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Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/9780470177334.ch2openalex-snapshot
Antioxidant Molecules and Redox Cofactors
inferredcites →https://doi.org/10.1006/bbrc.1998.9315openalex-snapshot
Iron-Binding Catechols Oxidating Lignin and Chlorolignin
inferredcites →https://doi.org/10.1016/0006-291x(78)91010-0openalex-snapshot
The role of ascorbate in the prolyl hydroxylase reaction
inferredcites →https://doi.org/10.1016/0167-4838(82)90162-5openalex-snapshot
Prolyl 4-hydroxylase activity in relation to the oxidation state of enzyme-bound iron
inferredcites →https://doi.org/10.1016/0167-4838(84)90113-4openalex-snapshot
Stoicheiometry and kinetics of the prolyl 4-hydroxylase partial reaction
inferredcites →https://doi.org/10.1016/j.jinorgbio.2006.01.024openalex-snapshot
Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins
inferredcites →https://doi.org/10.1016/j.jmb.2009.07.070openalex-snapshot
Asparaginyl β-Hydroxylation of Proteins Containing Ankyrin Repeat Domains Influences Their Stability and Function
inferredcites →https://doi.org/10.1016/j.molcel.2008.04.009openalex-snapshot
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
inferredcites →https://doi.org/10.1016/j.str.2009.06.002openalex-snapshot
Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases
inferredcites →https://doi.org/10.1016/s0002-9440(10)64554-3openalex-snapshot
The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages
inferredcites →https://doi.org/10.1016/s0021-9258(18)91023-9openalex-snapshot
Ascorbate is consumed stoichiometrically in the uncoupled reactions catalyzed by prolyl 4-hydroxylase and lysyl hydroxylase.
inferredcites →https://doi.org/10.1016/s0021-9258(19)57475-0openalex-snapshot
Partial identity of the 2-oxoglutarate and ascorbate binding sites of prolyl 4-hydroxylase.
inferredcites →https://doi.org/10.1016/s0076-6879(07)35004-0openalex-snapshot
Characterization of Ankyrin Repeat–Containing Proteins as Substrates of the Asparaginyl Hydroxylase Factor Inhibiting Hypoxia‐Inducible Transcription Factor
inferredcites →https://doi.org/10.1016/s0092-8674(01)00507-4openalex-snapshot
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
inferredcites →https://doi.org/10.1016/s0378-1119(01)00633-3openalex-snapshot
Characterization and comparative analysis of the EGLN gene family
inferredcites →https://doi.org/10.1016/s0945-053x(98)90009-9openalex-snapshot
Prolyl 4-hydroxylases and their protein disulfide isomerase subunit
inferredcites →https://doi.org/10.1016/s0959-440x(99)00036-6openalex-snapshot
Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes
inferredcites →https://doi.org/10.1038/nchembio0308-152openalex-snapshot
Expanding chemical biology of 2-oxoglutarate oxygenases
inferredcites →https://doi.org/10.1039/b511249bopenalex-snapshot
Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate
inferredcites →https://doi.org/10.1039/b815271copenalex-snapshot
Asparagine β-hydroxylation stabilizes the ankyrin repeat domain fold
inferredcites →https://doi.org/10.1042/bj3000075openalex-snapshot
Structural requirements for the utilization of ascorbate analogues in the prolyl 4-hydroxylase reaction
inferredcites →https://doi.org/10.1042/bj3130185openalex-snapshot
Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis
inferredcites →https://doi.org/10.1073/pnas.0601283103openalex-snapshot
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)
inferredcites →https://doi.org/10.1073/pnas.0804226105openalex-snapshot
Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice
inferredcites →https://doi.org/10.1073/pnas.92.12.5510openalex-snapshot
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
inferredcites →https://doi.org/10.1073/pnas.96.14.7905openalex-snapshot
Role of the nonheme Fe(II) center in the biosynthesis of the plant hormone ethylene
inferredcites →https://doi.org/10.1074/jbc.c200273200openalex-snapshot
Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family
inferredcites →https://doi.org/10.1074/jbc.m304982200openalex-snapshot
Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor
inferredcites →https://doi.org/10.1074/jbc.m403057200openalex-snapshot
Depletion of Intracellular Ascorbate by the Carcinogenic Metals Nickel and Cobalt Results in the Induction of Hypoxic Stress
inferredcites →https://doi.org/10.1074/jbc.m507528200openalex-snapshot
Structure of Human Phytanoyl-CoA 2-Hydroxylase Identifies Molecular Mechanisms of Refsum Disease*
inferredcites →https://doi.org/10.1074/jbc.m704102200openalex-snapshot
Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor
inferredcites →https://doi.org/10.1074/mcp.m800340-mcp200openalex-snapshot
Proteomics-based Identification of Novel Factor Inhibiting Hypoxia-inducible Factor (FIH) Substrates Indicates Widespread Asparaginyl Hydroxylation of Ankyrin Repeat Domain-containing Proteins
inferredcites →https://doi.org/10.1080/10409230490440541openalex-snapshot
Fe(II)/α-Ketoglutarate-Dependent Hydroxylases and Related Enzymes
inferredcites →https://doi.org/10.1091/mbc.e07-06-0612openalex-snapshot
Hypoxia-inducible Factor-1α Stabilization in Nonhypoxic Conditions: Role of Oxidation and Intracellular Ascorbate Depletion
inferredcites →https://doi.org/10.1093/emboj/21.11.2646openalex-snapshot
Paradoxical redox properties of DsbB and DsbA in the protein disulfide‐introducing reaction cascade
inferredcites →https://doi.org/10.1093/emboj/cdg392openalex-snapshot
HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia
inferredcites →https://doi.org/10.1126/science.1059796openalex-snapshot
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
inferredcites →https://doi.org/10.1126/science.1059817openalex-snapshot
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
inferredcites →https://doi.org/10.1126/science.1066373openalex-snapshot
A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF
inferredcites →https://doi.org/10.1126/science.1068592openalex-snapshot
Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch
inferredcites →https://doi.org/10.1128/mcb.12.12.5447openalex-snapshot
A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional Activation
inferredcites →https://doi.org/10.1152/physiol.00001.2004openalex-snapshot
Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level
inferredcites →https://doi.org/10.1161/circulationaha.107.701516openalex-snapshot
Essential Role for Prolyl Hydroxylase Domain Protein 2 in Oxygen Homeostasis of the Adult Vascular System
inferredcites →https://doi.org/10.1189/jlb.0806541openalex-snapshot
Ascorbate deficiency results in impaired neutrophil apoptosis and clearance and is associated with up-regulation of hypoxia-inducible factor 1α
inferredcites →https://doi.org/10.1503/cmaj.060228openalex-snapshot
High-dose vitamin C therapy: Renewed hope or false promise?
inferredcites →https://doi.org/10.2174/0929867053764635openalex-snapshot
Metals, Toxicity and Oxidative Stress
inferredcites →https://doi.org/10.2174/1381612043452884openalex-snapshot
Modulating the Hypoxia-Inducible Factor Signaling Pathway: Applications From Cardiovascular Disease to Cancer
inferredcites →https://doi.org/10.2307/3579271openalex-snapshot
Catalytic Metals, Ascorbate and Free Radicals: Combinations to Avoid
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4176870openalex-extracted
Two-Week Repair Alleviates Hexavalent Chromium-Induced Hepatotoxicity, Hepatic Metabolic and Gut Microbial Changes: A Subchronic Dynamic Inhalation Exposure Model in Male Mice
inferred← citeshttps://doi.org/10.1002/cam4.349openalex-snapshot
Restoring physiological levels of ascorbate slows tumor growth and moderates HIF‐1 pathway activity in Gulo−/− mice
inferred← citeshttps://doi.org/10.1002/cbic.201800246openalex-snapshot
Studies on the Substrate Selectivity of the Hypoxia‐Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain
inferred← citeshttps://doi.org/10.1002/jbmr.2258openalex-snapshot
Conditional Disruption of the Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Defines Its Key Role in Skeletal Development
inferred← citeshttps://doi.org/10.1002/jlb.1mr1219-245ropenalex-snapshot
A comparative view on vitamin C effects on αβ- versus γδ T-cell activation and differentiation
inferred← citeshttps://doi.org/10.1002/term.2671openalex-snapshot
Chondrogenic differentiation of human chondrocytes cultured in the absence of ascorbic acid
inferred← citeshttps://doi.org/10.1007/978-1-137-00689-9_3openalex-snapshot
Vitamin C and Its Role in Brain Development and Cognition
inferred← citeshttps://doi.org/10.1007/978-1-4614-9167-5_4openalex-snapshot
Hypoxia and Reactive Oxygen Species
inferred← citeshttps://doi.org/10.1007/978-1-4939-7665-2_2openalex-snapshot
Kinetic Analysis of HIF Prolyl Hydroxylases
inferred← citeshttps://doi.org/10.1007/s00018-015-1978-zopenalex-snapshot
2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process
inferred← citeshttps://doi.org/10.1007/s00204-022-03285-3openalex-snapshot
Renal hypoxia–HIF–PHD–EPO signaling in transition metal nephrotoxicity: friend or foe?
