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Role of the Transcription Factor ATF4 in the Anabolic Actions of Insulin and the Anti-anabolic Actions of Glucocorticoids

https://doi.org/10.1074/jbc.m610510200
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/dbio.2000.9699openalex-snapshot
Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor
inferredcites →https://doi.org/10.1016/0016-6480(89)90187-1openalex-snapshot
Textbook of endocrine physiology
inferredcites →https://doi.org/10.1016/0092-8674(89)90793-9openalex-snapshot
Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis
inferredcites →https://doi.org/10.1016/j.bbrc.2003.07.020openalex-snapshot
Amino acids as regulators of gene expression: molecular mechanisms
inferredcites →https://doi.org/10.1016/j.ceb.2005.09.009openalex-snapshot
Growing roles for the mTOR pathway
inferredcites →https://doi.org/10.1016/j.cell.2005.02.002openalex-snapshot
The Plasticity of Aging: Insights from Long-Lived Mutants
inferredcites →https://doi.org/10.1016/j.cell.2006.01.016openalex-snapshot
TOR Signaling in Growth and Metabolism
inferredcites →https://doi.org/10.1016/j.semcdb.2004.11.009openalex-snapshot
Role of amino acids in the translational control of protein synthesis in mammals
inferredcites →https://doi.org/10.1016/s0021-9258(18)70932-0openalex-snapshot
THE SPECIFIC AMINO ACID REQUIREMENTS OF A MAMMALIAN CELL (STRAIN L) IN TISSUE CULTURE
inferredcites →https://doi.org/10.1016/s0021-9258(18)96424-0openalex-snapshot
The Effect of Glucocorticoids on Protein and Nucleic Acid Synthesis in Mouse Fibroblasts Growing in Vitro
inferredcites →https://doi.org/10.1016/s0092-8674(04)00344-7openalex-snapshot
ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology
inferredcites →https://doi.org/10.1016/s0092-8674(04)00400-3openalex-snapshot
Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy
inferredcites →https://doi.org/10.1016/s0092-8674(04)00452-0openalex-snapshot
FoxOs at the Crossroads of Cellular Metabolism, Differentiation, and Transformation
inferredcites →https://doi.org/10.1016/s1097-2765(00)00108-8openalex-snapshot
Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
inferredcites →https://doi.org/10.1016/s1097-2765(03)00105-9openalex-snapshot
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
inferredcites →https://doi.org/10.1016/s1097-2765(04)00211-4openalex-snapshot
The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors
inferredcites →https://doi.org/10.1038/414799aopenalex-snapshot
Insulin signalling and the regulation of glucose and lipid metabolism
inferredcites →https://doi.org/10.1038/nature01667openalex-snapshot
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
inferredcites →https://doi.org/10.1038/ncb1101-1009openalex-snapshot
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
inferredcites →https://doi.org/10.1042/0264-6021:3510095openalex-snapshot
Specificity and mechanism of action of some commonly used protein kinase inhibitors
inferredcites →https://doi.org/10.1042/bj20030022openalex-snapshot
Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation
inferredcites →https://doi.org/10.1042/bj20030405openalex-snapshot
Amino acid transporters: roles in amino acid sensing and signalling in animal cells
inferredcites →https://doi.org/10.1042/bj20060941openalex-snapshot
A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation
inferredcites →https://doi.org/10.1042/bj3510095openalex-snapshot
Specificity and mechanism of action of some commonly used protein kinase inhibitors
inferredcites →https://doi.org/10.1073/pnas.1534923100openalex-snapshot
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
inferredcites →https://doi.org/10.1074/jbc.m004898200openalex-snapshot
Regulation of Phosphoenolpyruvate Carboxykinase and Insulin-like Growth Factor-binding Protein-1 Gene Expression by Insulin
inferredcites →https://doi.org/10.1074/jbc.m109533200openalex-snapshot
CCAAT/Enhancer-binding Protein-β Is a Mediator of the Nutrient-sensing Response Pathway That Activates the Human Asparagine Synthetase Gene
inferredcites →https://doi.org/10.1074/jbc.m111421200openalex-snapshot
Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c
inferredcites →https://doi.org/10.1074/jbc.m201959200openalex-snapshot
ATF4 Is a Mediator of the Nutrient-sensing Response Pathway That Activates the Human Asparagine Synthetase Gene
inferredcites →https://doi.org/10.1074/jbc.m410010200openalex-snapshot
ATF4, the Osteoblast Accumulation of Which Is Determined Post-translationally, Can Induce Osteoblast-specific Gene Expression in Non-osteoblastic Cells
inferredcites →https://doi.org/10.1074/jbc.m410302200openalex-snapshot
