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Biosynthesis of fungal polyketides by collaborating and trans -acting enzymes

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Reversible Product Release and Recapture by a Fungal Polyketide Synthase Using a Carnitine Acyltransferase Domain

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Control of the Stereochemical Course of [4+2] Cycloaddition during trans‐Decalin Formation by Fsa2‐Family Enzymes

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Diels–Alder Reactions During the Biosynthesis of Sorbicillinoids

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One Polyketide Synthase, Two Distinct Products: Trans ‐Acting Enzyme‐Controlled Product Divergence in Calbistrin Biosynthesis

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Biosynthesis of 6‐Hydroxymellein Requires a Collaborating Polyketide Synthase‐like Enzyme

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Fusarin C Biosynthesis in Fusarium moniliforme and Fusarium venenatum

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Identification of a Hybrid PKS/NRPS Required for Pseurotin A Biosynthesis in the Human Pathogen Aspergillus fumigatus

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Authentic Heterologous Expression of the Tenellin Iterative Polyketide Synthase Nonribosomal Peptide Synthetase Requires Coexpression with an Enoyl Reductase

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Acyl‐Carrier Protein–Phosphopantetheinyltransferase Partnerships in Fungal Fatty Acid Synthases

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Synthetic Strategy of Nonreducing Iterative Polyketide Synthases and the Origin of the Classical “Starter‐Unit Effect”

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Demonstration of Starter Unit Interprotein Transfer from a Fatty Acid Synthase to a Multidomain, Nonreducing Polyketide Synthase

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Three Acyltetronic Acid Derivatives: Noncanonical Cryptic Polyketides from Aspergillus niger Identified by Genome Mining

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Biosynthetic Machinery of 6‐Hydroxymellein Derivatives Leading to Cyclohelminthols and Palmaenones

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Core Steps to the Azaphilone Family of Fungal Natural Products

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Biosynthesis of a Tricyclo[6.2.2.02,7]dodecane System by a Berberine Bridge Enzyme‐Like Aldolase

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The npgA/cfwA gene encodes a putative 4'-phosphopantetheinyl transferase which is essential for penicillin biosynthesis in Aspergillus nidulans

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4′-Phosphopantetheinyl transferase-encoding npgA is essential for siderophore biosynthesis in Aspergillus nidulans

inferredcites →https://doi.org/10.1007/s00438-002-0697-yopenalex-snapshot

Molecular cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum

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Characterization of NpgA, a 4′-phosphopantetheinyl transferase of Aspergillus nidulans, and evidence of its involvement in fungal growth and formation of conidia and cleistothecia for development

inferredcites →https://doi.org/10.1016/0040-4020(81)85056-9openalex-snapshot

Biosynthesis of pseurotin A

inferredcites →https://doi.org/10.1016/0968-0004(85)90266-xopenalex-snapshot

The metabolon

inferredcites →https://doi.org/10.1016/b978-0-12-409547-2.14780-8openalex-snapshot

Fungal Non-Reducing Polyketide Synthases

inferredcites →https://doi.org/10.1016/j.bioorg.2007.11.002openalex-snapshot

Starter unit specificity directs genome mining of polyketide synthase pathways in fungi

inferredcites →https://doi.org/10.1016/j.chembiol.2008.05.010openalex-snapshot

Molecular Genetic Mining of the Aspergillus Secondary Metabolome: Discovery of the Emericellamide Biosynthetic Pathway

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Functional Characterization of the Biosynthesis of Radicicol, an Hsp90 Inhibitor Resorcylic Acid Lactone from Chaetomium chiversii

inferredcites →https://doi.org/10.1016/j.chembiol.2009.04.004openalex-snapshot

Physically Discrete β-Lactamase-Type Thioesterase Catalyzes Product Release in Atrochrysone Synthesis by Iterative Type I Polyketide Synthase

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Directed Evolution and Structural Characterization of a Simvastatin Synthase

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Identification of the Viridicatumtoxin and Griseofulvin Gene Clusters from Penicillium aethiopicum