inferred← citeshttps://doi.org/10.1007/s00394-014-0809-6openalex-snapshot
Maternal vitamin C deficiency during pregnancy results in transient fetal and placental growth retardation in guinea pigs
inferred← citeshttps://doi.org/10.1007/s00424-022-02714-7openalex-snapshot
Fount, fate, features, and function of renal erythropoietin-producing cells
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2022.738849openalex-snapshot
Hypoxia mediates Hif-1α to affect myofiber development and Vc regulates the influence by activating Shh-Gli pathway in channel catfish (Ictalurus punctatus)
inferred← citeshttps://doi.org/10.1016/j.arr.2024.102551openalex-snapshot
Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2013.02.010openalex-snapshot
Transferrin iron uptake is stimulated by ascorbate via an intracellular reductive mechanism
inferred← citeshttps://doi.org/10.1016/j.biochi.2017.12.011openalex-snapshot
L-ascorbic acid: A true substrate for HIF prolyl hydroxylase?
inferred← citeshttps://doi.org/10.1016/j.biopha.2016.12.056openalex-snapshot
Ascorbic acid, but not dehydroascorbic acid increases intracellular vitamin C content to decrease Hypoxia Inducible Factor -1 alpha activity and reduce malignant potential in human melanoma
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117407openalex-snapshot
Iron chelators as mitophagy agents: Potential and limitations
inferred← citeshttps://doi.org/10.1016/j.cbpa.2024.102428openalex-snapshot
Biochemistry of the hypoxia-inducible factor hydroxylases
inferred← citeshttps://doi.org/10.1016/j.cell.2016.05.042openalex-snapshot
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
inferred← citeshttps://doi.org/10.1016/j.chembiol.2011.03.007openalex-snapshot
A Photoreactive Small-Molecule Probe for 2-Oxoglutarate Oxygenases
inferred← citeshttps://doi.org/10.1016/j.dnarep.2012.02.005openalex-snapshot
Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts
inferred← citeshttps://doi.org/10.1016/j.envexpbot.2020.104173openalex-snapshot
Is ascorbic acid a key signaling molecule integrating the activities of 2-oxoglutarate-dependent dioxygenases? Shifting the paradigm
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2011.05.017openalex-snapshot
Vitamins C and E: Beneficial effects from a mechanistic perspective
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2012.11.018openalex-snapshot
Manganese superoxide dismutase depletion in murine hematopoietic stem cells perturbs iron homeostasis, globin switching, and epigenetic control in erythrocyte precursorcells
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2014.01.033openalex-snapshot
Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2014.07.007openalex-snapshot
The active role of vitamin C in mammalian iron metabolism: Much more than just enhanced iron absorption!
