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Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1006/bbrc.1999.0920openalex-snapshot
l-Asparaginase Inhibits the Rapamycin-Targeted Signaling Pathway
inferredcites →https://doi.org/10.1007/s00018-007-6381-yopenalex-snapshot
Calorie restriction and the nutrient sensing signaling pathways
inferredcites →https://doi.org/10.1007/s00726-007-0607-zopenalex-snapshot
Antagonistic effects of leucine and glutamine on the mTOR pathway in myogenic C2C12 cells
inferredcites →https://doi.org/10.1016/0047-6374(76)90012-9openalex-snapshot
Patho-physiologic findings after chronic tryptophan deficiency in rats: A model for delayed growth and aging
inferredcites →https://doi.org/10.1016/0047-6374(88)90099-1openalex-snapshot
Histology and survival in age-delayed low-tryptophan-fed rats
inferredcites →https://doi.org/10.1016/0378-1119(94)90599-1openalex-snapshot
Genetic and biochemical evidence for yeast GCN2 protein kinase polymerization
inferredcites →https://doi.org/10.1016/j.bbabio.2006.01.009openalex-snapshot
Mitochondrial oxidative stress, aging and caloric restriction: The protein and methionine connection
inferredcites →https://doi.org/10.1016/j.bbrc.2004.11.015openalex-snapshot
Glutamine is a key regulator for amino acid-controlled cell growth through the mTOR signaling pathway in rat intestinal epithelial cells
inferredcites →https://doi.org/10.1016/j.bbrc.2008.12.079openalex-snapshot
ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression
inferredcites →https://doi.org/10.1016/j.ceb.2009.11.014openalex-snapshot
Mammalian autophagy: core molecular machinery and signaling regulation
inferredcites →https://doi.org/10.1016/j.cell.2008.02.031openalex-snapshot
SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs
inferredcites →https://doi.org/10.1016/j.cell.2008.02.037openalex-snapshot
Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4
inferredcites →https://doi.org/10.1016/j.cell.2008.11.044openalex-snapshot
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
inferredcites →https://doi.org/10.1016/j.cell.2009.07.034openalex-snapshot
4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila
inferredcites →https://doi.org/10.1016/j.cell.2010.02.024openalex-snapshot
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
inferredcites →https://doi.org/10.1016/j.cell.2012.02.044openalex-snapshot
Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway
inferredcites →https://doi.org/10.1016/j.cell.2012.07.032openalex-snapshot
Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
inferredcites →https://doi.org/10.1016/j.cmet.2007.01.001openalex-snapshot
The GCN2 eIF2α Kinase Regulates Fatty-Acid Homeostasis in the Liver during Deprivation of an Essential Amino Acid
inferredcites →https://doi.org/10.1016/j.cmet.2008.01.008openalex-snapshot
ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic β Cell Survival under Endoplasmic Reticulum Stress
inferredcites →https://doi.org/10.1016/j.cmet.2011.06.002openalex-snapshot
Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
inferredcites →https://doi.org/10.1016/j.cub.2004.08.061openalex-snapshot
SKAR Is a Specific Target of S6 Kinase 1 in Cell Growth Control
inferredcites →https://doi.org/10.1016/j.exger.2005.07.007openalex-snapshot
Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
inferredcites →https://doi.org/10.1016/j.febslet.2006.04.068openalex-snapshot
The amino acid sensitive TOR pathway from yeast to mammals
inferredcites →https://doi.org/10.1016/j.immuni.2005.03.013openalex-snapshot
GCN2 Kinase in T Cells Mediates Proliferative Arrest and Anergy Induction in Response to Indoleamine 2,3-Dioxygenase
inferredcites →https://doi.org/10.1016/j.immuni.2008.08.012openalex-snapshot
The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response
inferredcites →https://doi.org/10.1016/j.molcel.2009.06.033openalex-snapshot
The Vam6 GEF Controls TORC1 by Activating the EGO Complex
inferredcites →https://doi.org/10.1016/j.molcel.2010.06.022openalex-snapshot
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
inferredcites →https://doi.org/10.1016/j.molcel.2012.05.043openalex-snapshot
Glutaminolysis Activates Rag-mTORC1 Signaling
inferredcites →https://doi.org/10.1016/j.molcel.2012.06.009openalex-snapshot
TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
inferredcites →https://doi.org/10.1016/j.molmed.2012.05.007openalex-snapshot
Amino acids and mTORC1: from lysosomes to disease
inferredcites →https://doi.org/10.1016/j.tem.2009.05.008openalex-snapshot
ATF4-dependent transcription mediates signaling of amino acid limitation
inferredcites →https://doi.org/10.1016/j.tem.2010.12.003openalex-snapshot
mTOR couples cellular nutrient sensing to organismal metabolic homeostasis
inferredcites →https://doi.org/10.1016/j.tibs.2008.09.005openalex-snapshot
mTOR signaling: RAG GTPases transmit the amino acid signal
inferredcites →https://doi.org/10.1016/s0092-8674(04)00344-7openalex-snapshot
ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology
inferredcites →https://doi.org/10.1016/s0960-9822(02)01037-0openalex-snapshot
Activation of GCN2 in UV-Irradiated Cells Inhibits Translation
inferredcites →https://doi.org/10.1016/s1097-2765(00)00028-9openalex-snapshot
Uncharged tRNA Activates GCN2 by Displacing the Protein Kinase Moiety from a Bipartite tRNA-Binding Domain
inferredcites →https://doi.org/10.1016/s1097-2765(02)00656-1openalex-snapshot
Dissection of the Mechanism for the Stringent Factor RelA
inferredcites →https://doi.org/10.1016/s1097-2765(03)00105-9openalex-snapshot
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
inferredcites →https://doi.org/10.1038/238381a0openalex-snapshot
MSI and MSII made on Ribosome in Idling Step of Protein Synthesis
inferredcites →https://doi.org/10.1038/nature08221openalex-snapshot
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
inferredcites →https://doi.org/10.1038/nature08619openalex-snapshot
Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
inferredcites →https://doi.org/10.1038/nature11083openalex-snapshot
A unifying model for mTORC1-mediated regulation of mRNA translation
inferredcites →https://doi.org/10.1038/ncb1753openalex-snapshot
Regulation of TORC1 by Rag GTPases in nutrient response
inferredcites →https://doi.org/10.1038/nchembio.790openalex-snapshot
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase
inferredcites →https://doi.org/10.1038/nrm2672openalex-snapshot
Molecular mechanisms of mTOR-mediated translational control
inferredcites →https://doi.org/10.1038/nrm3025openalex-snapshot
mTOR: from growth signal integration to cancer, diabetes and ageing
inferredcites →https://doi.org/10.1042/0264-6021:3500361openalex-snapshot
l-Leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the l-leucine-induced up-regulation of System A amino acid transport
inferredcites →https://doi.org/10.1042/bj20080281openalex-snapshot
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
inferredcites →https://doi.org/10.1042/bj3340261openalex-snapshot
Amino acid availability regulates p70 S6 kinase and multiple translation factors
inferredcites →https://doi.org/10.1046/j.1432-1033.2002.03069.xopenalex-snapshot
Signalling pathways and combinatory effects of insulin and amino acids in isolated rat hepatocytes
inferredcites →https://doi.org/10.1073/pnas.012485299openalex-snapshot
Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway
inferredcites →https://doi.org/10.1073/pnas.0400541101openalex-snapshot
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
inferredcites →https://doi.org/10.1073/pnas.81.20.6442openalex-snapshot
Evidence for translational regulation of the activator of general amino acid control in yeast.