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Characterization of a Silent Azaphilone Gene Cluster from Aspergillus niger ATCC 1015 Reveals a Hydroxylation-Mediated Pyran-Ring Formation

inferredcites →https://doi.org/10.1016/j.chembiol.2014.03.010openalex-snapshot

Terrein Biosynthesis in Aspergillus terreus and Its Impact on Phytotoxicity

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Structure and biosynthesis of fumosorinone, a new protein tyrosine phosphatase 1B inhibitor firstly isolated from the entomogenous fungus Isaria fumosorosea

inferredcites →https://doi.org/10.1016/j.fgb.2015.05.010openalex-snapshot

An Aspergillus flavus secondary metabolic gene cluster containing a hybrid PKS–NRPS is necessary for synthesis of the 2-pyridones, leporins

inferredcites →https://doi.org/10.1016/j.fgb.2020.103378openalex-snapshot

Acurin A, a novel hybrid compound, biosynthesized by individually translated PKS- and NRPS-encoding genes in Aspergillus aculeatus

inferredcites →https://doi.org/10.1016/j.str.2014.09.016openalex-snapshot

Evolutionary Origins of the Multienzyme Architecture of Giant Fungal Fatty Acid Synthase

inferredcites →https://doi.org/10.1016/j.tetlet.2016.05.043openalex-snapshot

Genome mining approach for harnessing the cryptic gene cluster in Alternaria solani: production of PKS–NRPS hybrid metabolite, didymellamide B

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Strategies for Engineering Natural Product Biosynthesis in Fungi

inferredcites →https://doi.org/10.1016/j.ymben.2011.09.008openalex-snapshot

Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1

inferredcites →https://doi.org/10.1016/s0040-4039(00)91190-0openalex-snapshot

Isolation of phytotoxic substances produced by allington & chamberlain

inferredcites →https://doi.org/10.1016/s1074-5521(00)90068-1openalex-snapshot

Identification of Claisen cyclase domain in fungal polyketide synthase WA, a naphthopyrone synthase of Aspergillus nidulans

inferredcites →https://doi.org/10.1016/s1074-5521(02)00213-2openalex-snapshot

Initial Characterization of a Type I Fatty Acid Synthase and Polyketide Synthase Multienzyme Complex NorS in the Biosynthesis of Aflatoxin B1

inferredcites →https://doi.org/10.1016/s1074-5521(96)90094-0openalex-snapshot

Demonstration of the catalytic roles and evidence for the physical association of type I fatty acid synthases and a polyketide synthase in the biosynthesis of aflatoxin B1

inferredcites →https://doi.org/10.1021/acs.biochem.9b00702openalex-snapshot

Functional and Structural Analyses of trans C-Methyltransferase in Fungal Polyketide Biosynthesis

inferredcites →https://doi.org/10.1021/acs.chemrev.9b00525openalex-snapshot

Evolution and Diversity of Assembly-Line Polyketide Synthases

inferredcites →https://doi.org/10.1021/acs.jnatprod.8b00983openalex-snapshot

Genome Mining Reveals Neurospora crassa Can Produce the Salicylaldehyde Sordarial

inferredcites →https://doi.org/10.1021/acs.orglett.0c00440openalex-snapshot

Biosynthesis of the Prenylated Salicylaldehyde Flavoglaucin Requires Temporary Reduction to Salicyl Alcohol for Decoration before Reoxidation to the Final Product

inferredcites →https://doi.org/10.1021/acs.orglett.0c01975openalex-snapshot

Genome Mining-Based Discovery of Fungal Macrolides Modified by glycosylphosphatidylinositol (GPI)–Ethanolamine Phosphate Transferase Homologues

inferredcites →https://doi.org/10.1021/acs.orglett.1c00458openalex-snapshot

Genome Mining Discovery of a C4-Alkylated Dihydroisocoumarin Pathway in Fungi

inferredcites →https://doi.org/10.1021/acs.orglett.5b00715openalex-snapshot

Biosynthesis of the Tetramic Acids Sch210971 and Sch210972

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Elucidation of Pyranonigrin Biosynthetic Pathway Reveals a Mode of Tetramic Acid, Fused γ-Pyrone, and exo-Methylene Formation

inferredcites →https://doi.org/10.1021/acs.orglett.5b02934openalex-snapshot

Biosynthetic Study on Antihypercholesterolemic Agent Phomoidride: General Biogenesis of Fungal Dimeric Anhydrides

inferredcites →https://doi.org/10.1021/acs.orglett.6b00110openalex-snapshot

Diversity-Oriented Combinatorial Biosynthesis of Hybrid Polyketide Scaffolds from Azaphilone and Benzenediol Lactone Biosynthons

inferredcites →https://doi.org/10.1021/acs.orglett.6b00380openalex-snapshot

Combinatorial Generation of Chemical Diversity by Redox Enzymes in Chaetoviridin Biosynthesis

