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Current knowledge on the tissue distribution of mRNA nanocarriers for therapeutic protein expression

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1 of the 200 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1016/j.yexmp.2016.03.012 (notice 2016-04-11).

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Use of Poly(ethylene glycol)–Lipid Conjugates to Regulate the Surface Attributes and Transfection Activity of Lipid–DNA Particles
inferredcites →https://doi.org/10.1002/(sici)1521-2254(199909/10)1:5<331::aid-jgm60>3.0.co;2-8openalex-snapshot
Interaction of liposomal and polycationic transfection complexes with pulmonary surfactant
inferredcites →https://doi.org/10.1002/adma.201204346openalex-snapshot
Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability
inferredcites →https://doi.org/10.1002/adma.201606944openalex-snapshot
Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes
inferredcites →https://doi.org/10.1002/adma.201801151openalex-snapshot
Ionizable Amino‐Polyesters Synthesized via Ring Opening Polymerization of Tertiary Amino‐Alcohols for Tissue Selective mRNA Delivery
inferredcites →https://doi.org/10.1002/adma.201805116openalex-snapshot
Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium
inferredcites →https://doi.org/10.1002/adma.201805308openalex-snapshot
Dendrimer‐Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I
inferredcites →https://doi.org/10.1002/adma.201807748openalex-snapshot
Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses
inferredcites →https://doi.org/10.1002/adma.202004452openalex-snapshot
Leveraging mRNA Sequences and Nanoparticles to Deliver SARS‐CoV‐2 Antigens In Vivo
inferredcites →https://doi.org/10.1002/adma.202006619openalex-snapshot
All‐In‐One Dendrimer‐Based Lipid Nanoparticles Enable Precise HDR‐Mediated Gene Editing In Vivo
inferredcites →https://doi.org/10.1002/adma.202101707openalex-snapshot
Secreted Expression of mRNA‐Encoded Truncated ACE2 Variants for SARS‐CoV‐2 via Lipid‐Like Nanoassemblies
inferredcites →https://doi.org/10.1002/anie.201203263openalex-snapshot
Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**
inferredcites →https://doi.org/10.1002/anie.201603648openalex-snapshot
A Single Methylene Group in Oligoalkylamine‐Based Cationic Polymers and Lipids Promotes Enhanced mRNA Delivery
inferredcites →https://doi.org/10.1002/anie.201608450openalex-snapshot
Polymer–Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs
inferredcites →https://doi.org/10.1002/anie.201610209openalex-snapshot
Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA
inferredcites →https://doi.org/10.1002/anie.201809056openalex-snapshot
Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs
inferredcites →https://doi.org/10.1002/eji.1830230749openalex-snapshot
Induction of virus‐specific cytotoxic T lymphocytes in vivo by liposome‐entrapped mRNA
inferredcites →https://doi.org/10.1002/eji.200737984openalex-snapshot
Nanoparticles target distinct dendritic cell populations according to their size
inferredcites →https://doi.org/10.1002/hep.27406openalex-snapshot
The global burden of liver disease: The major impact of China
inferredcites →https://doi.org/10.1002/jcph.1553openalex-snapshot
Pharmacokinetics of Patisiran, the First Approved RNA Interference Therapy in Patients With Hereditary Transthyretin‐Mediated Amyloidosis
inferredcites →https://doi.org/10.1002/smll.201805097openalex-snapshot
Branched‐Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH
inferredcites →https://doi.org/10.1002/wrna.15openalex-snapshot
Regulation of mRNA decapping
inferredcites →https://doi.org/10.1006/mthe.1999.0021openalex-snapshot
Aerosol Delivery of Robust Polyethyleneimine– DNA Complexes for Gene Therapy and Genetic Immunization
inferredcites →https://doi.org/10.1006/mthe.2002.0698openalex-snapshot
Deposition and Expression of Aerosolized rAAV Vectors in the Lungs of Rhesus Macaques
inferredcites →https://doi.org/10.1007/978-1-4939-6588-5_10openalex-snapshot
Lipidoid mRNA Nanoparticles for Myocardial Delivery in Rodents
inferredcites →https://doi.org/10.1007/bf00210403openalex-snapshot
Molecular basis of phenotypic variation in patients with argininemia
