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Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Regio‐ and Stereoselective Monoamination of Diketones without Protecting Groups
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Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution
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Total Syntheses of (−)‐Huperzine Q and (+)‐Lycopladines B and C
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A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation
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Enzymatic and Chemoenzymatic Three‐Step Cascades for the Synthesis of Stereochemically Complementary Trisubstituted Tetrahydroisoquinolines
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Directed Evolution: Bringing New Chemistry to Life
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A Six‐Oxidase Cascade for Tandem C−H Bond Activation Revealed by Reconstitution of Bicyclomycin Biosynthesis
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Multi‐Functional Oxidase Activity of CYP102A1 (P450BM3) in the Oxidation of Quinolines and Tetrahydroquinolines
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Directed Evolution of a Tryptophan 2,3‐Dioxygenase for the Diastereoselective Monooxygenation of Tryptophans
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Biochemical characterization reveals the functional divergence of two tropinone reductases from Przewalskia tangutica
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Tools of pathway reconstruction and production of economically relevant plant secondary metabolites in recombinant microorganisms
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Library of Norcoclaurine Synthases and Their Immobilization for Biocatalytic Transformations
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Synthesis of 2,5‐Disubstituted Pyrrolidine Alkaloids via A One‐Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts
inferredcites →https://doi.org/10.1002/chem.201604620openalex-snapshot
Total Synthesis of Gelsedilam by Means of a Thiol‐Mediated Diastereoselective Conjugate Addition–Aldol Reaction
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Biological importance of the indole nucleus in recent years: A comprehensive review
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A Novel Enzymatic Strategy for the Synthesis of Substituted Tetrahydroisoquinolines
inferredcites →https://doi.org/10.1007/s00253-016-7365-3openalex-snapshot
Saturation mutagenesis on Arg244 of the tryptophan C4-prenyltransferase FgaPT2 leads to enhanced catalytic ability and different preferences for tryptophan-containing cyclic dipeptides
inferredcites →https://doi.org/10.1007/s00253-018-8761-7openalex-snapshot
Convenient synthetic approach for tri- and tetraprenylated cyclodipeptides by consecutive enzymatic prenylations
inferredcites →https://doi.org/10.1007/s00425-016-2610-7openalex-snapshot
Potato plants with genetically engineered tropane alkaloid precursors
inferredcites →https://doi.org/10.1007/s00438-015-1005-yopenalex-snapshot
Transcriptome exploration for further understanding of the tropane alkaloids biosynthesis in Anisodus acutangulus
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Present status of Catharanthus roseus monoterpenoid indole alkaloids engineering in homo- and hetero-logous systems
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Recent Advances in Re-engineering Modular PKS and NRPS Assembly Lines
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Molecular mechanism of metabolic NAD(P)H-dependent electron-transfer systems: The role of redox cofactors
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Comparison of two hyoscyamine 6β-hydroxylases in engineering scopolamine biosynthesis in root cultures of Scopolia lurida
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Beyond the outer limits of nature by directed evolution
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Directed enzyme evolution: climbing fitness peaks one amino acid at a time
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Pictet–Spenglerases in alkaloid biosynthesis: Future applications in biocatalysis
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Structural Basis for β-Carboline Alkaloid Production by the Microbial Homodimeric Enzyme McbB
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Exploiting plant alkaloids
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Microbial cell factories for the sustainable manufacturing of B vitamins
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Indoles — A promising scaffold for drug development
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Efficient biosynthesis of rare natural product scopolamine using E. coli cells expressing a S14P/K97A mutant of hyoscyamine 6β-hydroxylase AaH6H
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Characterization of a new microbial Pictet-Spenglerase NscbB affording the β-carboline skeletons from Nocardiopsis synnemataformans DSM 44143
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Engineering of Thermovibrio ammonificans carbonic anhydrase mutants with increased thermostability
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Characterization of Coptis japonica CjABCB2, an ATP-binding cassette protein involved in alkaloid transport
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Functional characterisation of a tropine-forming reductase gene from Brugmansia arborea, a woody plant species producing tropane alkaloids
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A multidrug and toxic compound extrusion transporter mediates berberine accumulation into vacuoles in Coptis japonica
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Alkaloids as drug leads – A predictive structural and biodiversity-based analysis