inferredcites →https://doi.org/10.1074/jbc.270.5.2320openalex-snapshot
Phosphorylation of Ribosomal Protein S6 Is Inhibitory for Autophagy in Isolated Rat Hepatocytes
inferredcites →https://doi.org/10.1074/jbc.271.39.23884openalex-snapshot
Transcriptional Pausing of RNA Polymerase in the Presence of Guanosine Tetraphosphate Depends on the Promoter and Gene Sequence
inferredcites →https://doi.org/10.1074/jbc.273.23.14484openalex-snapshot
Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism
inferredcites →https://doi.org/10.1074/jbc.273.43.28178openalex-snapshot
Branched-chain Amino Acids Are Essential in the Regulation of PHAS-I and p70 S6 Kinase by Pancreatic β-Cells
inferredcites →https://doi.org/10.1074/jbc.274.2.1058openalex-snapshot
Regulation of Translational Effectors by Amino Acid and Mammalian Target of Rapamycin Signaling Pathways
inferredcites →https://doi.org/10.1074/jbc.274.2.1092openalex-snapshot
Amino Acid-dependent Control of p70s6k
inferredcites →https://doi.org/10.1074/jbc.c300133200openalex-snapshot
Rapamycin-induced Translational Derepression of GCN4 mRNA Involves a Novel Mechanism for Activation of the eIF2α Kinase GCN2
inferredcites →https://doi.org/10.1074/jbc.m109.000877openalex-snapshot
Genome-wide Analysis of tRNA Charging and Activation of the eIF2 Kinase Gcn2p
inferredcites →https://doi.org/10.1074/jbc.m109.047910openalex-snapshot
GCN2 Protein Kinase Is Required to Activate Amino Acid Deprivation Responses in Mice Treated with the Anti-cancer Agent l-Asparaginase
inferredcites →https://doi.org/10.1074/jbc.m110.121947openalex-snapshot
Integration of General Amino Acid Control and Target of Rapamycin (TOR) Regulatory Pathways in Nitrogen Assimilation in Yeast
inferredcites →https://doi.org/10.1074/jbc.m402228200openalex-snapshot
Dimerization Is Required for Activation of eIF2 Kinase Gcn2 in Response to Diverse Environmental Stress Conditions
inferredcites →https://doi.org/10.1074/jbc.m404559200openalex-snapshot
Preservation of Liver Protein Synthesis during Dietary Leucine Deprivation Occurs at the Expense of Skeletal Muscle Mass in Mice Deleted for eIF2 Kinase GCN2
inferredcites →https://doi.org/10.1074/jbc.m414499200openalex-snapshot
The Tuberous Sclerosis Protein TSC2 Is Not Required for the Regulation of the Mammalian Target of Rapamycin by Amino Acids and Certain Cellular Stresses
inferredcites →https://doi.org/10.1074/jbc.m610510200openalex-snapshot
Role of the Transcription Factor ATF4 in the Anabolic Actions of Insulin and the Anti-anabolic Actions of Glucocorticoids
inferredcites →https://doi.org/10.1074/jbc.m801331200openalex-snapshot
Insulin Signaling and the General Amino Acid Control Response
inferredcites →https://doi.org/10.1093/abbs/gmr066openalex-snapshot
Spatial regulation of the mTORC1 system in amino acids sensing pathway
inferredcites →https://doi.org/10.1093/jn/10.1.63openalex-snapshot
The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size
inferredcites →https://doi.org/10.1093/jn/123.2.269openalex-snapshot
Low Methionine Ingestion by Rats Extends Life Span
inferredcites →https://doi.org/10.1093/jn/133.1.261sopenalex-snapshot
The Role of Leucine in Weight Loss Diets and Glucose Homeostasis
inferredcites →https://doi.org/10.1093/jn/75.2.197openalex-snapshot
Length of Life and Nutrition in the Rat
inferredcites →https://doi.org/10.1093/nar/gkp1048openalex-snapshot
An internal ribosomal entry site mediates redox-sensitive translation of Nrf2
inferredcites →https://doi.org/10.1093/nar/gkr701openalex-snapshot
IRES-mediated translation of cellular messenger RNA operates in eIF2α- independent manner during stress
inferredcites →https://doi.org/10.1101/gad.1069003openalex-snapshot
Translational control by TOR and TAP42 through dephosphorylation of eIF2α kinase GCN2
inferredcites →https://doi.org/10.1101/gad.516509openalex-snapshot
Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes
inferredcites →https://doi.org/10.1111/j.1365-2958.1990.tb00563.xopenalex-snapshot
Uncharged tRNA, protein synthesis, and the bacterial stringent response
inferredcites →https://doi.org/10.1111/j.1474-9726.2005.00152.xopenalex-snapshot
Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance
inferredcites →https://doi.org/10.1111/j.1474-9726.2009.00469.xopenalex-snapshot
Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae
inferredcites →https://doi.org/10.1124/mol.107.035360openalex-snapshot
Translational Control of Nrf2 Protein in Activation of Antioxidant Response by Oxidants
inferredcites →https://doi.org/10.1126/sageke.2003.8.re2openalex-snapshot
Subfield History: Caloric Restriction, Slowing Aging, and Extending Life
inferredcites →https://doi.org/10.1126/science.1059497openalex-snapshot
Regulation of Longevity and Stress Resistance by Sch9 in Yeast
inferredcites →https://doi.org/10.1126/science.1104882openalex-snapshot
Uncharged tRNA and Sensing of Amino Acid Deficiency in Mammalian Piriform Cortex
inferredcites →https://doi.org/10.1126/science.1124147openalex-snapshot
Hypothalamic mTOR Signaling Regulates Food Intake
inferredcites →https://doi.org/10.1126/science.1157535openalex-snapshot
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
inferredcites →https://doi.org/10.1126/science.1172638openalex-snapshot
Halofuginone Inhibits T H 17 Cell Differentiation by Activating the Amino Acid Starvation Response
inferredcites →https://doi.org/10.1126/science.1177221openalex-snapshot
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
inferredcites →https://doi.org/10.1126/science.1207056openalex-snapshot
mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase
inferredcites →https://doi.org/10.1126/scitranslmed.3002629openalex-snapshot
Surgical Stress Resistance Induced by Single Amino Acid Deprivation RequiresGcn2in Mice
inferredcites →https://doi.org/10.1128/mcb.11.1.486openalex-snapshot
Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control.
