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The role of APOE4 in Alzheimer’s disease: strategies for future therapeutic interventions

https://doi.org/10.1042/ns20180203

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Outgoing claims: the papers this work cites, builds on, or argues with.

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PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia

inferredcites →https://doi.org/10.1001/jama.2015.4668openalex-snapshot

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

inferredcites →https://doi.org/10.1002/(sici)1097-4547(19980301)51:5<658::aid-jnr13>3.0.co;2-zopenalex-snapshot

Apolipoprotein E (ApoE) peptide regulates tau phosphorylation via two different signaling pathways

inferredcites →https://doi.org/10.1002/(sici)1097-4652(199710)173:1<73::aid-jcp9>3.0.co;2-gopenalex-snapshot

Rapid elevation of neuronal cytoplasmic calcium by apolipoprotein E peptide

inferredcites →https://doi.org/10.1002/14651858openalex-snapshot

Cochrane Database of Systematic Reviews

inferredcites →https://doi.org/10.1002/14651858.cd007514.pub3openalex-snapshot

Statins for the treatment of dementia

inferredcites →https://doi.org/10.1002/ana.21843openalex-snapshot

APOE predicts amyloid‐beta but not tau Alzheimer pathology in cognitively normal aging

inferredcites →https://doi.org/10.1002/ana.24628openalex-snapshot

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations

inferredcites →https://doi.org/10.1002/brb3.1037openalex-snapshot

Protective effects of omega‐3 fatty acids against Alzheimer's disease in rat brain endothelial cells

inferredcites →https://doi.org/10.1002/cbin.11015openalex-snapshot

Rapamycin improves insulin resistance and hepatic steatosis in type 2 diabetes rats through activation of autophagy

inferredcites →https://doi.org/10.1002/glia.22289openalex-snapshot

APOE genotype alters glial activation and loss of synaptic markers in mice

inferredcites →https://doi.org/10.1002/hipo.22272openalex-snapshot

Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice

inferredcites →https://doi.org/10.1007/s00395-016-0555-4openalex-snapshot

Pioglitazone increases PGC1-α signaling within chronically ischemic myocardium

inferredcites →https://doi.org/10.1007/s00401-010-0666-1openalex-snapshot

Accumulation of intraneuronal Aβ correlates with ApoE4 genotype

inferredcites →https://doi.org/10.1007/s005990050030openalex-snapshot

The relationship between apolipoprotein E and serum oxidation-related variables is apolipoprotein E phenotype dependent

inferredcites →https://doi.org/10.1007/s11883-012-0307-3openalex-snapshot

Dyslipidemia and the Risk of Alzheimer’s Disease

inferredcites →https://doi.org/10.1007/s40263-014-0147-5openalex-snapshot

Cognitive Effects of Statin Medications

inferredcites →https://doi.org/10.1016/0006-291x(74)90882-1openalex-snapshot

An apolipoprotein preferentially enriched in cholesteryl ester-rich very low density lipoproteins

inferredcites →https://doi.org/10.1016/0021-9150(96)05880-7openalex-snapshot

The effect of probucol on low density lipoprotein oxidation and femoral atherosclerosis

inferredcites →https://doi.org/10.1016/0166-2236(95)92772-iopenalex-snapshot

The endosomal-lysosomal system of neurons: new roles

inferredcites →https://doi.org/10.1016/j.addr.2011.11.002openalex-snapshot

Intranasal delivery of biologics to the central nervous system

inferredcites →https://doi.org/10.1016/j.atherosclerosis.2009.04.002openalex-snapshot

Where are we with probucol: A new life for an old drug?

inferredcites →https://doi.org/10.1016/j.celrep.2015.04.017openalex-snapshot

Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease

inferredcites →https://doi.org/10.1016/j.febslet.2010.01.017openalex-snapshot

mTOR regulation of autophagy

inferredcites →https://doi.org/10.1016/j.ijcard.2014.03.018openalex-snapshot

Statin use and incident dementia: A nationwide cohort study of Taiwan

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P2‐157: Apolipoprotein E4 impairs mitochondrial function and increases reactive oxygen species in neuronal cells

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Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.jalz.2017.07.754openalex-snapshot

Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs

inferredcites →https://doi.org/10.1016/j.jalz.2018.02.001openalex-snapshot

2018 Alzheimer's disease facts and figures

inferredcites →https://doi.org/10.1016/j.jconrel.2018.05.011openalex-snapshot

Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

inferredcites →https://doi.org/10.1016/j.lfs.2017.12.025openalex-snapshot

Mechanism of intranasal drug delivery directly to the brain

inferredcites →https://doi.org/10.1016/j.nbd.2012.10.002openalex-snapshot

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2014.03.037openalex-snapshot

Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2014.09.007openalex-snapshot

Human secreted tau increases amyloid-beta production

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2015.09.011openalex-snapshot

Association of APOE with tau-tangle pathology with and without β-amyloid

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2016.04.020openalex-snapshot

Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models

inferredcites →https://doi.org/10.1016/j.neuron.2012.03.023openalex-snapshot

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

inferredcites →https://doi.org/10.1016/j.neuron.2013.08.024openalex-snapshot

Reelin Mobilizes a VAMP7-Dependent Synaptic Vesicle Pool and Selectively Augments Spontaneous Neurotransmission

inferredcites →https://doi.org/10.1016/j.neuron.2014.01.045openalex-snapshot

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

inferredcites →https://doi.org/10.1016/j.neuron.2017.09.003openalex-snapshot

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

inferredcites →https://doi.org/10.1016/j.neuropharm.2016.03.015openalex-snapshot

Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.omtm.2017.11.007openalex-snapshot

Emerging Issues in AAV-Mediated In Vivo Gene Therapy

inferredcites →https://doi.org/10.1016/j.trci.2018.03.009openalex-snapshot

Alzheimer's disease drug development pipeline: 2018

inferredcites →https://doi.org/10.1016/s0002-9440(10)64963-2openalex-snapshot

Expression of Human Apolipoprotein E4 in Neurons Causes Hyperphosphorylation of Protein Tau in the Brains of Transgenic Mice

inferredcites →https://doi.org/10.1016/s0006-8993(98)00510-1openalex-snapshot

Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment

inferredcites →https://doi.org/10.1016/s0021-9258(18)47945-8openalex-snapshot

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

inferredcites →https://doi.org/10.1016/s0022-2275(20)38838-6openalex-snapshot

Abnormal low density lipoprotein metabolism in apolipoprotein E deficiency.

inferredcites →https://doi.org/10.1016/s0092-8674(00)80782-5openalex-snapshot

Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2

inferredcites →https://doi.org/10.1016/s0197-4580(00)00112-3openalex-snapshot

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients

inferredcites →https://doi.org/10.1016/s0197-4580(99)00053-6openalex-snapshot

The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms☆

inferredcites →https://doi.org/10.1016/s0735-1097(01)01783-1openalex-snapshot

Effects of probucol and pravastatin on common carotid atherosclerosis in patients with asymptomatic hypercholesterolemia

inferredcites →https://doi.org/10.1021/acs.biochem.6b00324openalex-snapshot

ApoE: In Vitro Studies of a Small Molecule Effector

inferredcites →https://doi.org/10.1021/jm3008618openalex-snapshot

Small-Molecule Structure Correctors Target Abnormal Protein Structure and Function: Structure Corrector Rescue of Apolipoprotein E4–Associated Neuropathology

inferredcites →https://doi.org/10.1038/jcbfm.2013.82openalex-snapshot

Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease

inferredcites →https://doi.org/10.1038/nature12776openalex-snapshot

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

inferredcites →https://doi.org/10.1038/nature24016openalex-snapshot

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

inferredcites →https://doi.org/10.1038/nn.4328openalex-snapshot

Neuronal activity enhances tau propagation and tau pathology in vivo

inferredcites →https://doi.org/10.1038/nn1703openalex-snapshot

Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo

inferredcites →https://doi.org/10.1038/s41467-017-01444-0openalex-snapshot

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology

inferredcites →https://doi.org/10.1038/s41598-017-08604-8openalex-snapshot

Targeting Apolipoprotein E/Amyloid β Binding by Peptoid CPO_Aβ17-21 P Ameliorates Alzheimer’s Disease Related Pathology and Cognitive Decline

inferredcites →https://doi.org/10.1038/srep26119openalex-snapshot

ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer’s disease mouse model

inferredcites →https://doi.org/10.1042/0264-6021:3480359openalex-snapshot

Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid β peptides

inferredcites →https://doi.org/10.1046/j.1471-4159.1998.70041458.xopenalex-snapshot

β‐Amyloid Peptides Increase the Binding and Internalization of Apolipoprotein E to Hippocampal Neurons

inferredcites →https://doi.org/10.1056/nejmoa1202753openalex-snapshot

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

inferredcites →https://doi.org/10.1073/pnas.1207022109openalex-snapshot

Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer’s disease

inferredcites →https://doi.org/10.1073/pnas.1220484110openalex-snapshot

ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

inferredcites →https://doi.org/10.1073/pnas.1609896113openalex-snapshot

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

inferredcites →https://doi.org/10.1073/pnas.91.23.11183openalex-snapshot

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.