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Alkaloid chemodiversity in Mandragora spp. is associated with loss-of-functionality of MoH6H, a hyoscyamine 6β-hydroxylase gene
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Discovery and modification of cytochrome P450 for plant natural products biosynthesis
inferredcites →https://doi.org/10.1016/s0065-2725(16)x0003-7openalex-snapshot
Heterocyclic Chemistry in the 21st Century - A Tribute to Alan Katritzky
inferredcites →https://doi.org/10.1016/s0140-6736(18)31813-0openalex-snapshot
Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial
inferredcites →https://doi.org/10.1021/acs.chemrev.9b00525openalex-snapshot
Evolution and Diversity of Assembly-Line Polyketide Synthases
inferredcites →https://doi.org/10.1021/acs.jnatprod.7b00430openalex-snapshot
Mutations of Residues in Pocket P1 of a Cyclodipeptide Synthase Strongly Increase Product Formation
inferredcites →https://doi.org/10.1021/acs.joc.8b00517openalex-snapshot
Improved Synthesis of 4-Cyanotryptophan and Other Tryptophan Analogues in Aqueous Solvent Using Variants of TrpB from Thermotoga maritima
inferredcites →https://doi.org/10.1021/acs.joc.9b01971openalex-snapshot
Catalytic Asymmetric Total Syntheses of (−)-Galanthamine and (−)-Lycoramine
inferredcites →https://doi.org/10.1021/acs.orglett.0c01132openalex-snapshot
Enzyme-Catalyzed Azepinoindole Formation in Clavine Alkaloid Biosynthesis
inferredcites →https://doi.org/10.1021/acs.orglett.6b02322openalex-snapshot
Asymmetric Total Synthesis of (−)-Lycospidine A
inferredcites →https://doi.org/10.1021/acs.orglett.8b03124openalex-snapshot
Complete Decoration of the Indolyl Residue in cyclo- l -Trp- l -Trp with Geranyl Moieties by Using Engineered Dimethylallyl Transferases
inferredcites →https://doi.org/10.1021/acs.orglett.8b03236openalex-snapshot
A Phenylpyruvic Acid Reductase Is Required for Biosynthesis of Tropane Alkaloids
inferredcites →https://doi.org/10.1021/acscatal.0c02400openalex-snapshot
Biocatalytic Access to 1,4-Diazepanes via Imine Reductase-Catalyzed Intramolecular Asymmetric Reductive Amination
inferredcites →https://doi.org/10.1021/acscatal.5b01839openalex-snapshot
Stereoselective Cascade to C3-Methylated Strictosidine Derivatives Employing Transaminases and Strictosidine Synthases
inferredcites →https://doi.org/10.1021/acscatal.6b00855openalex-snapshot
One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts
inferredcites →https://doi.org/10.1021/acscatal.8b00291openalex-snapshot
Biocatalytic Access to Piperazines from Diamines and Dicarbonyls
inferredcites →https://doi.org/10.1021/acscatal.9b04617openalex-snapshot
Rational Engineered C-Acyltransferase Transforms Sterically Demanding Acyl Donors
inferredcites →https://doi.org/10.1021/acscatal.9b04691openalex-snapshot
Directed Evolution of an Fe II -Dependent Halogenase for Asymmetric C(sp 3 )–H Chlorination
inferredcites →https://doi.org/10.1021/acscatal.9b05417openalex-snapshot
Structure-Guided Engineering of a Scoulerine 9- O -Methyltransferase Enables the Biosynthesis of Tetrahydropalmatrubine and Tetrahydropalmatine in Yeast
inferredcites →https://doi.org/10.1021/acssynbio.5b00120openalex-snapshot
Two Distinct Cyclodipeptide Synthases from a Marine Actinomycete Catalyze Biosynthesis of the Same Diketopiperazine Natural Product
inferredcites →https://doi.org/10.1021/acssynbio.8b00339openalex-snapshot
A Highly Characterized Synthetic Landing Pad System for Precise Multicopy Gene Integration in Yeast
inferredcites →https://doi.org/10.1021/acssynbio.8b00483openalex-snapshot
Building Microbial Hosts for Heterologous Production of N-Methylpyrrolinium
inferredcites →https://doi.org/10.1021/acssynbio.9b00152openalex-snapshot
De Novo Production of the Plant-Derived Tropine and Pseudotropine in Yeast
inferredcites →https://doi.org/10.1021/acssynbio.9b00461openalex-snapshot
Engineering Tropane Alkaloid Production Based on Metabolic Characterization of Ornithine Decarboxylase in Atropa belladonna
inferredcites →https://doi.org/10.1021/cr200398yopenalex-snapshot
2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products
inferredcites →https://doi.org/10.1021/ja2089348openalex-snapshot
Reengineering a Tryptophan Halogenase To Preferentially Chlorinate a Direct Alkaloid Precursor
inferredcites →https://doi.org/10.1021/jacs.6b04836openalex-snapshot
Synthesis of β-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan Synthase
inferredcites →https://doi.org/10.1021/jacs.7b05007openalex-snapshot
Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues
inferredcites →https://doi.org/10.1021/jacs.9b08704openalex-snapshot
Inverted Binding of Non-natural Substrates in Strictosidine Synthase Leads to a Switch of Stereochemical Outcome in Enzyme-Catalyzed Pictet–Spengler Reactions
inferredcites →https://doi.org/10.1021/ol5036497openalex-snapshot
Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis
inferredcites →https://doi.org/10.1038/nature18634openalex-snapshot
Human commensals producing a novel antibiotic impair pathogen colonization
inferredcites →https://doi.org/10.1038/nchembio.1717openalex-snapshot
Acetylation serves as a protective group in noscapine biosynthesis in opium poppy
inferredcites →https://doi.org/10.1038/nchembio.2411openalex-snapshot
A heme-dependent enzyme forms the nitrogen–nitrogen bond in piperazate
inferredcites →https://doi.org/10.1038/ncomms10390openalex-snapshot
Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli
inferredcites →https://doi.org/10.1038/ncomms12137openalex-snapshot
Engineering biosynthesis of the anticancer alkaloid noscapine in yeast
inferredcites →https://doi.org/10.1038/s41467-017-01695-xopenalex-snapshot
Combinatorial metabolic engineering using an orthogonal tri-functional CRISPR system
inferredcites →https://doi.org/10.1038/s41467-018-07671-3openalex-snapshot
Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization
