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From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites

https://doi.org/10.1039/c7np00032d
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A Global View of Metabolites
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SMURF: Genomic mapping of fungal secondary metabolite clusters
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Highly efficient CRISPR mutagenesis by microhomology-mediated end joining in Aspergillus fumigatus
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Insights into natural products biosynthesis from analysis of 490 polyketide synthases from Fusarium
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Chapter 8 Methods for In Silico Prediction of Microbial Polyketide and Nonribosomal Peptide Biosynthetic Pathways from DNA Sequence Data
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XCMS: Processing Mass Spectrometry Data for Metabolite Profiling Using Nonlinear Peak Alignment, Matching, and Identification
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Computing Fragmentation Trees from Tandem Mass Spectrometry Data
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Automatic Chemical Structure Annotation of an LC–MSn Based Metabolic Profile from Green Tea
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X13CMS: Global Tracking of Isotopic Labels in Untargeted Metabolomics
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Automated LC-HRMS(/MS) Approach for the Annotation of Fragment Ions Derived from Stable Isotope Labeling-Assisted Untargeted Metabolomics
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Combining Stable Isotope Labeling and Molecular Networking for Biosynthetic Pathway Characterization
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Automated Detection of Natural Halogenated Compounds from LC-MS Profiles–Application to the Isolation of Bioactive Chlorinated Compounds from Marine-Derived Fungi
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MZmine 2 Data-Preprocessing To Enhance Molecular Networking Reliability
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Functional Reconstitution of a Fungal Natural Product Gene Cluster by Advanced Genome Editing
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Chemistry and Biology of Mycotoxins and Related Fungal Metabolites
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Illuminating the Diversity of Aromatic Polyketide Synthases in Aspergillus nidulans
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An Efficient System for Heterologous Expression of Secondary Metabolite Genes in Aspergillus nidulans
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Fluorescent Profiling of Modular Biosynthetic Enzymes by Complementary Metabolic and Activity Based Probes
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A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, in Aspergillus nidulans
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Differential Analysis of Mycoalexins in Confrontation Zones of Grapevine Fungal Pathogens by Ultrahigh Pressure Liquid Chromatography/Time-of-Flight Mass Spectrometry and Capillary Nuclear Magnetic Resonance
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Navigating the Fungal Polyketide Chemical Space: From Genes to Molecules
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Pestalone, a New Antibiotic Produced by a Marine Fungus in Response to Bacterial Challenge
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Trichodermamides A and B, Cytotoxic Modified Dipeptides from the Marine-Derived Fungus Trichoderma virens
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Arugosins G and H: Prenylated Polyketides from the Marine-Derived Fungus Emericella nidulans var. acristata
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Induced Production of Emericellamides A and B from the Marine-Derived Fungus Emericella sp. in Competing Co-culture
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Natural Products as Sources of New Drugs over the Last 25 Years
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Isoechinulin-type Alkaloids, Variecolorins A–L, from Halotolerant Aspergillus variecolor
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Epicoccamides B–D, Glycosylated Tetramic Acid Derivatives from an Epicoccum sp. Associated with the Tree Fungus Pholiota squarrosa
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Uncovering Biosynthetic Potential of Plant-Associated Fungi: Effect of Culture Conditions on Metabolite Production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii
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Novel Open-Chain Cytochalsins from the Marine-Derived Fungus Spicaria elegans
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Chemical Epigenetics Alters the Secondary Metabolite Composition of Guttate Excreted by an Atlantic-Forest-Soil-Derived Penicillium citreonigrum
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Cyclic Tripeptides from the Halotolerant Fungus Aspergillus sclerotiorum PT06-1
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Induced Production ofN-Formyl Alkaloids fromAspergillus fumigatusby Co-culture withStreptomyces peucetius
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Cytotoxic Alkaloids from Fusarium incarnatum Associated with the Mangrove Tree Aegiceras corniculatum
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Ligerin, an Antiproliferative Chlorinated Sesquiterpenoid from a Marine-Derived Penicillium Strain
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De Novo Production of Metabolites by Fungal Co-culture of Trichophyton rubrum and Bionectria ochroleuca
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Molecular Networking as a Dereplication Strategy
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High-Resolution MS, MS/MS, and UV Database of Fungal Secondary Metabolites as a Dereplication Protocol for Bioactive Natural Products
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Inducing Secondary Metabolite Production by the Endophytic Fungus Fusarium tricinctum through Coculture with Bacillus subtilis
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Structure Elucidation and Antimalarial Activity of Apicidin F: An Apicidin-like Compound Produced by Fusarium fujikuroi
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NRPquest: Coupling Mass Spectrometry and Genome Mining for Nonribosomal Peptide Discovery
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Antisense-Guided Isolation and Structure Elucidation of Pannomycin, a Substituted cis-Decalin from Geomyces pannorum
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Glionitrin A, an Antibiotic−Antitumor Metabolite Derived from Competitive Interaction between Abandoned Mine Microbes