inferredcites →https://doi.org/10.1073/pnas.92.21.9480openalex-snapshot

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.

inferredcites →https://doi.org/10.1074/jbc.270.34.19791openalex-snapshot

The Inhibitory Effect of Apolipoprotein E4 on Neurite Outgrowth Is Associated with Microtubule Depolymerization

inferredcites →https://doi.org/10.1074/jbc.m110.149419openalex-snapshot

Spectroscopic Studies of GSK3β Phosphorylation of the Neuronal Tau Protein and Its Interaction with the N-terminal Domain of Apolipoprotein E

inferredcites →https://doi.org/10.1074/jbc.m110.151084openalex-snapshot

Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease

inferredcites →https://doi.org/10.1074/jbc.m110.186411openalex-snapshot

Macroautophagy Is Not Directly Involved in the Metabolism of Amyloid Precursor Protein

inferredcites →https://doi.org/10.1074/jbc.m203934200openalex-snapshot

Apolipoprotein E (ApoE) Isoform-dependent Lipid Release from Astrocytes Prepared from Human ApoE3 and ApoE4 Knock-in Mice

inferredcites →https://doi.org/10.1074/jbc.m205147200openalex-snapshot

Reelin and ApoE Receptors Cooperate to Enhance Hippocampal Synaptic Plasticity and Learning

inferredcites →https://doi.org/10.1074/jbc.m311256200openalex-snapshot

Apolipoprotein E4 Domain Interaction Occurs in Living Neuronal Cells as Determined by Fluorescence Resonance Energy Transfer

inferredcites →https://doi.org/10.1074/jbc.m408127200openalex-snapshot

Increased tau Phosphorylation in Apolipoprotein E4 Transgenic Mice Is Associated with Activation of Extracellular Signal-regulated Kinase

inferredcites →https://doi.org/10.1080/1028415x.2017.1321813openalex-snapshot

Omega-3 fatty acids' supplementation in Alzheimer's disease: A systematic review

inferredcites →https://doi.org/10.1080/15548627.2018.1438807openalex-snapshot

Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion

inferredcites →https://doi.org/10.1084/jem.20121274openalex-snapshot

Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis

inferredcites →https://doi.org/10.1084/jem.20131685openalex-snapshot

Neuronal activity regulates extracellular tau in vivo

inferredcites →https://doi.org/10.1093/cercor/bhq106openalex-snapshot

Cognitive Decline Is Associated with Reduced Reelin Expression in the Entorhinal Cortex of Aged Rats

inferredcites →https://doi.org/10.1093/gerona/glw064openalex-snapshot

Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice

inferredcites →https://doi.org/10.1093/jnen/64.2.113openalex-snapshot

Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

inferredcites →https://doi.org/10.1096/fj.02-0434fjeopenalex-snapshot

Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an Apolipoprotein E receptor/disabled‐1/glycogen synthase kinase‐3β cascade

inferredcites →https://doi.org/10.1101/cshperspect.a006312openalex-snapshot

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

inferredcites →https://doi.org/10.1111/acel.12057openalex-snapshot

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

inferredcites →https://doi.org/10.1111/ggi.12044openalex-snapshot

Association of statin use with risk of dementia: A meta‐analysis of prospective cohort studies

inferredcites →https://doi.org/10.1111/ijs.12519openalex-snapshot

Rationale and Design of the Prevention of Cardiovascular Events in Ischemic Stroke Patients with High Risk of Cerebral Hemorrhage (Picasso) Study: A Randomized Controlled Trial

inferredcites →https://doi.org/10.1111/j.1471-4159.2007.05135.xopenalex-snapshot

Increased intraneuronal resting [Ca2+] in adult Alzheimer’s disease mice

inferredcites →https://doi.org/10.1111/j.1471-4159.2012.07908.xopenalex-snapshot

APOE genotype affects the pre‐synaptic compartment of glutamatergic nerve terminals

inferredcites →https://doi.org/10.1111/j.1749-6632.2000.tb05564.xopenalex-snapshot