Cholesterol and 25-Hydroxycholesterol Inhibit Activation of SREBPs by Different Mechanisms, Both Involving SCAP and Insigs
inferredcites →https://doi.org/10.1074/jbc.m502876200openalex-snapshot
Akt Activates the Mammalian Target of Rapamycin by Regulating Cellular ATP Level and AMPK Activity
inferredcites →https://doi.org/10.1074/jbc.m505294200openalex-snapshot
p300 Modulates ATF4 Stability and Transcriptional Activity Independently of Its Acetyltransferase Domain
inferredcites →https://doi.org/10.1074/jbc.m610023200openalex-snapshot
Dexamethasone Represses Signaling through the Mammalian Target of Rapamycin in Muscle Cells by Enhancing Expression of REDD1
inferredcites →https://doi.org/10.1093/gerona/50a.2.b78openalex-snapshot
Hyperadrenocorticism, Attenuated Inflammation, and the Life-Prolonging Action of Food Restriction in Mice
inferredcites →https://doi.org/10.1093/geronj/46.5.b171openalex-snapshot
Assessment of the Role of the Glucocorticoid System in Aging Processes and in the Action of Food Restriction
inferredcites →https://doi.org/10.1093/jn/109.10.1766openalex-snapshot
Interaction of Glucocorticoid and Insulin in the Responses of Rats to Starvation-Refeeding
inferredcites →https://doi.org/10.1093/jn/113.11.2260openalex-snapshot
Interaction of Glucocorticoid and Thyroxine in the Responses of Rats to Starvation-Refeeding
inferredcites →https://doi.org/10.1101/gad.1052903openalex-snapshot
How does calorie restriction work?
inferredcites →https://doi.org/10.1128/mcb.21.6.2192-2202.2001openalex-snapshot
ATF4 Degradation Relies on a Phosphorylation-Dependent Interaction with the SCFβTrCPUbiquitin Ligase
inferredcites →https://doi.org/10.1128/mcb.22.15.5575-5584.2002openalex-snapshot
The Immunosuppressant Rapamycin Mimics a Starvation-Like Signal Distinct from Amino Acid and Glucose Deprivation
inferredcites →https://doi.org/10.1136/pgmj.70.819.57-aopenalex-snapshot
Textbook of Endocrine Physiology
inferredcites →https://doi.org/10.1146/annurev.nutr.24.012003.132145openalex-snapshot
NUTRITIONAL CONTROL OF GENE EXPRESSION: How Mammalian Cells Respond to Amino Acid Limitation
inferredcites →https://doi.org/10.1146/annurev.ph.37.030175.001333openalex-snapshot
Peripheral Actions of Glucocorticoids
inferredcites →https://doi.org/10.1146/annurev.ph.54.030192.004321openalex-snapshot
Molecular Physiology Of The Regulation Of Hepatic Gluconeogenesis And Glycolysis
inferredcites →https://doi.org/10.1182/blood.v99.3.736openalex-snapshot
Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice
inferredcites →https://doi.org/10.1242/jcs.107.3.719openalex-snapshot
Genetic deficiency in low density lipoprotein receptor-related protein confers cellular resistance to Pseudomonas exotoxin A Evidence that this protein is required for uptake and degradation of multiple ligands
inferredcites →https://doi.org/10.1515/bc.2005.102openalex-snapshot
Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP
inferredcites →https://doi.org/10.2337/diabetes.53.4.899openalex-snapshot
Protein Kinase B-α Inhibits Human Pyruvate Dehydrogenase Kinase-4 Gene Induction by Dexamethasone Through Inactivation of FOXO Transcription Factors

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Protein metabolism in health and diabetes
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Regulation of immune cell metabolism by cancer cell oncogenic mutations
inferred← citeshttps://doi.org/10.1002/jcb.21888openalex-snapshot
Activating transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts
inferred← citeshttps://doi.org/10.1002/jcb.22349openalex-snapshot
Regulation of REDD1 by insulin‐like growth factor‐I in skeletal muscle and myotubes
inferred← citeshttps://doi.org/10.1002/jcb.23268openalex-snapshot
Glucocorticoid receptor‐mediated transcriptional activation of S100P gene coding for cancer‐related calcium‐binding protein
inferred← citeshttps://doi.org/10.1002/jcp.22412openalex-snapshot
Developmentally regulated inhibition of cell cycle progression by glucocorticoids through repression of cyclin a transcription in primary osteoblast cultures
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Mechanism and application of nonessential amino acid deprivation associated with tumor therapy
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Insulin increases mRNA abundance of the amino acid transporter SLC7A5/LAT1 via an mTORC1-dependent mechanism in skeletal muscle cells
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The Interaction of Exercise, Stress, and Inflammation on Growth
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ATF4, Hypoxia and Treatment Resistance in Cancer
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Glucose Metabolism and Liver
