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Rocaglamide and silvestrol: a long story from anti-tumor to anti-coronavirus compounds

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ps.2780360109openalex-snapshot

Activity of rocaglamide, an insecticidal natural product, against the variegated cutworm, Peridroma saucia (lepidoptera: noctuidae)

inferredcites →https://doi.org/10.1016/j.antiviral.2004.05.001openalex-snapshot

Application of real-time PCR for testing antiviral compounds against Lassa virus, SARS coronavirus and Ebola virus in vitro

inferredcites →https://doi.org/10.1016/j.antiviral.2016.11.011openalex-snapshot

The natural compound silvestrol is a potent inhibitor of Ebola virus replication

inferredcites →https://doi.org/10.1016/j.antiviral.2017.12.010openalex-snapshot

Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses

inferredcites →https://doi.org/10.1016/j.antiviral.2018.07.010openalex-snapshot

The natural compound silvestrol inhibits hepatitis E virus (HEV) replication in vitro and in vivo

inferredcites →https://doi.org/10.1016/j.antiviral.2020.104706openalex-snapshot

Comparison of broad-spectrum antiviral activities of the synthetic rocaglate CR-31-B (−) and the eIF4A-inhibitor Silvestrol

inferredcites →https://doi.org/10.1016/j.ceb.2008.12.011openalex-snapshot

PI3K and mTOR inhibitors — a new generation of targeted anticancer agents

inferredcites →https://doi.org/10.1016/j.drudis.2011.02.008openalex-snapshot

Targeting the mTOR kinase domain: the second generation of mTOR inhibitors

inferredcites →https://doi.org/10.1016/j.jcv.2010.09.018openalex-snapshot

Complete sequence and phylogenetic characterisation of Crimean–Congo hemorrhagic fever virus from Afghanistan

inferredcites →https://doi.org/10.1016/j.molcel.2018.11.026openalex-snapshot

The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA

inferredcites →https://doi.org/10.1016/j.phytochem.2007.06.016openalex-snapshot

Flavaglines and triterpenoids from the leaves of Aglaia forbesii

inferredcites →https://doi.org/10.1016/s0031-9422(98)00751-1openalex-snapshot

An insecticidal rocaglamide derivatives and related compounds from Aglaia odorata (Meliaceae)

inferredcites →https://doi.org/10.1021/ja00180a081openalex-snapshot

An unusual oxidative cyclization. A synthesis and absolute stereochemical assignment of (-)-rocaglamide

inferredcites →https://doi.org/10.1021/jf990509hopenalex-snapshot

Cyclopenta[b]benzofurans from Aglaia Species with Pronounced Antifungal Activity against Rice Blast Fungus (Pyricularia grisea)

inferredcites →https://doi.org/10.1021/jo040120fopenalex-snapshot

Silvestrol and Episilvestrol, Potential Anticancer Rocaglate Derivatives from Aglaia silvestris

inferredcites →https://doi.org/10.1021/np100503qopenalex-snapshot

Isolation and Characterization of Minor Analogues of Silvestrol and Other Constituents from a Large-Scale Re-collection of Aglaia foveolata

inferredcites →https://doi.org/10.1021/np3007588openalex-snapshot

Bioactive Flavaglines and Other Constituents Isolated from Aglaia perviridis

inferredcites →https://doi.org/10.1038/d41573-020-00016-0openalex-snapshot

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

inferredcites →https://doi.org/10.1038/nrd4505openalex-snapshot

Targeting the translation machinery in cancer

inferredcites →https://doi.org/10.1038/s41421-020-0153-3openalex-snapshot

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

inferredcites →https://doi.org/10.1039/c39820001150openalex-snapshot

X-Ray crystal structure of rocaglamide, a novel antileulemic 1H-cyclopenta[b]benzofuran from Aglaia elliptifolia

inferredcites →https://doi.org/10.1039/c4np00006dopenalex-snapshot

Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species

inferredcites →https://doi.org/10.1056/nejmoa1100391openalex-snapshot

Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis

inferredcites →https://doi.org/10.1074/jbc.m208003200openalex-snapshot

Rocaglamide Derivatives Are Potent Inhibitors of NF-κB Activation in T-cells

inferredcites →https://doi.org/10.1093/annonc/mdi113openalex-snapshot

mTOR-targeted therapy of cancer with rapamycin derivatives

inferredcites →https://doi.org/10.1172/jci34753openalex-snapshot

Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model

inferredcites →https://doi.org/10.1172/jci44145openalex-snapshot

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

inferredcites →https://doi.org/10.1371/journal.pone.0005223openalex-snapshot

Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

inferredcites →https://doi.org/10.1515/znc-1999-1-210openalex-snapshot

Structure Activity Relationships of Antiproliferative Rocaglamide Derivatives from Aglaia Species (Meliaceae)

inferredcites →https://doi.org/10.3390/ijms19061578openalex-snapshot

Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery

inferredcites →https://doi.org/10.3390/v10040149openalex-snapshot

Inhibition of Zika Virus Replication by Silvestrol

inferredcites →https://doi.org/10.3390/v10060301openalex-snapshot

Inhibition of Hepatitis E Virus Spread by the Natural Compound Silvestrol

inferredcites →https://doi.org/10.7164/antibiotics.28.727openalex-snapshot

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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A/D-rings-seco limonoids from the fruits of Aglaia edulis and their bioactivities

inferred← citeshttps://doi.org/10.2139/ssrn.4665170openalex-extracted

Assessment of Rocaglates and Targeted Derivatives as Selective Inhibitors of Glioblastoma Stem Cells

inferred← citeshttps://doi.org/10.3897/pharmacia.70.e111111zenodo-depositor-declared