Apolipoprotein E and Alzheimer's Disease A Role in Amyloid Catabolism

inferredcites →https://doi.org/10.1111/jnc.12967openalex-snapshot

P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway

inferredcites →https://doi.org/10.1111/joim.12262openalex-snapshot

Statin use reduces the risk of dementia in elderly patients: a nationwide data survey and propensity analysis

inferredcites →https://doi.org/10.1126/science.1062097openalex-snapshot

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

inferredcites →https://doi.org/10.1126/science.3283935openalex-snapshot

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

inferredcites →https://doi.org/10.1126/science.8346443openalex-snapshot

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

inferredcites →https://doi.org/10.1126/scisignal.aaa6674openalex-snapshot

Reelin protects against amyloid β toxicity in vivo

inferredcites →https://doi.org/10.1126/scitranslmed.3002156openalex-snapshot

Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance

inferredcites →https://doi.org/10.1128/cmr.00008-08openalex-snapshot

Gene Therapy Using Adeno-Associated Virus Vectors

inferredcites →https://doi.org/10.1152/ajpregu.00219.2012openalex-snapshot

Apolipoprotein E does not cross the blood-cerebrospinal fluid barrier, as revealed by an improved technique for sampling CSF from mice

inferredcites →https://doi.org/10.1155/2018/2010675openalex-snapshot

Signaling Mechanisms of Selective PPARγ Modulators in Alzheimer’s Disease

inferredcites →https://doi.org/10.1155/2018/4593530openalex-snapshot

Role of Adiponectin in Central Nervous System Disorders

inferredcites →https://doi.org/10.1159/000337230openalex-snapshot

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

inferredcites →https://doi.org/10.1161/01.cir.97.5.429openalex-snapshot

Prevention of Restenosis After Angioplasty in Small Coronary Arteries With Probucol

inferredcites →https://doi.org/10.1172/jci113849openalex-snapshot

Changes of genetic apolipoprotein phenotypes caused by liver transplantation. Implications for apolipoprotein synthesis.

inferredcites →https://doi.org/10.1172/jci117407openalex-snapshot

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.

inferredcites →https://doi.org/10.1172/jci96429openalex-snapshot

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

inferredcites →https://doi.org/10.1177/0271678x15621575openalex-snapshot

Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease

inferredcites →https://doi.org/10.1186/1742-2094-9-8openalex-snapshot

Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice

inferredcites →https://doi.org/10.1186/1750-1326-1-18openalex-snapshot

Apolipoprotein E decreases tau kinases and phospho-tau levels in primary neurons

inferredcites →https://doi.org/10.1186/1750-1326-4-35openalex-snapshot

Apolipoprotein E4 (1–272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells

inferredcites →https://doi.org/10.1186/s13195-018-0430-7openalex-snapshot

Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer’s dementia?

inferredcites →https://doi.org/10.1208/s12248-015-9719-7openalex-snapshot

Intranasal Delivery of Proteins and Peptides in the Treatment of Neurodegenerative Diseases

inferredcites →https://doi.org/10.1212/01.wnl.0000265401.62434.36openalex-snapshot

Intranasal insulin improves cognition and modulates β-amyloid in early AD

inferredcites →https://doi.org/10.1212/wnl.0b013e318217e7a4openalex-snapshot

Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease

inferredcites →https://doi.org/10.1242/jcs.040717openalex-snapshot

Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis

inferredcites →https://doi.org/10.1291/hypres.27.311openalex-snapshot

Long-Term Treatment with Probucol Improves Endothelial Function in Patients with Coronary Artery Disease

inferredcites →https://doi.org/10.1371/journal.pone.0002466openalex-snapshot

Pioglitazone Enhances Mitochondrial Biogenesis and Ribosomal Protein Biosynthesis in Skeletal Muscle in Polycystic Ovary Syndrome

inferredcites →https://doi.org/10.1371/journal.pone.0047760openalex-snapshot

The Apolipoprotein E (APOE) Gene Appears Functionally Monomorphic in Chimpanzees (Pan troglodytes)

inferredcites →https://doi.org/10.1371/journal.pone.0123864openalex-snapshot

Anti-Diabetes Drug Pioglitazone Ameliorates Synaptic Defects in AD Transgenic Mice by Inhibiting Cyclin-Dependent Kinase5 Activity

inferredcites →https://doi.org/10.14336/ad.2015.1007openalex-snapshot

Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies

inferredcites →https://doi.org/10.15017/19317openalex-snapshot

Effect of probucol on elderly hypercholesterolemic patients in the FAST study.

inferredcites →https://doi.org/10.1523/jneurosci.3442-16.2017openalex-snapshot

Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition

inferredcites →https://doi.org/10.1523/jneurosci.5180-14.2015openalex-snapshot

Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain

inferredcites →https://doi.org/10.15252/embr.201540614openalex-snapshot

ApoE4 upregulates the activity of mitochondria‐associated ER membranes

inferredcites →https://doi.org/10.18632/aging.101117openalex-snapshot

Rapamycin treatment benefits glucose metabolism in mouse models of type 2 diabetes

inferredcites →https://doi.org/10.18865/ed.25.3.345openalex-snapshot

Statin Use, Incident Dementia and Alzheimer Disease in Elderly African Americans

inferredcites →https://doi.org/10.2174/1567205013666160415154550openalex-snapshot