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2018.03.033openalex-snapshot
Ascorbic acid metabolism and functions: A comparison of plants and mammals
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.100397openalex-snapshot
Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2010.12.001openalex-snapshot
Effects of polynitrogen compounds on the activity of recombinant human HIF-1α prolyl hydroxylase 3 in E. coli
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2017.08.032openalex-snapshot
NMR studies of the non-haem Fe(II) and 2-oxoglutarate-dependent oxygenases
inferred← citeshttps://doi.org/10.1016/j.jmb.2011.04.075openalex-snapshot
Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (EGLN1)
inferred← citeshttps://doi.org/10.1016/j.jmb.2019.07.031openalex-snapshot
Recruitment of Histone Methyltransferase Ehmt1 to Foxp3 TSDR Counteracts Differentiation of Induced Regulatory T Cells
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2020.108459openalex-snapshot
The role of vitamin C in stress-related disorders
inferred← citeshttps://doi.org/10.1016/j.jtemb.2021.126882openalex-snapshot
Triad role of hepcidin, ferroportin, and Nrf2 in cardiac iron metabolism: From health to disease
inferred← citeshttps://doi.org/10.1016/j.matbio.2026.102007openalex-snapshot
Hypoxia and ascorbic acid: two interconnected microenvironmental factors driving collagen biosynthesis
inferred← citeshttps://doi.org/10.1016/j.mcn.2017.05.008openalex-snapshot
Interplay between mitochondrial metabolism and oxidative stress in ischemic stroke: An epigenetic connection
inferred← citeshttps://doi.org/10.1016/j.mehy.2013.07.023openalex-snapshot
Expression and/or activity of the SVCT2 ascorbate transporter may be decreased in many aggressive cancers, suggesting potential utility for sodium bicarbonate and dehydroascorbic acid in cancer therapy
inferred← citeshttps://doi.org/10.1016/j.mehy.2022.110845openalex-snapshot
Hypothesis: Mutual dependency of ascorbate and calcidiol for optimal performance of the immune system
inferred← citeshttps://doi.org/10.1016/j.molcel.2017.06.002openalex-snapshot
The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks
inferred← citeshttps://doi.org/10.1016/j.redox.2023.102753openalex-snapshot
Vitamin C: From nutrition to oxygen sensing and epigenetics
inferred← citeshttps://doi.org/10.1016/j.sbi.2010.08.006openalex-snapshot
Structural studies on human 2-oxoglutarate dependent oxygenases
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2022.159429openalex-snapshot
Two-week repair alleviates hexavalent chromium-induced hepatotoxicity, hepatic metabolic and gut microbial changes: A dynamic inhalation exposure model in male mice
inferred← citeshttps://doi.org/10.1016/j.str.2015.01.014openalex-snapshot
Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases
inferred← citeshttps://doi.org/10.1017/s0007114515000690openalex-snapshot
Distribution of vitamin C is tissue specific with early saturation of the brain and adrenal glands following differential oral dose regimens in guinea pigs
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.0c00348openalex-snapshot
Nuclear and Cytoplasmic Functions of Vitamin C
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c02342openalex-snapshot
Exploring the Ascorbate Requirement of the 2-Oxoglutarate-Dependent Dioxygenases
inferred← citeshttps://doi.org/10.1021/cn500042topenalex-snapshot
Synthesis of a FTO Inhibitor with Anticonvulsant Activity
inferred← citeshttps://doi.org/10.1021/jm301583mopenalex-snapshot
Reporter Ligand NMR Screening Method for 2-Oxoglutarate Oxygenase Inhibitors
inferred← citeshttps://doi.org/10.1021/jm400386jopenalex-snapshot
Inhibition of Hypoxia-Inducible Factor Prolyl Hydroxylase Domain Oxygen Sensors: Tricking the Body into Mounting Orchestrated Survival and Repair Responses
inferred← citeshttps://doi.org/10.1038/mi.2013.6openalex-snapshot
Fundamental role for HIF-1α in constitutive expression of human β defensin-1