inferredcites →https://doi.org/10.1007/s12195-019-00573-4openalex-snapshot
Cell Subtypes Within the Liver Microenvironment Differentially Interact with Lipid Nanoparticles
inferredcites →https://doi.org/10.1016/j.actbio.2019.11.022openalex-snapshot
Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles
inferredcites →https://doi.org/10.1016/j.addr.2008.09.011openalex-snapshot
Extracellular barriers in respiratory gene therapy
inferredcites →https://doi.org/10.1016/j.addr.2016.01.022openalex-snapshot
The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery
inferredcites →https://doi.org/10.1016/j.addr.2017.08.010openalex-snapshot
PEGylation for enhancing nanoparticle diffusion in mucus
inferredcites →https://doi.org/10.1016/j.addr.2020.06.026openalex-snapshot
Lipid nanoparticle technology for therapeutic gene regulation in the liver
inferredcites →https://doi.org/10.1016/j.bbrc.2005.12.105openalex-snapshot
mRNA transfection of dendritic cells: Synergistic effect of ARCA mRNA capping with Poly(A) chains in cis and in trans for a high protein expression level
inferredcites →https://doi.org/10.1016/j.bbrc.2018.12.137openalex-snapshot
Dendritic targeted mRNA expression via a cis-acting RNA UTR element
inferredcites →https://doi.org/10.1016/j.biocel.2019.105562openalex-snapshot
Lymphatic and blood systems: Identical or fraternal twins?
inferredcites →https://doi.org/10.1016/j.biomaterials.2008.12.076openalex-snapshot
The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles
inferredcites →https://doi.org/10.1016/j.biomaterials.2016.09.006openalex-snapshot
Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo
inferredcites →https://doi.org/10.1016/j.biomaterials.2021.120966openalex-snapshot
Systemic delivery of mRNA and DNA to the lung using polymer-lipid nanoparticles
inferredcites →https://doi.org/10.1016/j.celrep.2017.11.081openalex-snapshot
Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia
inferredcites →https://doi.org/10.1016/j.celrep.2018.02.014openalex-snapshot
A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing
inferredcites →https://doi.org/10.1016/j.cld.2016.08.001openalex-snapshot
Drug Metabolism in the Liver
inferredcites →https://doi.org/10.1016/j.clinre.2011.05.016openalex-snapshot
Gene therapy of liver diseases: A 2011 perspective
inferredcites →https://doi.org/10.1016/j.ebiom.2019.07.003openalex-snapshot
Long-term efficacy and safety of mRNA therapy in two murine models of methylmalonic acidemia
inferredcites →https://doi.org/10.1016/j.ejpb.2013.07.002openalex-snapshot
Lipid–polymer hybrid nanoparticles as a new generation therapeutic delivery platform: A review
inferredcites →https://doi.org/10.1016/j.ijpharm.2011.07.013openalex-snapshot
Design of multifunctional non-viral gene vectors to overcome physiological barriers: Dilemmas and strategies
inferredcites →https://doi.org/10.1016/j.ijpharm.2021.120586openalex-snapshot
mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability
inferredcites →https://doi.org/10.1016/j.immuni.2005.06.008openalex-snapshot
Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA
inferredcites →https://doi.org/10.1016/j.jconrel.2005.06.014openalex-snapshot
Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids
inferredcites →https://doi.org/10.1016/j.jconrel.2006.01.006openalex-snapshot
In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles
inferredcites →https://doi.org/10.1016/j.jconrel.2011.09.098openalex-snapshot
The journey of a drug-carrier in the body: An anatomo-physiological perspective
inferredcites →https://doi.org/10.1016/j.jconrel.2012.09.009openalex-snapshot
A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo
inferredcites →https://doi.org/10.1016/j.jconrel.2016.02.043openalex-snapshot
Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathways
inferredcites →https://doi.org/10.1016/j.jconrel.2016.05.059openalex-snapshot
Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA
inferredcites →https://doi.org/10.1016/j.jconrel.2016.06.001openalex-snapshot
Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles
inferredcites →https://doi.org/10.1016/j.jconrel.2017.09.044openalex-snapshot
Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus
inferredcites →https://doi.org/10.1016/j.jconrel.2018.10.015openalex-snapshot
PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake
inferredcites →https://doi.org/10.1016/j.jconrel.2019.04.015openalex-snapshot
Lipid nanoparticles for delivery of messenger RNA to the back of the eye
inferredcites →https://doi.org/10.1016/j.jconrel.2019.06.042openalex-snapshot
Non-viral delivery of chemically modified mRNA to the retina: Subretinal versus intravitreal administration
inferredcites →https://doi.org/10.1016/j.jconrel.2021.11.022openalex-snapshot
Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery
inferredcites →https://doi.org/10.1016/j.jconrel.2022.03.046openalex-snapshot
The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs
inferredcites →https://doi.org/10.1016/j.jhep.2016.07.009openalex-snapshot
Liver sinusoidal endothelial cells: Physiology and role in liver diseases
inferredcites →https://doi.org/10.1016/j.jhep.2018.09.014openalex-snapshot
Burden of liver diseases in the world
inferredcites →https://doi.org/10.1016/j.nantod.2015.06.006openalex-snapshot
Nanoparticle uptake: The phagocyte problem
inferredcites →https://doi.org/10.1016/j.nantod.2015.09.003openalex-snapshot
RNA as a stable polymer to build controllable and defined nanostructures for material and biomedical applications
inferredcites →https://doi.org/10.1016/j.neuron.2018.03.030openalex-snapshot
Alternative 3′ UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments
inferredcites →https://doi.org/10.1016/j.omtm.2018.04.003openalex-snapshot
Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine
inferredcites →https://doi.org/10.1016/j.omtn.2017.04.006openalex-snapshot
Translation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNA
inferredcites →https://doi.org/10.1016/j.progpolymsci.2010.04.007openalex-snapshot
Hydrophobic modifications of cationic polymers for gene delivery
inferredcites →https://doi.org/10.1016/j.vaccine.2004.06.028openalex-snapshot
Genetically programmed B lymphocytes are highly efficient in inducing anti-virus protective immunity mediated by central memory CD8 T cells
inferredcites →https://doi.org/10.1016/j.yexmp.2016.03.012openalex-snapshot
RETRACTED: Endothelial PECAM-1 and its function in vascular physiology and atherogenic pathology
inferredcites →https://doi.org/10.1016/j.ymeth.2003.11.023openalex-snapshot
Advanced transfection with Lipofectamine 2000 reagent: primary neurons, siRNA, and high-throughput applications
inferredcites →https://doi.org/10.1016/j.ymthe.2017.03.013openalex-snapshot
Lipid Nanoparticle Systems for Enabling Gene Therapies
inferredcites →https://doi.org/10.1016/j.ymthe.2017.03.016openalex-snapshot
Optimizing Cardiac Delivery of Modified mRNA
inferredcites →https://doi.org/10.1016/j.ymthe.2017.12.024openalex-snapshot
Targeted mRNA Therapy for Ornithine Transcarbamylase Deficiency
inferredcites →https://doi.org/10.1016/j.ymthe.2018.01.006openalex-snapshot
G6PC mRNA Therapy Positively Regulates Fasting Blood Glucose and Decreases Liver Abnormalities in a Mouse Model of Glycogen Storage Disease 1a
inferredcites →https://doi.org/10.1016/j.ymthe.2018.03.010openalex-snapshot
A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates
inferredcites →https://doi.org/10.1016/j.ymthe.2018.05.014openalex-snapshot
Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis
inferredcites →https://doi.org/10.1016/j.ymthe.2018.11.018openalex-snapshot
mRNA-Based Protein Replacement Therapy for the Heart
inferredcites →https://doi.org/10.1016/j.ymthe.2019.02.012openalex-snapshot
Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery
inferredcites →https://doi.org/10.1016/j.ymthe.2019.02.019openalex-snapshot
Recent Developments in mRNA-Based Protein Supplementation Therapy to Target Lung Diseases
inferredcites →https://doi.org/10.1016/j.ymthe.2019.05.012openalex-snapshot
mRNA Delivery for Therapeutic Anti-HER2 Antibody Expression In Vivo
inferredcites →https://doi.org/10.1016/j.ymthe.2020.06.015openalex-snapshot
Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug
inferredcites →https://doi.org/10.1016/j.ymthe.2021.06.004openalex-snapshot
Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs
inferredcites →https://doi.org/10.1016/s0021-9258(18)47945-8openalex-snapshot
Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.
