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Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

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1 of the 52 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1038/onc.2011.365 (notice 2023-05-23).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jcp.1041070215openalex-snapshot
Mechanism of growth promotion of mouse lymphoma L1210 cells in vitro by feeder layer or 2‐mercaptoethanol
inferredcites →https://doi.org/10.1007/s00109-011-0855-yopenalex-snapshot
Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis
inferredcites →https://doi.org/10.1007/s00702-014-1182-6openalex-snapshot
Glutamate and its receptors in cancer
inferredcites →https://doi.org/10.1007/s10549-009-0556-1openalex-snapshot
Breast cancer expresses functional NMDA receptors
inferredcites →https://doi.org/10.1007/s10549-011-1624-xopenalex-snapshot
Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer
inferredcites →https://doi.org/10.1007/s10585-009-9277-4openalex-snapshot
Cancer cell lines release glutamate into the extracellular environment
inferredcites →https://doi.org/10.1016/0003-2697(66)90249-1openalex-snapshot
Modified procedure for the assay of H3- or C14-labeled hydroxyproline
inferredcites →https://doi.org/10.1016/0006-291x(78)91010-0openalex-snapshot
The role of ascorbate in the prolyl hydroxylase reaction
inferredcites →https://doi.org/10.1016/j.ab.2009.06.029openalex-snapshot
Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2
inferredcites →https://doi.org/10.1016/j.bbrc.2009.10.168openalex-snapshot
Cancer cells release glutamate via the cystine/glutamate antiporter
inferredcites →https://doi.org/10.1016/j.ccr.2013.08.020openalex-snapshot
Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target
inferredcites →https://doi.org/10.1016/j.cell.2012.03.042openalex-snapshot
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
inferredcites →https://doi.org/10.1016/j.cell.2013.12.010openalex-snapshot
Regulation of Ferroptotic Cancer Cell Death by GPX4
inferredcites →https://doi.org/10.1016/j.cmet.2005.05.006openalex-snapshot
ROS: Really involved in Oxygen Sensing
inferredcites →https://doi.org/10.1016/j.jmb.2011.04.075openalex-snapshot
Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (EGLN1)
inferredcites →https://doi.org/10.1016/j.molcel.2008.04.009openalex-snapshot
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
inferredcites →https://doi.org/10.1016/j.molmed.2012.08.001openalex-snapshot
Molecular mechanisms mediating metastasis of hypoxic breast cancer cells
inferredcites →https://doi.org/10.1016/j.scr.2011.09.002openalex-snapshot
Hypoxic preconditioning involves system Xc− regulation in mouse neural stem cells
inferredcites →https://doi.org/10.1016/s0002-9440(10)64554-3openalex-snapshot
The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages
inferredcites →https://doi.org/10.1016/s0021-9258(19)83829-2openalex-snapshot
Contrasts in transport systems for anionic amino acids in hepatocytes and a hepatoma cell line HTC.
inferredcites →https://doi.org/10.1016/s1535-6108(03)00194-6openalex-snapshot
The hypoxic response of tumors is dependent on their microenvironment
inferredcites →https://doi.org/10.1038/nature09472openalex-snapshot
Quantitative reactivity profiling predicts functional cysteines in proteomes
inferredcites →https://doi.org/10.1038/nature11207openalex-snapshot
SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors
inferredcites →https://doi.org/10.1038/nature13119openalex-snapshot
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
inferredcites →https://doi.org/10.1038/nprot.2007.194openalex-snapshot
Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)—a general method for mapping sites of probe modification in proteomes
inferredcites →https://doi.org/10.1038/nrc3183openalex-snapshot
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
inferredcites →https://doi.org/10.1038/nrc3278openalex-snapshot
NRF2 and cancer: the good, the bad and the importance of context
inferredcites →https://doi.org/10.1038/nrmicro1022openalex-snapshot
Bacterial redox sensors
inferredcites →https://doi.org/10.1038/onc.2011.365openalex-snapshot
RETRACTED ARTICLE: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
inferredcites →https://doi.org/10.1038/sj.jcbfm.9600445openalex-snapshot
The NMDA and AMPA/KA Receptors are Involved in Glutamate-Induced Alterations of Occludin Expression and Phosphorylation in Brain Endothelial Cells
inferredcites →https://doi.org/10.1038/srep18928openalex-snapshot
Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation
inferredcites →https://doi.org/10.1042/bj20091609openalex-snapshot
Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents
inferredcites →https://doi.org/10.1042/bst0391247openalex-snapshot
Redox signalling via the cellular thiolstat
inferredcites →https://doi.org/10.1073/pnas.1214019109openalex-snapshot
Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells
inferredcites →https://doi.org/10.1073/pnas.1513433112openalex-snapshot
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
inferredcites →https://doi.org/10.1074/jbc.m508718200openalex-snapshot