inferredcites →https://doi.org/10.1128/mcb.13.3.1920openalex-snapshot
Evidence that GCD6 and GCD7, Translational Regulators of GCN4, Are Subunits of the Guanine Nucleotide Exchange Factor for eIF-2 in Saccharomyces cerevisiae
inferredcites →https://doi.org/10.1128/mcb.15.8.4497openalex-snapshot
The Histidyl-tRNA Synthetase-Related Sequence in the eIF-2α Protein Kinase GCN2 Interacts with tRNA and Is Required for Activation in Response to Starvation for Different Amino Acids
inferredcites →https://doi.org/10.1128/mcb.20.14.5285-5299.2000openalex-snapshot
The B56α Regulatory Subunit of Protein Phosphatase 2A Is a Target for Regulation by Double-Stranded RNA-Dependent Protein Kinase PKR
inferredcites →https://doi.org/10.1128/mcb.22.19.6681-6688.2002openalex-snapshot
The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice
inferredcites →https://doi.org/10.1146/annurev.biochem.77.061206.171059openalex-snapshot
Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction
inferredcites →https://doi.org/10.1146/annurev.micro.59.031805.133833openalex-snapshot
TRANSLATIONAL REGULATION OFGCN4AND THE GENERAL AMINO ACID CONTROL OF YEAST
inferredcites →https://doi.org/10.1146/annurev.micro.62.081307.162903openalex-snapshot
(p)ppGpp: Still Magical?
inferredcites →https://doi.org/10.1146/annurev.nutr.27.061406.093726openalex-snapshot
Mechanisms of Food Intake Repression in Indispensable Amino Acid Deficiency
inferredcites →https://doi.org/10.1152/ajpcell.1998.274.1.c206openalex-snapshot
Amino acids stimulate phosphorylation of p70 S6k and organization of rat adipocytes into multicellular clusters
inferredcites →https://doi.org/10.1152/ajpendo.90645.2008openalex-snapshot
Amino acid regulation of TOR complex 1
inferredcites →https://doi.org/10.1152/physiolgenomics.90396.2008openalex-snapshot
eIF2α kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver
inferredcites →https://doi.org/10.1152/physrev.1970.50.3.428openalex-snapshot
Effects of ingestion of disproportionate amounts of amino acids.
inferredcites →https://doi.org/10.1159/000334144openalex-snapshot
Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression
inferredcites →https://doi.org/10.1159/000373980openalex-snapshot
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
inferredcites →https://doi.org/10.1194/jlr.m700194-jlr200openalex-snapshot
Methionine restriction effects on 11β-HSD1 activity and lipogenic/lipolytic balance in F344 rat adipose tissue
inferredcites →https://doi.org/10.1371/journal.pbio.0030223openalex-snapshot
Calories Do Not Explain Extension of Life Span by Dietary Restriction in Drosophila
inferredcites →https://doi.org/10.2337/db10-1246openalex-snapshot
Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways
inferredcites →https://doi.org/10.3892/ijmm.13.4.537openalex-snapshot
Arginine and Leucine regulate p70 S6 kinase and 4E-BP1 in intestinal epithelial cells
inferredcites →https://doi.org/10.3892/ijmm.19.3.475openalex-snapshot
GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress
inferredcites →https://doi.org/10.4049/jimmunol.1003655openalex-snapshot
Inhibition of Mammalian Target of Rapamycin Augments Lipopolysaccharide-Induced Lung Injury and Apoptosis
inferredcites →https://doi.org/10.4161/auto.6.7.12753openalex-snapshot
Induction of autophagic flux by amino acid deprivation is distinct from nitrogen starvation-induced macroautophagy
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/mbo3.1176openalex-snapshot
Magnesium depletion extends fission yeast lifespan via general amino acid control activation
inferred← citeshttps://doi.org/10.1002/mnfr.201300758openalex-snapshot
Dietary deprivation of each essential amino acid induces differential systemic adaptive responses in mice
inferred← citeshttps://doi.org/10.1002/mnfr.202400662openalex-snapshot
Pterostilbene Targets Hallmarks of Aging in the Gene Expression Landscape in Blood of Healthy Rats
inferred← citeshttps://doi.org/10.1002/pmic.201700395openalex-snapshot
Colonic Mucosal Proteome Signature Reveals Reduced Energy Metabolism and Protein Synthesis but Activated Autophagy during Anorexia‐Induced Malnutrition in Mice
inferred← citeshttps://doi.org/10.1002/yea.3836openalex-snapshot
The arginine transporter Can1 acts as a transceptor for regulation of proline utilization in the yeast Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1007/978-1-4939-1683-2_5openalex-snapshot
Response to Acidity: The MondoA–TXNIP Checkpoint Couples the Acidic Tumor Microenvironment to Cell Metabolism
inferred← citeshttps://doi.org/10.1007/978-3-030-23629-8_8openalex-snapshot
Understanding Obesity as a Risk Factor for Uterine Tumors Using Drosophila
inferred← citeshttps://doi.org/10.1007/978-3-030-31206-0_15openalex-snapshot
Plausible Links Between Metabolic Networks, Stem Cells, and Longevity
inferred← citeshttps://doi.org/10.1007/978-3-319-14874-8_18openalex-snapshot
The Potential Impact of Maternal Milk Consumption During Pregnancy on mTORC1-Driven Fetal Growth
inferred← citeshttps://doi.org/10.1007/978-3-319-15630-9_14openalex-snapshot
Indoleamine 2,3-Dioxygenase-Competent Regulatory Dendritic Cells and Their Role in Alloimmune Regulation and Transplant Immune Tolerance
inferred← citeshttps://doi.org/10.1007/978-3-319-55942-1_15openalex-snapshot
Adequate Protein in Nutrition: Arguments for More or Less?