Isolation and activity test of antioxidant, antibacterial, and cytotoxic compounds from the stem bark of Aglaia foveolata Pannell

inferred← citeshttps://doi.org/10.1002/9783527840458.ch4openalex-snapshot

Screening and Lead Generation Techniques for RNA Binders

inferred← citeshttps://doi.org/10.1002/ardp.202200367openalex-snapshot

Synthetic flavagline derivative 1‐chloroacetylrocaglaol promotes apoptosis in K562 erythroleukemia cells through miR‐17‐92 cluster genes

inferred← citeshttps://doi.org/10.1002/cssc.202102557openalex-snapshot

Progress in the Electrochemical Reactions of Sulfonyl Compounds

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Comparative phytochemistry of flavaglines (= rocaglamides), a group of highly bioactive flavolignans from Aglaia species (Meliaceae)

inferred← citeshttps://doi.org/10.1016/j.antiviral.2022.105359openalex-snapshot

Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication

inferred← citeshttps://doi.org/10.1016/j.antiviral.2024.105976openalex-snapshot

Amidino-rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis

inferred← citeshttps://doi.org/10.1016/j.apsb.2025.12.010openalex-snapshot

Targeting RNA binding proteins with small-molecule inhibitors: Advances, challenges, and therapeutic opportunities

inferred← citeshttps://doi.org/10.1016/j.bcp.2026.118060openalex-snapshot

RNA splicing regulation and tumor: A focus on the multifunctional SRSF family as a therapeutic target

inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108612openalex-snapshot

A natural flavagline derivative A2073 inhibits the proliferation of erythroleukemia cells by targeting the MAPK, PI3K, NF-κB, and cell cycle pathways

inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113041openalex-snapshot

RETRACTED: Natural therapeutics and nutraceuticals for lung diseases: Traditional significance, phytochemistry, and pharmacology

inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117047openalex-snapshot

Silvestrol, a potent anticancer agent with unfavourable pharmacokinetics: Current knowledge on its pharmacological properties and future directions for the development of novel drugs

inferred← citeshttps://doi.org/10.1016/j.celrep.2021.109806openalex-snapshot

Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

inferred← citeshttps://doi.org/10.1016/j.chempr.2022.04.006openalex-snapshot

Stereodivergent total synthesis of rocaglaol initiated by synergistic dual-metal-catalyzed asymmetric allylation of benzofuran-3(2H)-one

inferred← citeshttps://doi.org/10.1016/j.jbc.2025.110173openalex-snapshot

The nucleocapsid protein of Crimean–Congo hemorrhagic fever virus interacts with eIF4A to promote the translation of viral mRNA in cells

inferred← citeshttps://doi.org/10.1016/j.molstruc.2024.141195openalex-snapshot

Steroids and terpenoids from Aglaia edulis and their anti-inflammatory activities

inferred← citeshttps://doi.org/10.1016/j.phrs.2022.106116openalex-snapshot

Pediatric acute lymphoblastic leukemia management using multitargeting bioactive natural compounds: A systematic and critical review

inferred← citeshttps://doi.org/10.1016/j.phrs.2024.107449openalex-snapshot

Harnessing natural inhibitors of protein synthesis for cancer therapy: A comprehensive review

inferred← citeshttps://doi.org/10.1016/j.tet.2025.134899openalex-snapshot

Recent advances in the synthesis of heteropolyquinanes

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c01357openalex-snapshot

Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c01330openalex-snapshot

RNA-Binding Small Molecules in Drug Discovery and Delivery: An Overview from Fundamentals

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.4c01194openalex-snapshot

Cyclopenta[bc]benzopyran Derivatives and Limonoids from Aglaia edulis with Cytotoxic and Anti-DENV Activity

inferred← citeshttps://doi.org/10.1021/acs.joc.1c00968openalex-snapshot

Aglatestine A, a Rearranged Limonoid with a 3/6/6 Tricarbocyclic Framework from the Fruits of Aglaia edulis

inferred← citeshttps://doi.org/10.1021/acs.orglett.2c01403openalex-snapshot

Regioselective Cycloaddition and Substitution Reaction of Tertiary Propargylic Alcohols and Heteroareneboronic Acids via Acid Catalysis

inferred← citeshttps://doi.org/10.1021/acs.orglett.2c03472openalex-snapshot

Synthesis of Annulated Benzofuran Derivatives from α-(Iodophenyl)-β-oxoesters

inferred← citeshttps://doi.org/10.1021/acs.orglett.4c04242openalex-snapshot

Enzyme-Catalyzed Dynamic Kinetic Resolution for the Asymmetric Synthesis of 2,3-Dihydrobenzofuran Esters and Evaluation of Their Anti-inflammatory Activity