inferredcites →https://doi.org/10.1016/s0300-9084(02)01445-1openalex-snapshot
mRNA degradation machines in eukaryotic cells
inferredcites →https://doi.org/10.1016/s0735-1097(00)01144-xopenalex-snapshot
Efficacy of intracoronary or intravenous VEGF165in a pig model of chronic myocardial ischemia
inferredcites →https://doi.org/10.1016/s1569-1993(21)02006-3openalex-snapshot
583: Variant-agnostic CFTR rescue using aerosolized delivery of CFTR mRNA using the SORT-LNP in primary human bronchial epithelial cells derived from patients with cystic fibrosis
inferredcites →https://doi.org/10.1016/s2213-2600(20)30105-3openalex-snapshot
Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
inferredcites →https://doi.org/10.1021/acs.accounts.1c00521openalex-snapshot
Immunogenicity of In Vitro -Transcribed RNA
inferredcites →https://doi.org/10.1021/acs.biomac.5b00795openalex-snapshot
Development of Guanidinium-Rich Protein Mimics for Efficient siRNA Delivery into Human T Cells
inferredcites →https://doi.org/10.1021/acs.biomac.6b00900openalex-snapshot
Mapping Optimal Charge Density and Length of ROMP-Based PTDMs for siRNA Internalization
inferredcites →https://doi.org/10.1021/acs.biomac.7b01356openalex-snapshot
Systemic mRNA Delivery to the Lungs by Functional Polyester-based Carriers
inferredcites →https://doi.org/10.1021/acs.chemrev.1c00244openalex-snapshot
Lipids and Lipid Derivatives for RNA Delivery
inferredcites →https://doi.org/10.1021/acs.molpharmaceut.7b01084openalex-snapshot
In Vivo Introduction of mRNA Encapsulated in Lipid Nanoparticles to Brain Neuronal Cells and Astrocytes via Intracerebroventricular Administration
inferredcites →https://doi.org/10.1021/acs.nanolett.0c00596openalex-snapshot
A Potent Branched-Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing In Vivo
inferredcites →https://doi.org/10.1021/acs.nanolett.0c01386openalex-snapshot
Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery
inferredcites →https://doi.org/10.1021/acs.nanolett.5b02428openalex-snapshot
Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo
inferredcites →https://doi.org/10.1021/acs.nanolett.5b02497openalex-snapshot
Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs
inferredcites →https://doi.org/10.1021/acs.nanolett.6b03329openalex-snapshot
Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy
inferredcites →https://doi.org/10.1021/acs.nanolett.8b02917openalex-snapshot
Optimization of a Degradable Polymer–Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells
inferredcites →https://doi.org/10.1021/acs.nanolett.8b03149openalex-snapshot
Modifying a Commonly Expressed Endocytic Receptor Retargets Nanoparticles in Vivo
inferredcites →https://doi.org/10.1021/acs.nanolett.9b04246openalex-snapshot
Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering
inferredcites →https://doi.org/10.1021/acsami.1c14975openalex-snapshot
Hybrid Lipid/Polymer Nanoparticles to Tackle the Cystic Fibrosis Mucus Barrier in siRNA Delivery to the Lungs: Does PEGylation Make the Difference?