inferred← citeshttps://doi.org/10.1007/978-3-319-74932-7_1openalex-snapshot
Cellular Metabolism at a Glance
inferred← citeshttps://doi.org/10.1007/978-3-7091-1232-8_2openalex-snapshot
Aging in the Single-Celled Eukaryote, S. cerevisiae
inferred← citeshttps://doi.org/10.1007/978-94-017-9078-9_9openalex-snapshot
The eIF2 Complex and eIF2α
inferred← citeshttps://doi.org/10.1007/978-981-32-9005-1_18openalex-snapshot
Interplay Between Nutrient-Sensing Molecules During Aging and Longevity
inferred← citeshttps://doi.org/10.1007/978-981-32-9005-1_21openalex-snapshot
The Biology of Aging and Cancer: A Complex Association
inferred← citeshttps://doi.org/10.1007/s00210-021-02140-zopenalex-snapshot
Combinatorial antitumor effects of amino acids and epigenetic modulations in hepatocellular carcinoma cell lines
inferred← citeshttps://doi.org/10.1007/s00424-013-1339-4openalex-snapshot
Nutritional models of foetal programming and nutrigenomic and epigenomic dysregulations of fatty acid metabolism in the liver and heart
inferred← citeshttps://doi.org/10.1007/s00438-019-01592-6openalex-snapshot
Leucine depletion extends the lifespans of leucine-auxotrophic fission yeast by inducing Ecl1 family genes via the transcription factor Fil1
inferred← citeshttps://doi.org/10.1007/s00726-013-1500-6openalex-snapshot
Functional amino acids in nutrition and health
inferred← citeshttps://doi.org/10.1007/s10340-021-01371-6openalex-snapshot
The frequency of cannibalism by Spodoptera frugiperda larvae determines their probability of surviving food deprivation
inferred← citeshttps://doi.org/10.1007/s10545-015-9820-1openalex-snapshot
Signal transduction in inherited metabolic disorders: a model for a possible pathogenetic mechanism
inferred← citeshttps://doi.org/10.1007/s10695-024-01312-xopenalex-snapshot
Addition of α-ketoglutaric acid (AKG) reduces deamination in Chinese perch (Siniperca chuatsi) fed with fermented soybean meal as a substitute for fishmeal
inferred← citeshttps://doi.org/10.1007/s11010-016-2915-7openalex-snapshot
Tryptophan depletion under conditions that imitate insulin resistance enhances fatty acid oxidation and induces endothelial dysfunction through reactive oxygen species-dependent and independent pathways
inferred← citeshttps://doi.org/10.1007/s11255-017-1596-9openalex-snapshot
Preconditioning of primary human renal proximal tubular epithelial cells without tryptophan increases survival under hypoxia by inducing autophagy
inferred← citeshttps://doi.org/10.1007/s11357-015-9823-8openalex-snapshot
An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly
inferred← citeshttps://doi.org/10.1007/s12035-013-8505-8openalex-snapshot
Targeting the mTOR Signaling Network for Alzheimer’s Disease Therapy
inferred← citeshttps://doi.org/10.1016/b978-0-12-802167-5.00005-0openalex-snapshot
Role of Amino Acid Transporters in Protein Metabolism
inferred← citeshttps://doi.org/10.1016/b978-0-12-811353-0.00008-7openalex-snapshot
A Framework for Uncovering the Roles of Calories and Macronutrients in Health and Aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-819587-1.00012-4openalex-snapshot
Protein and amino acids
inferred← citeshttps://doi.org/10.1016/b978-0-323-90581-7.00023-2openalex-snapshot
Dietary restriction, vegetarian diet, and aging intervention
inferred← citeshttps://doi.org/10.1016/bs.pmbts.2017.12.015openalex-snapshot
Metabolic Aspects of Aging
inferred← citeshttps://doi.org/10.1016/j.aninu.2021.09.004openalex-snapshot
Regulation of pancreatic exocrine in ruminants and the related mechanism: The signal transduction and more
inferred← citeshttps://doi.org/10.1016/j.apsb.2025.04.022openalex-snapshot
Indoleamine-2,3-dioxygenase: An important controller in maintaining mesenchymal stem cell-mediated immunomodulatory homeostasis
inferred← citeshttps://doi.org/10.1016/j.aqrep.2021.100642openalex-snapshot
Effects of dietary methionine on growth performance and metabolism through modulating nutrient-related pathways in largemouth bass (Micropterus salmoides)
inferred← citeshttps://doi.org/10.1016/j.aqrep.2022.101313openalex-snapshot
Replacement of dietary fishmeal by cottonseed protein concentrate on growth performance, feed utilization and protein metabolism of large yellow croaker Larimichthys crocea
inferred← citeshttps://doi.org/10.1016/j.aqrep.2022.101395openalex-snapshot
Dietary phenylalanine level could improve growth performance, glucose metabolism and insulin and mTOR signaling pathways of juvenile swimming crabs, Portunus trituberculatus
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2021.737324openalex-snapshot
A study to explore the effects of low dietary protein levels on the growth performance and nutritional metabolism of grass carp (Ctenopharyngodon idella) fry
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2023.739750openalex-snapshot
Dietary acetate promotes growth and nutrients deposition in Nile tilapia (Oreochromis niloticus) through increasing acetyl-CoA-triggered energy production
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2024.741176openalex-snapshot
Dietary cottonseed protein concentrate affected the flesh texture and myofiber characteristics of large yellow croaker Larimichthys crocea
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2024.741473openalex-snapshot
Fasting time after feeding affects the evaluation of metabolic response in abalone Haliotis discus hannai to nutrients using dietary methionine as an example
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2014.04.006openalex-snapshot
Keeping the eIF2 alpha kinase Gcn2 in check
inferred← citeshttps://doi.org/10.1016/j.cbpa.2014.01.014openalex-snapshot
Characterization of the endocrine, digestive and morphological adjustments of the intestine in response to food deprivation and torpor in cunner, Tautogolabrus adspersus
inferred← citeshttps://doi.org/10.1016/j.cbpc.2017.10.012openalex-snapshot
Dietary methionine restriction: Effects on glucose tolerance, lipid content and micro-RNA composition in the muscle of rainbow trout
inferred← citeshttps://doi.org/10.1016/j.celrep.2014.07.018openalex-snapshot
The TSC Complex Is Required for the Benefits of Dietary Protein Restriction on Stress Resistance In Vivo
inferred← citeshttps://doi.org/10.1016/j.celrep.2016.10.079openalex-snapshot
Stress Kinase GCN2 Controls the Proliferative Fitness and Trafficking of Cytotoxic T Cells Independent of Environmental Amino Acid Sensing
inferred← citeshttps://doi.org/10.1016/j.clnu.2019.07.030openalex-snapshot
Effect of calorie restriction or protein intake on circulating levels of insulin like growth factor I in humans: A systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1016/j.cmet.2014.02.006openalex-snapshot
Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population
inferred← citeshttps://doi.org/10.1016/j.cois.2017.07.005openalex-snapshot
Amino acid modulation of lifespan and reproduction in Drosophila
inferred← citeshttps://doi.org/10.1016/j.ddmod.2019.03.002openalex-snapshot
The geometric framework: An approach for studying the impact of nutrition on healthy aging
inferred← citeshttps://doi.org/10.1016/j.drudis.2018.02.008openalex-snapshot
The integrated stress response system in cardiovascular disease
inferred← citeshttps://doi.org/10.1016/j.ebiom.2019.04.005openalex-snapshot
The impact of dietary protein intake on longevity and metabolic health
inferred← citeshttps://doi.org/10.1016/j.exger.2018.11.021openalex-snapshot
Implications of amino acid sensing and dietary protein to the aging process
inferred← citeshttps://doi.org/10.1016/j.fob.2015.04.012openalex-snapshot
Differential adaptive responses to 1‐ or 2‐day fasting in various mouse tissues revealed by quantitative PCR analysis
inferred← citeshttps://doi.org/10.1016/j.foodres.2020.109002openalex-snapshot
A biotechnological approach for the production of branched chain amino acid containing bioactive peptides to improve human health: A review
inferred← citeshttps://doi.org/10.1016/j.ibmb.2021.103667openalex-snapshot
Halofuginone triggers a transcriptional program centered on ribosome biogenesis and function in honey bees
inferred← citeshttps://doi.org/10.1016/j.immuni.2020.08.013openalex-snapshot
Dietary Regulation of Immunity
inferred← citeshttps://doi.org/10.1016/j.jfca.2015.05.005openalex-snapshot
Amino acids, major carotenoids and vitamin A activity of some traditional sauces consumed in the Far North Region of Cameroon
inferred← citeshttps://doi.org/10.1016/j.jfca.2023.105295openalex-snapshot
Amino acid composition and protein quality of commonly consumed cooked foods in Nigeria
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2017.08.015openalex-snapshot
Nutrient sensing and metabolic changes after methionine deprivation in primary muscle cells of turbot (Scophthalmus maximus L.)