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Genome Mining of a Prenylated and Immunosuppressive Polyketide from Pathogenic Fungi
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Discovery of Cryptic Polyketide Metabolites from Dermatophytes Using Heterologous Expression in Aspergillus nidulans
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Antibacterial activity of marine-derived fungi
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Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans
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Enhancement of metabolites productivity of Penicillium pinophilum FKI-5653, by co-culture with Trichoderma harzianum FKI-5655
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Insights into microbial cryptic gene activation and strain improvement: principle, application and technical aspects
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Genome sequencing and analysis of Aspergillus oryzae
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Emerging fungal threats to animal, plant and ecosystem health
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Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12
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A proteomics approach to discovering natural products and their biosynthetic pathways
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Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
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Chromatin-level regulation of biosynthetic gene clusters
inferredcites →https://doi.org/10.1038/nchembio.1890openalex-snapshot
Minimum Information about a Biosynthetic Gene cluster
inferredcites →https://doi.org/10.1038/nchembio.2219openalex-snapshot
Dereplication of peptidic natural products through database search of mass spectra
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A scalable platform to identify fungal secondary metabolites and their gene clusters
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Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans
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Dereplication and de novo sequencing of nonribosomal peptides
inferredcites →https://doi.org/10.1038/nmicrobiol.2017.44openalex-snapshot
Global analysis of biosynthetic gene clusters reveals vast potential of secondary metabolite production in Penicillium species
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RNA-Seq: a revolutionary tool for transcriptomics
inferredcites →https://doi.org/10.1038/nrmicro1286openalex-snapshot
Fungal secondary metabolism — from biochemistry to genomics
inferredcites →https://doi.org/10.1038/nrmicro2916openalex-snapshot
Regulation of fungal secondary metabolism
inferredcites →https://doi.org/10.1039/b607011fopenalex-snapshot
Discovery of aspoquinolones A–D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining
inferredcites →https://doi.org/10.1039/b804701dopenalex-snapshot
Epigenetic remodeling of the fungal secondary metabolome
inferredcites →https://doi.org/10.1039/b819208aopenalex-snapshot
A chemical epigenetics approach for engineering the in situbiosynthesis of a cryptic natural product from Aspergillus niger
inferredcites →https://doi.org/10.1039/b821578bopenalex-snapshot
Triggering cryptic natural product biosynthesis in microorganisms
inferredcites →https://doi.org/10.1039/b920860gopenalex-snapshot
Epigenome manipulation as a pathway to new natural product scaffolds and their congeners
inferredcites →https://doi.org/10.1039/c0np00061bopenalex-snapshot
Secondary metabolites of fungi from marine habitats
inferredcites →https://doi.org/10.1039/c4np00134fopenalex-snapshot
Dereplication: racing to speed up the natural products discovery process
inferredcites →https://doi.org/10.1039/c5np00050eopenalex-snapshot
Dereplication, sequencing and identification of peptidic natural products: from genome mining to peptidogenomics to spectral networks
inferredcites →https://doi.org/10.1039/c6np00024jopenalex-snapshot
Modern mass spectrometry for synthetic biology and structure-based discovery of natural products
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The evolution of genome mining in microbes – a review
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Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites
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Highly efficient gene replacements in Neurospora strains deficient for nonhomologous end-joining
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Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation
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Accurate prediction of secondary metabolite gene clusters in filamentous fungi
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Dereplicating nonribosomal peptides using an informatic search algorithm for natural products (iSNAP) discovery
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Interkingdom metabolic transformations captured by microbial imaging mass spectrometry
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Prototype of an intertwined secondary-metabolite supercluster
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Searching molecular structure databases with tandem mass spectra using CSI:FingerID
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Topic modeling for untargeted substructure exploration in metabolomics
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Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
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A Novel Automethylation Reaction in the Aspergillus nidulans LaeA Protein Generates S-Methylmethionine
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Bioinformatics tools for the identification of gene clusters that biosynthesize specialized metabolites
inferredcites →https://doi.org/10.1093/bioinformatics/btr659openalex-snapshot
NRPSsp: non-ribosomal peptide synthase substrate predictor
inferredcites →https://doi.org/10.1093/bioinformatics/btv713openalex-snapshot
CASSIS and SMIPS: promoter-based prediction of secondary metabolite gene clusters in eukaryotic genomes
inferredcites →https://doi.org/10.1093/dnares/dsu010openalex-snapshot
Motif-Independent Prediction of a Secondary Metabolism Gene Cluster Using Comparative Genomics: Application to Sequenced Genomes of Aspergillus and Ten Other Filamentous Fungal Species
inferredcites →https://doi.org/10.1093/genetics/165.3.1095openalex-snapshot
Pka, Ras and RGS Protein Interactions Regulate Activity of AflR, a Zn(II)2Cys6 Transcription Factor in Aspergillus nidulans
inferredcites →https://doi.org/10.1093/jxb/eri068openalex-snapshot
Metabolite profiling of fungi and yeast: from phenotype to metabolome by MS and informatics
inferredcites →https://doi.org/10.1093/molbev/mst025openalex-snapshot
Detecting Sequence Homology at the Gene Cluster Level with MultiGeneBlast
inferredcites →https://doi.org/10.1093/nar/gkg607openalex-snapshot