Reversible Inactivation of HIF-1 Prolyl Hydroxylases Allows Cell Metabolism to Control Basal HIF-1
inferredcites →https://doi.org/10.1074/jbc.m604628200openalex-snapshot
The Length of Peptide Substrates Has a Marked Effect on Hydroxylation by the Hypoxia-inducible Factor Prolyl 4-Hydroxylases
inferredcites →https://doi.org/10.1096/fj.04-3399fjeopenalex-snapshot
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway
inferredcites →https://doi.org/10.1111/j.1432-1033.1992.tb17421.xopenalex-snapshot
Effect of 2‐mercaptoethanol on glutathione levels, cystine uptake and insulin secretion in insulin‐secreting cells
inferredcites →https://doi.org/10.1158/0008-5472.can-13-0523openalex-snapshot
Breast Tumor Kinase (Brk/PTK6) Is a Mediator of Hypoxia-Associated Breast Cancer Progression
inferredcites →https://doi.org/10.1158/0008-5472.can-13-1803openalex-snapshot
IGF-I Regulates Redox Status in Breast Cancer Cells by Activating the Amino Acid Transport Molecule xC−
inferredcites →https://doi.org/10.1158/1535-7163.mct-13-0870openalex-snapshot
Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer
inferredcites →https://doi.org/10.1159/000100812openalex-snapshot
Sulfasalazine-Induced Reduction of Glutathione Levels in Breast Cancer Cells: Enhancement of Growth-Inhibitory Activity of Doxorubicin
inferredcites →https://doi.org/10.1159/000455166openalex-snapshot
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
inferredcites →https://doi.org/10.1161/circresaha.112.268680openalex-snapshot
Cysteine Oxidative Posttranslational Modifications
inferredcites →https://doi.org/10.1172/jci64993openalex-snapshot
Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis
inferredcites →https://doi.org/10.1172/jci69244openalex-snapshot
Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis
inferredcites →https://doi.org/10.1182/blood-2010-09-307637openalex-snapshot
Vitamin C is dispensable for oxygen sensing in vivo
inferredcites →https://doi.org/10.1186/1746-1596-7-27openalex-snapshot
Immunohistochemistry profiles of breast ductal carcinoma: factor analysis of digital image analysis data
inferredcites →https://doi.org/10.1200/jco.20.2.379openalex-snapshot
Biologic Correlates of 18Fluorodeoxyglucose Uptake in Human Breast Cancer Measured by Positron Emission Tomography
inferredcites →https://doi.org/10.1371/journal.pone.0069851openalex-snapshot
Metabotropic Glutamate Receptor 1 Expression and Its Polymorphic Variants Associate with Breast Cancer Phenotypes
inferredcites →https://doi.org/10.7150/ijbs.6475openalex-snapshot
Glutamate Signaling in Benign and Malignant Disorders: Current Status, Future Perspectives, and Therapeutic Implications

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3335776openalex-extracted
Distinct Hypoxia-Responsive lncRNA Variants Oppositely Control Tumorigenesis Via Interplay on CA9
inferred← citeshttps://doi.org/10.1002/advs.202402557openalex-snapshot
Controlling Pericellular Oxygen Tension in Cell Culture Reveals Distinct Breast Cancer Responses to Low Oxygen Tensions
inferred← citeshttps://doi.org/10.1002/advs.202513380openalex-snapshot
NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression
inferred← citeshttps://doi.org/10.1002/cbin.11212openalex-snapshot
Up‐regulation of the pentose phosphate pathway and HIF‐1α expression during neural progenitor cell induction following glutamate treatment in rat ex vivo retina
inferred← citeshttps://doi.org/10.1002/ijc.33262openalex-snapshot
Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice
inferred← citeshttps://doi.org/10.1002/jgm.2998openalex-snapshot
Co‐delivery of hypoxia inducible factor‐1α small interfering RNA and 5‐fluorouracil to overcome drug resistance in gastric cancer SGC‐7901 cells
inferred← citeshttps://doi.org/10.1002/jnr.24366openalex-snapshot
The insights into molecular pathways of hypoxia‐inducible factor in the brain
inferred← citeshttps://doi.org/10.1002/mco2.144openalex-snapshot
Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities
inferred← citeshttps://doi.org/10.1002/mco2.70556openalex-snapshot
Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets
inferred← citeshttps://doi.org/10.1002/mnfr.202200186openalex-snapshot
Cystine Induced‐mTORC2 Activation through Promoting Sin1 Phosphorylation to Suppress Cancer Cell Ferroptosis
inferred← citeshttps://doi.org/10.1002/prca.201800038openalex-snapshot
iTRAQ‐Based Quantitative Proteomics Approach Identifies Novel Diagnostic Biomarkers That Were Essential for Glutamine Metabolism and Redox Homeostasis for Gastric Cancer
inferred← citeshttps://doi.org/10.1007/82_2018_120openalex-snapshot
Applications of Reactive Cysteine Profiling
inferred← citeshttps://doi.org/10.1007/978-1-4939-7665-2_2openalex-snapshot
Kinetic Analysis of HIF Prolyl Hydroxylases
inferred← citeshttps://doi.org/10.1007/978-981-16-0522-2_7openalex-snapshot
Cysteine Metabolism in Cancer Progression and Therapy Resistance
inferred← citeshttps://doi.org/10.1007/s00204-021-03167-0openalex-snapshot
Ascorbate: antioxidant and biochemical activities and their importance for in vitro models
inferred← citeshttps://doi.org/10.1007/s00204-022-03285-3openalex-snapshot
Renal hypoxia–HIF–PHD–EPO signaling in transition metal nephrotoxicity: friend or foe?