inferredcites →https://doi.org/10.1021/acs.orglett.7b01534openalex-snapshot

Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway

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Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii

inferredcites →https://doi.org/10.1021/acs.orglett.9b01344openalex-snapshot

Targeted Gene Inactivations Expose Silent Cytochalasans in Magnaporthe grisea NI980

inferredcites →https://doi.org/10.1021/acs.orglett.9b01674openalex-snapshot

The Discovery of Fungal Polyene Macrolides via a Postgenomic Approach Reveals a Polyketide Macrocyclization by trans-Acting Thioesterase in Fungi

inferredcites →https://doi.org/10.1021/acschembio.0c00466openalex-snapshot

Unveiling of Swainsonine Biosynthesis via a Multibranched Pathway in Fungi

inferredcites →https://doi.org/10.1021/acschembio.6b00523openalex-snapshot

Direct Evidence for Metabolon Formation and Substrate Channeling in Recombinant TCA Cycle Enzymes

inferredcites →https://doi.org/10.1021/acschembio.8b00679openalex-snapshot

Hybrid Transcription Factor Engineering Activates the Silent Secondary Metabolite Gene Cluster for (+)-Asperlin in Aspergillus nidulans

inferredcites →https://doi.org/10.1021/acschembio.9b00791openalex-snapshot

Genomics-Driven Discovery of Phytotoxic Cytochalasans Involved in the Virulence of the Wheat Pathogen Parastagonospora nodorum

inferredcites →https://doi.org/10.1021/bi902176vopenalex-snapshot

Solution Structure of an Acyl Carrier Protein Domain from a Fungal Type I Polyketide Synthase,

inferredcites →https://doi.org/10.1021/cb500043gopenalex-snapshot

Insights into the Biosynthesis of 12-Membered Resorcylic Acid Lactones from Heterologous Production in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1021/cb500284topenalex-snapshot

Fungal Polyketide Synthase Product Chain-Length Control by Partnering Thiohydrolase

inferredcites →https://doi.org/10.1021/ja078091oopenalex-snapshot

Redirecting the Cyclization Steps of Fungal Polyketide Synthase

inferredcites →https://doi.org/10.1021/ja100060kopenalex-snapshot

Enzymatic Synthesis of Resorcylic Acid Lactones by Cooperation of Fungal Iterative Polyketide Synthases Involved in Hypothemycin Biosynthesis

inferredcites →https://doi.org/10.1021/ja201138vopenalex-snapshot

Double Oxidation of the Cyclic Nonaketide Dihydromonacolin L to Monacolin J by a Single Cytochrome P450 Monooxygenase, LovA

inferredcites →https://doi.org/10.1021/ja206906dopenalex-snapshot

Comparative Characterization of Fungal Anthracenone and Naphthacenedione Biosynthetic Pathways Reveals an α-Hydroxylation-Dependent Claisen-like Cyclization Catalyzed by a Dimanganese Thioesterase

inferredcites →https://doi.org/10.1021/ja3016389openalex-snapshot

Interrogation of Global Active Site Occupancy of a Fungal Iterative Polyketide Synthase Reveals Strategies for Maintaining Biosynthetic Fidelity

inferredcites →https://doi.org/10.1021/ja3090498openalex-snapshot

Identification and Characterization of the Chaetoviridin and Chaetomugilin Gene Cluster in Chaetomium globosum Reveal Dual Functions of an Iterative Highly-Reducing Polyketide Synthase

inferredcites →https://doi.org/10.1021/ja312503yopenalex-snapshot

The Fumagillin Biosynthetic Gene Cluster in Aspergillus fumigatus Encodes a Cryptic Terpene Cyclase Involved in the Formation of β-trans-Bergamotene

inferredcites →https://doi.org/10.1021/ja402828wopenalex-snapshot

Combinatorial Generation of Complexity by Redox Enzymes in the Chaetoglobosin A Biosynthesis

inferredcites →https://doi.org/10.1021/ja5007299openalex-snapshot

Systematic Domain Swaps of Iterative, Nonreducing Polyketide Synthases Provide a Mechanistic Understanding and Rationale For Catalytic Reprogramming

inferredcites →https://doi.org/10.1021/ja8088185openalex-snapshot

A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, in Aspergillus nidulans

inferredcites →https://doi.org/10.1021/ja8091054openalex-snapshot

A PLP-Dependent Polyketide Chain Releasing Mechanism in the Biosynthesis of Mycotoxin Fumonisins inFusarium verticillioides