SEARCHPKS: a program for detection and analysis of polyketide synthase domains
inferredcites →https://doi.org/10.1093/nar/gkh359openalex-snapshot
NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases
inferredcites →https://doi.org/10.1093/nar/gki449openalex-snapshot
SEARCHGTr: a program for analysis of glycosyltransferases involved in glycosylation of secondary metabolites
inferredcites →https://doi.org/10.1093/nar/gkn194openalex-snapshot
MassTRIX: mass translator into pathways
inferredcites →https://doi.org/10.1093/nar/gkn685openalex-snapshot
ClustScan : an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures
inferredcites →https://doi.org/10.1093/nar/gkq340openalex-snapshot
SBSPKS: structure based sequence analysis of polyketide synthases
inferredcites →https://doi.org/10.1093/nar/gkr323openalex-snapshot
NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity
inferredcites →https://doi.org/10.1093/nar/gkr466openalex-snapshot
antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
inferredcites →https://doi.org/10.1093/nar/gkt449openalex-snapshot
antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers
inferredcites →https://doi.org/10.1093/nar/gku436openalex-snapshot
CFM-ID: a web server for annotation, spectrum prediction and metabolite identification from tandem mass spectra
inferredcites →https://doi.org/10.1093/nar/gkv1012openalex-snapshot
Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM)
inferredcites →https://doi.org/10.1093/nar/gkv437openalex-snapshot
antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters
inferredcites →https://doi.org/10.1093/nar/gkw159openalex-snapshot
Repurposing the CRISPR-Cas9 system for targeted DNA methylation
inferredcites →https://doi.org/10.1093/nar/gkx319openalex-snapshot
antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification
inferredcites →https://doi.org/10.1097/00000658-197411000-00011openalex-snapshot
Ergot Intoxication
inferredcites →https://doi.org/10.1099/mic.0.2008/018523-0openalex-snapshot
Mining microbial genomes for new natural products and biosynthetic pathways
inferredcites →https://doi.org/10.1101/gr.087551.108openalex-snapshot
Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives
inferredcites →https://doi.org/10.1105/tpc.112.105957openalex-snapshot
In Planta Stage-Specific Fungal Gene Profiling Elucidates the Molecular Strategies of Fusarium graminearum Growing inside Wheat Coleoptiles
inferredcites →https://doi.org/10.1111/1462-2920.13427openalex-snapshot
Knock‐down of the methyltransferase Kmt6 relieves H3K27me3 and results in induction of cryptic and otherwise silent secondary metabolite gene clusters in Fusarium fujikuroi
inferredcites →https://doi.org/10.1111/j.1364-3703.2011.00770.xopenalex-snapshot
Transcriptome analysis of Stagonospora nodorum : gene models, effectors, metabolism and pantothenate dispensability
inferredcites →https://doi.org/10.1111/j.1365-2672.2006.03037.xopenalex-snapshot
Host-derived media used as a predictor for low abundant, in planta metabolite production from necrotrophic fungi
inferredcites →https://doi.org/10.1111/j.1365-2958.2010.07051.xopenalex-snapshot
Heterochromatic marks are associated with the repression of secondary metabolism clusters in Aspergillus nidulans
inferredcites →https://doi.org/10.1111/j.1365-2958.2012.08142.xopenalex-snapshot
veA‐dependent RNA‐pol II transcription elongation factor‐like protein, RtfA, is associated with secondary metabolism and morphological development in Aspergillus nidulans
inferredcites →https://doi.org/10.1111/j.1365-2958.2012.08195.xopenalex-snapshot
Overexpression of the A spergillus nidulans histone 4 acetyltransferase EsaA increases activation of secondary metabolite production
inferredcites →https://doi.org/10.1111/j.1462-2920.2011.02696.xopenalex-snapshot
Production of novel fusarielins by ectopic activation of the polyketide synthase 9 cluster in Fusarium graminearum
inferredcites →https://doi.org/10.1111/mmi.13528openalex-snapshot
The SAGA complex in the rice pathogen F usarium fujikuroi: structure and functional characterization
inferredcites →https://doi.org/10.1111/mmi.13562openalex-snapshot
Discovery of McrA, a master regulator of Aspergillus secondary metabolism
inferredcites →https://doi.org/10.1126/science.1225829openalex-snapshot
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
inferredcites →https://doi.org/10.1126/science.1258096openalex-snapshot
The new frontier of genome engineering with CRISPR-Cas9
inferredcites →https://doi.org/10.1126/science.aaa6097openalex-snapshot
How to bolster the antifungal pipeline
inferredcites →https://doi.org/10.1128/aem.00683-10openalex-snapshot
Activation of a Silent Fungal Polyketide Biosynthesis Pathway through Regulatory Cross Talk with a Cryptic Nonribosomal Peptide Synthetase Gene Cluster
inferredcites →https://doi.org/10.1128/aem.01578-13openalex-snapshot
Distinct Amino Acids of Histone H3 Control Secondary Metabolism in Aspergillus nidulans
inferredcites →https://doi.org/10.1128/aem.33.1.147-158.1977openalex-snapshot
Conidiogenesis and secondary metabolism in Penicillium urticae
inferredcites →https://doi.org/10.1128/aem.54.7.1806-1811.1988openalex-snapshot
Fumonisins--novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme
inferredcites →https://doi.org/10.1128/aem.61.6.2372-2377.1995openalex-snapshot
Increased expression of Aspergillus parasiticus aflR, encoding a sequence-specific DNA-binding protein, relieves nitrate inhibition of aflatoxin biosynthesis
inferredcites →https://doi.org/10.1128/cmr.16.3.497-516.2003openalex-snapshot
Mycotoxins
inferredcites →https://doi.org/10.1128/ec.00186-07openalex-snapshot
Histone Deacetylase Activity Regulates Chemical Diversity in Aspergillus
inferredcites →https://doi.org/10.1128/ec.3.2.527-535.2004openalex-snapshot
LaeA, a Regulator of Secondary Metabolism in Aspergillus spp
inferredcites →https://doi.org/10.1128/ec.5.1.207-211.2006openalex-snapshot
The akuB KU80 Mutant Deficient for Nonhomologous End Joining Is a Powerful Tool for Analyzing Pathogenicity in Aspergillus fumigatus
inferredcites →https://doi.org/10.1128/ec.5.1.212-215.2006openalex-snapshot
Gene Targeting in Aspergillus fumigatus by Homologous Recombination Is Facilitated in a Nonhomologous End- Joining-Deficient Genetic Background
inferredcites →https://doi.org/10.1128/microbiolspec.funk-0009-2016openalex-snapshot
Biologically Active Secondary Metabolites from the Fungi
inferredcites →https://doi.org/10.1128/mmbr.65.1.106-118.2001openalex-snapshot
Biosynthesis of Polyketides in Heterologous Hosts
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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Piperazine-2,5-dione derivatives and an α-pyrone polyketide from Penicillium griseofulvum and their immunosuppression activity
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Metabolic Engineering of Filamentous Fungi