inferred← citeshttps://doi.org/10.1007/s00262-018-2185-1openalex-snapshot
Fighting breast cancer stem cells through the immune-targeting of the xCT cystine–glutamate antiporter
inferred← citeshttps://doi.org/10.1007/s00401-026-02984-wopenalex-snapshot
A HIF1A variant impacts long-term disability and smoldering inflammation in multiple sclerosis
inferred← citeshttps://doi.org/10.1007/s00428-017-2083-5openalex-snapshot
Glutaminase expression is a poor prognostic factor in node-positive triple-negative breast cancer patients with a high level of tumor-infiltrating lymphocytes
inferred← citeshttps://doi.org/10.1007/s00441-018-2801-6openalex-snapshot
Metabolic implications of hypoxia and pseudohypoxia in pheochromocytoma and paraganglioma
inferred← citeshttps://doi.org/10.1007/s10585-018-9876-zopenalex-snapshot
Pharmacologic ascorbate (P-AscH−) suppresses hypoxia-inducible Factor-1α (HIF-1α) in pancreatic adenocarcinoma
inferred← citeshttps://doi.org/10.1007/s10585-018-9930-xopenalex-snapshot
The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies
inferred← citeshttps://doi.org/10.1007/s10646-018-1943-3openalex-snapshot
Investigation of the molecular mechanisms of hepatic injury upon naphthalene exposure in zebrafish (Danio rerio)
inferred← citeshttps://doi.org/10.1007/s12672-025-02790-yopenalex-snapshot
Glutamate promotes triple-negative breast cancer development through IRE1α/XBP1-mediated macrophage polarization: mechanism insights and therapy
inferred← citeshttps://doi.org/10.1007/s40610-018-0090-1openalex-snapshot
Signaling Pathways Underlying Bone Metastasis: Hypoxia Signaling in Bone Metastasis and Beyond
inferred← citeshttps://doi.org/10.1016/bs.enz.2026.06.001openalex-snapshot
Carbonic anhydrase IX and XII
inferred← citeshttps://doi.org/10.1016/j.abb.2020.108659openalex-snapshot
Metabolic interventions: A new insight into the cancer immunotherapy
inferred← citeshttps://doi.org/10.1016/j.bbadis.2020.165769openalex-snapshot
Cysteine becomes conditionally essential during hypobaric hypoxia and regulates adaptive neuro-physiological responses through CBS/H2S pathway
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2020.118733openalex-snapshot
Role of the HIF oxygen sensing pathway in cell defense and proliferation through the control of amino acid metabolism
inferred← citeshttps://doi.org/10.1016/j.bbcan.2016.09.004openalex-snapshot
New Insights into Protein Hydroxylation and Its Important Role in Human Diseases
inferred← citeshttps://doi.org/10.1016/j.bbcan.2018.05.002openalex-snapshot
Targeting cancer's metabolic co-dependencies: A landscape shaped by genotype and tissue context
inferred← citeshttps://doi.org/10.1016/j.bbcan.2025.189465openalex-snapshot
Rewiring amino acids in cancer
inferred← citeshttps://doi.org/10.1016/j.bbcan.2026.189575openalex-snapshot
Neuro-tumor-immune crosstalk in pancreatic cancer: Mechanisms and therapeutic insights
inferred← citeshttps://doi.org/10.1016/j.bbi.2024.03.001openalex-snapshot
Compartmentalized role of xCT in supporting pancreatic tumor growth, inflammation and mood disturbance in mice
inferred← citeshttps://doi.org/10.1016/j.biopha.2017.12.104openalex-snapshot
The hypoxia-responsive long non-coding RNAs may impact on the tumor biology and subsequent management of breast cancer
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113861openalex-snapshot
Targeting hypoxia-inducible factor-1alpha: A new strategy for triple-negative breast cancer therapy
inferred← citeshttps://doi.org/10.1016/j.bmc.2019.05.050openalex-snapshot
Opportunities and challenges for the development of covalent chemical immunomodulators
inferred← citeshttps://doi.org/10.1016/j.canlet.2017.01.003openalex-snapshot
Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells
inferred← citeshttps://doi.org/10.1016/j.ccell.2019.12.011openalex-snapshot
Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer
inferred← citeshttps://doi.org/10.1016/j.ccell.2025.10.007openalex-snapshot
Decoding the spatial dynamics of tumor and immune cell interactions in solid cancers
inferred← citeshttps://doi.org/10.1016/j.cell.2024.03.022openalex-snapshot
Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB
inferred← citeshttps://doi.org/10.1016/j.celrep.2017.02.054openalex-snapshot
Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.108340openalex-snapshot
Mitochondrial UQCC3 Modulates Hypoxia Adaptation by Orchestrating OXPHOS and Glycolysis in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.1016/j.celrep.2022.111756openalex-snapshot
Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence
inferred← citeshttps://doi.org/10.1016/j.clbc.2025.05.005openalex-snapshot
Metabolomics Biomarkers for Breast Cancer: An updated perspective
inferred← citeshttps://doi.org/10.1016/j.clnves.2025.100049openalex-snapshot
Targeting ferroptosis in cancer therapy: Mechanisms, strategies, and clinical applications
inferred← citeshttps://doi.org/10.1016/j.cmet.2019.11.012openalex-snapshot
Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids
inferred← citeshttps://doi.org/10.1016/j.cmet.2020.06.010openalex-snapshot
Amino Assets: How Amino Acids Support Immunity
inferred← citeshttps://doi.org/10.1016/j.devcel.2024.06.022openalex-snapshot
Autocrine glutamate signaling drives cell competition in Drosophila
inferred← citeshttps://doi.org/10.1016/j.drup.2021.100787openalex-snapshot
Hypoxia as a driver of resistance to immunotherapy
inferred← citeshttps://doi.org/10.1016/j.ejmech.2026.118705openalex-snapshot
The application prospects of amino acid deprivation for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2023.06.015openalex-snapshot
Environmental and behavioral regulation of HIF-mitochondria crosstalk
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e14896openalex-snapshot
Profiling of immune responses by lactate modulation in cervical cancer reveals key features driving clinical outcome
inferred← citeshttps://doi.org/10.1016/j.immuni.2025.07.008openalex-snapshot
Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.100397openalex-snapshot
Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins
inferred← citeshttps://doi.org/10.1016/j.jbc.2022.101645openalex-snapshot
Expression of hypoxia inducible factor–dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation
inferred← citeshttps://doi.org/10.1016/j.jbc.2022.101703openalex-snapshot
Expression of gamma-glutamyltransferase 1 in glioblastoma cells confers resistance to cystine deprivation–induced ferroptosis
inferred← citeshttps://doi.org/10.1016/j.jbc.2023.104624openalex-snapshot
H2O2 transit through the mitochondrial intermembrane space promotes tumor cell growth in vitro and in vivo
inferred← citeshttps://doi.org/10.1016/j.molcel.2017.05.030openalex-snapshot
mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
inferred← citeshttps://doi.org/10.1016/j.molcel.2017.06.002openalex-snapshot
The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks
inferred← citeshttps://doi.org/10.1016/j.molcel.2021.08.026openalex-snapshot
Supply and demand: Cellular nutrient uptake and exchange in cancer
inferred← citeshttps://doi.org/10.1016/j.molcel.2026.02.004openalex-snapshot
Aspartate availability drives differential engagement of the malate-aspartate shuttle
inferred← citeshttps://doi.org/10.1016/j.molmed.2018.10.004openalex-snapshot
Hypoxia-Inducible Factor Prolyl 4-Hydroxylases and Metabolism
inferred← citeshttps://doi.org/10.1016/j.phrs.2016.11.003openalex-snapshot
Hypoxia-inducible factor prolyl 4-hydroxylase inhibition in cardiometabolic diseases
inferred← citeshttps://doi.org/10.1016/j.pmatsci.2025.101593openalex-snapshot
Self-adaptive biomaterials for tissue repair: from design to application
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Mitochondrial composition and function under the control of hypoxia
inferred← citeshttps://doi.org/10.1016/j.redox.2017.05.020openalex-snapshot
Redox signaling during hypoxia in mammalian cells
inferred← citeshttps://doi.org/10.1016/j.redox.2023.102753openalex-snapshot
Vitamin C: From nutrition to oxygen sensing and epigenetics
inferred← citeshttps://doi.org/10.1016/j.redox.2024.103364openalex-snapshot
The mitochondrial Na+/Ca2+ exchanger NCLX is implied in the activation of hypoxia-inducible factors
inferred← citeshttps://doi.org/10.1016/j.saa.2022.122163openalex-snapshot
Euclidean distance-based Raman spectroscopy (EDRS) for the prognosis analysis of gastric cancer: A solution to tumor heterogeneity
inferred← citeshttps://doi.org/10.1016/j.taap.2022.116041openalex-snapshot
Vulnerability of HIF1α and HIF2α to damage by proteotoxic stressors
inferred← citeshttps://doi.org/10.1016/j.taap.2023.116696openalex-snapshot
ATR activation by Cr-DNA damage is a major survival response establishing late S and G2 checkpoints after Cr(VI) exposure
inferred← citeshttps://doi.org/10.1016/j.tem.2018.02.002openalex-snapshot
Mitochondria and Hypoxia: Metabolic Crosstalk in Cell-Fate Decisions
inferred← citeshttps://doi.org/10.1016/j.tranon.2021.101258openalex-snapshot
Dual roles of AMAP1 in the transcriptional regulation and intracellular trafficking of carbonic anhydrase IX
inferred← citeshttps://doi.org/10.1016/j.yexcr.2017.03.034openalex-snapshot
Mitochondria control acute and chronic responses to hypoxia
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.0c00348openalex-snapshot
Nuclear and Cytoplasmic Functions of Vitamin C
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.2c00131openalex-snapshot
HIF1, HSF1, and NRF2: Oxidant-Responsive Trio Raising Cellular Defenses and Engaging Immune System
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b01596openalex-snapshot
Small-Molecule Modulators of the Hypoxia-Inducible Factor Pathway: Development and Therapeutic Applications
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.1c00085openalex-snapshot
Reversing Hypoxia with PLGA-Encapsulated Manganese Dioxide Nanoparticles Improves Natural Killer Cell Response to Tumor Spheroids