APOE4 Induces Site-Specific Tau Phosphorylation Through Calpain-CDK5 Signaling Pathway in EFAD-Tg Mice

inferredcites →https://doi.org/10.3233/jad-150348openalex-snapshot

Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer’s Disease Prevention and Early Intervention

inferredcites →https://doi.org/10.3233/jad-151101openalex-snapshot

Impaired Autophagy in APOE4 Astrocytes

inferredcites →https://doi.org/10.3233/jad-160163openalex-snapshot

Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer’s Disease Pathology

inferredcites →https://doi.org/10.3233/jad-2010-090934openalex-snapshot

Omega-3 Fatty Acids, Cognitive Decline, and Alzheimer's Disease: A Critical Review and Evaluation of the Literature

inferredcites →https://doi.org/10.3233/jad-2010-091570openalex-snapshot

Can Statins Prevent or Help Treat Alzheimer's Disease?

inferredcites →https://doi.org/10.3389/fnagi.2018.00004openalex-snapshot

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

inferredcites →https://doi.org/10.3945/ajcn.117.155648openalex-snapshot

DHA-rich n–3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study

inferredcites →https://doi.org/10.4161/cam.2.2.6374openalex-snapshot

LRP-1

inferredcites →https://doi.org/10.5551/jat.32813openalex-snapshot

Rationale and Design of the PROSPECTIVE Trial: Probucol Trial for Secondary Prevention of Atherosclerotic Events in Patients with Prior Coronary Heart Disease

inferredcites →https://doi.org/10.7554/elife.16351openalex-snapshot

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Identification of Predictive Protein Signature in Mci and Ad in Body Fluids (Blood and Csf)

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Alzheimer Disease and Related Dementia Following Hormone-Modulating Therapy in Patients With Breast Cancer

inferred← citeshttps://doi.org/10.1002/alz.12292openalex-snapshot

Application of the ATN classification scheme in a population without dementia: Findings from the EPAD cohort

inferred← citeshttps://doi.org/10.1002/alz.13775openalex-snapshot

APOE ε4 is associated with decreased synaptic density in cognitively impaired participants

inferred← citeshttps://doi.org/10.1002/biof.70071openalex-snapshot

BACE1 : Biological Functions and Involvement in the Pathophysiology of Alzheimer's Disease and Other Neurological Disorders

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AOP report: Development of an adverse outcome pathway for deposition of energy leading to learning and memory impairment

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Adverse Outcome Pathways Applied to Space Radiation Research

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Role of APOE in the Development of Diabetes Mellitus

inferred← citeshttps://doi.org/10.1007/978-3-031-91072-2_11openalex-snapshot

Long Noncoding RNAs: Emerging Players in Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.1007/978-3-032-15602-0_6openalex-snapshot

Maladaptive Memories

inferred← citeshttps://doi.org/10.1007/s11010-021-04334-8openalex-snapshot

Protein degradation-associated mechanisms that are affected in Alzheimer´s disease

inferred← citeshttps://doi.org/10.1007/s12035-025-05028-8openalex-snapshot

Intervention Role of APOE in CNS Diseases: APOE Actions and APOE Neurogenesis Capability

inferred← citeshttps://doi.org/10.1007/s44174-024-00180-6openalex-snapshot

Recent Advances and Applications of Graphene-Based Biosensors for Blood-Based Biomarkers in Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.1016/b978-0-443-18800-8.00023-xopenalex-snapshot

Implications of stem cell–associated signals in pathogenesis of lipid disorders

inferred← citeshttps://doi.org/10.1016/b978-0-443-19088-9.00013-5openalex-snapshot

Structural changes to the basal forebrain cholinergic system in the continuum of Alzheimer disease

inferred← citeshttps://doi.org/10.1016/b978-0-443-40563-1.00010-7openalex-snapshot

