therapy
inferred← citeshttps://doi.org/10.1039/d2md00356bopenalex-snapshot
Therapeutic significance of molecular hybrids for breast cancer research and treatment
inferred← citeshttps://doi.org/10.1039/d3dt01348kopenalex-snapshot
Synthesis, characterization, photophysical and electrochemical properties, and biomolecular interaction of 2,2′-biquinoline based phototoxic Ru( ii )/Ir( ii ) complexes
inferred← citeshttps://doi.org/10.1039/d3qi00908dopenalex-snapshot
Folate-targeted iridium complexes amplify photodynamic therapy efficacy through ferroptosis
inferred← citeshttps://doi.org/10.1039/d4dt00766bopenalex-snapshot
Aqueous emissive cyclometalated iridium photoreductants: synthesis, computational analysis and the photocatalytic reduction of 4-nitrophenol
inferred← citeshttps://doi.org/10.1039/d4dt01571aopenalex-snapshot
Multi-functional biotinylated platinum( iv )–SAHA conjugate for tumor-targeted chemotherapy
inferred← citeshttps://doi.org/10.1039/d5sc07181jopenalex-snapshot
Phosphorescent iridium complexes activated by endogenous zinc as a mitochondrial DNA nuclease for stimulation of the cGAS-STING pathway
inferred← citeshttps://doi.org/10.1039/d6dt01255hopenalex-snapshot
Exploring the self-assembling ability of cyclometallated Rh( iii ) complexes with different N,N-chelating ligands in water
inferred← citeshttps://doi.org/10.1039/d6qi00422aopenalex-snapshot
Multifunctional SAHA-derived 8-hydroxyquinoline metallopharmacophores: HDAC inhibition and antiproliferative activity
inferred← citeshttps://doi.org/10.1055/a-2684-3595openalex-snapshot
Recent Development of Metallopharmaceuticals in Cancer Therapy: Ruthenium Complexes and Their Analogues
inferred← citeshttps://doi.org/10.1080/00958972.2018.1564911openalex-snapshot
Four Ni(II), Co(III), Cd(II) complexes based on 5-(pyrazol-1-yl)nicotinic acid: synthesis, X-ray single crystal structure, in vitro cytotoxicity, apoptosis and molecular docking studies
inferred← citeshttps://doi.org/10.1093/mtomcs/mfac068openalex-snapshot
Lysosome-targeted cyclometalated iridium(III) complexes: JMJD inhibition, dual induction of apoptosis, and autophagy
inferred← citeshttps://doi.org/10.1142/s0219633620500066openalex-snapshot
A theoretical study on cyclometalated iridium (III) complexes by using a density functional theory
inferred← citeshttps://doi.org/10.1186/s13148-017-0359-xopenalex-snapshot
Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of CDKN1A
inferred← citeshttps://doi.org/10.1517/17460441.2016.1135125openalex-snapshot
An overview of molecular hybrids in drug discovery
inferred← citeshttps://doi.org/10.2174/0929867325666180307112029openalex-snapshot
Mitochondria-Targeting Anticancer Metal Complexes
inferred← citeshttps://doi.org/10.3389/fchem.2020.00402openalex-snapshot
Zinc-Containing Metalloenzymes: Inhibition by Metal-Based Anticancer Agents
inferred← citeshttps://doi.org/10.3390/molecules25102383openalex-snapshot
Anticancer Ruthenium Complexes with HDAC Isoform Selectivity
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