inferred← citeshttps://doi.org/10.1021/acschembio.8b00951openalex-snapshot
Metabolic Regulation of the Epitranscriptome
inferred← citeshttps://doi.org/10.1038/s12276-020-0375-3openalex-snapshot
Amino acids in cancer
inferred← citeshttps://doi.org/10.1038/s41388-019-1006-0openalex-snapshot
Neurotransmitters: emerging targets in cancer
inferred← citeshttps://doi.org/10.1038/s41388-022-02378-8openalex-snapshot
The multifaceted role of EGLN family prolyl hydroxylases in cancer: going beyond HIF regulation
inferred← citeshttps://doi.org/10.1038/s41388-023-02842-zopenalex-snapshot
UBE3B promotes breast cancer progression by antagonizing HIF-2α degradation
inferred← citeshttps://doi.org/10.1038/s41419-025-08058-1openalex-snapshot
Cancer-associated fibroblast-induced lncRNA WARS2-IT1 confers radioresistance of colorectal cancer via enhancing HIF-1α stability
inferred← citeshttps://doi.org/10.1038/s41420-024-01799-6openalex-snapshot
Extracellular vesicle-mediated ferroptosis, pyroptosis, and necroptosis: potential clinical applications in cancer therapy
inferred← citeshttps://doi.org/10.1038/s41467-017-02101-2openalex-snapshot
Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
inferred← citeshttps://doi.org/10.1038/s41556-019-0299-0openalex-snapshot
Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells
inferred← citeshttps://doi.org/10.1038/s41568-019-0149-1openalex-snapshot
Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
inferred← citeshttps://doi.org/10.1038/s41568-020-00303-3openalex-snapshot
2-Oxoglutarate-dependent dioxygenases in cancer
inferred← citeshttps://doi.org/10.1038/s41571-021-00549-2openalex-snapshot
The MYC oncogene — the grand orchestrator of cancer growth and immune evasion
inferred← citeshttps://doi.org/10.1038/s41580-020-0227-yopenalex-snapshot
Cellular adaptation to hypoxia through hypoxia inducible factors and beyond
inferred← citeshttps://doi.org/10.1038/s41581-019-0182-zopenalex-snapshot
Mechanisms of hypoxia signalling: new implications for nephrology
inferred← citeshttps://doi.org/10.1038/s41585-020-0314-zopenalex-snapshot
The diverse roles of SPOP in prostate cancer and kidney cancer
inferred← citeshttps://doi.org/10.1038/s41586-019-1576-6openalex-snapshot
Synaptic proximity enables NMDAR signalling to promote brain metastasis
inferred← citeshttps://doi.org/10.1038/s41589-024-01716-zopenalex-snapshot
Direct inhibition of tumor hypoxia response with synthetic transcriptional repressors
inferred← citeshttps://doi.org/10.1038/s41598-019-44734-xopenalex-snapshot
Glutamate induces synthesis of thrombogenic peptides and extracellular vesicle release from human platelets
inferred← citeshttps://doi.org/10.1038/s42255-024-01150-4openalex-snapshot
Branched-chain α-ketoacids aerobically activate HIF1α signalling in vascular cells
inferred← citeshttps://doi.org/10.1038/s44318-024-00065-wopenalex-snapshot
Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia
inferred← citeshttps://doi.org/10.1038/sigtrans.2017.36openalex-snapshot
Redox regulation in tumor cell epithelial–mesenchymal transition: molecular basis and therapeutic strategy
inferred← citeshttps://doi.org/10.1073/pnas.2010275117openalex-snapshot
The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype
inferred← citeshttps://doi.org/10.1073/pnas.2100050118openalex-snapshot
Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation
inferred← citeshttps://doi.org/10.1073/pnas.2119518119openalex-snapshot
EBF1 promotes triple-negative breast cancer progression by surveillance of the HIF1α pathway
inferred← citeshttps://doi.org/10.1073/pnas.2317343121openalex-snapshot
Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production
inferred← citeshttps://doi.org/10.1074/jbc.m117.814392openalex-snapshot
Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation
inferred← citeshttps://doi.org/10.1074/jbc.ra120.015238openalex-snapshot
Serum lipoprotein–derived fatty acids regulate hypoxia-inducible factor
inferred← citeshttps://doi.org/10.1080/03009734.2020.1769231openalex-snapshot
Oxygen sensing; a stunningly elegant molecular machinery highjacked in cancer
inferred← citeshttps://doi.org/10.1080/15384101.2021.1959988openalex-snapshot
NAD+ metabolism controls growth inhibition by HIF1 in normoxia and determines differential sensitivity of normal and cancer cells
inferred← citeshttps://doi.org/10.1080/19382014.2020.1802183openalex-snapshot
The role of α-ketoglutarate and the hypoxia sensing pathway in the regulation of pancreatic β-cell function
inferred← citeshttps://doi.org/10.1080/2162402x.2017.1408746openalex-snapshot
A Virus-Like-Particle immunotherapy targeting Epitope-Specific anti-xCT expressed on cancer stem cell inhibits the progression of metastatic cancerin vivo
inferred← citeshttps://doi.org/10.1089/ars.2022.0173openalex-snapshot
Mitochondrial Cristae Morphology Reflecting Metabolism, Superoxide Formation, Redox Homeostasis, and Pathology
inferred← citeshttps://doi.org/10.1096/fj.201901384rropenalex-snapshot