inferred← citeshttps://doi.org/10.1038/ncomms4423openalex-snapshot
Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases
inferred← citeshttps://doi.org/10.1038/s41390-025-03926-0openalex-snapshot
Neuroprotective effects of vitamin C on hypoxic-ischemic brain injury in neonatal mice
inferred← citeshttps://doi.org/10.1038/s41568-020-00303-3openalex-snapshot
2-Oxoglutarate-dependent dioxygenases in cancer
inferred← citeshttps://doi.org/10.1038/s41581-019-0182-zopenalex-snapshot
Mechanisms of hypoxia signalling: new implications for nephrology
inferred← citeshttps://doi.org/10.1038/s41598-024-75761-yopenalex-snapshot
Human prolyl hydroxylase domain 2 reacts with O2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes
inferred← citeshttps://doi.org/10.1039/9781782621959-00169openalex-snapshot
The Role of 2-Oxoglutarate-Dependent Oxygenases in Hypoxia Sensing
inferred← citeshttps://doi.org/10.1039/c0cs00203hopenalex-snapshot
Inhibition of 2-oxoglutarate dependent oxygenases
inferred← citeshttps://doi.org/10.1039/c1md00225bopenalex-snapshot
Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6
inferred← citeshttps://doi.org/10.1039/c3cc47581fopenalex-snapshot
Fluoromethylated derivatives of carnitine biosynthesis intermediates – synthesis and applications
inferred← citeshttps://doi.org/10.1039/d4cb00311jopenalex-snapshot
Biochemical investigations using mass spectrometry to monitor JMJD6-catalysed hydroxylation of multi-lysine containing bromodomain-derived substrates
inferred← citeshttps://doi.org/10.1042/bj20140779openalex-snapshot
Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen
inferred← citeshttps://doi.org/10.1042/bst20140118openalex-snapshot
Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer
inferred← citeshttps://doi.org/10.1042/bst20180169openalex-snapshot
Vitamin C and immune cell function in inflammation and cancer
inferred← citeshttps://doi.org/10.1042/bst20190333openalex-snapshot
Human 2-oxoglutarate-dependent oxygenases: nutrient sensors, stress responders, and disease mediators
inferred← citeshttps://doi.org/10.1073/pnas.1409916111openalex-snapshot
Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation
inferred← citeshttps://doi.org/10.1073/pnas.2517730122openalex-snapshot
Loss of vitamin C biosynthesis protects from the pathology of a parasitic infection
inferred← citeshttps://doi.org/10.1074/jbc.m110.193540openalex-snapshot
Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor
inferred← citeshttps://doi.org/10.1074/jbc.m111.262808openalex-snapshot
Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation
inferred← citeshttps://doi.org/10.1074/jbc.ra118.003496openalex-snapshot
The plant cysteine oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors
inferred← citeshttps://doi.org/10.1074/jbc.ra119.012202openalex-snapshot
Kinetic parameters of human aspartate/asparagine–β-hydroxylase suggest that it has a possible function in oxygen sensing
inferred← citeshttps://doi.org/10.1080/01635581.2015.1078823openalex-snapshot
Effect of Glucose on GLUT1-Dependent Intracellular Ascorbate Accumulation and Viability of Thyroid Cancer Cells
inferred← citeshttps://doi.org/10.1080/19382014.2020.1802183openalex-snapshot
The role of α-ketoglutarate and the hypoxia sensing pathway in the regulation of pancreatic β-cell function
inferred← citeshttps://doi.org/10.1084/jem.20151438openalex-snapshot
Control of Foxp3 stability through modulation of TET activity
inferred← citeshttps://doi.org/10.1089/ars.2010.3492openalex-snapshot
The Redox Basis of Epigenetic Modifications: From Mechanisms to Functional Consequences
inferred← citeshttps://doi.org/10.1089/ars.2011.4271openalex-snapshot
Mammalian Iron Homeostasis in Health and Disease: Uptake, Storage, Transport, and Molecular Mechanisms of Action
inferred← citeshttps://doi.org/10.1089/ars.2019.7903openalex-snapshot
Ascorbate and Tumor Cell Iron Metabolism: The Evolving Story and Its Link to Pathology