inferred← citeshttps://doi.org/10.1016/j.mad.2015.09.006openalex-snapshot
Cytoplasmic mRNA turnover and ageing
inferred← citeshttps://doi.org/10.1016/j.mce.2016.11.014openalex-snapshot
Regulation of metabolic health and aging by nutrient-sensitive signaling pathways
inferred← citeshttps://doi.org/10.1016/j.mehy.2014.06.014openalex-snapshot
GCN2 and FGF21 are likely mediators of the protection from cancer, autoimmunity, obesity, and diabetes afforded by vegan diets
inferred← citeshttps://doi.org/10.1016/j.metabol.2014.03.006openalex-snapshot
Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice
inferred← citeshttps://doi.org/10.1016/j.molcel.2015.06.020openalex-snapshot
ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate
inferred← citeshttps://doi.org/10.1016/j.pdpdt.2023.103346openalex-snapshot
Genetic deviation associated with photodynamic therapy in HeLa cell
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2020.107673openalex-snapshot
A natural product solution to aging and aging-associated diseases
inferred← citeshttps://doi.org/10.1016/j.phrs.2023.106892openalex-snapshot
Amino acids contribute to adaptive thermogenesis. New insights into the mechanisms of action of recent drugs for metabolic disorders are emerging
inferred← citeshttps://doi.org/10.1016/j.tem.2014.07.002openalex-snapshot
Protein and amino acid restriction, aging and disease: from yeast to humans
inferred← citeshttps://doi.org/10.1016/j.tibs.2016.04.005openalex-snapshot
Biochemical Basis of Sestrin Physiological Activities
inferred← citeshttps://doi.org/10.1016/j.tma.2019.09.001openalex-snapshot
Amino acids in the regulation of aging and aging-related diseases
inferred← citeshttps://doi.org/10.1016/j.trsl.2013.11.007openalex-snapshot
Drugs that modulate aging: the promising yet difficult path ahead
inferred← citeshttps://doi.org/10.1016/j.ydbio.2018.10.001openalex-snapshot
CDK8 mediates the dietary effects on developmental transition in Drosophila
inferred← citeshttps://doi.org/10.1016/j.ygeno.2024.110832openalex-snapshot
GCN2-eIF2α signaling pathway negatively regulates the growth of triploid crucian carp
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2016.04.007openalex-snapshot
Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress
inferred← citeshttps://doi.org/10.1016/j.ymgme.2017.11.011openalex-snapshot
DNA methylation signatures at endoplasmic reticulum stress genes are associated with adiposity and insulin resistance
inferred← citeshttps://doi.org/10.1017/s0029665120007880openalex-snapshot
Protein metabolism and related body function: mechanistic approaches and health consequences
inferred← citeshttps://doi.org/10.1021/acs.jafc.8b01111openalex-snapshot
Leucine Affects α-Amylase Synthesis through PI3K/Akt-mTOR Signaling Pathways in Pancreatic Acinar Cells of Dairy Calves
inferred← citeshttps://doi.org/10.1038/ncb2763openalex-snapshot
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
inferred← citeshttps://doi.org/10.1038/onc.2013.153openalex-snapshot
Translation factors and ribosomal proteins control tumor onset and progression: how?