GPER‐regulated lncRNA‐Glu promotes glutamate secretion to enhance cellular invasion and metastasis in triple‐negative breast cancer
inferred← citeshttps://doi.org/10.1097/cad.0000000000001630openalex-snapshot
Targeting xCT with sulfasalazine suppresses triple-negative breast cancer growth via inducing autophagy and coordinating cell cycle and proliferation
inferred← citeshttps://doi.org/10.1101/2020.12.21.423796openalex-snapshot
Identification of Key Genes Potentially Related to Triple Receptor Negative Breast Cancer by Microarray Analysis
inferred← citeshttps://doi.org/10.1101/2021.09.10.459864openalex-snapshot
Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production
inferred← citeshttps://doi.org/10.1101/2022.10.02.510540openalex-snapshot
The MLL3/TP53/PIK3CA cancer driver mutations promote HIF1α-dependent recruitment and differentiation of pro-tumor ICOS hi GITR hi Blimp-1 + effector regulatory T cells in breast tumors
inferred← citeshttps://doi.org/10.1101/2023.05.04.538701openalex-snapshot
Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1101/2023.09.06.556522openalex-snapshot
GOT1 primes the cellular response to hypoxia by supporting glycolysis and HIF1α stabilisation
inferred← citeshttps://doi.org/10.1101/2023.12.03.569825openalex-snapshot
Saturation resistance profiling of EGFR variants against tyrosine kinase inhibitors using prime editing
inferred← citeshttps://doi.org/10.1101/2024.05.29.595538openalex-snapshot
Branched chain α-ketoacids aerobically activate HIF1α signaling in vascular cells
inferred← citeshttps://doi.org/10.1101/2025.06.18.660436openalex-snapshot
Coenzyme A homeostasis regulates hypoxic signalling via UBFD1 in triple-negative breast cancer
inferred← citeshttps://doi.org/10.1101/606541openalex-snapshot
Lysosomal cystine mobilization shapes the response of mTORC1 and tissue growth to fasting
inferred← citeshttps://doi.org/10.1101/818245openalex-snapshot
Glutathione Peroxidase 8 (GPX8)-IL6 axis is essential in maintaining breast cancer mesenchymal stem-like state and aggressive phenotype
inferred← citeshttps://doi.org/10.1111/cas.15006openalex-snapshot
Amino acid transporters as emerging therapeutic targets in cancer
inferred← citeshttps://doi.org/10.1111/cas.15131openalex-snapshot
Ferroptosis‐related gene signature associates with immunity and predicts prognosis accurately in patients with osteosarcoma
inferred← citeshttps://doi.org/10.1111/cen.15209openalex-snapshot
Breast Cancer Risk and Management in the Endocrine Clinic: A Comprehensive Review
inferred← citeshttps://doi.org/10.1111/febs.70013openalex-snapshot
Redox imbalance and hypoxia‐inducible factors: a multifaceted crosstalk
inferred← citeshttps://doi.org/10.1111/jcmm.18017openalex-snapshot
USP11 promotes glycolysis by regulating HIF ‐1α stability in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1126/sciadv.aaz8534openalex-snapshot
Cystathione β-synthase regulates HIF-1α stability through persulfidation of PHD2
inferred← citeshttps://doi.org/10.1126/sciadv.adq7305openalex-snapshot
Identifying metabolic limitations in the tumor microenvironment
inferred← citeshttps://doi.org/10.1126/science.abc4203openalex-snapshot
Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting
inferred← citeshttps://doi.org/10.1134/s1990519x24700421openalex-snapshot
esiRNA Mediated Silencing of HIF1A Regulates Migration, Invasion, Apoptosis, and Proliferation of MDA-MB-231 Cells
inferred← citeshttps://doi.org/10.1146/annurev-cancerbio-030617-050527openalex-snapshot
The von Hippel–Lindau Tumor Suppressor Protein
inferred← citeshttps://doi.org/10.1155/2018/4038397openalex-snapshot
Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications
inferred← citeshttps://doi.org/10.1158/0008-5472.can-22-2045openalex-snapshot
Enhanced Glutaminolysis Drives Hypoxia-Induced Chemoresistance in Pancreatic Cancer
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-18-4145openalex-snapshot
ERK Regulates HIF1α-Mediated Platinum Resistance by Directly Targeting PHD2 in Ovarian Cancer
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-23-1526openalex-snapshot
The VEGF-Hypoxia Signature Is Upregulated in Basal-like Breast Tumors from Women of African Ancestry and Associated with Poor Outcomes in Breast Cancer
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-18-0345openalex-snapshot
Molecular Portrait of Hypoxia in Breast Cancer: A Prognostic Signature and Novel HIF-Regulated Genes
inferred← citeshttps://doi.org/10.1158/2326-6066.c.6550513openalex-snapshot
Data from Immunotargeting of the xCT Cystine/Glutamate Antiporter Potentiates the Efficacy of HER2-Targeted Immunotherapies in Breast Cancer
inferred← citeshttps://doi.org/10.1158/2326-6066.c.6550513.v1openalex-snapshot
Data from Immunotargeting of the xCT Cystine/Glutamate Antiporter Potentiates the Efficacy of HER2-Targeted Immunotherapies in Breast Cancer
inferred← citeshttps://doi.org/10.1158/2326-6066.cir-18-0902openalex-snapshot