inferred← citeshttps://doi.org/10.1021/acs.orglett.5c04290openalex-snapshot

Accessing Dihydroazepines and Cyclopentanes from Enynyl Ketones

inferred← citeshttps://doi.org/10.1021/acscatal.1c01321openalex-snapshot

Enantioselective Intermolecular Mannich-Type Interception of Phenolic Oxonium Ylide for the Direct Assembly of Chiral 2,2-Disubstituted Dihydrobenzofurans

inferred← citeshttps://doi.org/10.1021/acscentsci.4c01073openalex-snapshot

Identification of Rocaglate Acyl Sulfamides as Selective Inhibitors of Glioblastoma Stem Cells

inferred← citeshttps://doi.org/10.1021/jacs.3c03182openalex-snapshot

Catalytic Enantioselective Intramolecular Oxa-Michael Reaction to α,β-Unsaturated Esters and Amides

inferred← citeshttps://doi.org/10.1021/jacs.6c06480openalex-snapshot

A Near-Infrared-Triggered Luminescence-Activated System for In Vivo Biomacromolecular Tagging and Photocatalytic Crosslinking for Large-Scale Investigation of RNA-Protein Complexes in Living Mice

inferred← citeshttps://doi.org/10.1038/s41573-022-00521-4openalex-snapshot

Targeting RNA structures with small molecules

inferred← citeshttps://doi.org/10.1039/9781837676842-00114openalex-snapshot

Routes to Production of Plant Natural Products for Use as Active Ingredients in Bioinsecticides

inferred← citeshttps://doi.org/10.1039/d2np00080fopenalex-snapshot

Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study

inferred← citeshttps://doi.org/10.1039/d3ra01383aopenalex-snapshot

Anticancer therapeutic potential of benzofuran scaffolds

inferred← citeshttps://doi.org/10.1039/d5np00073dopenalex-snapshot

Green gold of the Pacific: unlocking compounds from terrestrial flora for antitumor and immunomodulatory drug discovery

inferred← citeshttps://doi.org/10.1055/a-1401-9562openalex-snapshot

Update on Phytochemical and Biological Studies on Rocaglate Derivatives from Aglaia Species

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Medicinal plants of Sabah (North Borneo): lest we forget

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Antiviral plant-derived natural products to combat RNA viruses: Targets throughout the viral life cycle

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The eIF4A Inhibitor Silvestrol Blocks the Growth of Human Glioblastoma Cells by Inhibiting AKT/mTOR and ERK1/2 Signaling Pathway

inferred← citeshttps://doi.org/10.1186/s12885-022-10280-5openalex-snapshot

Methionine regulates self-renewal, pluripotency, and cell death of GIC through cholesterol—rRNA axis

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Progress in the study of non-limonoid natural products of the Meliaceae family

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Flavaglines: Their Discovery from Plants Used in Traditional Chinese Medicine, Synthesis, and Drug Development Against Cancer and Immune Disorders

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Antioxidant, Antibacterial and Antibiofilm Activities of an Endophytic Fungi, Penicillium Sp. SAF6-EGY Strain AFL.2 and Arthrinium Sp. R22-1 Strain AFL.3 Isolated from Aglaia Foveolata

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Silvestrol alleviates glioblastoma progression through ERK pathway modulation and MANBA and NRG-1 expression

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Broad-spectrum host-targeting antivirals for rhinovirus infections: mechanisms and future perspectives

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Naturally Occurring Bioactives as Antivirals: Emphasis on Coronavirus Infection

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Differential Effects on the Translation of Immune-Related Alternatively Polyadenylated mRNAs in Melanoma and T Cells by eIF4A Inhibition

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Targeting the DEAD-Box RNA Helicase eIF4A with Rocaglates—A Pan-Antiviral Strategy for Minimizing the Impact of Future RNA Virus Pandemics

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Design, Synthesis, and Cytotoxic Activity of Novel Natural Arylsulfonamide-Inspired Molecules

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Additional file 1 of Methionine regulates self-renewal, pluripotency, and cell death of GIC through cholesterol—rRNA axis

inferred← citeshttps://doi.org/10.6084/m9.figshare.22603387openalex-snapshot

Additional file 2 of Methionine regulates self-renewal, pluripotency, and cell death of GIC through cholesterol—rRNA axis

inferred← citeshttps://doi.org/10.6084/m9.figshare.22603390openalex-snapshot

Additional file 3 of Methionine regulates self-renewal, pluripotency, and cell death of GIC through cholesterol—rRNA axis

inferred← citeshttps://doi.org/10.6084/m9.figshare.22603393openalex-snapshot

Additional file 4 of Methionine regulates self-renewal, pluripotency, and cell death of GIC through cholesterol—rRNA axis

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Pre-mRNA 3'-end polyadenylation : impact on UV-induced DNA damage and on the translatability of immune-related genes

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Mécanismes d'infection, pathogenèse et persistance du virus de l'hépatite E chez l'humain : étude des compartiments digestif et urinaire

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