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Collaborative Biosynthesis of a Class of Bioactive Azaphilones by Two Separate Gene Clusters Containing Four PKS/NRPSs with Transcriptional Crosstalk in Fungi
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Collaborative Biosynthesis of a Class of Bioactive Azaphilones by Two Separate Gene Clusters Containing Four PKS/NRPSs with Transcriptional Crosstalk in Fungi
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Horizons of Systems Biocatalysis and Renaissance of Metabolite Synthesis
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Natural Product Synthesis by Fungi: Recent Trends and Future Prospects
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11 New Avenues Toward Drug Discovery in Fungi
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Marine Fungi
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Influence of Genetics on the Secondary Metabolism of Fungi
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Unveiling Microbial Chemical Interactions Based on Metabolomics Approaches
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Discovering New Natural Products Using Metabolomics-Based Approaches
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Endophytic Fungi and the Health Benefits from Their Potential Bioactive Secondary Metabolites
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Introduction to Fungal Secondary Metabolites
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Future Directions in Fungal Secondary Metabolite Research
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Strategies for Tapping into Hidden Potential of Endophytic Fungi as Sources of Novel Biomolecules: Need for an Integrated Approach
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CRISPR-Cas Technology: The Production of Nutritious and Safe Food
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Metabolomic profiling of virulent and non-virulent Beauveria bassiana strains: insights into the pathogenicity of Tetranychus truncatus
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Microbial allies: exploring fungal endophytes for biosynthesis of terpenoid indole alkaloids
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Fungal secondary metabolites in food and pharmaceuticals in the era of multi-omics
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Next-Generation Sequencing in Medicinal Plants: Recent Progress, Opportunities, and Challenges
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Untargeted metabolomics as a hypothesis-generation tool in plant protection product discovery: Highlighting the potential of trehalose and glycerol metabolism of fungal conidiospores as novel targets
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The Ubiquitin–Proteasome System in Brain Disorders: Pathogenic Pathways, Post-Translational Tweaks, and Therapeutic Frontiers
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Exploring the modern approaches to enhance fungal endophyte-derived bioactive secondary metabolites
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Current trends, limitations and future research in the fungi?
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Genome mining and functional characterization of four type I sesquiterpene synthases from the Tiger Milk Mushroom Lignosus rhinocerus
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Chemical Activation of Natural Product Biosynthesis in Filamentous Fungi
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Computational approach to understand fungal secondary metabolites and responsible biological molecules
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Microbial secondary metabolites in plant health
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Molecular approaches to screen bioactive compounds from endophytic fungi
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Industrially important enzymes of endophytic fungi
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Extraction, purification, and identification strategies
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Antiobesity effects of secondary metabolites: Molecular mechanisms and therapeutic potential
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Leveraging artificial intelligence (AI) and machine learning (ML) for enhanced drug discovery and development from microbes
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Pegriseofamines A−E: Five cyclopiazonic acid related indole alkaloids from the fungus Penicillium griseofulvum
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Griseofulvin analogues from the fungus Penicillium griseofulvum and their anti-inflammatory activity
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Lipidomics reveals different therapeutic potential for natural and synthetic vitamin D formulations in hepatocyte lipotoxicity
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Strategies to establish the link between biosynthetic gene clusters and secondary metabolites
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Characterization of a silent azaphilone biosynthesis gene cluster in Aspergillus terreus NIH 2624
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Radicicol - A multifaceted natural product with promising anticancer and anti-inflammatory activities: Insights into its mechanisms and therapeutic perspectives
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Application and prospect of metabolomics-related technologies in food inspection
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Can we control potato fungal and bacterial diseases? — microbial regulation
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A PCR method to identify ochratoxin A-producing Aspergillus westerdijkiae strains on dried and aged foods
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Establishment of GC–MS method for the determination of Pseudomonas aeruginosa biofilm and its application in metabolite enrichment analysis
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Scorpionicidal activity of secondary metabolites from Paecilomyces sp. CMAA1686 against Tityus serrulatus
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Biological control of banana aphid Pentalonia nigronervosa by Akanthomyces lecanii, role of volatile-mediated interactions
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Untapping the potential of plant mycobiomes for applications in agriculture
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Metabolomics reveals differential mechanisms of toxicity of hyperbranched poly(ethyleneimine)-derived nanoparticles to the soil-borne fungus Verticillium dahliae Kleb
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Bergamotane-family sesquiterpenes from histone deacetylase inhibitor modified cultures of the fungicolous fungus Montagnula donacina (Niessl) Wanas., E.B.G. Jones & K.D. Hyde