inferred← citeshttps://doi.org/10.1089/ars.2020.8148openalex-snapshot
NRF2 and Hypoxia-Inducible Factors: Key Players in the Redox Control of Systemic Iron Homeostasis
inferred← citeshttps://doi.org/10.1089/ars.2022.0003openalex-snapshot
The Asparagine Hydroxylase FIH: A Unique Oxygen Sensor
inferred← citeshttps://doi.org/10.1093/abbs/gms004openalex-snapshot
Ascorbate antagonizes nickel ion to regulate JMJD1A expression in kidney cancer cells
inferred← citeshttps://doi.org/10.1093/mutage/ger095openalex-snapshot
Undetectable role of oxidative DNA damage in cell cycle, cytotoxic and clastogenic effects of Cr(VI) in human lung cells with restored ascorbate levels
inferred← citeshttps://doi.org/10.1111/apha.12096openalex-snapshot
Prolyl 4‐hydroxylases, master regulators of the hypoxia response
inferred← citeshttps://doi.org/10.1111/j.1742-4658.2010.07804.xopenalex-snapshot
Evidence for the slow reaction of hypoxia‐inducible factor prolyl hydroxylase 2 with oxygen
inferred← citeshttps://doi.org/10.1111/j.1742-4658.2012.08496.xopenalex-snapshot
Autocatalysed oxidative modifications to 2‐oxoglutarate dependent oxygenases
inferred← citeshttps://doi.org/10.1111/odi.12446openalex-snapshot
Vitamin C: the known and the unknown and Goldilocks
inferred← citeshttps://doi.org/10.1155/2011/391074openalex-snapshot
The Loss of HIF1 α Leads to Increased Susceptibility to Cadmium-Chloride-Induced Toxicity in Mouse Embryonic Fibroblasts
inferred← citeshttps://doi.org/10.1155/2021/6141591openalex-snapshot
Exploring the Pivotal Neurophysiologic and Therapeutic Potentials of Vitamin C in Glioma
inferred← citeshttps://doi.org/10.1155/2022/1558860openalex-snapshot
Metadichol®, A Novel Nano Lipid Formulation that Inhibits SARS-CoV-2 and a Multitude of Pathological Viruses in Vitro
inferred← citeshttps://doi.org/10.1165/rcmb.2011-0196ocopenalex-snapshot
Post-Exposure Antioxidant Treatment in Rats Decreases Airway Hyperplasia and Hyperreactivity Due to Chlorine Inhalation
inferred← citeshttps://doi.org/10.1182/blood-2010-09-307637openalex-snapshot
Vitamin C is dispensable for oxygen sensing in vivo
inferred← citeshttps://doi.org/10.1182/blood-2011-03-340414openalex-snapshot
Two antioxidants are better than one
inferred← citeshttps://doi.org/10.1186/2049-3002-2-3openalex-snapshot
Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways
inferred← citeshttps://doi.org/10.1186/s12864-017-3635-4openalex-snapshot
Genome-wide expression profiling establishes novel modulatory roles of vitamin C in THP-1 human monocytic cell line
inferred← citeshttps://doi.org/10.1186/s12885-019-5503-xopenalex-snapshot
Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels
inferred← citeshttps://doi.org/10.1186/s12967-023-04756-6openalex-snapshot
Hypoxia-inducible factor 1α modulates interstitial pneumonia-mediated lung cancer progression
inferred← citeshttps://doi.org/10.12659/ajcr.899754openalex-snapshot
High-Dose Intravenous Vitamin C Treatment of a Child with Neurofibromatosis Type 1 and Optic Pathway Glioma: A Case Report
inferred← citeshttps://doi.org/10.14814/phy2.12220openalex-snapshot
Contrasting effects of ascorbate and iron on the pulmonary vascular response to hypoxia in humans
inferred← citeshttps://doi.org/10.1556/1886.2019.00016openalex-snapshot
Immunomodulatory and antimicrobial effects of vitamin C
inferred← citeshttps://doi.org/10.2147/hp.s201643openalex-snapshot
Ascorbate modulates the hypoxic pathway by increasing intracellular activity of the HIF hydroxylases in renal cell carcinoma cells
inferred← citeshttps://doi.org/10.2147/hp.s47968openalex-snapshot
Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism
inferred← citeshttps://doi.org/10.22271/tpi.2020.v9.i9b.5102openalex-snapshot
Fruits: A potential source of vitamin c as essential human nutrition and immunity development: A review
inferred← citeshttps://doi.org/10.2741/4160openalex-snapshot
Effects of Vitamin C on health: a review of evidence
