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Alkynol natural products target ALDH2 in cancer cells by irreversible binding to the active site

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/1521-3773(20020715)41:14<2596::aid-anie2596>3.0.co;2-4openalex-snapshot

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

inferredcites →https://doi.org/10.1002/ange.201106334openalex-snapshot

Duocarmycin Analogues Target Aldehyde Dehydrogenase 1 in Lung Cancer Cells

inferredcites →https://doi.org/10.1002/anie.201106334openalex-snapshot

Duocarmycin Analogues Target Aldehyde Dehydrogenase 1 in Lung Cancer Cells

inferredcites →https://doi.org/10.1002/anie.201300683openalex-snapshot

Design and Synthesis of Minimalist Terminal Alkyne‐Containing Diazirine Photo‐Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell‐ and Tissue‐Based Proteome Profiling

inferredcites →https://doi.org/10.1002/anie.201302538openalex-snapshot

Catalytic Z‐Selective Cross‐Metathesis with Secondary Silyl‐ and Benzyl‐Protected Allylic Ethers: Mechanistic Aspects and Applications to Natural Product Synthesis

inferredcites →https://doi.org/10.1002/chem.201500934openalex-snapshot

Chemoproteomic Evaluation of the Polyacetylene Callyspongynic Acid

inferredcites →https://doi.org/10.1006/abbi.1995.1028openalex-snapshot

The Hepatocellular Metabolism of 4-Hydroxynonenal by Alcohol Dehydrogenase, Aldehyde Dehydrogenase, and Glutathione S-Transferase

inferredcites →https://doi.org/10.1016/j.bcp.2010.02.015openalex-snapshot

Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin

inferredcites →https://doi.org/10.1016/j.ejphar.2013.11.005openalex-snapshot

Dietary polyacetylenes of the falcarinol type are inhibitors of breast cancer resistance protein (BCRP/ABCG2)

inferredcites →https://doi.org/10.1016/j.febslet.2005.09.082openalex-snapshot

Inhibition of mitochondrial aldehyde dehydrogenase by nitric oxide‐mediated S‐nitrosylation

inferredcites →https://doi.org/10.1016/j.jpba.2006.01.057openalex-snapshot

Bioactive polyacetylenes in food plants of the Apiaceae family: Occurrence, bioactivity and analysis

inferredcites →https://doi.org/10.1016/j.tifs.2003.12.003openalex-snapshot

Health promoting compounds in vegetables and fruits

inferredcites →https://doi.org/10.1016/s0021-9258(18)50153-8openalex-snapshot

Esters of Methanesulfonic Acid as Irreversible Inhibitors of Acetylcholinesterase

inferredcites →https://doi.org/10.1021/bi00008a025openalex-snapshot

Investigation of the Active Site Cysteine Residue of Rat Liver Mitochondrial Aldehyde Dehydrogenase by Site-Directed Mutagenesis

inferredcites →https://doi.org/10.1021/cr050288gopenalex-snapshot

Mechanism-Based Profiling of Enzyme Families

inferredcites →https://doi.org/10.1021/ja204289qopenalex-snapshot

From Highly Enantioselective Catalytic Reaction of 1,3-Diynes with Aldehydes to Facile Asymmetric Synthesis of Polycyclic Compounds

inferredcites →https://doi.org/10.1021/jf048041sopenalex-snapshot

Polyacetylenes from the Apiaceae Vegetables Carrot, Celery, Fennel, Parsley, and Parsnip and Their Cytotoxic Activities

inferredcites →https://doi.org/10.1021/jf0616154openalex-snapshot

Biphasic Effect of Falcarinol on CaCo-2 Cell Proliferation, DNA Damage, and Apoptosis

inferredcites →https://doi.org/10.1021/jo011148jopenalex-snapshot

Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides

inferredcites →https://doi.org/10.1021/jo0515475openalex-snapshot

Total Synthesis as a Resource in Drug Discovery: The First In Vivo Evaluation of Panaxytriol and Its Derivatives