Apolipoprotein E as a therapeutic target in Alzheimer's disease: A review of basic research and clinical evidence

inferred← citeshttps://doi.org/10.1016/bs.apha.2026.04.001openalex-snapshot

Decoding disease progression: Biomarker in Alzheimer’s and Parkinson’s disease

inferred← citeshttps://doi.org/10.1016/bs.irn.2026.08.002openalex-snapshot

Endolysosomal pathway and autophagy dysregulation in Alzheimer’s disease

inferred← citeshttps://doi.org/10.1016/j.annepidem.2026.01.007openalex-snapshot

Machine learning-based LASSO-Cox model for dementia prediction: The role of midlife cardiometabolic, inflammatory, and genetic risk factors in a US cohort

inferred← citeshttps://doi.org/10.1016/j.archger.2024.105420openalex-snapshot

APOE and Alzheimer's disease: Pathologic clues from transgenic Drosophila melanogaster

inferred← citeshttps://doi.org/10.1016/j.bbii.2024.100048openalex-snapshot

Natural products as potential modulators of pro-inflammatory cytokines signalling in Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.bcp.2023.115576openalex-snapshot

A perspective on autophagy and transcription factor EB in Alcohol-Associated Alzheimer’s disease

inferred← citeshttps://doi.org/10.1016/j.bionps.2023.100064openalex-snapshot

Biomarkers of delirium and relation to dementia among the elderly in the intensive care unit: A narrative review

inferred← citeshttps://doi.org/10.1016/j.biopha.2022.114127openalex-snapshot

From degenerative disease to malignant tumors: Insight to the function of ApoE

inferred← citeshttps://doi.org/10.1016/j.brainres.2024.149262openalex-snapshot

A multifactorial lens on risk factors promoting the progression of Alzheimer’s disease

inferred← citeshttps://doi.org/10.1016/j.bspc.2026.110601openalex-snapshot

Incomplete multimodal association analysis based on modality-specific graph constraint and dual-level self-representation learning for AD-related biomarker detection

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2026.08.054openalex-snapshot

APOE4-AGE axis is linked to mtDNA release and cGAS-STING-mediated neuroinflammation in the aging brain

inferred← citeshttps://doi.org/10.1016/j.lfs.2020.118401openalex-snapshot

Insulin resistance and bioenergetic manifestations: Targets and approaches in Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.neuron.2026.04.027openalex-snapshot

Hepatic expression of APOE3 Christchurch mitigates APOE4-related Alzheimer’s disease pathologies in mice

inferred← citeshttps://doi.org/10.1016/j.ymgme.2021.01.011openalex-snapshot

Therapies for Alzheimer’s disease: a metabolic perspective

inferred← citeshttps://doi.org/10.1021/acs.biochem.5c00503openalex-snapshot

ApoE is Secreted as a Lipid Nanoparticle by Mammalian Cells: Implications for Alzheimer’s Disease Pathogenesis

inferred← citeshttps://doi.org/10.1021/acschemneuro.4c00160openalex-snapshot

Inflammasome-Inhibiting Nanoligomers Are Neuroprotective against Space-Induced Pathology in Healthy and Diseased Three-Dimensional Human Motor and Prefrontal Cortex Brain Organoids

inferred← citeshttps://doi.org/10.1038/s41398-022-01881-6openalex-snapshot

Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice

inferred← citeshttps://doi.org/10.1038/s41419-022-05378-4openalex-snapshot

Muscular Swedish mutant APP-to-Brain axis in the development of Alzheimer’s disease

inferred← citeshttps://doi.org/10.1038/s41467-026-68933-zopenalex-snapshot

Genetic modifiers of APOE-ε4-associated cognitive decline

inferred← citeshttps://doi.org/10.1080/07391102.2023.2252094openalex-snapshot

In-silico modeling of the interplay between APOE4, NLRP3, and ACE2-SPIKE complex in neurodegeneration between Alzheimer and SARS-CoV: implications for understanding pathogenesis and developing therapeutic strategies

inferred← citeshttps://doi.org/10.1089/neu.2022.0226openalex-snapshot

Interaction between APOE ɛ4 and Age Is Associated with Emotional Distress One Year after Moderate-Severe Traumatic Brain Injury

inferred← citeshttps://doi.org/10.1093/braincomms/fcaf097openalex-snapshot

Unraveling the role of proteins in dementia: insights from two UK cohorts with causal evidence

inferred← citeshttps://doi.org/10.1093/infdis/jiaf275openalex-snapshot

Herpes Simplex Virus Neurovirulence Across the Human Lifespan

inferred← citeshttps://doi.org/10.1101/2024.03.19.585802openalex-snapshot

Inflammasome-Inhibiting Nanoligomers are Neuroprotective Against Space-Induced Pathology in Healthy and Diseased 3D Human Motor and Pre-Frontal Cortex Brain Organoids