inferred← citeshttps://doi.org/10.1038/s41430-018-0240-9openalex-snapshot
Protein: what’s on in research on clinical nutrition
inferred← citeshttps://doi.org/10.1038/s41467-022-32220-4openalex-snapshot
Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation
inferred← citeshttps://doi.org/10.1038/s41467-024-47465-4openalex-snapshot
Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion
inferred← citeshttps://doi.org/10.1038/s41586-021-03522-2openalex-snapshot
Response of the microbiome–gut–brain axis in Drosophila to amino acid deficit
inferred← citeshttps://doi.org/10.1038/s41598-017-00446-8openalex-snapshot
Drosophila dyskerin is required for somatic stem cell homeostasis
inferred← citeshttps://doi.org/10.1038/s41598-019-57132-0openalex-snapshot
Global translational repression induced by iron deficiency in yeast depends on the Gcn2/eIF2α pathway
inferred← citeshttps://doi.org/10.1038/s41598-023-34674-yopenalex-snapshot
Systemic changes in cell size throughout the body of Drosophila melanogaster associated with mutations in molecular cell cycle regulators
inferred← citeshttps://doi.org/10.1038/s42003-019-0673-2openalex-snapshot
A conserved odorant binding protein is required for essential amino acid detection in Drosophila
inferred← citeshttps://doi.org/10.1038/srep08068openalex-snapshot
Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines
inferred← citeshttps://doi.org/10.1038/srep36888openalex-snapshot
A proteomic adaptation of small intestinal mucosa in response to dietary protein limitation
inferred← citeshttps://doi.org/10.1038/srep40901openalex-snapshot
A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction
inferred← citeshttps://doi.org/10.1039/c9ra01317bopenalex-snapshot
Development of specific l -methionine sensors by FRET-based protein engineering
inferred← citeshttps://doi.org/10.1042/bcj20160822openalex-snapshot
Amino acid homeostasis and signalling in mammalian cells and organisms
inferred← citeshttps://doi.org/10.1053/j.gastro.2016.10.007openalex-snapshot
Isocaloric Diets High in Animal or Plant Protein Reduce Liver Fat and Inflammation in Individuals With Type 2 Diabetes
inferred← citeshttps://doi.org/10.1073/pnas.1913788117openalex-snapshot
Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells
inferred← citeshttps://doi.org/10.1073/pnas.2101977118openalex-snapshot
The effects of graded calorie restriction XVII: Multitissue metabolomics reveals synthesis of carnitine and NAD, and tRNA charging as key pathways
inferred← citeshttps://doi.org/10.1074/jbc.m115.706200openalex-snapshot
The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator
inferred← citeshttps://doi.org/10.1080/15384101.2015.1044188openalex-snapshot
mTORC1 signaling activates NRF1 to increase cellular proteasome levels
inferred← citeshttps://doi.org/10.1089/ars.2017.7434openalex-snapshot
Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity
inferred← citeshttps://doi.org/10.1089/ars.2022.0157openalex-snapshot
Run, Ribosome, Run: From Compromised Translation to Human Health
inferred← citeshttps://doi.org/10.1091/mbc.e13-10-0631openalex-snapshot
A comprehensive protein–protein interactome for yeast PAS kinase 1 reveals direct inhibition of respiration through the phosphorylation of Cbf1
inferred← citeshttps://doi.org/10.1093/cvr/cvz086openalex-snapshot
Short-term preoperative protein restriction attenuates vein graft disease via induction of cystathionine γ-lyase
inferred← citeshttps://doi.org/10.1093/femsyr/foac020openalex-snapshot
Response to leucine in Schizosaccharomyces pombe (fission yeast)
inferred← citeshttps://doi.org/10.1093/g3journal/jkae056openalex-snapshot
Dietary restriction fails to extend lifespan of Drosophila model of Werner syndrome
inferred← citeshttps://doi.org/10.1093/gerona/glu040openalex-snapshot
Elevated ATF4 Function in Fibroblasts and Liver of Slow-Aging Mutant Mice
inferred← citeshttps://doi.org/10.1093/hmg/ddu741openalex-snapshot
Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein-mediated neurodegeneration
inferred← citeshttps://doi.org/10.1093/jn/nxaa187openalex-snapshot
Mitochondrial Fatty Acid β-Oxidation Inhibition Promotes Glucose Utilization and Protein Deposition through Energy Homeostasis Remodeling in Fish
inferred← citeshttps://doi.org/10.1093/jn/nxy172openalex-snapshot
90th Anniversary Commentary: The mTORC1 Complex—A Central Player in the Control and Regulation of Amino Acid Sufficiency
inferred← citeshttps://doi.org/10.1093/molbev/msab369openalex-snapshot
Positive Selection and Enhancer Evolution Shaped Lifespan and Body Mass in Great Apes
inferred← citeshttps://doi.org/10.1095/biolreprod.113.109702openalex-snapshot
Maternal Overweight Induced by a Diet with High Content of Saturated Fat Activates Placental mTOR and eIF2alpha Signaling and Increases Fetal Growth in Rats1
inferred← citeshttps://doi.org/10.1096/fj.15-282475openalex-snapshot
Circadian clocks govern calorie restriction—mediated life span extension through BMAL1‐ and IGF‐1‐dependent mechanisms
inferred← citeshttps://doi.org/10.1097/mco.0000000000000019openalex-snapshot
Caloric restriction, caloric restriction mimetics, and healthy aging in Okinawa
inferred← citeshttps://doi.org/10.1097/mco.0000000000000239openalex-snapshot
The conserved role of protein restriction in aging and disease
inferred← citeshttps://doi.org/10.1098/rsob.220319openalex-snapshot
Restricting a single amino acid cross-protects Drosophila melanogaster from nicotine poisoning through mTORC1 and GCN2 signalling
inferred← citeshttps://doi.org/10.1098/rstb.2019.0416openalex-snapshot
Impact of mitonuclear interactions on life-history responses to diet
inferred← citeshttps://doi.org/10.1101/2021.11.03.467051openalex-snapshot
Restricting a single amino acid cross-protects D. melanogaster from nicotine poisoning through mTORC1 and GCN2 signalling
inferred← citeshttps://doi.org/10.1111/acel.12277openalex-snapshot
Effects of nutritional components on aging
inferred← citeshttps://doi.org/10.1111/acel.12338openalex-snapshot
Interventions to Slow Aging in Humans: Are We Ready?
inferred← citeshttps://doi.org/10.1111/imm.12502openalex-snapshot
Indoleamine 2,3‐dioxygenase depletes tryptophan, activates general control non‐derepressible 2 kinase and down‐regulates key enzymes involved in fatty acid synthesis in primary human CD 4+ T cells
inferred← citeshttps://doi.org/10.1111/liv.14596openalex-snapshot
High‐protein diet more effectively reduces hepatic fat than low‐protein diet despite lower autophagy and FGF21 levels
inferred← citeshttps://doi.org/10.1111/mmi.14627openalex-snapshot
Genes affecting the extension of chronological lifespan in Schizosaccharomyces pombe (fission yeast)
inferred← citeshttps://doi.org/10.1111/mmi.15134openalex-snapshot
ecl family genes: Factors linking starvation and lifespan extension in Schizosaccharomyces pombe
inferred← citeshttps://doi.org/10.1111/phen.70029openalex-snapshot
Macronutrient composition in pollen affects development and survival in wild bees
inferred← citeshttps://doi.org/10.1126/sciadv.adn7167openalex-snapshot
Context-dependent impact of the dietary non-essential amino acid tyrosine on Drosophila physiology and longevity
inferred← citeshttps://doi.org/10.1126/science.aab2674openalex-snapshot
Sestrin2 is a leucine sensor for the mTORC1 pathway
inferred← citeshttps://doi.org/10.1126/scisignal.aaf2885openalex-snapshot
Sestrin regulation of TORC1: Is Sestrin a leucine sensor?