inferredcites →https://doi.org/10.1038/s41467-019-09610-2openalex-snapshot
Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids
inferredcites →https://doi.org/10.1038/s41467-019-09848-wopenalex-snapshot
Synthetic biology strategies for microbial biosynthesis of plant natural products
inferredcites →https://doi.org/10.1038/s41467-019-11588-wopenalex-snapshot
Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids
inferredcites →https://doi.org/10.1038/s41467-019-11987-zopenalex-snapshot
Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation
inferredcites →https://doi.org/10.1038/s41467-020-17172-xopenalex-snapshot
A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids
inferredcites →https://doi.org/10.1038/s41586-020-2546-8openalex-snapshot
Discovery and engineering of colchicine alkaloid biosynthesis
inferredcites →https://doi.org/10.1038/s41589-018-0059-7openalex-snapshot
A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis
inferredcites →https://doi.org/10.1038/s41589-019-0247-0openalex-snapshot
Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy
inferredcites →https://doi.org/10.1039/c4cc09598gopenalex-snapshot
Enantioselective total synthesis of (+)-methoxystemofoline and (+)-isomethoxystemofoline
inferredcites →https://doi.org/10.1039/c4gc02325kopenalex-snapshot
One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine
inferredcites →https://doi.org/10.1039/c8cc06759gopenalex-snapshot
Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction
inferredcites →https://doi.org/10.1039/c8np00013aopenalex-snapshot
Natural products from thioester reductase containing biosynthetic pathways
inferredcites →https://doi.org/10.1039/c8np00022kopenalex-snapshot
Protein–protein interactions in polyketide synthase–nonribosomal peptide synthetase hybrid assembly lines
inferredcites →https://doi.org/10.1039/c8ob02710bopenalex-snapshot
StnK2 catalysing a Pictet–Spengler reaction involved in the biosynthesis of the antitumor reagent streptonigrin
inferredcites →https://doi.org/10.1039/c8ob03063dopenalex-snapshot
The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases
inferredcites →https://doi.org/10.1039/c9np00047jopenalex-snapshot
Type II non-ribosomal peptide synthetase proteins: structure, mechanism, and protein–protein interactions
inferredcites →https://doi.org/10.1039/c9sc03773jopenalex-snapshot
Biosynthesis of plant tetrahydroisoquinoline alkaloids through an imine reductase route
inferredcites →https://doi.org/10.1039/d0np00045kopenalex-snapshot
Polyketide β-branching: diversity, mechanism and selectivity
inferredcites →https://doi.org/10.1039/d0ra04133eopenalex-snapshot
Enzymatic synthesis of 2-hydroxy-4 H -quinolizin-4-one scaffolds by integrating coenzyme a ligases and a type III PKS from Huperzia serrata
inferredcites →https://doi.org/10.1073/pnas.0134257100openalex-snapshot
Involvement of CjMDR1, a plant multidrug-resistance-type ATP-binding cassette protein, in alkaloid transport in Coptis japonica
inferredcites →https://doi.org/10.1073/pnas.1721469115openalex-snapshot
Complete biosynthesis of noscapine and halogenated alkaloids in yeast
inferredcites →https://doi.org/10.1074/jbc.270.52.31091openalex-snapshot
Acetyl Coenzyme A:Salutaridinol-7-O-Acetyltransferase from Papaver somniferum Plant Cell Cultures:
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Biosynthesis of nitrogen-containing natural products, C7N aminocyclitols and bis-indoles, from actinomycetes
inferredcites →https://doi.org/10.1104/pp.100.2.836openalex-snapshot
Two Tropinone Reductases with Distinct Stereospecificities from Cultured Roots of Hyoscyamus niger
inferredcites →https://doi.org/10.1104/pp.19.00565openalex-snapshot
Purine Permease-Type Benzylisoquinoline Alkaloid Transporters in Opium Poppy
inferredcites →https://doi.org/10.1111/1541-4337.12491openalex-snapshot
Global Concerns with B Vitamin Statuses: Biofortification, Fortification, Hidden Hunger, Interactions, and Toxicity
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Effects of Spascupreel versus hyoscine butylbromide for gastrointestinal cramps in children
inferredcites →https://doi.org/10.1111/nph.16317openalex-snapshot
Functional genomics analysis reveals two novel genes required for littorine biosynthesis
inferredcites →https://doi.org/10.1111/pbi.12494openalex-snapshot
Metabolic engineering for the production of plant isoquinoline alkaloids
inferredcites →https://doi.org/10.1111/tpj.13975openalex-snapshot
Codeinone reductase isoforms with differential stability, efficiency and product selectivity in opium poppy
inferredcites →https://doi.org/10.1126/science.1220757openalex-snapshot
A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine
inferredcites →https://doi.org/10.1126/science.aat4096openalex-snapshot
The opium poppy genome and morphinan production
inferredcites →https://doi.org/10.1186/s12934-015-0288-3openalex-snapshot
CrEdit: CRISPR mediated multi-loci gene integration in Saccharomyces cerevisiae
inferredcites →https://doi.org/10.1186/s12934-020-01401-5openalex-snapshot
De novo resveratrol production through modular engineering of an Escherichia coli–Saccharomyces cerevisiae co-culture
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Pervasive coexpression of spatially proximal genes is buffered at the protein level
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Anti-fatigue Effects of Active Ingredients from Traditional Chinese Medicine: A Review
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Secondary Metabolites from Cyanobacteria: Complex Structures and Powerful Bioactivities
inferredcites →https://doi.org/10.2174/1385272821666170207114214openalex-snapshot
Isoquinoline Alkaloids and Their Antiviral, Antibacterial, and Antifungal Activities and Structure-activity Relationship
inferredcites →https://doi.org/10.2174/1570193x13666161017141517openalex-snapshot
Nitrogenous Compounds from Marine Aspergillus sp.