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An overview of transcriptional regulation in response to toxicological insult
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Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorononanoic acid (PFNA) increase triglyceride levels and decrease cholesterogenic gene expression in human HepaRG liver cells
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Determination of in vitro hepatotoxic potencies of a series of perfluoroalkyl substances (PFASs) based on gene expression changes in HepaRG liver cells
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Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis
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The combined expression of solute carriers is associated with a poor prognosis in highly proliferative ER+ breast cancer
inferred← citeshttps://doi.org/10.1007/s10565-021-09608-xopenalex-snapshot
Cooperation of ATF4 and CTCF promotes adipogenesis through transcriptional regulation
inferred← citeshttps://doi.org/10.1007/s12192-016-0741-1openalex-snapshot
Sublethal endoplasmic reticulum stress caused by the mutation of immunoglobulin heavy chain-binding protein induces the synthesis of a mitochondrial protein, pyrroline-5-carboxylate reductase 1
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Skeletal Actions of Insulin
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Quantification of the inputs and outputs of serine and glycine metabolism in cancer cells
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Insulin inhibits melanoma tumor growth through the expression of activating transcription factor 4, without detectable expression of transcription factor CHOP: an in vivo model
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10.1016/j.abdp.2024.04.012
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Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia
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Activating transcription factor 4 mediates up-regulation of alanine aminotransferase 2 gene expression under metabolic stress
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ATF4 regulates SREBP1c expression to control fatty acids synthesis in 3T3-L1 adipocytes differentiation
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Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells
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Mitochondria are midfield players in steroid synthesis
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Pro-osteogenic trophic effects by PKA activation in human mesenchymal stromal cells
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The PHGDH enigma: Do cancer cells only need serine or also a redox modulator?
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KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism
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Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells
inferred← citeshttps://doi.org/10.1016/j.celrep.2017.04.042openalex-snapshot
mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4
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Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis
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Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism
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Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway
inferred← citeshttps://doi.org/10.1016/j.cmet.2013.11.004openalex-snapshot
The Histone H3 Methyltransferase G9A Epigenetically Activates the Serine-Glycine Synthesis Pathway to Sustain Cancer Cell Survival and Proliferation
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Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells
inferred← citeshttps://doi.org/10.1016/j.cmet.2019.02.015openalex-snapshot
Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting
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Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells
inferred← citeshttps://doi.org/10.1016/j.ehb.2014.04.002openalex-snapshot
Macronutrients and obesity: Revisiting the calories in, calories out framework
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A comprehensive review on signaling attributes of serine and serine metabolism in health and disease
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Disrupting ATF4 Expression Mechanisms Provides an Effective Strategy for BRAF-Targeted Melanoma Therapy
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Pre-cachectic changes in amino acid homeostasis precede activation of eIF2α signaling in the liver at the onset of C26 cancer-induced cachexia
inferred← citeshttps://doi.org/10.1016/j.isci.2025.112138openalex-snapshot