inferred← citeshttps://doi.org/10.1101/2024.06.04.24308415openalex-snapshot

Unraveling the role of plasma proteins in dementia: insights from two cohort studies in the UK, with causal evidence from Mendelian randomization

inferred← citeshttps://doi.org/10.1109/icsec67360.2025.11298071openalex-snapshot

AI-Driven Longitudinal Modeling of APOE Genotype and Hippocampal Atrophy in Alzheimer’s Disease Cognitive Decline

inferred← citeshttps://doi.org/10.1111/ejn.14949openalex-snapshot

Novel therapeutic strategies for Alzheimer’s disease targeting brain cholesterol homeostasis

inferred← citeshttps://doi.org/10.1134/s1022795425700425openalex-snapshot

Investigating the Effect of Human APOE Gene on Mitochondrial Dynamics of Nervous System Cells in Drosophila Models of Alzheimer’s Disease

inferred← citeshttps://doi.org/10.1177/13872877261422449openalex-snapshot

Increased vulnerability to low-density lipoprotein cholesterol in apolipoprotein E4-positive females: Longitudinal effects on neurodegeneration and cognition

inferred← citeshttps://doi.org/10.1177/15333175231214833openalex-snapshot

Music Engagement as a Source of Cognitive Reserve

inferred← citeshttps://doi.org/10.1177/25424823261493062openalex-snapshot

Brain health in older adults: At the crossroads of frailty and resilience

inferred← citeshttps://doi.org/10.1186/s12883-025-04279-1openalex-snapshot

Relationship between cytomegalovirus antibody levels and cognitive performance is dependent on age and genetic risk

inferred← citeshttps://doi.org/10.1186/s12974-026-03876-2openalex-snapshot

Convergence of neuroinflammation across major neurotropic viral exposomes in AD and ADRD

inferred← citeshttps://doi.org/10.1186/s13195-020-00585-7openalex-snapshot

Quantification of total apolipoprotein E and its isoforms in cerebrospinal fluid from patients with neurodegenerative diseases

inferred← citeshttps://doi.org/10.1186/s13195-022-01084-7openalex-snapshot

Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and Alzheimer’s dementia

inferred← citeshttps://doi.org/10.1186/s13195-023-01167-zopenalex-snapshot

Hippocampus-centred grey matter covariance networks predict the development and reversion of mild cognitive impairment

inferred← citeshttps://doi.org/10.1186/s13195-023-01330-6openalex-snapshot

A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice

inferred← citeshttps://doi.org/10.1186/s44477-026-00028-xopenalex-snapshot

ApoE expression across the CNS: Who, What, Where, When, and How (much)?

inferred← citeshttps://doi.org/10.1371/journal.pcbi.1012407openalex-snapshot

Quantitative and Kinetic Proteomics Reveal ApoE Isoform-dependent Proteostasis Adaptations in Mouse Brain

inferred← citeshttps://doi.org/10.21203/rs.3.rs-1491984/v1openalex-snapshot

Eicosanoid Lipidome Activation in the APOE4 Brain with Dementia

inferred← citeshttps://doi.org/10.21608/bjas.2023.227673.1222openalex-snapshot

Assessment of Serum level of Apolipoprotein E4 in Patients with Vitiligo: A Comparative Review

inferred← citeshttps://doi.org/10.2174/1874609812666190917155400openalex-snapshot

Cholesterol and Dementia: A Long and Complicated Relationship

inferred← citeshttps://doi.org/10.31083/j.fbl2705146openalex-snapshot

Impact of New Drugs for Therapeutic Intervention in Alzheimer’s Disease

inferred← citeshttps://doi.org/10.31083/j.fbl2810258openalex-snapshot

Alzheimer's Disease; Mechanism, Mutations, and Applications of Nano-Medicine

inferred← citeshttps://doi.org/10.3233/jad-201418openalex-snapshot

A Tau-Driven Adverse Outcome Pathway Blueprint Toward Memory Loss in Sporadic (Late-Onset) Alzheimer’s Disease with Plausible Molecular Initiating Event Plug-Ins for Environmental Neurotoxicants

inferred← citeshttps://doi.org/10.3233/jad-230072openalex-snapshot

Mitochondrial Dysfunction Links to Impaired Hippocampal Serotonin Release in a Mouse Model of Alzheimer’s Disease

inferred← citeshttps://doi.org/10.32383/farmpol/204016openalex-snapshot

Targeted protein degradation via the endosome–lysosome pathway: A novel pharmacological strategy for modulating extracellular protein function

inferred← citeshttps://doi.org/10.3389/fnagi.2023.1279343openalex-snapshot

APOE genotype and sex modulate Alzheimer’s disease pathology in aged EFAD transgenic mice