inferredcites →https://doi.org/10.2174/1871520619666181224121004openalex-snapshot
Current Perspectives in the Application of Medicinal Plants Against Cancer: Novel Therapeutic Agents
inferredcites →https://doi.org/10.3109/1040841x.2014.959892openalex-snapshot
Endophytic fungi with antitumor activities: Their occurrence and anticancer compounds
inferredcites →https://doi.org/10.3389/fmicb.2018.00046openalex-snapshot
A Comprehensive Overview of the Cyclodipeptide Synthase Family Enriched with the Characterization of 32 New Enzymes
inferredcites →https://doi.org/10.3389/fpls.2019.01058openalex-snapshot
Molecular Origins of Functional Diversity in Benzylisoquinoline Alkaloid Methyltransferases
inferredcites →https://doi.org/10.3390/microorganisms8040519openalex-snapshot
Engineering Improves Enzymatic Synthesis of L-Tryptophan by Tryptophan Synthase from Escherichia coli
inferredcites →https://doi.org/10.3390/molecules21081078openalex-snapshot
Evaluation of Biosynthetic Pathway and Engineered Biosynthesis of Alkaloids
inferredcites →https://doi.org/10.3390/toxins6123281openalex-snapshot
Biosynthetic Pathways of Ergot Alkaloids
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Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides
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Molecular basis for the plasticity of aromatic prenyltransferases in hapalindole biosynthesis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Catalytic Enantioselective Intramolecular Aza‐Michael Addition to α,β‐Unsaturated Esters
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Hydroxylation with Unusual Stereoinversion Catalyzed by an FeII/2‐OG Dependent Oxidase and 3,6‐Diene‐2,5‐diketopiperazine Formation in the Biosynthesis of Brevianamide K
inferred← citeshttps://doi.org/10.1002/anie.5995443openalex-snapshot
Catalytic Enantioselective Intramolecular Aza‐Michael Addition to α,β‐Unsaturated Esters
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Myxococcus xanthus as Host for the Production of Benzoxazoles
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Direct Electrochemical Synthesis of 2,3‐Disubstituted Quinoline N‐oxides by Cathodic Reduction of Nitro Arenes
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I2‐Promoted Synthesis of N‐Heteroaromatic Benzothiazoles and 2,2’‐Biquinolines via Deaminative Cyclization of Tertiary Amines
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Photochemical Multicomponent Synthesis of Six‐Membered Heterocycles
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Gold‐Catalyzed Photoannulation: Access to Cyclic Scaffolds
inferred← citeshttps://doi.org/10.1002/slct.202300150openalex-snapshot
Synthesis of 1,2‐Dihydrofuro[3,4‐d]pyrimidine Derivatives as Potential VEGFR‐2 Inhibitors, and Proposed Mechanism for the 5,6‐Dihydro‐4H‐furo[3,4‐c]pyrrol‐4‐one
inferred← citeshttps://doi.org/10.1002/slct.202403762openalex-snapshot
Update on Pharmacological Drugs and Macrocyclic Compounds as Corrosion Inhibitors
inferred← citeshttps://doi.org/10.1002/slct.202502830openalex-snapshot
Photochemical Direct Mono/Di/Trifluoro‐Functionalization of Quinoxalin‐2(1 H )‐ones
inferred← citeshttps://doi.org/10.1002/slct.202503283openalex-snapshot
Ultrasonication‐Assisted Green Synthesis of 2‐Aryldihydroperimidines as Potent Antiviral Agents Against DENV and CHIKV Proteases: Virtual Screening, Molecular Docking, MD Simulation Studies
inferred← citeshttps://doi.org/10.1002/tcr.202300066openalex-snapshot
From Three‐ to Six‐Membered Heterocycles Bearing a Quaternary Stereocenter: an Asymmetric Organocatalytic Approach
inferred← citeshttps://doi.org/10.1007/s10973-025-14628-4openalex-snapshot
Analysis of bipyridine derivatives by calorimetry and thermogravimetry: a thermochemical perspective
inferred← citeshttps://doi.org/10.1007/s11101-025-10197-4openalex-snapshot
A review of chemical diversity of Kappaphycus alvarezii: biological properties, health benefits, and food applications
inferred← citeshttps://doi.org/10.1007/s11274-026-04825-0openalex-snapshot
A metagenomic survey of the rhizosphere bacterial community of P. longum from the herbal garden, Dayalbagh Educational Institute (D.E.I), Agra, India
inferred← citeshttps://doi.org/10.1007/s11696-024-03593-1openalex-snapshot
The cyclization and functionalization reactions involving N-phenacylpyridinium salts
inferred← citeshttps://doi.org/10.1007/s11696-024-03674-1openalex-snapshot
Arylglyoxal-based multicomponent synthesis of C-3 functionalized imidazoheterocycles