inferredcites →https://doi.org/10.1021/np500615jopenalex-snapshot

Dietary Acetylenic Oxylipin Falcarinol Differentially Modulates GABAA Receptors

inferredcites →https://doi.org/10.1039/c0cs00004copenalex-snapshot

Activity-based probes: discovering new biology and new drug targets

inferredcites →https://doi.org/10.1039/c2mb25144bopenalex-snapshot

Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy

inferredcites →https://doi.org/10.1074/mcp.m200025-mcp200openalex-snapshot

Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression Proteomics

inferredcites →https://doi.org/10.1111/j.1600-0536.1986.tb01167.xopenalex-snapshot

Allergic contact dermatitis from falcarinol isolated from Schefflera arboricola

inferredcites →https://doi.org/10.1126/scitranslmed.3009027openalex-snapshot

Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system

inferredcites →https://doi.org/10.1586/14789450.5.5.721openalex-snapshot

Activity-based probes as a tool for functional proteomic analysis of proteases

inferredcites →https://doi.org/10.2174/2212798411103010064openalex-snapshot

Aliphatic C17-Polyacetylenes of the Falcarinol Type as Potential Health Promoting Compounds in Food Plants of the Apiaceae Family

inferredcites →https://doi.org/10.5012/bkcs.2011.32.9.3513openalex-snapshot

Polyacetylenes from Panax stipuleanatus and their Cytotoxic Effects on Human Cancer Cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4807357openalex-extracted

Dissecting the Natural Phytochemical Diversity of Carrot Roots with its Colour Using High Performance Liquid Chromatography and Uv-Visible Spectrophotometry

inferred← citeshttps://doi.org/10.1002/9783527818242.ch2openalex-snapshot

Affinity‐Based Chemoproteomics for Target Identification

inferred← citeshttps://doi.org/10.1002/adsc.202300993openalex-snapshot

Rhodium‐Catalyzed Direct Enantioselective Alkynylation of Trifluoropyruvates with Terminal 1,3‐Diynes

inferred← citeshttps://doi.org/10.1002/ange.201605993openalex-snapshot

Eine Gesamtproteom‐basierte Auflistung der Hintergrundbinder von Photovernetzern

inferred← citeshttps://doi.org/10.1002/anie.201605993openalex-snapshot

A Whole Proteome Inventory of Background Photocrosslinker Binding

inferred← citeshttps://doi.org/10.1002/cbic.201500519openalex-snapshot

Furospinosulin‐1, Marine Spongean Furanosesterterpene, Suppresses the Growth of Hypoxia‐Adapted Cancer Cells by Binding to Transcriptional Regulators p54nrb and LEDGF/p75

inferred← citeshttps://doi.org/10.1002/cbic.201800458openalex-snapshot

Highly Enantioselective Synthesis and Anticancer Activities of Chiral Conjugated Diynols

inferred← citeshttps://doi.org/10.1002/chem.202005397openalex-snapshot

One‐Pot Dual C−C Coupling Reaction via Site Selective Cascade Formation by PdII‐Cryptate of an Amino‐Ether Heteroditopic Macrobicycle

inferred← citeshttps://doi.org/10.1002/pmic.201600212openalex-snapshot

Target identification with quantitative activity based protein profiling (ABPP)

inferred← citeshttps://doi.org/10.1007/978-981-19-3627-2_51-1openalex-snapshot

Health-Enhancing Compounds in Carrots: Genetics, Genomics, and Molecular Breeding

inferred← citeshttps://doi.org/10.1007/978-981-19-4169-6_51openalex-snapshot

Health-Enhancing Compounds in Carrots: Genetics, Genomics, and Molecular Breeding

inferred← citeshttps://doi.org/10.1007/s00210-025-04085-zopenalex-snapshot

Disafynol: A polyacetylene dimer from Centaurea schmidii enhancing breast cancer cell apoptosis via oxidative and ER stress pathways

inferred← citeshttps://doi.org/10.1007/s11696-019-00962-zopenalex-snapshot

Synthesis of unsymmetric 1,3-diynes from bromoallenes using the catalysis of CuI and amino acid

inferred← citeshttps://doi.org/10.1007/s13659-020-00283-9openalex-snapshot

Anticancer Properties of Lobetyolin, an Essential Component of Radix Codonopsis (Dangshen)

inferred← citeshttps://doi.org/10.1016/b978-0-323-96025-0.00063-6openalex-snapshot