inferredcites →https://doi.org/10.1021/ja903203gopenalex-snapshot

Acyltransferase Mediated Polyketide Release from a Fungal Megasynthase

inferredcites →https://doi.org/10.1021/jacs.0c02337openalex-snapshot

Molecular Basis for the Biosynthesis of an Unusual Chain-Fused Polyketide, Gregatin A

inferredcites →https://doi.org/10.1021/jacs.0c03438openalex-snapshot

Iterative Catalysis in the Biosynthesis of Mitochondrial Complex II Inhibitors Harzianopyridone and Atpenin B

inferredcites →https://doi.org/10.1021/jacs.0c09352openalex-snapshot

Biosynthesis of Mycotoxin Fusaric Acid and Application of a PLP-Dependent Enzyme for Chemoenzymatic Synthesis of Substituted l -Pipecolic Acids

inferredcites →https://doi.org/10.1021/jacs.0c11226openalex-snapshot

A Polyketide Cyclase That Forms Medium-Ring Lactones

inferredcites →https://doi.org/10.1021/jacs.1c00098openalex-snapshot

Biosynthesis of para-Cyclophane-Containing Hirsutellone Family of Fungal Natural Products

inferredcites →https://doi.org/10.1021/jacs.1c01516openalex-snapshot

Targeted Genome Mining Reveals the Biosynthetic Gene Clusters of Natural Product CYP51 Inhibitors

inferredcites →https://doi.org/10.1021/jacs.5b04520openalex-snapshot

Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis

inferredcites →https://doi.org/10.1021/jacs.5b07816openalex-snapshot

Efficient Biosynthesis of Fungal Polyketides Containing the Dioxabicyclo-octane Ring System

inferredcites →https://doi.org/10.1021/jacs.6b10452openalex-snapshot

Biochemical Characterization of a Eukaryotic Decalin-Forming Diels–Alderase

inferredcites →https://doi.org/10.1021/jacs.7b02432openalex-snapshot

Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases

inferredcites →https://doi.org/10.1021/jacs.7b13350openalex-snapshot

Biosynthesis of Long-Chain N -Acyl Amide by a Truncated Polyketide Synthase–Nonribosomal Peptide Synthetase Hybrid Megasynthase in Fungi

inferredcites →https://doi.org/10.1021/jacs.8b00056openalex-snapshot

Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids

inferredcites →https://doi.org/10.1021/jacs.8b12010openalex-snapshot

Genome-Mined Diels–Alderase Catalyzes Formation of the cis-Octahydrodecalins of Varicidin A and B

inferredcites →https://doi.org/10.1021/jacs.9b01083openalex-snapshot

Thioesterase-Catalyzed Aminoacylation and Thiolation of Polyketides in Fungi

inferredcites →https://doi.org/10.1021/jacs.9b02204openalex-snapshot

Enzyme-Catalyzed Inverse-Electron Demand Diels–Alder Reaction in the Biosynthesis of Antifungal Ilicicolin H

inferredcites →https://doi.org/10.1021/jacs.9b09669openalex-snapshot

Fungal Highly Reducing Polyketide Synthases Biosynthesize Salicylaldehydes That Are Precursors to Epoxycyclohexenol Natural Products

inferredcites →https://doi.org/10.1021/jacs.9b11410openalex-snapshot

Heterologous and Engineered Biosynthesis of Nematocidal Polyketide–Nonribosomal Peptide Hybrid Macrolactone from Extreme Thermophilic Fungi

inferredcites →https://doi.org/10.1021/jf035429zopenalex-snapshot

Determining the Biosynthetic Sequence in the Early Steps of the Fumonisin Pathway by Use of Three Gene-Disruption Mutants of Fusarium verticillioides

inferredcites →https://doi.org/10.1021/jo301592kopenalex-snapshot

Navigating the Fungal Polyketide Chemical Space: From Genes to Molecules

inferredcites →https://doi.org/10.1021/jo951424sopenalex-snapshot

Biosynthesis of Pyripyropene A

inferredcites →https://doi.org/10.1021/np8000514openalex-snapshot

Functional Complementation of Fumonisin Biosynthesis in FUM1-Disrupted Fusarium verticillioides by the AAL-Toxin Polyketide Synthase Gene ALT1 from Alternaria alternata f. sp. Lycopersici