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Induction of funitatin A, a new polyketide from the Yellow River wetland-derived fungus Talaromyces funiculosus
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Functional analysis of potential fumiquinazoline biosynthetic gene clusters in Penicillium digitatum of citrus
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Genetically-modified activation strategy facilitates the discovery of sesquiterpene-derived metabolites from Penicillium brasilianum
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Dalestones A and B, two anti-inflammatory cyclopentenones from Daldinia eschscholzii with an edited strong promoter for the global regulator LaeA-like gene
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Heterologous production of bioactive xenoacremone analogs in Aspergillus nidulans
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Artificial intelligence in natural products research
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Histone Deacetylase UvHST2 Is a Global Regulator of Secondary Metabolism in Ustilaginoidea virens
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Integrating Genomics and Metabolomics for the Targeted Discovery of New Cyclopeptides with Antifungal Activity from a Marine-Derived Fungus Beauveria felina
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Irpexine, an Isoindolinone Alkaloid Produced by Coculture of Endophytic Fungi, Irpex lacteus and Phaeosphaeria oryzae
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Probing Indole Diketopiperazine-Based Hybrids as Environmental-Induced Products from Aspergillus sp. EGF 15-0-3
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Diasperonins A–F: Anti-inflammatory Aspertetronin Dimers Discovered via BBMN and Heterologous Expression Strategy
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Design of α-Keto Carboxylic Acid Dimers by Domain Recombination of Nonribosomal Peptide Synthetase (NRPS)-Like Enzymes
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The Discovery of Fungal Polyene Macrolides via a Postgenomic Approach Reveals a Polyketide Macrocyclization by trans-Acting Thioesterase in Fungi
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Emeriones A–C: Three Highly Methylated Polyketides with Bicyclo[4.2.0]octene and 3,6-Dioxabicyclo[3.1.0]hexane Functionalities from Emericella nidulans
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Molecular Networking Combined with MALDI-MSI Reveals New Lanostane-Type Triterpenoids with Anti-Hepatocellular Carcinoma Activity and Their Spatial Distribution in the Fruit Body of Ganoderma leucocontextum
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A community resource for paired genomic and metabolomic data mining
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Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices
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Antarctic Streptomyces fildesensis So13.3 strain as a promising source for antimicrobials discovery
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Harnessing diverse transcriptional regulators for natural product discovery in fungi
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Searching for original natural products by molecular networking: detection, isolation and total synthesis of chloroaustralasines
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Dalmanol biosyntheses require coupling of two separate polyketide gene clusters
inferred← citeshttps://doi.org/10.1039/d0np00007hopenalex-snapshot
Secondary metabolites from hypocrealean entomopathogenic fungi: genomics as a tool to elucidate the encoded parvome
inferred← citeshttps://doi.org/10.1039/d0np00080aopenalex-snapshot
Biosynthesis of azaphilones: a review
inferred← citeshttps://doi.org/10.1039/d0ob00989jopenalex-snapshot
Isocoumarin formation by heterologous gene expression and modification by host enzymes
inferred← citeshttps://doi.org/10.1039/d0qo00557fopenalex-snapshot
Molecular networking-based for the target discovery of potent antiproliferative polycyclic macrolactam ansamycins from Streptomyces cacaoi subsp. asoensis
inferred← citeshttps://doi.org/10.1039/d1np00036eopenalex-snapshot
Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities
inferred← citeshttps://doi.org/10.1039/d1np00037copenalex-snapshot
The isolation of water-soluble natural products – challenges, strategies and perspectives
inferred← citeshttps://doi.org/10.1039/d2np00035kopenalex-snapshot
Artificial intelligence in microbial natural product drug discovery: current and emerging role
inferred← citeshttps://doi.org/10.1039/d2ra02092kopenalex-snapshot
Molecular investigations on Candida glabrata clinical isolates for pharmacological targeting
inferred← citeshttps://doi.org/10.1039/d3mo00182bopenalex-snapshot
Metabolomics approach to understand molecular mechanisms involved in fungal pathogen–citrus pathosystems
inferred← citeshttps://doi.org/10.1039/d3np00045aopenalex-snapshot
Harnessing the potential: advances in cyanobacterial natural product research and biotechnology
inferred← citeshttps://doi.org/10.1039/d3ob01850dopenalex-snapshot
Synthesis and biological evaluation of coprinoferrin, an acylated tripeptide hydroxamate siderophore
inferred← citeshttps://doi.org/10.1039/d4fb00357hopenalex-snapshot
Artificial intelligence-driven innovation in Ganoderma spp.: potentialities of their bioactive compounds as functional foods
inferred← citeshttps://doi.org/10.1039/d5nj01897hopenalex-snapshot
Penicillium brefeldianum B. O. Dodge, 1933: insights into its secondary metabolites, pharmacologically active compounds and biotechnological potential
inferred← citeshttps://doi.org/10.1039/d5np00017copenalex-snapshot
Advances in the discovery and study of Trichoderma natural products for biological control applications
inferred← citeshttps://doi.org/10.1073/pnas.2123379119openalex-snapshot
Chemometrics and genome mining reveal an unprecedented family of sugar acid–containing fungal nonribosomal cyclodepsipeptides
inferred← citeshttps://doi.org/10.1073/pnas.2217383120openalex-snapshot
Plant and microbial sciences as key drivers in the development of metabolomics research
inferred← citeshttps://doi.org/10.1079/9781800626911.0009openalex-snapshot
Applied Metabolomics for Plant Biotechnology
inferred← citeshttps://doi.org/10.1080/00275514.2020.1851135openalex-snapshot
Genome sequencing and annotation and phylogenomic analysis of the medicinal mushroom Amauroderma rugosum, a traditional medicinal species in the family Ganodermataceae
inferred← citeshttps://doi.org/10.1080/14786419.2019.1656629openalex-snapshot
New metabolites produced by endophyte Clonostachys rosea B5 − 2
inferred← citeshttps://doi.org/10.1080/14786419.2020.1762191openalex-snapshot
Myrothecol A, a new alkylresorcinol with cytotoxicity from Myrothecium sp.