inferredcites →https://doi.org/10.1021/acsbiomaterials.8b01062openalex-snapshot
Nanomaterial Interactions with Human Neutrophils
inferredcites →https://doi.org/10.1021/acsnano.8b03640openalex-snapshot
Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery
inferredcites →https://doi.org/10.1021/bi00018a025openalex-snapshot
Transbilayer Movement and Net Flux of Cholesterol and Cholesterol Sulfate between Liposomal Membranes
inferredcites →https://doi.org/10.1021/ja505986aopenalex-snapshot
Multivalent N -Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing
inferredcites →https://doi.org/10.1021/jacs.1c09822openalex-snapshot
Zwitterionic Phospholipidation of Cationic Polymers Facilitates Systemic mRNA Delivery to Spleen and Lymph Nodes
inferredcites →https://doi.org/10.1021/la104590kopenalex-snapshot
Ionization Behavior of Amino Lipids for siRNA Delivery: Determination of Ionization Constants, SAR, and the Impact of Lipid pKa on Cationic Lipid−Biomembrane Interactions
inferredcites →https://doi.org/10.1021/mp400140uopenalex-snapshot
Stabilization of Distearoylphosphatidylcholine Lamellar Phases in Propylene Glycol Using Cholesterol
inferredcites →https://doi.org/10.1021/nn406018qopenalex-snapshot
Protein Corona Fingerprinting Predicts the Cellular Interaction of Gold and Silver Nanoparticles
inferredcites →https://doi.org/10.1038/cr.2013.112openalex-snapshot
Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA
inferredcites →https://doi.org/10.1038/cr.2017.16openalex-snapshot
A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and pcsk9 in vivo
inferredcites →https://doi.org/10.1038/d41586-021-02483-wopenalex-snapshot
The tangled history of mRNA vaccines
inferredcites →https://doi.org/10.1038/emboj.2011.286openalex-snapshot
Endosome maturation
inferredcites →https://doi.org/10.1038/gt.2011.17openalex-snapshot
Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation
inferredcites →https://doi.org/10.1038/gt.2011.55openalex-snapshot
Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung
inferredcites →https://doi.org/10.1038/gt.2015.68openalex-snapshot
Efficient expression of stabilized mRNA PEG-peptide polyplexes in liver
inferredcites →https://doi.org/10.1038/gt.2016.46openalex-snapshot
Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system
inferredcites →https://doi.org/10.1038/mt.2008.200openalex-snapshot
Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability
inferredcites →https://doi.org/10.1038/mt.2009.70openalex-snapshot
VEGF Gene Therapy Fails to Improve Perfusion of Ischemic Myocardium in Patients With Advanced Coronary Disease: Results of the NORTHERN Trial
inferredcites →https://doi.org/10.1038/mt.2010.85openalex-snapshot
Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms
inferredcites →https://doi.org/10.1038/mt.2013.124openalex-snapshot
Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics
inferredcites →https://doi.org/10.1038/mt.2013.49openalex-snapshot
Adenoviral Gene Transfer Corrects the Ion Transport Defect in the Sinus Epithelia of a Porcine CF Model
inferredcites →https://doi.org/10.1038/mt.2015.103openalex-snapshot
Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals
inferredcites →https://doi.org/10.1038/mt.2015.193openalex-snapshot
Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression
inferredcites →https://doi.org/10.1038/mtna.2013.65openalex-snapshot
Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain
inferredcites →https://doi.org/10.1038/natrevmats.2017.56openalex-snapshot
Tools for translation: non-viral materials for therapeutic mRNA delivery
inferredcites →https://doi.org/10.1038/nature18300openalex-snapshot
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
inferredcites →https://doi.org/10.1038/nature23003openalex-snapshot
Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer
inferredcites →https://doi.org/10.1038/nbt.2682openalex-snapshot
Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction
inferredcites →https://doi.org/10.1038/nbt.3802openalex-snapshot
Overcoming cellular barriers for RNA therapeutics
inferredcites →https://doi.org/10.1038/nbt.4005openalex-snapshot