Immunosuppressive Immature Myeloid Cell Generation Is Controlled by Glutamine Metabolism in Human Cancer
inferred← citeshttps://doi.org/10.1158/2326-6066.cir-20-0082openalex-snapshot
Immunotargeting of the xCT Cystine/Glutamate Antiporter Potentiates the Efficacy of HER2-Targeted Immunotherapies in Breast Cancer
inferred← citeshttps://doi.org/10.1158/2326-6066.cir-20-1043openalex-snapshot
Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation
inferred← citeshttps://doi.org/10.1172/jci.insight.128439openalex-snapshot
Mutant p53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma
inferred← citeshttps://doi.org/10.1172/jci.insight.87380openalex-snapshot
PML promotes metastasis of triple-negative breast cancer through transcriptional regulation of HIF1A target genes
inferred← citeshttps://doi.org/10.1172/jci137552openalex-snapshot
HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer
inferred← citeshttps://doi.org/10.1172/jci191940openalex-snapshot
What’s on the menu?: metabolic constraints in the pancreatic tumor microenvironment
inferred← citeshttps://doi.org/10.1172/jci96153openalex-snapshot
Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer
inferred← citeshttps://doi.org/10.1186/s11658-024-00617-2openalex-snapshot
The marine-derived HIF-1α inhibitor, Yardenone 2, reduces prostate cancer cell proliferation by targeting HIF-1 target genes
inferred← citeshttps://doi.org/10.1186/s11658-024-00682-7openalex-snapshot
Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancer
inferred← citeshttps://doi.org/10.1186/s12862-018-1214-1openalex-snapshot
Cysteine boosters the evolutionary adaptation to CoCl2 mimicked hypoxia conditions, favouring carboplatin resistance in ovarian cancer
inferred← citeshttps://doi.org/10.1186/s12885-020-06885-3openalex-snapshot
Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer
inferred← citeshttps://doi.org/10.1186/s13046-020-01824-3openalex-snapshot
Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons
inferred← citeshttps://doi.org/10.1186/s13046-023-02830-xopenalex-snapshot
Cystine/glutamate antiporter xCT deficiency reduces metastasis without impairing immune system function in breast cancer mouse models
inferred← citeshttps://doi.org/10.1186/s40170-021-00245-wopenalex-snapshot
The PD-L1 metabolic interactome intersects with choline metabolism and inflammation
inferred← citeshttps://doi.org/10.1186/s40170-022-00289-6openalex-snapshot
Integrative analysis of plasma metabolomics and proteomics reveals the metabolic landscape of breast cancer
inferred← citeshttps://doi.org/10.1186/s40364-022-00412-1openalex-snapshot
Impact of NSCLC metabolic remodeling on immunotherapy effectiveness
inferred← citeshttps://doi.org/10.1186/s40880-017-0248-xopenalex-snapshot
Chromatin remodeling factor lymphoid-specific helicase inhibits ferroptosis through lipid metabolic genes in lung cancer progression
inferred← citeshttps://doi.org/10.1210/endocr/bqad080openalex-snapshot
α-Ketoglutarate-dependent Enzymes in Breast Cancer and Therapeutic Implications
inferred← citeshttps://doi.org/10.1242/dev.200030openalex-snapshot
Oxygen-sensing mechanisms in development and tissue repair
inferred← citeshttps://doi.org/10.1242/dmm.034272openalex-snapshot
Immunometabolism in cancer at a glance
inferred← citeshttps://doi.org/10.15252/embj.2023113743openalex-snapshot
A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress
inferred← citeshttps://doi.org/10.15252/embj.2023114093openalex-snapshot
Thiol reductive stress activates the hypoxia response pathway
inferred← citeshttps://doi.org/10.15252/embr.202050781openalex-snapshot
MIG-6 is essential for promoting glucose metabolic reprogramming and tumor growth in triple-negative breast cancer
inferred← citeshttps://doi.org/10.17760/d20621546openalex-snapshot
Developing oxygen-controlling strategies to boost vaccine immunity and understand hypoxic tumor responses
inferred← citeshttps://doi.org/10.18632/oncotarget.17737openalex-snapshot
The oxido-metabolic driver ATF4 enhances temozolamide chemo-resistance in human gliomas
inferred← citeshttps://doi.org/10.20892/j.issn.2095-3941.2019.0210openalex-snapshot
Metabolic reprogramming in triple-negative breast cancer
inferred← citeshttps://doi.org/10.20892/j.issn.2095-3941.2025.0115openalex-snapshot
Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies
inferred← citeshttps://doi.org/10.21037/atm-21-1392openalex-snapshot
The predictive prognostic values of CBFA2T3, STX3, DENR, EGLN1, FUT4, and PCDH7 in lung cancer
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3055740/v1openalex-snapshot
Disulfidoptosis-related gene SLC7A11, as a potential prognostic and immunological biomarker: Insights from pan-cancer analysis and validation in renal cancer
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3897305/v1openalex-snapshot
Molecular mechanisms of Rhizoma Dioscoreae in breast cancer treatment: a network pharmacology and experimental verification
inferred← citeshttps://doi.org/10.2147/cmar.s258196openalex-snapshot