inferred← citeshttps://doi.org/10.1080/21501203.2024.2354302openalex-snapshot
New bioactive secondary metabolites from fungi: 2023
inferred← citeshttps://doi.org/10.1093/femsre/fuaf028openalex-snapshot
Stepping out of the dark: how metabolomics shed light on fungal biology
inferred← citeshttps://doi.org/10.1109/bip63158.2024.10885379openalex-snapshot
In Silico Identification of Potential Plastic-Active Proteins in Fungi Through a Proteome Comparison Using the Pazy Database
inferred← citeshttps://doi.org/10.1111/1541-4337.12638openalex-snapshot
Chemical repertoire and biosynthetic machinery of the Aspergillus flavus secondary metabolome: A review
inferred← citeshttps://doi.org/10.1111/efp.12766openalex-snapshot
Using a systematic approach to synthesize existing knowledge on Gymnopus fusipes (syn. Collybia fusipes), the cause of Collybia root rot
inferred← citeshttps://doi.org/10.1111/ppa.70293openalex-snapshot
Genome‐Enabled Characterisation of Fusarium sacchari as a Novel Root Rot Pathogen of Coconut
inferred← citeshttps://doi.org/10.1134/s002626172560082xopenalex-snapshot
Metabolic Potential of Pseudogymnoascus spp. Fungi
inferred← citeshttps://doi.org/10.1155/2022/3710791openalex-snapshot
Bioprospecting the Metabolome of Plant Urtica dioica L.: A Fast Dereplication and Annotation Workflow in Plant Metabolomics
inferred← citeshttps://doi.org/10.1177/15578100251392371openalex-snapshot
Integrative Multi-Omics and Artificial Intelligence: A New Paradigm for Systems Biology
inferred← citeshttps://doi.org/10.1186/s12864-023-09656-zopenalex-snapshot
Integrated omic profiling of the medicinal mushroom Inonotus obliquus under submerged conditions
inferred← citeshttps://doi.org/10.1186/s13321-025-01051-yopenalex-snapshot
mineMS2: annotation of spectral libraries with exact fragmentation patterns
inferred← citeshttps://doi.org/10.1186/s43014-026-00393-wopenalex-snapshot
Bioactive secondary metabolites of mushrooms and their potential applications in nutraceuticals, functional foods and cosmeceuticals with selected formulation approaches
inferred← citeshttps://doi.org/10.1360/ssv-2019-0267openalex-snapshot
Antibiotic resistance genes in the soil ecosystem and planetary health: Progress and prospect
inferred← citeshttps://doi.org/10.1371/journal.pone.0277124openalex-snapshot
“Metabolomic diversity of local strains of Beauveria bassiana (Balsamo) Vuillemin and their efficacy against the cassava mite, Tetranychus truncatus Ehara (Acari: Tetranychidae)”
inferred← citeshttps://doi.org/10.14427/jipai.2021.3.66openalex-snapshot
Mycotoxin producers in the VKM mycelial fungi collection
inferred← citeshttps://doi.org/10.22146/jpti.62116openalex-snapshot
Effectiveness of Secondary Metabolites from Entomopathogenic Fungi for Control Nilaparvata lugens Stål. in the Laboratory Scale
inferred← citeshttps://doi.org/10.22207/jpam.16.1.61openalex-snapshot
Characteristics Changes on Applications of Antibiotics and Current Approaches to Enhance Productivity with Soil Microbiome
inferred← citeshttps://doi.org/10.22481/exon.v14i1.20528openalex-snapshot
Metabolismo secundário em fungos e análises in silico: o papel da Bioinformática na predição de clusters de genes biossintéticos
inferred← citeshttps://doi.org/10.22541/au.159646770.00457953openalex-snapshot
Combined comparative genomics and molecular biology approaches provide insights into the terpene synthases inventory in Trichoderma
inferred← citeshttps://doi.org/10.25135/rnp.134.19.01.1243openalex-snapshot
Histone Deacetylase Inhibitor Induced Lipase Inhibitors from Endophytic Phomopsis sp. 0391
inferred← citeshttps://doi.org/10.25177/jeses.5.1.ra.10625openalex-snapshot
The role of marine microorganisms in offshore pollution remediation
inferred← citeshttps://doi.org/10.31315/agrivet.v28i1.6819openalex-snapshot
JAMUR ENDOFIT PADA TANAMAN CABAI (Capsicum sp.) SEBAGAI AGEN PENGENDALI Colletotrichum sp. PENYEBAB PENYAKIT ANTRAKNOSA
inferred← citeshttps://doi.org/10.32657/10356/170083openalex-snapshot
Discovery and characterization of bioactive compounds from endophytic fungi
inferred← citeshttps://doi.org/10.3389/fbioe.2021.649906openalex-snapshot
Current State and Future Directions of Genetics and Genomics of Endophytic Fungi for Bioprospecting Efforts
inferred← citeshttps://doi.org/10.3389/fgene.2020.00114openalex-snapshot