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing
inferredcites →https://doi.org/10.1038/nbt1372openalex-snapshot
Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state
inferredcites →https://doi.org/10.1038/ncomms14630openalex-snapshot
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
inferredcites →https://doi.org/10.1038/ncomms5277openalex-snapshot
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
inferredcites →https://doi.org/10.1038/ng0992-21openalex-snapshot
Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis
inferredcites →https://doi.org/10.1038/nm.4356openalex-snapshot
Elimination of large tumors in mice by mRNA-encoded bispecific antibodies
inferredcites →https://doi.org/10.1038/nmat3187openalex-snapshot
Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery
inferredcites →https://doi.org/10.1038/nmat4718openalex-snapshot
Mechanism of hard-nanomaterial clearance by the liver
inferredcites →https://doi.org/10.1038/nrd.2018.93openalex-snapshot
Principles for targeting RNA with drug-like small molecules
inferredcites →https://doi.org/10.1038/nrd4278openalex-snapshot
mRNA-based therapeutics — developing a new class of drugs
inferredcites →https://doi.org/10.1038/nrd892openalex-snapshot
The druggable genome
inferredcites →https://doi.org/10.1038/nrm2336openalex-snapshot
Cellular cholesterol trafficking and compartmentalization
inferredcites →https://doi.org/10.1038/onc.2009.211openalex-snapshot
Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties
inferredcites →https://doi.org/10.1038/s41423-020-0488-6openalex-snapshot
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications
inferredcites →https://doi.org/10.1038/s41467-018-06936-1openalex-snapshot
Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes
inferredcites →https://doi.org/10.1038/s41467-020-14527-2openalex-snapshot
Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA
inferredcites →https://doi.org/10.1038/s41467-020-16248-yopenalex-snapshot
Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver
inferredcites →https://doi.org/10.1038/s41467-020-17029-3openalex-snapshot
Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
inferredcites →https://doi.org/10.1038/s41467-020-19156-3openalex-snapshot
Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia
inferredcites →https://doi.org/10.1038/s41467-021-23318-2openalex-snapshot
mRNA therapy restores euglycemia and prevents liver tumors in murine model of glycogen storage disease
inferredcites →https://doi.org/10.1038/s41467-021-23546-6openalex-snapshot
Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema
inferredcites →https://doi.org/10.1038/s41551-019-0378-3openalex-snapshot
Visualization of early events in mRNA vaccine delivery in non-human primates via PET–CT and near-infrared imaging
inferredcites →https://doi.org/10.1038/s41551-021-00786-xopenalex-snapshot
Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs
inferredcites →https://doi.org/10.1038/s41551-021-00794-xopenalex-snapshot
Lipid nanoparticles for the inhalation of mRNA
inferredcites →https://doi.org/10.1038/s41563-020-00886-0openalex-snapshot
Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing
inferredcites →https://doi.org/10.1038/s41565-018-0358-xopenalex-snapshot
Self-assembled peptide–poloxamine nanoparticles enable in vitro and in vivo genome restoration for cystic fibrosis
inferredcites →https://doi.org/10.1038/s41565-019-0591-yopenalex-snapshot
The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
inferredcites →https://doi.org/10.1038/s41565-020-0669-6openalex-snapshot
Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing
inferredcites →https://doi.org/10.1038/s41565-021-00898-0openalex-snapshot
The current landscape of nucleic acid therapeutics
inferredcites →https://doi.org/10.1038/s41565-022-01071-xopenalex-snapshot
Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines
inferredcites →https://doi.org/10.1038/s41569-018-0036-6openalex-snapshot
Therapeutic approaches for cardiac regeneration and repair
inferredcites →https://doi.org/10.1038/s41576-021-00439-4openalex-snapshot