inferred← citeshttps://doi.org/10.1007/s44372-026-00777-9openalex-snapshot
Endophytic bacteria as biocontrol agents against Curvularia lunata in Musa paradisiaca
inferred← citeshttps://doi.org/10.1016/bs.aihch.2025.01.003openalex-snapshot
The literature of heterocyclic chemistry, part XXII, 2022
inferred← citeshttps://doi.org/10.1016/j.engmic.2022.100064openalex-snapshot
Advances on the biosynthesis of pyridine rings
inferred← citeshttps://doi.org/10.1016/j.enmf.2024.01.003openalex-snapshot
N-Acetonitrile functionalized 3-nitrotriazole: Precursor to nitrogen rich stable and insensitive energetic materials
inferred← citeshttps://doi.org/10.1016/j.envpol.2026.127719openalex-snapshot
Comparative study on the ecotoxicity of nanoformulated and conventional emamectin benzoate to Raphidocelis subcapitata: A mechanistic disparity analysis
inferred← citeshttps://doi.org/10.1016/j.inoche.2026.117353openalex-snapshot
An air tolerant N-heterocyclic imine–Pd(II) catalyst for oxidative dehydrogenative annulation of alcohol towards quinazolinones scaffolds
inferred← citeshttps://doi.org/10.1016/j.mcat.2025.115361openalex-snapshot
Cascade chemo-enzymatic synthesis of disubstituted 1,2,3-triazole derivatives: Enhancing the activity by immobilized enzyme on g-C3N4
inferred← citeshttps://doi.org/10.1016/j.mcat.2026.115871openalex-snapshot
UV-induced radical cascade cyclization of S-phenyl thiobenzenesulfonate: Access to sulfonyl oxindoles and isoquinolinediones
inferred← citeshttps://doi.org/10.1016/j.micromeso.2024.113113openalex-snapshot
Immobilization of ionic liquids (ILs) on magnetic mesoporous silica nanotubes: A high throughput and reusable nanocatalyst for the green synthesis of indeno[1,2-b]indolone derivatives
inferred← citeshttps://doi.org/10.1016/j.molliq.2022.119305openalex-snapshot
Surfactant based nanoreactor micellar assembly: An innovative route for synthesis of 2-thioxo-2,3-dihydroquinazolin-4(1H)-ones
inferred← citeshttps://doi.org/10.1016/j.molstruc.2024.138450openalex-snapshot
Investigation on the pharmacological profile for new synthesized bis heterocyclic analogs containing nitrogen atom as anti-cancer therapy target
inferred← citeshttps://doi.org/10.1016/j.molstruc.2024.139121openalex-snapshot
Exploring the potential therapeutic role of benzofuran derivatives in cancer treatment
inferred← citeshttps://doi.org/10.1016/j.molstruc.2025.144856openalex-snapshot
Sonogashira-Hydroamination based Annulation of 2-(2‑chloro-1-methyl-1H-indol-3-yl)-5-methyl-1H-benzo[d]imidazole: Antiproliferative Activity, DFT, and Molecular Docking Studies
inferred← citeshttps://doi.org/10.1016/j.pmpp.2026.103237openalex-snapshot
Unlocking the potential of plant secondary metabolites in pest management and stress defense
inferred← citeshttps://doi.org/10.1016/j.tet.2023.133353openalex-snapshot
Synthesis of Trifluoromethylpyrrolopyrazole Derivatives Via [3+2] Cycloaddition of Trifluoromethyl N-Acylhydrazones or Trifluoroacetohydrazonoyl Bromides with Maleimides
inferred← citeshttps://doi.org/10.1016/j.tet.2024.134039openalex-snapshot
Emerging strategies for synthesis of heterocyclic compounds enabled by titanium oxide nanoparticles as heterogeneous catalyst
inferred← citeshttps://doi.org/10.1016/j.tet.2025.134467openalex-snapshot
Recent advances on electrochemical generation of sulfonyl radical triggered cyclization of alkene/alkynes
inferred← citeshttps://doi.org/10.1016/j.tetlet.2025.155533openalex-snapshot
Synthesis of Ortho-nitrochalcones by solvent-free grinding method: Facilitating the synthesis of 2,3-Disubstituted Quinoline N-oxides via bimolecular reaction
inferred← citeshttps://doi.org/10.1016/j.tetlet.2026.156139openalex-snapshot
Recent advances on photoinduced X-H (X = N, O, S) bond activation
inferred← citeshttps://doi.org/10.1021/acs.accounts.6c00488openalex-snapshot
Electrochemical Synthesis and Transformation of Heteroaromatic Compounds via Mediated Electrolysis
inferred← citeshttps://doi.org/10.1021/acs.jafc.5c06565openalex-snapshot
Discovery of Nitrogen-Containing Heterocyclic Chain Amide Derivatives as Novel Fungicidal Agents via Multicomponent Strategies
inferred← citeshttps://doi.org/10.1021/acs.jafc.5c09345openalex-snapshot
Improving the Activity of Aminophenoxazinones: Synthesis, CPC Purification, and Phytotoxicity Potential
inferred← citeshttps://doi.org/10.1021/acs.joc.2c02373openalex-snapshot
Photoinduced Decarbonylative Rearrangement of Diazabicyclo[2.2.2]Octenones: A Photochemical Approach of Diazabicyclo[4.1.0]heptene Skeleton from Masked o-Benzoquinone