Coupling Reactions Between sp Carbon Centers

inferred← citeshttps://doi.org/10.1016/j.bmc.2019.03.022openalex-snapshot

Profiling withanolide A for therapeutic targets in neurodegenerative diseases

inferred← citeshttps://doi.org/10.1016/j.cclet.2016.11.032openalex-snapshot

Total syntheses of bupleurynol and its analog

inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e35918openalex-snapshot

Dissecting the natural phytochemical diversity of carrot roots with its colour using high performance liquid chromatography and UV–Visible spectrophotometry

inferred← citeshttps://doi.org/10.1016/j.tet.2016.09.001openalex-snapshot

Ethynylogation approach in pharmacophore design: from alkynyl-to butadiynyl-carbinols vs antitumoral cytotoxicity

inferred← citeshttps://doi.org/10.1016/j.tetlet.2018.04.045openalex-snapshot

Studies towards the synthesis of trocheliophorolides

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c00859openalex-snapshot

Phenyl dialkynylcarbinols, a Bioinspired Series of Synthetic Antitumor Acetylenic Lipids

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b00595openalex-snapshot

Probing the Existence of a Metastable Binding Site at the β 2 -Adrenergic Receptor with Homobivalent Bitopic Ligands

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c00642openalex-snapshot

CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells

inferred← citeshttps://doi.org/10.1021/acs.joc.8b00961openalex-snapshot

Evidence for a Sigmatropic and an Ionic Pathway in the Winstein Rearrangement

inferred← citeshttps://doi.org/10.1021/acs.orglett.8b02975openalex-snapshot

Synthesis of 1,3-Diynes via Cadiot–Chodkiewicz Coupling of Volatile, in Situ Generated Bromoalkynes

inferred← citeshttps://doi.org/10.1021/acschembio.7b01092openalex-snapshot

Identification of Protein Targets of 12/15-Lipoxygenase-Derived Lipid Electrophiles in Mouse Peritoneal Macrophages Using Omega-Alkynyl Fatty Acid

inferred← citeshttps://doi.org/10.1021/acschembio.8b01097openalex-snapshot

Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10–2474

inferred← citeshttps://doi.org/10.1039/c6np00001kopenalex-snapshot

Chemical proteomics approaches for identifying the cellular targets of natural products

inferred← citeshttps://doi.org/10.1039/c7fo00110jopenalex-snapshot

Dietary polyacetylenes, falcarinol and falcarindiol, isolated from carrots prevents the formation of neoplastic lesions in the colon of azoxymethane-induced rats

inferred← citeshttps://doi.org/10.1039/c7qo00082kopenalex-snapshot

Synthesis of 1,4-enyne-3-ones via palladium-catalyzed sequential decarboxylation and carbonylation of allyl alkynoates

inferred← citeshttps://doi.org/10.1039/c7ra01268copenalex-snapshot

Discovery of 1,3-diyne compounds as novel and potent antidepressant agents: synthesis, cell-based assay and behavioral studies

inferred← citeshttps://doi.org/10.1039/d4ob01595aopenalex-snapshot

Synthesis, and antitumoral and antiviral evaluation of polyacetylene glycoside derivatives

inferred← citeshttps://doi.org/10.1055/s-0043-109558openalex-snapshot

Targeting Multiple Myeloma Cancer Stem Cells with Natural Products – Lessons from Other Hematological Malignancies