Ribosomal protein deficiencies linked to Diamond-Blackfan anemia induce distinctive alterations of ATF4 expression
inferred← citeshttps://doi.org/10.1016/j.isci.2025.114277openalex-snapshot
Basal level of ATF4 promotes T cell readiness for activation-induced proliferation
inferred← citeshttps://doi.org/10.1016/j.jare.2026.03.017openalex-snapshot
The stress responsive transcription factor ATF4: from molecular structure to disease mechanisms
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.100989openalex-snapshot
Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK–eIF2α–ATF4 axis
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From the integrated stress response to oxidative stress: A historical perspective
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1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase
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Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes
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Serine metabolism in the central nervous system: advances and challenges on a conditionally essential amino acid
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Possible link between the synthesis of GR alpha isoforms and eIF2 alpha phosphorylation state
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Downregulation of PHGDH expression and hepatic serine level contribute to the development of fatty liver disease
inferred← citeshttps://doi.org/10.1016/j.molcel.2021.05.008openalex-snapshot
ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia
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Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin
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Resistance exercise enhances long-term mTORC1 sensitivity to leucine
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Upregulation of amino acid transporter expression induced by l-leucine availability in L6 myotubes is associated with ATF4 signaling through mTORC1-dependent mechanism
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Musculoskeletal crosstalk in chronic obstructive pulmonary disease and comorbidities: Emerging roles and therapeutic potentials
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Amino acid management in cancer
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Effects of exercise training on glucocorticoid-induced muscle atrophy: Literature review
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Myopathies toxiques : vue d’ensemble
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Myopathies induites par les médicaments
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Inhibition of protein translation as a mechanism of acidotic pH protection against ischaemic injury through inhibition of CREB mediated tRNA synthetase expression
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Warburg and Krebs and related effects in cancer
inferred← citeshttps://doi.org/10.1017/s0029665115003250openalex-snapshot
Skeletal muscle hypertrophy in pigs is associated with an increased expression of serine biosynthetic pathway genes along with genes associated with an endoplasmic reticulum stress response
inferred← citeshttps://doi.org/10.1017/s1751731120000245openalex-snapshot
Effects of glucocorticoids on the gene expression of nutrient transporters in different rabbit intestinal segments
inferred← citeshttps://doi.org/10.1038/ncomms11127openalex-snapshot
mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
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Implications of glucocorticoid therapy in idiopathic inflammatory myopathies
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p73 regulates serine biosynthesis in cancer
inferred← citeshttps://doi.org/10.1038/s41388-021-01749-xopenalex-snapshot
Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis
inferred← citeshttps://doi.org/10.1038/s41388-023-02632-7openalex-snapshot
L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis
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Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat
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De novo serine synthesis regulates chondrocyte proliferation during bone development and repair
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A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites
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mTOR signalling and cellular metabolism are mutual determinants in cancer
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Hydrocortisone-induced parkin prevents dopaminergic cell death via CREB pathway in Parkinson’s disease model