inferred← citeshttps://doi.org/10.1021/acs.joc.3c00462openalex-snapshot
Cascade Nucleophilic Addition–Cyclic Michael Addition of Arynes and Indoles Bearing Michael Acceptor: A Strategy to Construct Pyrroloacridines and Study of Their Physicochemical Properties
inferred← citeshttps://doi.org/10.1021/acs.joc.4c00908openalex-snapshot
Synthesis of Sulfone Methylene-Substituted Indolines by Radical Cascade Cyclization of 2-Alkynylaniline Derivatives
inferred← citeshttps://doi.org/10.1021/acs.joc.4c02927openalex-snapshot
One-Pot Multicomponent Synthesis of Fully Substituted 1,3-Thiazoles Appended with Naturally Occurring Lawsone
inferred← citeshttps://doi.org/10.1021/acs.joc.5c01531openalex-snapshot
Microwave-Driven Solventless Nickel Metalloradical-Catalyzed [2 + 2 + 1 + 1] Cascade Annulation of Polysubstituted Pyridines
inferred← citeshttps://doi.org/10.1021/acs.joc.6c00803openalex-snapshot
Gold-Catalyzed ( n + 4) ( n = 5, 6) High-Order Dipolar Annulation of Alkynylcyclopropane Ketones: Unified Synthesis of Medium-Sized Diazaheterocycles
inferred← citeshttps://doi.org/10.1021/acs.joc.6c01425openalex-snapshot
Palladium-Catalyzed Narasaka–Heck Carbonylation Using Cr(CO)6 as Carbonyl Source: Access to Ester-Containing Pyrrolines
inferred← citeshttps://doi.org/10.1021/acs.orglett.2c02561openalex-snapshot
Copper-Catalyzed Cycloadditions of Diazo Compounds with Imidazolidines/Hexahydropyrimidines for the Syntheses of N-Heterocycles
inferred← citeshttps://doi.org/10.1021/acs.orglett.2c02620openalex-snapshot
Unexpected Copper-Catalyzed Cascade Reaction of 1,6-Enynes with Sulfoxonium Ylides
inferred← citeshttps://doi.org/10.1021/acs.orglett.3c02137openalex-snapshot
Domino Cyclization Reaction of o -Diisocyanoarenes for the Synthesis of Imidazo[1,2- a ]pyridinobenzimidazole Backbones
inferred← citeshttps://doi.org/10.1021/acs.orglett.4c02647openalex-snapshot
Nickel-Catalyzed Narasaka–Heck Cyclization Carbonylation of Unsaturated Oxime Esters with Arylboronic Acids
inferred← citeshttps://doi.org/10.1021/acs.orglett.5c01533openalex-snapshot
N-Heterocyclic Carbene/Organic Photoredox-Cocatalyzed Acyl Azolation of Alkenes with Acyl Azoles
inferred← citeshttps://doi.org/10.1021/acs.orglett.5c03024openalex-snapshot
Mechanistic Insights into the Regioselective Defluorofunctionalization of Trifluoromethylanilines via Photocatalytic SET: A Combined Experimental and Computational Study
inferred← citeshttps://doi.org/10.1021/acs.orglett.5c04018openalex-snapshot
Copper-Catalyzed (5+1) Annulation of Imidazolidines with Cyclopropenes: Synthesis of Functionalized 2-Vinylpiperazines
inferred← citeshttps://doi.org/10.1021/acs.orglett.5c05297openalex-snapshot
Collective Total Synthesis of (+)- and (−)-Baoslingzhines F–H, (+)- and (−)-Chizhiene C, and (+)- and (−)-Lingzhines E and F
inferred← citeshttps://doi.org/10.1021/acs.orglett.6c00898openalex-snapshot
Visible Light-Induced Synthesis of Esterified Quinolines and Pyrrolidones Controlled by Different Electrical Anilines
inferred← citeshttps://doi.org/10.1021/acs.orglett.6c02071openalex-snapshot
Unspecific Peroxygenase Catalyzed Benzylic C–H Functionalization of di N -Heterocycles and Its Application
inferred← citeshttps://doi.org/10.1021/acs.orglett.6c03179openalex-snapshot
Site-Selective Sequential Isocyanide Insertion at Dual sp3- and sp2-Carbon Centers Enables Divergent Access to N/O-Containing Heterocycles
inferred← citeshttps://doi.org/10.1021/acscatal.3c03670openalex-snapshot
Uncovering Untapped Carboxylic Acid Reductases (CARs) for One-Step Biosynthesis and Diversification of Bioactive Nitrogen-Containing Heterocycles
inferred← citeshttps://doi.org/10.1021/acscatal.4c00718openalex-snapshot
Recent Advances in Catalytic Nitrogen–Nitrogen Bond Formation Reactions
inferred← citeshttps://doi.org/10.1021/acscatal.5c00608openalex-snapshot
Unlocking Isonitrile Insertion with N-Centered Radicals: A General Synthetic Strategy toward Quinazolinone Alkaloids by Synergistic Photo/Copper Catalysis
inferred← citeshttps://doi.org/10.1021/acsomega.2c07736openalex-snapshot
Metal-Free Synthesis of Functionalized Quinolines from 2-Styrylanilines and 2-Methylbenzothiazoles/2-Methylquinolines
inferred← citeshttps://doi.org/10.1021/acssuschemeng.3c06260openalex-snapshot
Specific Glycosylation System Enables the High-Level and Sustainable Production of Glycyrrhetinic Acid 3-O-monoglucuronide and Glycyrrhizin in Engineered Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1021/acssynbio.2c00371openalex-snapshot