Glucometabolic Reprogramming in the Hepatocellular Carcinoma Microenvironment: Cause and Effect
inferred← citeshttps://doi.org/10.31661/gmj.v8i.1646openalex-snapshot
Expression of Bioinformatically Candidate miRNAs including, miR-576-5p, miR-501-3p and miR-3143, Targeting PI3K Pathway in Triple-Negative Breast Cancer
inferred← citeshttps://doi.org/10.31661/gmj.v8i0.1646openalex-snapshot
Expression of Bioinformatically Candidate miRNAs including, miR-576-5p, miR-501-3p and miR-3143, Targeting PI3K Pathway in Triple-Negative Breast Cancer
inferred← citeshttps://doi.org/10.33549/physiolres.935269openalex-snapshot
Mitochondrial Physiology of Cellular Redox Regulations
inferred← citeshttps://doi.org/10.3389/fcell.2020.602668openalex-snapshot
Interplay of Carbonic Anhydrase IX With Amino Acid and Acid/Base Transporters in the Hypoxic Tumor Microenvironment
inferred← citeshttps://doi.org/10.3389/fcell.2021.688953openalex-snapshot
Shedding Light on the Role of Neurotransmitters in the Microenvironment of Pancreatic Cancer
inferred← citeshttps://doi.org/10.3389/fcell.2024.1338448openalex-snapshot
Current progress and prospects for G protein-coupled estrogen receptor in triple-negative breast cancer
inferred← citeshttps://doi.org/10.3389/fendo.2021.650284openalex-snapshot
Metabolic Regulation of Hypoxia-Inducible Factors in Hypothalamus
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1361992openalex-snapshot
Multi-omics analysis-based clinical and functional significance of a novel prognostic and immunotherapeutic gene signature derived from amino acid metabolism pathways in lung adenocarcinoma
inferred← citeshttps://doi.org/10.3389/fonc.2018.00189openalex-snapshot
Hypoxic Signalling in Tumour Stroma
inferred← citeshttps://doi.org/10.3389/fonc.2020.557730openalex-snapshot
Thrombospondin 2/Toll-Like Receptor 4 Axis Contributes to HIF-1α-Derived Glycolysis in Colorectal Cancer
inferred← citeshttps://doi.org/10.3389/fonc.2021.744940openalex-snapshot
Low Expression of SLC7A11 Confers Drug Resistance and Worse Survival in Ovarian Cancer via Inhibition of Cell Autophagy as a Competing Endogenous RNA
inferred← citeshttps://doi.org/10.3389/fonc.2022.1060495openalex-snapshot
Correlation between the Warburg effect and progression of triple-negative breast cancer
inferred← citeshttps://doi.org/10.3389/fonc.2022.833814openalex-snapshot
Induction of Ferroptosis by Ophiopogonin-B Through Regulating the Gene Signature AURKA in NSCLC
inferred← citeshttps://doi.org/10.3389/fonc.2022.859707openalex-snapshot
CNN1 Represses Bladder Cancer Progression and Metabolic Reprogramming by Modulating HIF-1α Signaling Pathway
inferred← citeshttps://doi.org/10.3389/fonc.2024.1492498openalex-snapshot
Clinicopathological characteristics of invasive stratified mucinous carcinoma of the cervix and the expression and clinical significance of SLC7A11, SLC3A2 and PD-L1
inferred← citeshttps://doi.org/10.3389/fphar.2021.667433openalex-snapshot
Qian Yang Yu Yin Granule Improves Renal Injury of Hypertension by Regulating Metabolic Reprogramming Mediated by HIF-1α/PKM2 Positive Feedback Loop
inferred← citeshttps://doi.org/10.3390/antiox10020197openalex-snapshot
The Pancreatic β-Cell: The Perfect Redox System
inferred← citeshttps://doi.org/10.3390/antiox10111838openalex-snapshot
Mitochondrial Redox Metabolism: The Epicenter of Metabolism during Cancer Progression
inferred← citeshttps://doi.org/10.3390/antiox11050921openalex-snapshot
Prospective Application of Ferroptosis in Hypoxic Cells for Tumor Radiotherapy
inferred← citeshttps://doi.org/10.3390/biom10010093openalex-snapshot
Redox Signaling from Mitochondria: Signal Propagation and Its Targets
inferred← citeshttps://doi.org/10.3390/biomedicines6020060openalex-snapshot
Metabolic Regulation of Hypoxia-Inducible Transcription Factors: The Role of Small Molecule Metabolites and Iron
inferred← citeshttps://doi.org/10.3390/biomedicines9121927openalex-snapshot
Unraveling Autocrine Signaling Pathways through Metabolic Fingerprinting in Serous Ovarian Cancer Cells
inferred← citeshttps://doi.org/10.3390/cancers11050678openalex-snapshot
The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival
inferred← citeshttps://doi.org/10.3390/cancers12092624openalex-snapshot
Metabolic Signaling Cascades Prompted by Glutaminolysis in Cancer
inferred← citeshttps://doi.org/10.3390/cancers12103023openalex-snapshot
Dissecting the Crosstalk between NRF2 Signaling and Metabolic Processes in Cancer
inferred← citeshttps://doi.org/10.3390/cancers13184699openalex-snapshot
Metabolic Flexibility Is a Determinant of Breast Cancer Heterogeneity and Progression
inferred← citeshttps://doi.org/10.3390/cancers14133059openalex-snapshot
The Role of SLC7A11 in Cancer: Friend or Foe?
inferred← citeshttps://doi.org/10.3390/cancers17233846openalex-snapshot
Exploring Emerging Therapeutic Targets in Osteosarcoma by Revisiting the Immune and Cancer-Intrinsic Hallmarks of Cancer
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