inferredcites →https://doi.org/10.1021/ol303435yopenalex-snapshot

Genome Mining of a Prenylated and Immunosuppressive Polyketide from Pathogenic Fungi

inferredcites →https://doi.org/10.1021/ol501595zopenalex-snapshot

Characterization of Thermolide Biosynthetic Genes and a New Thermolide from Sister Thermophilic Fungi

inferredcites →https://doi.org/10.1021/ol503179vopenalex-snapshot

Methylation-Dependent Acyl Transfer between Polyketide Synthase and Nonribosomal Peptide Synthetase Modules in Fungal Natural Product Biosynthesis

inferredcites →https://doi.org/10.1038/nature08475openalex-snapshot

Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization

inferredcites →https://doi.org/10.1038/nchembio.1503openalex-snapshot

The role of distant mutations and allosteric regulation on LovD active site dynamics

inferredcites →https://doi.org/10.1038/nchembio869openalex-snapshot

Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans

inferredcites →https://doi.org/10.1038/ncomms15212openalex-snapshot

Protein-protein interactions and metabolite channelling in the plant tricarboxylic acid cycle

inferredcites →https://doi.org/10.1038/ncomms9758openalex-snapshot

Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS–PKS hybrid enzyme

inferredcites →https://doi.org/10.1038/nrmicro2465openalex-snapshot

New insights into the formation of fungal aromatic polyketides

inferredcites →https://doi.org/10.1038/s41429-020-00368-0openalex-snapshot

Discovery and characterization of a cytochalasan biosynthetic cluster from the marine-derived fungus Aspergillus flavipes CNL-338

inferredcites →https://doi.org/10.1038/s41467-021-21174-8openalex-snapshot

Structural basis for the biosynthesis of lovastatin

inferredcites →https://doi.org/10.1038/s41477-018-0142-9openalex-snapshot

The scaffold proteins of lignin biosynthetic cytochrome P450 enzymes

inferredcites →https://doi.org/10.1038/s41589-018-0026-3openalex-snapshot

The structural organization of substrate loading in iterative polyketide synthases

inferredcites →https://doi.org/10.1038/s41598-018-21452-4openalex-snapshot

First evidence for a multienzyme complex of lipid biosynthesis pathway enzymes in Cunninghamella bainieri

inferredcites →https://doi.org/10.1039/b708614hopenalex-snapshot

Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis

inferredcites →https://doi.org/10.1039/c1sc00023copenalex-snapshot

The programming role of trans-acting enoyl reductases during the biosynthesis of highly reduced fungal polyketides

inferredcites →https://doi.org/10.1039/c3np70054bopenalex-snapshot

The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life

inferredcites →https://doi.org/10.1039/c4cc09512jopenalex-snapshot

Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis

inferredcites →https://doi.org/10.1039/c4np00065jopenalex-snapshot

Fungal polyketide biosynthesis – a personal perspective

inferredcites →https://doi.org/10.1039/c4sc03707copenalex-snapshot

Heterologous expression of the avirulence gene ACE1 from the fungal rice pathogen Magnaporthe oryzae

inferredcites →https://doi.org/10.1039/c5sc04027bopenalex-snapshot

The molecular steps of citrinin biosynthesis in fungi

inferredcites →https://doi.org/10.1039/c6cc02130aopenalex-snapshot

Identification of genes encoding squalestatin S1 biosynthesis and in vitro production of new squalestatin analogues

inferredcites →https://doi.org/10.1039/c7cc07079aopenalex-snapshot

In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis

inferredcites →https://doi.org/10.1039/c8np00019kopenalex-snapshot

Sphingolipid biosynthesis in man and microbes

inferredcites →https://doi.org/10.1039/c8np00039eopenalex-snapshot

The architectures of iterative type I PKS and FAS

inferredcites →https://doi.org/10.1039/c8ob00608copenalex-snapshot

Investigations into the biosynthesis of the antifungal strobilurins

inferredcites →https://doi.org/10.1039/c8ob02773kopenalex-snapshot

Heterologous biosynthesis of a fungal macrocyclic polylactone requires only two iterative polyketide synthases