inferred← citeshttps://doi.org/10.1126/scisignal.aav4717openalex-snapshot
Amino acid starvation enhances vaccine efficacy by augmenting neutralizing antibody production
inferred← citeshttps://doi.org/10.1146/annurev-nutr-121624-114918openalex-snapshot
Protein-Restricted Diets and Their Impact on Metabolic Health and Aging
inferred← citeshttps://doi.org/10.1152/ajpcell.00085.2025openalex-snapshot
Amino acid metabolism in cancer cachexia and chemotherapy myotoxicity
inferred← citeshttps://doi.org/10.1152/ajpregu.00334.2016openalex-snapshot
Hyperinsulinemic-normoglycemic clamp administered together with amino acids induces anabolism after cardiac surgery
inferred← citeshttps://doi.org/10.1155/2013/849186openalex-snapshot
mTOR Inhibition: From Aging to Autism and Beyond
inferred← citeshttps://doi.org/10.1155/2016/4010357openalex-snapshot
Dietary Restriction and Nutrient Balance in Aging
inferred← citeshttps://doi.org/10.1155/2022/4034922openalex-snapshot
Dietary Histidine Supplementation Maintained Amino Acid Homeostasis and Reduced Hepatic Lipid Accumulation of Juvenile Largemouth Bass, Micropterus Salmoides
inferred← citeshttps://doi.org/10.1159/000453109openalex-snapshot
Is Overnight Fasting before Surgery Too Much or Not Enough? How Basic Aging Research Can Guide Preoperative Nutritional Recommendations to Improve Surgical Outcomes: A Mini-Review
inferred← citeshttps://doi.org/10.1177/0884533617691245openalex-snapshot
Protein Delivery in the Intensive Care Unit: Optimal or Suboptimal?
inferred← citeshttps://doi.org/10.1177/0884533617693610openalex-snapshot
Summary Points and Consensus Recommendations From the International Protein Summit
inferred← citeshttps://doi.org/10.1186/1743-7075-10-60openalex-snapshot
Metabolic effects of milk protein intake strongly depend on pre-existing metabolic and exercise status
inferred← citeshttps://doi.org/10.1186/s12933-020-01188-0openalex-snapshot
Impact of peroxisome proliferator-activated receptor-α on diabetic cardiomyopathy
inferred← citeshttps://doi.org/10.1186/s12967-016-0767-2openalex-snapshot
Improving the outcome of kidney transplantation by ameliorating renal ischemia reperfusion injury: lost in translation?
inferred← citeshttps://doi.org/10.1186/s12986-022-00674-4openalex-snapshot
Comprehensive evaluation of caloric restriction-induced changes in the metabolome profile of mice
inferred← citeshttps://doi.org/10.1186/s13054-020-03208-7openalex-snapshot
Biomarkers in critical care nutrition
inferred← citeshttps://doi.org/10.1186/s40850-023-00174-9openalex-snapshot
Effects of morphological traits on body weight and analysis of growth-related genes of Parabramis pekinensis at different ages
inferred← citeshttps://doi.org/10.1201/b16638-17openalex-snapshot
Dietary Therapy for Psoriasis: Protein-Restricted Diets
inferred← citeshttps://doi.org/10.1242/dev.116467openalex-snapshot
Adipocyte amino acid sensing controls adult germline stem cell number via the amino acid response pathway and independently of Target of Rapamycin signaling in Drosophila
inferred← citeshttps://doi.org/10.12688/f1000research.5212.1openalex-snapshot
Aging and energetics’ ‘Top 40’ future research opportunities 2010-2013
inferred← citeshttps://doi.org/10.12691/jfnr-6-10-8openalex-snapshot
Leucine Exerts Lifespan Extension and Improvement in Three Types of Stress Resistance (Thermotolerance, Anti-Oxidation and Anti-UV Irradiation) in C. elegans
inferred← citeshttps://doi.org/10.1360/ssv-2019-0189openalex-snapshot
Advances in pig amino acid nutrition during 40 Years of Reform and Opening-up
inferred← citeshttps://doi.org/10.1371/journal.pone.0162475openalex-snapshot
Protein Restriction with Amino Acid-Balanced Diets Shrinks Circulating Pool Size of Amino Acid by Decreasing Expression of Specific Transporters in the Small Intestine
inferred← citeshttps://doi.org/10.1371/journal.pone.0165708openalex-snapshot
Comparative Study on the Cellular and Systemic Nutrient Sensing and Intermediary Metabolism after Partial Replacement of Fishmeal by Meat and Bone Meal in the Diet of Turbot (Scophthalmus maximus L.)
inferred← citeshttps://doi.org/10.1371/journal.pone.0200783openalex-snapshot
Amino acid deprivation triggers a novel GCN2-independent response leading to the transcriptional reactivation of non-native DNA sequences
inferred← citeshttps://doi.org/10.1371/journal.pone.0323980openalex-snapshot
The mitochondrial aspartate transporter Ucp4a regulates muscle aging and animal lifespan in Drosophila melanogaster
inferred← citeshttps://doi.org/10.1371/journal.ppat.1004851openalex-snapshot
GATA-Dependent Glutaminolysis Drives Appressorium Formation in Magnaporthe oryzae by Suppressing TOR Inhibition of cAMP/PKA Signaling
inferred← citeshttps://doi.org/10.14336/ad.2022.0318openalex-snapshot
Non-alcoholic Fatty Liver Disease and Liver Fibrosis during Aging
inferred← citeshttps://doi.org/10.1515/revneuro-2018-0073openalex-snapshot
The effects of dietary methionine restriction on the function and metabolic reprogramming in the liver and brain – implications for longevity
inferred← citeshttps://doi.org/10.15330/jpnu.2.1.51-60openalex-snapshot
Amino Acids: Sensing and Implication into Aging
inferred← citeshttps://doi.org/10.1590/0001-3765202020200437openalex-snapshot
Aging: a New Perspective on an Old Issue
inferred← citeshttps://doi.org/10.1590/1519-6984.258880openalex-snapshot
An investigation on protein and amino acid contents in scales and muscles of pomfret Parastromateus niger (Bloch, 1795) and Pampus argenteus (Eupharasen, 1788)
inferred← citeshttps://doi.org/10.18174/387386openalex-snapshot
Diet-induced phenotypic plasticity during aging
inferred← citeshttps://doi.org/10.18632/aging.100683openalex-snapshot
D-beta-hydroxybutyrate extends lifespan in C. elegans
inferred← citeshttps://doi.org/10.18632/oncoscience.258openalex-snapshot
Selective amino acid restriction therapy (SAART): a non- pharmacological strategy against all types of cancer cells
inferred← citeshttps://doi.org/10.18632/oncotarget.15501openalex-snapshot
Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition
inferred← citeshttps://doi.org/10.18632/oncotarget.2989openalex-snapshot