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The Beta-adrenergic agonist, Ractopamine, increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program
inferred← citeshttps://doi.org/10.1038/s41598-019-39395-9openalex-snapshot
Extensive epigenomic integration of the glucocorticoid response in primary human monocytes and in vitro derived macrophages
inferred← citeshttps://doi.org/10.1038/s41598-021-96000-8openalex-snapshot
Impaired skeletal muscle hypertrophy signaling and amino acid deprivation response in Apoe knockout mice with an unhealthy lipoprotein distribution
inferred← citeshttps://doi.org/10.1038/s41598-021-99432-4openalex-snapshot
Effect of AAV-mediated overexpression of ATF5 and downstream targets of an integrated stress response in murine skeletal muscle
inferred← citeshttps://doi.org/10.1038/s42255-020-00329-9openalex-snapshot
The ins and outs of serine and glycine metabolism in cancer
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Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR
inferred← citeshttps://doi.org/10.1073/pnas.1204176109openalex-snapshot
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
inferred← citeshttps://doi.org/10.1074/jbc.m111.258970openalex-snapshot
cAMP-response Element (CRE)-mediated Transcription by Activating Transcription Factor-4 (ATF4) Is Essential for Circadian Expression of the Period2 Gene
inferred← citeshttps://doi.org/10.1074/jbc.m113.466920openalex-snapshot
A Self-defeating Anabolic Program Leads to β-Cell Apoptosis in Endoplasmic Reticulum Stress-induced Diabetes via Regulation of Amino Acid Flux
inferred← citeshttps://doi.org/10.1074/jbc.m113.470526openalex-snapshot
ATF4 Protein Deficiency Protects against High Fructose-induced Hypertriglyceridemia in Mice
inferred← citeshttps://doi.org/10.1074/jbc.m801331200openalex-snapshot
Insulin Signaling and the General Amino Acid Control Response
inferred← citeshttps://doi.org/10.1074/jbc.ra117.001625openalex-snapshot
Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver
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A Scale-Free Approach for False Discovery Rate Control in Generalized Linear Models
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Determinants of nutrient limitation in cancer
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Glucocorticoid-induced muscle weakness in ECOPD: a perspective on mechanisms and emerging pharmacological interventions
inferred← citeshttps://doi.org/10.1083/jcb.201604085openalex-snapshot
The importance of serine metabolism in cancer
inferred← citeshttps://doi.org/10.1083/jcb.201907022openalex-snapshot
The complexity of the serine glycine one-carbon pathway in cancer
inferred← citeshttps://doi.org/10.1089/ars.2010.3600openalex-snapshot
Control of Redox State and Redox Signaling by Neural Antioxidant Systems
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Phosphoinositide 3-Kinases Upregulate System x c − via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy
inferred← citeshttps://doi.org/10.1093/jn/nxab440openalex-snapshot
Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy
inferred← citeshttps://doi.org/10.1093/nar/gkv222openalex-snapshot
Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability
inferred← citeshttps://doi.org/10.1093/nar/gkw667openalex-snapshot
The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes in response to amino acid limitation
inferred← citeshttps://doi.org/10.1097/mco.0b013e3283406f3eopenalex-snapshot
Essential amino acid sensing, signaling, and transport in the regulation of human muscle protein metabolism
inferred← citeshttps://doi.org/10.1097/mco.0b013e3283653ec5openalex-snapshot
Amino acid transporters in the regulation of human skeletal muscle protein metabolism
inferred← citeshttps://doi.org/10.1101/2022.09.10.507425openalex-snapshot
Comprehensive Analysis of Regenerative and Transformed Liver Reveals Distinct, Early Metabolic Alterations in Cancer
inferred← citeshttps://doi.org/10.1101/2024.04.11.589139openalex-snapshot
MAPK-mediated PHGDH induction is essential for melanoma formation and represents an actionable vulnerability
inferred← citeshttps://doi.org/10.1101/2025.02.10.637516openalex-snapshot
Lineage plasticity of the integrated stress response is a hallmark of cancer evolution
inferred← citeshttps://doi.org/10.1101/249250openalex-snapshot
Increased PHGDH expression uncouples hair follicle cycle progression and promotes inappropriate melanin accumulation
inferred← citeshttps://doi.org/10.1101/610220openalex-snapshot
Brown adipocyte NOSEMPE promotes nonmitochondrial thermogenesis and improves systemic metabolism through ATF4 activation
inferred← citeshttps://doi.org/10.1101/cshperspect.a041543openalex-snapshot
Growth Signaling Networks Orchestrate Cancer Metabolic Networks