Drug delivery systems for RNA therapeutics
inferredcites →https://doi.org/10.1038/s41578-021-00358-0openalex-snapshot
Lipid nanoparticles for mRNA delivery
inferredcites →https://doi.org/10.1038/s41586-020-2537-9openalex-snapshot
An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma
inferredcites →https://doi.org/10.1038/s41587-019-0015-4openalex-snapshot
Antigen-specific therapeutic approaches for autoimmunity
inferredcites →https://doi.org/10.1038/s41587-021-00822-wopenalex-snapshot
Treatment of influenza and SARS-CoV-2 infections via mRNA-encoded Cas13a in rodents
inferredcites →https://doi.org/10.1038/s41591-018-0199-zopenalex-snapshot
Systemic messenger RNA as an etiological treatment for acute intermittent porphyria
inferredcites →https://doi.org/10.1038/s41598-018-26298-4openalex-snapshot
mRNA treatment produces sustained expression of enzymatically active human ADAMTS13 in mice
inferredcites →https://doi.org/10.1038/s41598-018-34960-0openalex-snapshot
Chemically modified hCFTR mRNAs recuperate lung function in a mouse model of cystic fibrosis
inferredcites →https://doi.org/10.1038/s41598-019-49028-wopenalex-snapshot
Fate of nanoparticles in the central nervous system after intrathecal injection in healthy mice
inferredcites →https://doi.org/10.1038/s41598-020-64017-0openalex-snapshot
Systemic modified messenger RNA for replacement therapy in alpha 1-antitrypsin deficiency
inferredcites →https://doi.org/10.1038/s41598-020-75253-9openalex-snapshot
Investigating the optimum size of nanoparticles for their delivery into the brain assisted by focused ultrasound-induced blood–brain barrier opening
inferredcites →https://doi.org/10.1038/sj.gt.3301525openalex-snapshot
Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium
inferredcites →https://doi.org/10.1038/sj.gt.3301663openalex-snapshot
Pegylated GL67 lipoplexes retain their gene transfection activity after exposure to components of CF mucus
inferredcites →https://doi.org/10.1038/srep15810openalex-snapshot
Messenger RNA-based therapeutics for the treatment of apoptosis-associated diseases
inferredcites →https://doi.org/10.1038/srep20019openalex-snapshot
Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich’s ataxia
inferredcites →https://doi.org/10.1039/d0bm01609hopenalex-snapshot
Helper lipid structure influences protein adsorption and delivery of lipid nanoparticles to spleen and liver
inferredcites →https://doi.org/10.1039/d0bm01947jopenalex-snapshot
Illuminating endosomal escape of polymorphic lipid nanoparticles that boost mRNA delivery
inferredcites →https://doi.org/10.1039/d1bm01454dopenalex-snapshot
Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA)
inferredcites →https://doi.org/10.1056/nejmoa2107454openalex-snapshot
CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis
inferredcites →https://doi.org/10.1073/pnas.0910603106openalex-snapshot
Lipid-like materials for low-dose, in vivo gene silencing
inferredcites →https://doi.org/10.1073/pnas.1520756113openalex-snapshot
Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model
inferredcites →https://doi.org/10.1073/pnas.1619653114openalex-snapshot
Systemic delivery of factor IX messenger RNA for protein replacement therapy
inferredcites →https://doi.org/10.1073/pnas.1805358115openalex-snapshot
Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters
inferredcites →https://doi.org/10.1073/pnas.1811276115openalex-snapshot
High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing
inferredcites →https://doi.org/10.1073/pnas.1906182116openalex-snapshot
Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency
inferredcites →https://doi.org/10.1073/pnas.1912012117openalex-snapshot
Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier
inferredcites →https://doi.org/10.1073/pnas.2020401118openalex-snapshot
Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3
inferredcites →https://doi.org/10.1073/pnas.2109256118openalex-snapshot
On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles
inferredcites →https://doi.org/10.1073/pnas.86.16.6077openalex-snapshot
Cationic liposome-mediated RNA transfection.