inferred← citeshttps://doi.org/10.3109/14756366.2014.966704openalex-snapshot
Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium
inferred← citeshttps://doi.org/10.3389/fcell.2022.930205openalex-snapshot
The Anti-Leukemia Effect of Ascorbic Acid: From the Pro-Oxidant Potential to the Epigenetic Role in Acute Myeloid Leukemia
inferred← citeshttps://doi.org/10.3389/fonc.2014.00282openalex-snapshot
Current Limitations of Murine Models in Oncology for Ascorbate Research
inferred← citeshttps://doi.org/10.3389/fonc.2014.00359openalex-snapshot
Ascorbate as a Co-Factor for Fe- and 2-Oxoglutarate Dependent Dioxygenases: Physiological Activity in Tumor Growth and Progression
inferred← citeshttps://doi.org/10.3389/fonc.2021.619300openalex-snapshot
The Role of 2-Oxoglutarate Dependent Dioxygenases in Gliomas and Glioblastomas: A Review of Epigenetic Reprogramming and Hypoxic Response
inferred← citeshttps://doi.org/10.3389/fonc.2021.709543openalex-snapshot
Ascorbate Inhibits Proliferation and Promotes Myeloid Differentiation in TP53-Mutant Leukemia
inferred← citeshttps://doi.org/10.3389/fonc.2022.829524openalex-snapshot
Increased Ascorbate Content of Glioblastoma Is Associated With a Suppressed Hypoxic Response and Improved Patient Survival
inferred← citeshttps://doi.org/10.3390/biomedicines2010098openalex-snapshot
Gulonolactone Addition to Human Hepatocellular Carcinoma Cells with Gene Transfer of Gulonolactone Oxidase Restores Ascorbate Biosynthesis and Reduces Hypoxia Inducible Factor 1
inferred← citeshttps://doi.org/10.3390/cells12030485openalex-snapshot
Metabolic Hijacking of Hexose Metabolism to Ascorbate Synthesis Is the Unifying Biochemical Basis of Murine Liver Fibrosis
inferred← citeshttps://doi.org/10.3390/ijms23094909openalex-snapshot
New Insights into TETs in Psychiatric Disorders
inferred← citeshttps://doi.org/10.3390/ijms25094581openalex-snapshot
The Role of Oxygen Homeostasis and the HIF-1 Factor in the Development of Neurodegeneration
inferred← citeshttps://doi.org/10.3390/molecules24030453openalex-snapshot
Vitamin C as a Modulator of the Response to Cancer Therapy
inferred← citeshttps://doi.org/10.3390/nu13051685openalex-snapshot
Vitamin C Deficiency in the Young Brain—Findings from Experimental Animal Models
inferred← citeshttps://doi.org/10.3390/nu17071149openalex-snapshot
Nutritional Support of Chronic Obstructive Pulmonary Disease
inferred← citeshttps://doi.org/10.3390/nu5125161openalex-snapshot
Myths, Artifacts, and Fatal Flaws: Identifying Limitations and Opportunities in Vitamin C Research
inferred← citeshttps://doi.org/10.3390/nu6093818openalex-snapshot
Does Vitamin C Deficiency Affect Cognitive Development and Function?
inferred← citeshttps://doi.org/10.3390/ph11040137openalex-snapshot
Iron Regulation: Macrophages in Control
inferred← citeshttps://doi.org/10.3390/ph15060711openalex-snapshot
High-Dose Vitamin C for Cancer Therapy
inferred← citeshttps://doi.org/10.3791/51322openalex-snapshot
A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
inferred← citeshttps://doi.org/10.3945/ajcn.110.004853openalex-snapshot
Dietary ascorbate intake affects steady state tissue concentrations in vitamin C–deficient mice: tissue deficiency after suboptimal intake and superior bioavailability from a food source (kiwifruit)
inferred← citeshttps://doi.org/10.4236/jct.2015.66055openalex-snapshot
The Regulation and Interactions of the Hypoxia Inducible Factor Pathway in Carcinogenesis and Potential Cancer Therapeutic Strategies
inferred← citeshttps://doi.org/10.5772/intechopen.109434openalex-snapshot
The Function of Ascorbic Acid through Occam’s Razor: What We Know, What We Presume and What We Hope For
inferred← citeshttps://doi.org/10.6084/m9.figshare.24647200openalex-snapshot
Additional file 1 of Hypoxia-inducible factor 1α modulates interstitial pneumonia-mediated lung cancer progression
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