Direct Yeast Surface Codisplay of Sequential Enzymes with Complementary Anchor Motifs: Enabling Enhanced Glycosylation of Natural Products
inferred← citeshttps://doi.org/10.1021/jacs.5c12770openalex-snapshot
“Cut-and-Sew” Reactions of β-Lactams via C–C Bond Activation
inferred← citeshttps://doi.org/10.1021/jacs.6c08636openalex-snapshot
Grignard Reagents Unlock Three-Dimensional Nitrogen Heterocycles via Single-Carbon-Atom Insertion
inferred← citeshttps://doi.org/10.1038/s41467-022-34313-6openalex-snapshot
Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation
inferred← citeshttps://doi.org/10.1038/s41467-026-74395-0openalex-snapshot
Switchable annulation paths to diverse N-bridged bicyclic scaffolds via ligand-directed dicarbonylation
inferred← citeshttps://doi.org/10.1038/s41598-023-49632-xopenalex-snapshot
Utilizing magnetic xanthan gum nanocatalyst for the synthesis of acridindion derivatives via functionalized macrocycle Thiacalix[4]arene
inferred← citeshttps://doi.org/10.1039/d1gc04759kopenalex-snapshot
Construction of biocatalytic cascades for the synthesis of benzylisoquinoline alkaloids from p -coumaric acid derivatives and dopamine
inferred← citeshttps://doi.org/10.1039/d1qo01458gopenalex-snapshot
Electrochemically-mediated C–H functionalization of allenes and 1,3-dicarbonyl compounds to construct tetrasubstituted furans
inferred← citeshttps://doi.org/10.1039/d2qo01966copenalex-snapshot
Highly efficient construction of 2,3-disubstituted indoline derivatives by [4 + 1] annulation of sulfur ylides and o -sulfonamido aldimines
inferred← citeshttps://doi.org/10.1039/d3gc03971dopenalex-snapshot
Photocatalysis as a green alternative toolkit for the construction of nitrogen-enriched heterocycles via the direct and indirect activation of alkynes/alkenes
inferred← citeshttps://doi.org/10.1039/d3qo01159copenalex-snapshot
Recent advances in electrochemical C–H bond amination
inferred← citeshttps://doi.org/10.1039/d3qo01269gopenalex-snapshot
Rh-catalysed divergent synthesis of polysubstituted pyrroles from α,β-unsaturated ketones via selective single or double insertion of isocyanides
inferred← citeshttps://doi.org/10.1039/d3ra01383aopenalex-snapshot
Anticancer therapeutic potential of benzofuran scaffolds
inferred← citeshttps://doi.org/10.1039/d4cc05324aopenalex-snapshot
Trifluoromethylated lactams: promising small molecules in the search for effective drugs
inferred← citeshttps://doi.org/10.1039/d4np00023dopenalex-snapshot
Isolation, biological activity, and synthesis of isoquinoline alkaloids
inferred← citeshttps://doi.org/10.1039/d4ob01744gopenalex-snapshot
Visible-light-induced decarboxylative cyclization
inferred← citeshttps://doi.org/10.1039/d4qo02216eopenalex-snapshot
Lewis acid-catalyzed divergent synthesis of polysubstituted furans and pyrroles
inferred← citeshttps://doi.org/10.1039/d4ra00439fopenalex-snapshot
Multicomponent synthesis via acceptorless alcohol dehydrogenation: an easy access to tri-substituted pyridines
inferred← citeshttps://doi.org/10.1039/d4ra08280jopenalex-snapshot
Exploring the capabilities of 2-alkynyl aryl/benzyl azides: synthesis approaches for indoles, quinolines, and their derivatives via transition metal catalysis
inferred← citeshttps://doi.org/10.1039/d5cc00328hopenalex-snapshot
Visible-light-initiated selective synthesis of thiolated-, sulfoxinated-, and sulfonated benzoxazines from N -(2-vinylaryl)amides and thiols
inferred← citeshttps://doi.org/10.1039/d5cc00859jopenalex-snapshot
Palladium-catalyzed Narasaka–Heck carbonylation for the construction of functionalized ynones
inferred← citeshttps://doi.org/10.1039/d5md01011jopenalex-snapshot
Empowering molecular complexity via biocatalysis: emerging blueprints in the total synthesis of medicinally relevant natural products
inferred← citeshttps://doi.org/10.1039/d5ob01049gopenalex-snapshot
O -Aryl carbamates of 2-substituted piperidines: anionic Fries rearrangement and kinetic resolution by lithiation
inferred← citeshttps://doi.org/10.1039/d5ob01357gopenalex-snapshot
EDA complex-enabled annulation
inferred← citeshttps://doi.org/10.1039/d5ob01411eopenalex-snapshot
Recent advances in visible-light-driven photocatalytic synthesis of biologically active N-heterocycles
inferred← citeshttps://doi.org/10.1039/d5ob01812aopenalex-snapshot
Diazo retention transformations of aryldiazonium salts towards nitrogen rich heterocycles
inferred← citeshttps://doi.org/10.1039/d5ra06909bopenalex-snapshot