inferredcites →https://doi.org/10.1039/c8sc03697gopenalex-snapshot

Dalmanol biosyntheses require coupling of two separate polyketide gene clusters

inferredcites →https://doi.org/10.1039/c8sc03778gopenalex-snapshot

Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi

inferredcites →https://doi.org/10.1039/c8sc05126gopenalex-snapshot

Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungi

inferredcites →https://doi.org/10.1039/d0ob00519copenalex-snapshot

Synthetic-biology-based discovery of a fungal macrolide from Macrophomina phaseolina

inferredcites →https://doi.org/10.1039/d0ob02545copenalex-snapshot

Genome mining of cryptic tetronate natural products from a PKS-NRPS encoding gene cluster in Trichoderma harzianum t-22

inferredcites →https://doi.org/10.1039/d0ra05311bopenalex-snapshot

Investigating the biosynthesis of Sch-642305 in the fungus Phomopsis sp. CMU-LMA

inferredcites →https://doi.org/10.1039/d0sc04309eopenalex-snapshot

Uncovering biosynthetic relationships between antifungal nonadrides and octadrides

inferredcites →https://doi.org/10.1042/bj2960451openalex-snapshot

Characterization of the 3-dehydroquinase domain of the pentafunctional AROM protein, and the quinate dehydrogenase from Aspergillus nidulans, and the overproduction of the type II 3-dehydroquinase from neurospora crassa

inferredcites →https://doi.org/10.1073/pnas.0604112103openalex-snapshot

Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase

inferredcites →https://doi.org/10.1073/pnas.0809084105openalex-snapshot

Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli

inferredcites →https://doi.org/10.1073/pnas.0913531107openalex-snapshot

Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis

inferredcites →https://doi.org/10.1073/pnas.1113029109openalex-snapshot

Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis

inferredcites →https://doi.org/10.1073/pnas.1313258110openalex-snapshot

Prototype of an intertwined secondary-metabolite supercluster

inferredcites →https://doi.org/10.1073/pnas.1406999111openalex-snapshot

Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases

inferredcites →https://doi.org/10.1073/pnas.1603528113openalex-snapshot

Elucidation of cladofulvin biosynthesis reveals a cytochrome P450 monooxygenase required for anthraquinone dimerization

inferredcites →https://doi.org/10.1073/pnas.1819998116openalex-snapshot

Genome mining and biosynthesis of a polyketide from a biofertilizer fungus that can facilitate reductive iron assimilation in plant

inferredcites →https://doi.org/10.1073/pnas.1914777117openalex-snapshot

Pyridoxal-5′-phosphate–dependent bifunctional enzyme catalyzed biosynthesis of indolizidine alkaloids in fungi

inferredcites →https://doi.org/10.1073/pnas.72.5.1940openalex-snapshot

Presence of two polypeptide chains comprising fatty acid synthetase.

inferredcites →https://doi.org/10.1073/pnas.95.2.505openalex-snapshot

Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts

inferredcites →https://doi.org/10.1074/jbc.m110.107391openalex-snapshot

Hidden Function of Catalytic Domain in 6-Methylsalicylic Acid Synthase for Product Release

inferredcites →https://doi.org/10.1074/jbc.m110.183574openalex-snapshot

Insights into Radicicol Biosynthesis via Heterologous Synthesis of Intermediates and Analogs

inferredcites →https://doi.org/10.1074/jbc.m116.730531openalex-snapshot

Protein-Protein Interactions, Not Substrate Recognition, Dominate the Turnover of Chimeric Assembly Line Polyketide Synthases

inferredcites →https://doi.org/10.1074/jbc.m701239200openalex-snapshot

Pentaketide Resorcylic Acid Synthesis by Type III Polyketide Synthase from Neurospora crassa

inferredcites →https://doi.org/10.1080/15569540903092142openalex-snapshot

Genes, gene clusters, and biosynthesis of trichothecenes and fumonisins in Fusarium

inferredcites →https://doi.org/10.1093/molbev/msi193openalex-snapshot

Evolutionary Implications of Bacterial Polyketide Synthases

inferredcites →https://doi.org/10.1093/nar/gkab314openalex-snapshot

Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures

inferredcites →https://doi.org/10.1093/nar/gks1154openalex-snapshot

ESTHER, the database of the α/β-hydrolase fold superfamily of proteins: tools to explore diversity of functions

inferredcites →https://doi.org/10.1105/tpc.19.00403openalex-snapshot

The formation of a camalexin-biosynthetic metabolon

inferredcites →https://doi.org/10.1111/1462-2920.13007openalex-snapshot

Redundant synthesis of a conidial polyketide by two distinct secondary metabolite clusters in A spergillus fumigatus