inferred← citeshttps://doi.org/10.1055/s-007-34144openalex-snapshot

inferred← citeshttps://doi.org/10.1080/14786419.2020.1712381openalex-snapshot

A new alkynol compound from Platycodins folium and its cytotoxicity

inferred← citeshttps://doi.org/10.1093/chromsci/bmw134openalex-snapshot

HPLC Determination of Enantiomeric Purity for 1-Styrene-3-Hexyl Propynol

inferred← citeshttps://doi.org/10.1093/jxb/erac006openalex-snapshot

Structural diversity, biosynthesis, and function of plant falcarin-type polyacetylenic lipids

inferred← citeshttps://doi.org/10.1111/bph.13676openalex-snapshot

Cannabimimetic phytochemicals in the diet – an evolutionary link to food selection and metabolic stress adaptation?

inferred← citeshttps://doi.org/10.1155/2018/9186926openalex-snapshot

Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure‐Activity Relationship on Anticancer Effects

inferred← citeshttps://doi.org/10.1186/s12943-022-01579-9openalex-snapshot

An EHMT2/NFYA-ALDH2 signaling axis modulates the RAF pathway to regulate paclitaxel resistance in lung cancer

inferred← citeshttps://doi.org/10.12677/acm.2023.1392022openalex-snapshot

Research Progress of Panaxynol in the Treatment of Cancer

inferred← citeshttps://doi.org/10.2298/tsci190526047zopenalex-snapshot

Active constituents of Litsea cubeba

inferred← citeshttps://doi.org/10.24820/ark.5550190.p011.466openalex-snapshot

Cu-Catalyzed solvent-free, pot-economic synthesis of 1,3-dynes from 1,1-dibromoalkenes in the presence of DBU•H2O

inferred← citeshttps://doi.org/10.3389/fphar.2020.565524openalex-snapshot

Falcarindiol Purified From Carrots Leads to Elevated Levels of Lipid Droplets and Upregulation of Peroxisome Proliferator-Activated Receptor-γ Gene Expression in Cellular Models

inferred← citeshttps://doi.org/10.3389/fphar.2024.1482898openalex-snapshot

In vitro hair growth-promoting effects of araliadiol via the p38/PPAR-γ signaling pathway in human hair follicle stem cells and dermal papilla cells

inferred← citeshttps://doi.org/10.3390/molecules25112568openalex-snapshot

Bioactive C17 and C18 Acetylenic Oxylipins from Terrestrial Plants as Potential Lead Compounds for Anticancer Drug Development

inferred← citeshttps://doi.org/10.3390/molecules30132832openalex-snapshot

Crithmum maritimum L.: Phytochemical Profile, Biological Activities, and Therapeutic Potential

inferred← citeshttps://doi.org/10.3390/nu11092223openalex-snapshot

Dietary Polyacetylenic Oxylipins Falcarinol and Falcarindiol Prevent Inflammation and Colorectal Neoplastic Transformation: A Mechanistic and Dose-Response Study in A Rat Model

inferred← citeshttps://doi.org/10.3390/nu12020332openalex-snapshot

Carrot Intake and Risk of Colorectal Cancer: A Prospective Cohort Study of 57,053 Danes

inferred← citeshttps://doi.org/10.3390/nu15235002openalex-snapshot

Carrot Juice Intake Affects the Cytokine and Chemokine Response in Human Blood after Ex Vivo Lipopolysaccharide-Induced Inflammation

inferred← citeshttps://doi.org/10.3390/plants10112235openalex-snapshot

In Vitro Anti-Trypanosoma cruzi Activity of Halophytes from Southern Portugal Reloaded: A Special Focus on Sea Fennel (Crithmum maritimum L.)

inferred← citeshttps://doi.org/10.6084/m9.figshare.19670069openalex-snapshot

Additional file 1 of An EHMT2/NFYA-ALDH2 signaling axis modulates the RAF pathway to regulate paclitaxel resistance in lung cancer

inferred← citeshttps://doi.org/10.7554/elife.73913openalex-snapshot

SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species

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