inferredcites →https://doi.org/10.1074/jbc.m309026200openalex-snapshot
Enhanced Viscoelasticity of Human Cystic Fibrotic Sputum Correlates with Increasing Microheterogeneity in Particle Transport
inferredcites →https://doi.org/10.1080/17476348.2019.1634547openalex-snapshot
Emerging gene therapies for cystic fibrosis
inferredcites →https://doi.org/10.1089/hum.2006.17.1openalex-snapshot
Lentivirus-Mediated Gene Transfer to the Central Nervous System: Therapeutic and Research Applications
inferredcites →https://doi.org/10.1089/hum.2006.17.1027openalex-snapshot
Synthetic Messenger RNA as a Tool for Gene Therapy
inferredcites →https://doi.org/10.1089/hum.2020.137openalex-snapshot
Treating Cystic Fibrosis with mRNA and CRISPR
inferredcites →https://doi.org/10.1089/jop.2012.0138openalex-snapshot
The Vitreous Humor As a Barrier to Nanoparticle Distribution
inferredcites →https://doi.org/10.1089/nat.2018.0734openalex-snapshot
MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct
inferredcites →https://doi.org/10.1097/icu.0000000000000660openalex-snapshot
Gene therapy beyond luxturna: a new horizon of the treatment for inherited retinal disease
showing the first 200 of 249 · page through all 249

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4657914openalex-extracted
Delivery of Rna Drugs: Beyond the Liver, More than Vaccine
inferred← citeshttps://doi.org/10.1002/9781394300150.ch6openalex-snapshot
mRNA‐Based Vaccines and Therapeutics
inferred← citeshttps://doi.org/10.1002/ange.3823572openalex-snapshot
Retinoic‐Acid‐Derived Ionizable Lipids Enable Spleen‐Selective Antigen Expression for mRNA Cancer Vaccination
inferred← citeshttps://doi.org/10.1002/anie.3823572openalex-snapshot
Retinoic‐Acid‐Derived Ionizable Lipids Enable Spleen‐Selective Antigen Expression for mRNA Cancer Vaccination
inferred← citeshttps://doi.org/10.1002/mba2.70036openalex-snapshot
Investigations Into the Influence of Ionizable Lipids on the Stability of Lipid Nanoparticle
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2024.122853openalex-snapshot
Pharmaceutical strategies for optimized mRNA expression
inferred← citeshttps://doi.org/10.1016/j.ejpb.2024.114203openalex-snapshot
Recent trends in the delivery of RNA drugs: Beyond the liver, more than vaccine
inferred← citeshttps://doi.org/10.1016/j.molmed.2023.03.001openalex-snapshot
Recent insights into lysosomal acid lipase deficiency
inferred← citeshttps://doi.org/10.1016/j.ymthe.2025.06.018openalex-snapshot
Therapeutic effect of galactosyltransferase- and sialyltransferase-encoding mRNA in rheumatoid arthritis
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.5c00774openalex-snapshot
mRNA-Based Therapeutics: Advances in Drug Delivery, Comparative Innovations, and Biomedical Applications
inferred← citeshttps://doi.org/10.1021/acsami.4c11819openalex-snapshot
Gastrointestinal Device-Mediated Delivery of mRNA-Lipid Nanoparticles Achieves Distinct Expression and Biodistribution in Mice and Pigs
inferred← citeshttps://doi.org/10.1038/s41573-023-00859-3openalex-snapshot
Strategies to reduce the risks of mRNA drug and vaccine toxicity
inferred← citeshttps://doi.org/10.1039/d5bm00322aopenalex-snapshot
Non-viral mRNA delivery to the lungs
inferred← citeshttps://doi.org/10.1101/2024.12.07.627318openalex-snapshot
Lipid-based nanoparticles deliver mRNA to reverse the pathogenesis of lysosomal acid lipase deficiency in a preclinical model
inferred← citeshttps://doi.org/10.2147/cpaa.s418314openalex-snapshot
Recent Advances in Messenger Ribonucleic Acid (mRNA) Vaccines and Their Delivery Systems: A Review
inferred← citeshttps://doi.org/10.3390/vaccines13040370openalex-snapshot
Mind the Age Gap: Expanding the Age Window for mRNA Vaccine Testing in Mice
inferred← citeshttps://doi.org/10.37349/eemd.2024.00011openalex-snapshot
Genome editing in the adrenal gland: a novel strategy for treating congenital adrenal hyperplasia
inferred← citeshttps://doi.org/10.47570/joci.2024.004openalex-snapshot
Beyond the injection site: identifying the cellular targets of mRNA vaccines
inferred← citeshttps://doi.org/10.7150/thno.90071openalex-snapshot
Quaternization drives spleen-to-lung tropism conversion for mRNA-loaded lipid-like nanoassemblies
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