Ammonium is a key determinant on the dietary restriction of yeast chronological aging in culture medium
inferred← citeshttps://doi.org/10.18632/oncotarget.4602openalex-snapshot
p53 and rapamycin are additive
inferred← citeshttps://doi.org/10.2147/ott.s88873openalex-snapshot
A human leucyl-tRNA synthetase as an anticancer target
inferred← citeshttps://doi.org/10.2147/tacg.s68635openalex-snapshot
Pulmonary capillary hemangiomatosis: a focus on the EIF2AK4 mutation in onset and pathogenesis
inferred← citeshttps://doi.org/10.2174/1874288201408010001openalex-snapshot
Effects of L-amino Acids on Human Peripheral Neutrophil Granulocyte Activation
inferred← citeshttps://doi.org/10.2337/db20-0489openalex-snapshot
Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis
inferred← citeshttps://doi.org/10.2527/jas.2015-9432openalex-snapshot
L-Glutamate deficiency can trigger proliferation inhibition via down regulation of the mTOR/S6K1 pathway in pig intestinal epithelial cells1
inferred← citeshttps://doi.org/10.26497/ar190007openalex-snapshot
Influence of Caloric Restriction on Ageing
inferred← citeshttps://doi.org/10.2741/4283openalex-snapshot
Calorie restriction and NAD+/sirtuin counteract the hallmarks of aging
inferred← citeshttps://doi.org/10.3350/cmh.2020.0067openalex-snapshot
Evidence-based clinical advice for nutrition and dietary weight loss strategies for the management of NAFLD and NASH
inferred← citeshttps://doi.org/10.3389/fcell.2022.1079920openalex-snapshot
Caloric restriction induced epigenetic effects on aging
inferred← citeshttps://doi.org/10.3389/fcell.2022.822685openalex-snapshot
Target of Rapamycin Drives Unequal Responses to Essential Amino Acid Depletion for Egg Laying in Drosophila Melanogaster
inferred← citeshttps://doi.org/10.3389/fchem.2018.00243openalex-snapshot
The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health
inferred← citeshttps://doi.org/10.3389/fendo.2015.00007openalex-snapshot
Maintenance of Homeostasis in the Aging Hypothalamus: The Central and Peripheral Roles of Succinate
inferred← citeshttps://doi.org/10.3389/fendo.2018.00217openalex-snapshot
Physiological and Molecular Mechanisms of Methionine Restriction
inferred← citeshttps://doi.org/10.3389/fgene.2026.1832187openalex-snapshot
Roles of microRNA in aging and dietary restriction-induced longevity
inferred← citeshttps://doi.org/10.3389/fimmu.2017.01719openalex-snapshot
Amino Acid Sensing via General Control Nonderepressible-2 Kinase and Immunological Programming
inferred← citeshttps://doi.org/10.3389/fimmu.2018.01879openalex-snapshot
What May Constrain the Success of Indoleamine 2,3-Dioxygenase 1 Inhibitors in Cancer Immunotherapy?
inferred← citeshttps://doi.org/10.3389/fimmu.2020.600428openalex-snapshot
Immunosuppressive Amino-Acid Catabolizing Enzymes in Multiple Sclerosis
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1852583openalex-snapshot
Immune cells harbor their own microbiome-derived metabolome: a new layer of immunometabolic regulation
inferred← citeshttps://doi.org/10.3389/fmars.2020.00197openalex-snapshot
The Potential Role of Marine Protein Hydrolyzates in Elevating Nutritive Values of Diets for Largemouth Bass, Micropterus salmoides
inferred← citeshttps://doi.org/10.3389/fmars.2020.595682openalex-snapshot
Dietary Lysine Regulates Body Growth Performance via the Nutrient-Sensing Signaling Pathways in Largemouth Bass (Micropterus salmoides)
inferred← citeshttps://doi.org/10.3389/fmars.2021.775575openalex-snapshot
Changes in Growth Performance, Nutrient Metabolism, Antioxidant Defense and Immune Response After Fishmeal Was Replaced by Low-Gossypol Cottonseed Meal in Golden Pompano (Trachinotus ovatus)
inferred← citeshttps://doi.org/10.3389/fmicb.2018.03260openalex-snapshot
Bacillus amyloliquefaciens Ameliorates Dextran Sulfate Sodium-Induced Colitis by Improving Gut Microbial Dysbiosis in Mice Model
inferred← citeshttps://doi.org/10.3389/fmolb.2018.00045openalex-snapshot
Nutritional Stress Induced by Amino Acid Starvation Results in Changes for Slc38 Transporters in Immortalized Hypothalamic Neuronal Cells and Primary Cortex Cells
inferred← citeshttps://doi.org/10.3389/fnut.2019.00062openalex-snapshot
Dairy Products: Is There an Impact on Promotion of Prostate Cancer? A Review of the Literature
inferred← citeshttps://doi.org/10.3389/fragi.2022.944466openalex-snapshot
The Role of GCN2 Kinase in Mediating the Effects of Amino Acids on Longevity and Feeding Behaviour in Drosophila
inferred← citeshttps://doi.org/10.3389/fragi.2024.1447370openalex-snapshot
General control nonderepressible 2 (GCN2) as a therapeutic target in age-related diseases
inferred← citeshttps://doi.org/10.3389/fvets.2023.1273944openalex-snapshot
Effect of hexavalent chromium on growth performance and metabolism in broiler chicken
inferred← citeshttps://doi.org/10.3390/ani10091590openalex-snapshot
Dietary Insect Powder Protein Sources Improve Protein Utilization by Regulation on Intestinal Amino Acid-Chemosensing System
inferred← citeshttps://doi.org/10.3390/cells12121668openalex-snapshot
Starvation Protects Hepatocytes from Inflammatory Damage through Paradoxical mTORC1 Signaling
inferred← citeshttps://doi.org/10.3390/ijms18050915openalex-snapshot
NutrimiRAging: Micromanaging Nutrient Sensing Pathways through Nutrition to Promote Healthy Aging
inferred← citeshttps://doi.org/10.3390/ijms19113597openalex-snapshot
Development of Biomarkers for Inhibition of SLC6A19 (B0AT1)—A Potential Target to Treat Metabolic Disorders
inferred← citeshttps://doi.org/10.3390/ijms252313135openalex-snapshot
Phenylalanine Regulates Milk Protein Synthesis via LAT1–mTOR Signaling Pathways in Bovine Mammary Epithelial Cells
inferred← citeshttps://doi.org/10.3390/ijms26020776openalex-snapshot
Cellular Signaling of Amino Acid Metabolism in Prostate Cancer
inferred← citeshttps://doi.org/10.3390/jof9030340openalex-snapshot
The AMP-Activated Protein Kinase (AMPK) Positively Regulates Lysine Biosynthesis Induced by Citric Acid in Flammulina filiformis
inferred← citeshttps://doi.org/10.3390/microorganisms11010218openalex-snapshot
TORC1 Signaling in Fungi: From Yeasts to Filamentous Fungi
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