New 5,6-diphenyl-1,2,4-triazine-hydrazineylidene-phenoxy-1,2,3-triazole-acetamide derivatives as potent synthetic α-glucosidase inhibitors
inferred← citeshttps://doi.org/10.1039/d6cc03143aopenalex-snapshot
One-pot synthesis of polycyclic pyridines through a Suzuki–Miyaura cascade reaction and cyclization sequence
inferred← citeshttps://doi.org/10.1039/d6ob00395hopenalex-snapshot
One-pot multicomponent synthesis of indole-linked fully substituted fused pyrroles
inferred← citeshttps://doi.org/10.1039/d6ob00743kopenalex-snapshot
HBr as a dual functional catalyst enabling aerobic CDC coupling of quinoxalin-2(1 H )-ones with electron-rich heteroarenes
inferred← citeshttps://doi.org/10.1039/d6qo00433dopenalex-snapshot
Sulfinate-assisted, photoredox-catalyzed insertion of alkenes into the C–N bond of acyl azoles
inferred← citeshttps://doi.org/10.1039/d6ra01164kopenalex-snapshot
Fabrication of self-assembled CuO nanosheets for the sustainable synthesis of 2-substituted 1,3-benzothiazoles
inferred← citeshttps://doi.org/10.1039/d6ra05172copenalex-snapshot
Sustainable and efficient silver nano-catalysed C–N bond-forming approaches in organic synthesis
inferred← citeshttps://doi.org/10.1055/a-1892-0253openalex-snapshot
One-Pot Synthesis of 1,2,3-Triazole-Fused Polycyclic Systems via Sequential Annulation of 1,n-Enynes with Tosyl Azide
inferred← citeshttps://doi.org/10.1055/a-2201-9951openalex-snapshot
Synthesis of Piperazin-2-one Derivatives via Cascade Double Nucleophilic Substitution
inferred← citeshttps://doi.org/10.1080/00397911.2024.2387121openalex-snapshot
Synthesis, antimicrobial activity, and biofilm inhibition studies of 1,2,3-triazole-containing 2,3-dihydrothiazole
inferred← citeshttps://doi.org/10.1080/01496395.2026.2747015openalex-snapshot
Selective separation of aromatic N -heterocyclic compounds by cyclodextrins based on the size-matching effect
inferred← citeshttps://doi.org/10.1080/10406638.2023.2259572openalex-snapshot
Acidic Ionic Liquids in Ultrasonic Irradiation Conditions Promote the Nucleophilic Addition to Chalcone Derivatives
inferred← citeshttps://doi.org/10.1093/chemle/upae146openalex-snapshot
Electrochemical synthesis of heterocyclic compounds via carbon–heteroatom bond formation: direct and indirect electrolysis
inferred← citeshttps://doi.org/10.1186/s13321-024-00898-xopenalex-snapshot
RAIChU: automating the visualisation of natural product biosynthesis
inferred← citeshttps://doi.org/10.13005/ojc/390207openalex-snapshot
Synthesis and Design of novel morpholinyl mannich bases for Potential Inhibitory Activity of SARS-CoV-2 Main Protease
inferred← citeshttps://doi.org/10.1360/ssc-2024-0273openalex-snapshot
Alkaloids in the Cephalotaxus plants and the biosynthesis of phenethylisoquinolines: a review
inferred← citeshttps://doi.org/10.1360/ssc-2025-0109openalex-snapshot
Advances in the syntheses of alkaloid natural products and bioactive molecules based on ynamide building blocks
inferred← citeshttps://doi.org/10.2174/0113852728379590251112105811openalex-snapshot
A Review on the Synthesis and Biological Evaluation of N-containing Heterocyclic Derivatives
inferred← citeshttps://doi.org/10.2174/1570178620666230222100449openalex-snapshot
An Improved Synthesis of Disubstituted 2H-indazoles using Microwaves
inferred← citeshttps://doi.org/10.3390/catal13020229openalex-snapshot
Immobilization of the Amidohydrolase MxcM and Its Application for Biocatalytic Flow Synthesis of Pseudochelin A
inferred← citeshttps://doi.org/10.3390/molecules29051045openalex-snapshot
Novel 4-Chromanone-Derived Compounds as Plant Immunity Inducers against CMV Disease in Passiflora spp. (Passion Fruit)
inferred← citeshttps://doi.org/10.3390/molecules29204810openalex-snapshot
Heterocycles in Medicinal Chemistry II
inferred← citeshttps://doi.org/10.3390/ph19081191openalex-snapshot
Computational and Cellular Evaluation of the Anti-Melanogenic Potential of Gancidin W: Integrating Network Pharmacology and Free-Energy Analyses
inferred← citeshttps://doi.org/10.3762/bjoc.19.71openalex-snapshot
Clauson–Kaas pyrrole synthesis using diverse catalysts: a transition from conventional to greener approach
inferred← citeshttps://doi.org/10.4018/979-8-3693-0928-5.ch005openalex-snapshot
In Pursuit of Excellence
inferred← citeshttps://doi.org/10.6084/m9.figshare.26945814openalex-snapshot
Additional file 1 of RAIChU: automating the visualisation of natural product biosynthesis
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.