Metabolome Analysis Identified Okaramines in the Soybean Rhizosphere as a Legacy of Hairy Vetch
inferred← citeshttps://doi.org/10.3389/fgene.2020.600116openalex-snapshot
The Integration of Genome Mining, Comparative Genomics, and Functional Genetics for Biosynthetic Gene Cluster Identification
inferred← citeshttps://doi.org/10.3389/fmicb.2018.02212openalex-snapshot
A Class 1 Histone Deacetylase as Major Regulator of Secondary Metabolite Production in Aspergillus nidulans
inferred← citeshttps://doi.org/10.3389/fmicb.2019.00285openalex-snapshot
Mapping the Fungal Battlefield: Using in situ Chemistry and Deletion Mutants to Monitor Interspecific Chemical Interactions Between Fungi
inferred← citeshttps://doi.org/10.3389/fmicb.2021.638096openalex-snapshot
Applications of CRISPR/Cas9 in the Synthesis of Secondary Metabolites in Filamentous Fungi
inferred← citeshttps://doi.org/10.3389/fmicb.2022.1033823openalex-snapshot
Polyketides isolated from an endophyte Penicillium oxalicum 2021CDF-3 inhibit pancreatic tumor growth
inferred← citeshttps://doi.org/10.3389/fmicb.2022.897756openalex-snapshot
Editorial: Strategies for the Discovery of Fungal Natural Products
inferred← citeshttps://doi.org/10.3389/fmicb.2023.1253850openalex-snapshot
Editorial: The discovery of bioactive natural products: the isolation and structural elucidation, genome mining, OSMAC strategy, and biotransformation
inferred← citeshttps://doi.org/10.3389/fmicb.2023.1254609openalex-snapshot
Study on secondary metabolites of endophytic fungus Diaporthe sp. AC1 induced by tryptophan analogs
inferred← citeshttps://doi.org/10.3389/fmicb.2023.1287582openalex-snapshot
A novel endophytic fungus strain of Cladosporium: its identification, genomic analysis, and effects on plant growth
inferred← citeshttps://doi.org/10.3389/fmicb.2024.1411645openalex-snapshot
Mannitol mediates the mummification behavior of Thitarodes xiaojinensis larvae infected with Ophiocordyceps sinensis
inferred← citeshttps://doi.org/10.3389/fmicb.2026.1841716openalex-snapshot
The endophyte Fusarium oxysporum 3RR genome analysis identifies bioactive compounds targeting biofilm formation
inferred← citeshttps://doi.org/10.3390/agronomy15061350openalex-snapshot
Microbial Secondary Metabolites and Their Use in Achieving Sustainable Agriculture: Present Achievements and Future Challenges
inferred← citeshttps://doi.org/10.3390/genes12101470openalex-snapshot
Fungal Lysine Deacetylases in Virulence, Resistance, and Production of Small Bioactive Compounds
inferred← citeshttps://doi.org/10.3390/ijms19071986openalex-snapshot
Date Palm Trees Root-Derived Endophytes as Fungal Cell Factories for Diverse Bioactive Metabolites
inferred← citeshttps://doi.org/10.3390/ijms222413309openalex-snapshot
Fungal Secondary Metabolites as Inhibitors of the Ubiquitin–Proteasome System
inferred← citeshttps://doi.org/10.3390/jof10050320openalex-snapshot
Integrated Transcriptomics and Metabolomics Analysis Reveal the Regulatory Mechanisms Underlying Sodium Butyrate-Induced Carotenoid Biosynthesis in Rhodotorula glutinis
inferred← citeshttps://doi.org/10.3390/jof10070466openalex-snapshot
Preliminary Bioactivity Assessment of Myrothecium Species (Stachybotryaceae) Crude Extracts against Aedes aegypti (Diptera: Culicidae): A First Approach from This Phytopathogenic Fungi
inferred← citeshttps://doi.org/10.3390/jof10120826openalex-snapshot
Genomic Features of Taiwanofungus gaoligongensis and the Transcriptional Regulation of Secondary Metabolite Biosynthesis
inferred← citeshttps://doi.org/10.3390/jof11020093openalex-snapshot
Fungal Metabolomics: A Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying Potential Therapeutics
inferred← citeshttps://doi.org/10.3390/jof11040323openalex-snapshot
Genomic and Multi-Omics Analysis of Phlebopus portentosus: Effects of Cultivation on Secondary Metabolites
inferred← citeshttps://doi.org/10.3390/jof11060449openalex-snapshot
Engineering of Global Transcriptional Regulators (GTRs) in Aspergillus for Natural Product Discovery
inferred← citeshttps://doi.org/10.3390/jof11080546openalex-snapshot
Exploring the Anti-Alzheimer’s Disease Potential of Aspergillus terreus C23-3 Through Genomic Insights, Metabolomic Analysis, and Molecular Docking
inferred← citeshttps://doi.org/10.3390/jof7100786openalex-snapshot
Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds
inferred← citeshttps://doi.org/10.3390/jof9010009openalex-snapshot
Complementary Strategies to Unlock Biosynthesis Gene Clusters Encoding Secondary Metabolites in the Filamentous Fungus Podospora anserina
inferred← citeshttps://doi.org/10.3390/jof9020172openalex-snapshot
Recent Advances in Search of Bioactive Secondary Metabolites from Fungi Triggered by Chemical Epigenetic Modifiers
inferred← citeshttps://doi.org/10.3390/jof9040459openalex-snapshot
Secondary Metabolites Produced by the Blue-Cheese Ripening Mold Penicillium roqueforti; Biosynthesis and Regulation Mechanisms
inferred← citeshttps://doi.org/10.3390/jof9080785openalex-snapshot
Light-Induced Changes in Secondary Metabolite Production of Trichoderma atroviride
inferred← citeshttps://doi.org/10.3390/microorganisms10050853openalex-snapshot
Interacting Environmental Stress Factors Affect Metabolomics Profiles in Stored Naturally Contaminated Maize
inferred← citeshttps://doi.org/10.3390/microorganisms8101603openalex-snapshot
Combined Comparative Genomics and Gene Expression Analyses Provide Insights into the Terpene Synthases Inventory in Trichoderma
inferred← citeshttps://doi.org/10.3390/microorganisms9010197openalex-snapshot
Fungal Endophytes as Efficient Sources of Plant-Derived Bioactive Compounds and Their Prospective Applications in Natural Product Drug Discovery: Insights, Avenues, and Challenges
inferred← citeshttps://doi.org/10.3390/molecules27206797openalex-snapshot
Advances in Fungal Phenaloenones—Natural Metabolites with Great Promise: Biosynthesis, Bioactivities, and an In Silico Evaluation of Their Potential as Human Glucose Transporter 1 Inhibitors
inferred← citeshttps://doi.org/10.3390/toxins11090498openalex-snapshot
Insights into the Diversity of Secondary Metabolites of Planktothrix Using a Biphasic Approach Combining Global Genomics and Metabolomics
inferred← citeshttps://doi.org/10.3987/com-22-14669openalex-snapshot
Antimicrobial Acetophenone and Phenalenone Derivatives from a Soil-Derived Fungus Penicillium Verrucisporum JX1
inferred← citeshttps://doi.org/10.4014/jmb.2301.01017openalex-snapshot
Induction of Fungal Secondary Metabolites by Co-Culture with Actinomycete Producing HDAC Inhibitor Trichostatins
inferred← citeshttps://doi.org/10.4103/jpbs.jpbs_1390_25openalex-snapshot
Radicicol as a Dual-Site Inhibitor of Isoprenylcysteine Carboxyl Methyltransferase: A Computational Study
inferred← citeshttps://doi.org/10.4236/aim.2022.129037openalex-snapshot
Effect of Crude Drug Extracts on Trypacidin Production in Aspergillus fumigatus
inferred← citeshttps://doi.org/10.51847/c817qophisopenalex-snapshot
Who Actually Makes the Metabolite? A Critical Review of Plant–Endophyte Attribution, Reproducibility, and Biosynthetic Evidence in Medicinal-Plant Natural Products
inferred← citeshttps://doi.org/10.52832/jesh.v6i3.702openalex-snapshot
DIVERSIDADE SAZONAL E POTENCIAL BIOTECNOLÓGICO DE FUNGOS ANEMÓFILOS DO AGRESTE MERIDIONAL DE PERNAMBUCO
inferred← citeshttps://doi.org/10.52845/cmro/2023/6-12-5openalex-snapshot
In vitro Antimicrobial Activity of Plant Extracts on Pseudomonas aeruginosa and Screening of Bioactive Chemical Compounds
inferred← citeshttps://doi.org/10.57046/geju2863openalex-snapshot
Environmental contribution to antimicrobial resistance: A largely ignored global health issue
inferred← citeshttps://doi.org/10.5812/jjm-172325openalex-snapshot
Enhancement of Anti-MRSA Activity in Endophytic Streptomyces drozdowiczii Ca2- 5 Through OSMAC and Light-Regime Optimization
inferred← citeshttps://doi.org/10.6092/issn.2531-7342/12700openalex-snapshot
A review on different approaches to isolate antibiotic compounds from fungi
inferred← citeshttps://doi.org/10.70675/e4fc75f5zb1baz42d1zbbfaz24db3d704ba8openalex-snapshot
Interdisciplinary approach for the functional characterization of secondary metabolite gene clusters in the filamentous fungus Podospora anserina
inferred← citeshttps://doi.org/10.70675/f9f211c7zf244z4823zbf9az25e9adfe4295openalex-snapshot
Nouvelle stratégie de priorisation pour l’étude des produits naturels par l’approche des réseaux moléculaires multi-informatifs
inferred← citeshttps://doi.org/10.70675/fbafed8dz2a68z4b0ez8c94zffe5cd68f613openalex-snapshot
Étude de l'adaptation chez Penicillium roqueforti : approches fonctionnelle et de génomique évolutive
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.