inferred← citeshttps://doi.org/10.1101/gr.146654.112openalex-snapshot
CG methylated microarrays identify a novel methylated sequence bound by the CEBPB|ATF4 heterodimer that is active in vivo
inferred← citeshttps://doi.org/10.1111/asj.13861openalex-snapshot
Effects of low‐protein diet and feed restriction on mRNA expression of cationic amino acid transporters in porcine skeletal muscles
inferred← citeshttps://doi.org/10.1111/febs.15693openalex-snapshot
Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism
inferred← citeshttps://doi.org/10.1111/j.1749-6632.2009.04986.xopenalex-snapshot
Mechanisms Generating Diversity in Glucocorticoid Receptor Signaling
inferred← citeshttps://doi.org/10.1113/jphysiol.2012.228833openalex-snapshot
Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men
inferred← citeshttps://doi.org/10.1126/science.aad0489openalex-snapshot
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
inferred← citeshttps://doi.org/10.1126/scisignal.aav3048openalex-snapshot
mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β 1 –induced collagen biosynthesis
inferred← citeshttps://doi.org/10.1128/mbio.00689-24openalex-snapshot
Differential stability of Gcn4p controls its cell-specific activity in differentiated yeast colonies
inferred← citeshttps://doi.org/10.1128/mcb.00748-14openalex-snapshot
Electrophilic Lipid Mediator 15-Deoxy-Δ12,14-Prostaglandin J2 Modifies Glucocorticoid Signaling via Receptor SUMOylation
inferred← citeshttps://doi.org/10.1146/annurev-nutr-120919-041411openalex-snapshot
Nutrient Control of mRNA Translation
inferred← citeshttps://doi.org/10.1152/ajpendo.00603.2011openalex-snapshot
Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults
inferred← citeshttps://doi.org/10.1152/ajpendo.00690.2009openalex-snapshot
An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle
inferred← citeshttps://doi.org/10.1152/ajpendo.91002.2008openalex-snapshot
Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling
inferred← citeshttps://doi.org/10.1152/japplphysiol.01093.2013openalex-snapshot
Soy-dairy protein blend and whey protein ingestion after resistance exercise increases amino acid transport and transporter expression in human skeletal muscle
inferred← citeshttps://doi.org/10.1152/japplphysiol.01408.2010openalex-snapshot
Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise
inferred← citeshttps://doi.org/10.1152/physiol.00003.2019openalex-snapshot
Skeletal Muscle Atrophy: Discovery of Mechanisms and Potential Therapies
inferred← citeshttps://doi.org/10.1152/physiol.00041.2007openalex-snapshot
Signaling in Muscle Atrophy and Hypertrophy
inferred← citeshttps://doi.org/10.1155/2013/256043openalex-snapshot
Glucose Toxic Effects on Granulation Tissue Productive Cells: The Diabetics’ Impaired Healing
inferred← citeshttps://doi.org/10.1155/2017/9747256openalex-snapshot
L-Theanine Administration Modulates the Absorption of Dietary Nutrients and Expression of Transporters and Receptors in the Intestinal Mucosa of Rats
inferred← citeshttps://doi.org/10.1158/0008-5472.can-18-3541openalex-snapshot
Metabolic Reprogramming by MYCN Confers Dependence on the Serine-Glycine-One-Carbon Biosynthetic Pathway
inferred← citeshttps://doi.org/10.1158/0008-5472.can-24-2471openalex-snapshot
PHGDH Induction by MAPK Is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability
inferred← citeshttps://doi.org/10.1158/2159-8290.cd-20-0738openalex-snapshot
Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD–Driven Acute Myeloid Leukemia
inferred← citeshttps://doi.org/10.1159/000229762openalex-snapshot
Mechanisms of Muscle Atrophy Induced by Glucocorticoids
inferred← citeshttps://doi.org/10.11606/t.42.2015.tde-26082015-120432openalex-snapshot
Efeitos da L-glutamina sobre a atividade das vias de sinalização da síntese e degradação de proteínas no músculo esquelético de camundongos e no conteúdo intracelular de aminoácidos em miotubos cultivados.
inferred← citeshttps://doi.org/10.1161/circulationaha.110.012211openalex-snapshot
Calcineurin Splicing Variant Calcineurin Aβ1 Improves Cardiac Function After Myocardial Infarction Without Inducing Hypertrophy
inferred← citeshttps://doi.org/10.1165/rcmb.2020-0143ocopenalex-snapshot
TGF-β Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation
inferred← citeshttps://doi.org/10.1177/15330338221145994openalex-snapshot
Multi-omics Analysis of the Role of PHGDH in Colon Cancer
inferred← citeshttps://doi.org/10.1186/s12885-019-5933-5openalex-snapshot
Increased PHGDH expression promotes aberrant melanin accumulation
inferred← citeshttps://doi.org/10.1186/s12964-024-02016-8openalex-snapshot
FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction
inferred← citeshttps://doi.org/10.1186/s13058-018-0946-6openalex-snapshot
The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours
inferred← citeshttps://doi.org/10.1186/s40170-015-0131-7openalex-snapshot
An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation
inferred← citeshttps://doi.org/10.1186/s40364-023-00487-4openalex-snapshot
Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers
inferred← citeshttps://doi.org/10.1210/en.2007-1573openalex-snapshot
Parathyroid Hormone Increases Activating Transcription Factor 4 Expression and Activity in Osteoblasts: Requirement for Osteocalcin Gene Expression
inferred← citeshttps://doi.org/10.1210/me.2008-0284openalex-snapshot
Insulin Regulates TRB3 and Other Stress-Responsive Gene Expression through Induction of C/EBPβ
inferred← citeshttps://doi.org/10.1210/me.2009-0345openalex-snapshot
The Transcription Factor ATF4 Promotes Skeletal Myofiber Atrophy during Fasting
inferred← citeshttps://doi.org/10.1371/journal.pone.0201986openalex-snapshot
The effect of Tmem135 overexpression on the mouse heart
inferred← citeshttps://doi.org/10.14336/ad.2023.0520openalex-snapshot
MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products
inferred← citeshttps://doi.org/10.1517/14728222.2012.728207openalex-snapshot
Targeting the ATF4 pathway in cancer therapy
inferred← citeshttps://doi.org/10.15252/embj.2021109365openalex-snapshot
Airway secretory cell fate conversion via YAP‐mTORC1‐dependent essential amino acid metabolism
inferred← citeshttps://doi.org/10.1530/erc-12-0125openalex-snapshot
Stimulation of MC38 tumor growth by insulin analog X10 involves the serine synthesis pathway
inferred← citeshttps://doi.org/10.1631/jzus.b2200144openalex-snapshot
UPF1 increases amino acid levels and promotes cell proliferation in lung adenocarcinoma via the eIF2α-ATF4 axis
inferred← citeshttps://doi.org/10.1677/joe-07-0606openalex-snapshot
Mechanisms of glucocorticoid-induced myopathy
inferred← citeshttps://doi.org/10.21767/2171-6625.1000234openalex-snapshot
Dietary Quercetin Ameliorates Memory Impairment in a Murine Model of Alzheimer’s Disease with Obesity and Diabetes, Suppressing ATF4 Expression
inferred← citeshttps://doi.org/10.2217/17460875.3.1.43openalex-snapshot
Macronutrients and obesity: views, news and reviews
inferred← citeshttps://doi.org/10.2337/db09-0335openalex-snapshot
Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure
inferred← citeshttps://doi.org/10.3389/fcell.2021.770006openalex-snapshot
Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis
inferred← citeshttps://doi.org/10.3389/fnmol.2018.00062openalex-snapshot
Brain-Derived Neurotrophic Factor Elevates Activating Transcription Factor 4 (ATF4) in Neurons and Promotes ATF4-Dependent Induction of Sesn2
inferred← citeshttps://doi.org/10.3390/ijms242417423openalex-snapshot
Integrated Stress Response (ISR) Pathway: Unraveling Its Role in Cellular Senescence
inferred← citeshttps://doi.org/10.3390/ijms27010342openalex-snapshot
Subcellular Stress Markers in Epithelial Ovarian Cancer
inferred← citeshttps://doi.org/10.3390/metabo11020112openalex-snapshot
Transporters at the Interface between Cytosolic and Mitochondrial Amino Acid Metabolism
inferred← citeshttps://doi.org/10.3892/ijo.2020.5158openalex-snapshot
Serine, glycine and one‑carbon metabolism in cancer (Review)
inferred← citeshttps://doi.org/10.3945/jn.114.196691openalex-snapshot
Skeletal Muscle Ras-Related GTP Binding B mRNA and Protein Expression Is Increased after Essential Amino Acid Ingestion in Healthy Humans
inferred← citeshttps://doi.org/10.4149/av_2013_02_238openalex-snapshot
S100P, a peculiar member of S100 family of calcium-binding proteins implicated in cancer
inferred← citeshttps://doi.org/10.4172/2155-6156.1000285openalex-snapshot
Type 2 Diabetes Mellitus (T2DM): Biological Overview from Pathways to Organelles and its Translation toward a Torpid Wound Healing Process
inferred← citeshttps://doi.org/10.48550/arxiv.2007.01237openalex-snapshot
A Scale-Free Approach for False Discovery Rate Control in Generalized Linear Models
inferred← citeshttps://doi.org/10.70675/1a11a81bzf829z4ba2zba9az6f3f4841c773openalex-snapshot
Identification of new levers to fight muscle atrophy : benefit of the hibernating brown bear model
inferred← citeshttps://doi.org/10.7150/ijbs.41051openalex-snapshot
The Role of D-3-Phosphoglycerate Dehydrogenase in Cancer
inferred← citeshttps://doi.org/10.7554/elife.63326openalex-snapshot
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
inferred← citeshttps://doi.org/10.7762/cnr.2018.7.3.153openalex-snapshot
Links between Serine Biosynthesis Pathway and Epigenetics in Cancer Metabolism
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