inferredcites →https://doi.org/10.1111/1462-2920.14542openalex-snapshot

Dissection of patulin biosynthesis, spatial control and regulation mechanism in Penicillium expansum

inferredcites →https://doi.org/10.1111/j.1365-2958.2005.04884.xopenalex-snapshot

Two different polyketide synthase genes are required for synthesis of zearalenone in Gibberella zeae

inferredcites →https://doi.org/10.1126/science.1161269openalex-snapshot

The Crystal Structure of a Mammalian Fatty Acid Synthase

inferredcites →https://doi.org/10.1126/science.284.5418.1368openalex-snapshot

Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis

inferredcites →https://doi.org/10.1126/science.aag2347openalex-snapshot

Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum

inferredcites →https://doi.org/10.1128/aem.00478-08openalex-snapshot

Genes for the Biosynthesis of the Fungal Polyketides Hypothemycin from Hypomyces subiculosus and Radicicol from Pochonia chlamydosporia

inferredcites →https://doi.org/10.1128/aem.01743-08openalex-snapshot

Identification and Characterization of the Asperthecin Gene Cluster of Aspergillus nidulans

inferredcites →https://doi.org/10.1128/aem.02187-09openalex-snapshot

Characterization of the Aspergillus nidulans Monodictyphenone Gene Cluster

inferredcites →https://doi.org/10.1128/aem.02745-14openalex-snapshot

An In Planta -Expressed Polyketide Synthase Produces ( R )-Mellein in the Wheat Pathogen Parastagonospora nodorum

inferredcites →https://doi.org/10.1128/aem.03334-12openalex-snapshot

Characterization of the Biosynthetic Genes for 10,11-Dehydrocurvularin, a Heat Shock Response-Modulating Anticancer Fungal Polyketide from Aspergillus terreus

inferredcites →https://doi.org/10.1128/aem.72.3.1793-1799.2006openalex-snapshot

Characterization of Two Polyketide Synthase Genes Involved in Zearalenone Biosynthesis in Gibberella zeae

inferredcites →https://doi.org/10.1128/ec.00362-06openalex-snapshot

Phosphopantetheinyl Transferase CfwA/NpgA Is Required for Aspergillus nidulans Secondary Metabolism and Asexual Development

inferredcites →https://doi.org/10.1146/annurev.bi.56.070187.000513openalex-snapshot

COMPLEXES OF SEQUENTIAL METABOLIC ENZYMES

inferredcites →https://doi.org/10.1186/s40694-016-0020-zopenalex-snapshot

Identification and characterization of the ergochrome gene cluster in the plant pathogenic fungus Claviceps purpurea

inferredcites →https://doi.org/10.1371/journal.pone.0072871openalex-snapshot

Heterologous Reconstitution of the Intact Geodin Gene Cluster in Aspergillus nidulans through a Simple and Versatile PCR Based Approach

inferredcites →https://doi.org/10.1371/journal.pone.0161199openalex-snapshot

Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering

inferredcites →https://doi.org/10.3389/fmicb.2017.01685openalex-snapshot

Analysis of the Sequences, Structures, and Functions of Product-Releasing Enzyme Domains in Fungal Polyketide Synthases

inferredcites →https://doi.org/10.3389/fmicb.2019.01537openalex-snapshot

Interactome of Glyceraldehyde-3-Phosphate Dehydrogenase Points to the Existence of Metabolons in Paracoccidioides lutzii

inferredcites →https://doi.org/10.3389/fmicb.2019.03018openalex-snapshot

Evolutionary Histories of Type III Polyketide Synthases in Fungi

inferredcites →https://doi.org/10.3389/fmicb.2020.562063openalex-snapshot

Discovery of Pyranoviolin A and Its Biosynthetic Gene Cluster in Aspergillus violaceofuscus

inferredcites →https://doi.org/10.3389/fpls.2019.00821openalex-snapshot

Formation of Flavonoid Metabolons: Functional Significance of Protein-Protein Interactions and Impact on Flavonoid Chemodiversity

inferredcites →https://doi.org/10.3390/ijms22041938openalex-snapshot

Pseurotin D Inhibits the Activation of Human Lymphocytes

inferredcites →https://doi.org/10.3390/md13074331openalex-snapshot

Identification of the Scopularide Biosynthetic Gene Cluster in Scopulariopsis brevicaulis

inferredcites →https://doi.org/10.3390/molecules21121710openalex-snapshot

Functional Analysis of the Fusarielin Biosynthetic Gene Cluster

inferredcites →https://doi.org/10.3390/toxins9040126openalex-snapshot

Establishment of the Inducible Tet-On System for the Activation of the Silent Trichosetin Gene Cluster in Fusarium fujikuroi

inferredcites →https://doi.org/10.7164/antibiotics.49.958openalex-snapshot

Novel Neuritogenic Activities of Pseurotin A and Penicillic Acid.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Fungal polyketides from a rhizospheric soil-derived Penicillium sp. YUD17004 associated with Gastrodia elata

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Two Chroman Type Polyketides From Trichoderma sp. YUD24002 Associated With Aconitum

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Sustainable Biocatalytic Cascades: A Versatile Tool in the Synthesis of Natural Products With Therapeutic Potential

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Biochemistry of Secondary Metabolism of Fungi

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Structure, biological activity, and biosynthesis of natural chromanes and chromenes

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Biosynthesis of rumbrins and inspiration for discovery of HIV inhibitors

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Structural diversification of natural substrates modified by the O-methyltransferase AurJ from Fusarium Graminearum

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Advances in fungal enzyme cocktails for lignocellulosic biomass deconstruction and second-generation ethanol production

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Editing function of type II thioesterases in the biosynthesis of fungal polyketides

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Molecular landscape analysis of azinothricin-type natural products enables the identification of kettapeptin from Streptomyces durmitorensis

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Emerging diversity in polyketide synthase

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Genome-Guided Discovery and Heterologous Biosynthesis of Alkylresorcinols by Collaborating Highly Reducing and Type III Polyketide Synthases

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Curvulinic Acid–Gregatin Hybrids with Anti-inflammatory Activity from a Soil-Derived Fungus Penicillium sp. KYS-21

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Curvulinic Acid−Clavatol Hybrids and Curvulinic Acid Dimers with Anti-Inflammatory Activity from Penicillium sp. KYS-21

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Formation of 3-Orsellinoxypropanoic Acid in Penicillum crustosum is Catalyzed by a Bifunctional Nonreducing Polyketide Synthase

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Discovery and Biosynthesis of Cytotoxic Myroverols: A Phenalenone Scaffold Constructed by a Fungal Highly Reducing Polyketide Synthase and a Cytochrome P450

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Metabolic Competition between Non-reducing Polyketide Synthases Drives Hidden Chemodiversity in Deep-Sea Fungus Talaromyces radicus

inferred← citeshttps://doi.org/10.1021/acscatal.4c07664openalex-snapshot

Enzymatic Insights into the Unusual Formation of Benzolactone and Benzopyran in the Biosynthesis of Spiromarmycin

inferred← citeshttps://doi.org/10.1021/jacs.2c08585openalex-snapshot

Depside Bond Formation by the Starter-Unit Acyltransferase Domain of a Fungal Polyketide Synthase

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Biosynthesis of Cytosporones in Leotiomycetous Filamentous Fungi

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Genome mining-based discovery of an atypical fungal non-reducing polyketide synthase encoding dimeric alkylresorcinol biosynthesis

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Black yeasts emerge as hosts for fungal polyketide production

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Combinatorial biosynthesis for the engineering of novel fungal natural products

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Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases

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Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming

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Cupin-domain containing protein is not essential for the alkyl salicylaldehyde formation in Aspergillus ustus

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The chemical ecology and physiological functions of type I polyketide natural products: the emerging picture

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Coprophilous fungi in the search for new antimicrobials and other beneficial natural products

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Fungal polyketide biosynthesis as a platform for designer natural products

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Biosynthetic potential of endophytic fungi from tropical medicinal plants: genomic and metabolomic perspectives

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Subcellular localization of fungal specialized metabolites

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Transcription factor AaSom1 regulates development and pathogenicity with AapksA as a key target in Alternaria alternata

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Genome-Based Analysis of Verticillium Polyketide Synthase Gene Clusters

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The Role of Enoyl Reductase in the Monacolin K Biosynthesis Pathway in Monascus spp.

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Comparative Quantitative Proteomic Analysis of High and Low Toxin-Producing Karenia brevis Strains Reveals Differences in Polyketide Synthase Abundance and Redox Status of the Proteome

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Pigment Production by Pseudofusicoccum sp.: Extract Production, Cytotoxicity Activity, and Diketopiperazines Identified

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