inferred← citeshttps://doi.org/10.3389/fnagi.2023.1302185openalex-snapshot

ENHANCE: a comparative prospective longitudinal study of cognitive outcomes after 3 years of hearing aid use in older adults

inferred← citeshttps://doi.org/10.3389/fnins.2023.1245895openalex-snapshot

Flavonoids and fibrate modulate apoE4-induced processing of amyloid precursor protein in neuroblastoma cells

inferred← citeshttps://doi.org/10.3389/fnins.2025.1515374openalex-snapshot

The role of Apolipoprotein E4 on cognitive impairment in Parkinson’s disease and Parkinsonisms

inferred← citeshttps://doi.org/10.3389/fphar.2024.1399121openalex-snapshot

Alzheimer’s disease and its treatment–yesterday, today, and tomorrow

inferred← citeshttps://doi.org/10.3389/fphar.2024.1405423openalex-snapshot

Functionalized nanoparticles to deliver nucleic acids to the brain for the treatment of Alzheimer’s disease

inferred← citeshttps://doi.org/10.3390/ani10071194openalex-snapshot

Alzheimer’s Disease, and Breast and Prostate Cancer Research: Translational Failures and the Importance to Monitor Outputs and Impact of Funded Research

inferred← citeshttps://doi.org/10.3390/biom14020165openalex-snapshot

A Combination of Heavy Metals and Intracellular Pathway Modulators Induces Alzheimer Disease-like Pathologies in Organotypic Brain Slices

inferred← citeshttps://doi.org/10.3390/biom15081164openalex-snapshot

Neuronal Count, Brain Injury, and Sustained Cognitive Function in 5×FAD Alzheimer’s Disease Mice Fed DHA-Enriched Diets

inferred← citeshttps://doi.org/10.3390/biom16091352openalex-snapshot

Apolipoprotein E Mimetic Peptide-Mediated Modulation of Lipid Homeostasis

inferred← citeshttps://doi.org/10.3390/biomedicines12010099openalex-snapshot

Pharmacological Approaches Using Diabetic Drugs Repurposed for Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3390/brainsci14121279openalex-snapshot

COCHLEA: Longitudinal Cognitive Performance of Older Adults with Hearing Loss and Cochlear Implants at 4.5-Year Follow-Up

inferred← citeshttps://doi.org/10.3390/cimb46080483openalex-snapshot

The Role of Estrogen across Multiple Disease Mechanisms

inferred← citeshttps://doi.org/10.3390/ijms23094641openalex-snapshot

Antidiabetic Drugs in the Treatment of Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3390/ijms26178253openalex-snapshot

Navigation Between Alzheimer’s Disease (AD) and Its Various Pathophysiological Trajectories: The Pathogenic Link to Neuroimmunology—Genetics and Neuroinflammation

inferred← citeshttps://doi.org/10.3390/jdad2030031openalex-snapshot

An Analysis of the Relationship Between the APOE4 Allele Count, Age of Onset, and Cognitive Impairment Prevalence in the NACC Database: Evaluating the Nigerian Paradox

inferred← citeshttps://doi.org/10.3390/metabo12060475openalex-snapshot

Folate Related Pathway Gene Analysis Reveals a Novel Metabolic Variant Associated with Alzheimer’s Disease with a Change in Metabolic Profile

inferred← citeshttps://doi.org/10.3390/molecules30173479openalex-snapshot

Biologics as Therapeutical Agents Under Perspective Clinical Studies for Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3390/neurosci7020043openalex-snapshot

Effect of High-Salt Diet on Memory and Behavior in Mice Expressing Human Apolipoprotein Epsilon-4 (APOE4) Allele

inferred← citeshttps://doi.org/10.3724/cbls.2026070openalex-snapshot

Crossing the blood–brain barrier: Advances and frontiers of AAV gene therapy in central nervous system disorders

inferred← citeshttps://doi.org/10.37349/ent.2024.00091openalex-snapshot

Impaired glymphatic clearance is an important cause of Alzheimer’s disease

inferred← citeshttps://doi.org/10.5530/jyp.2024.16.22openalex-snapshot

Unveiling the Relationship between Cannabidiol, Apo-lipoprotein and Neurological Disorders: A Comprehensive Review of Molecular Targets and Current Findings

inferred← citeshttps://doi.org/10.59717/j.xinn-life.2026.100206openalex-snapshot

Maladaptive aging trajectory in late-onset Alzheimer's disease

inferred← citeshttps://doi.org/10.6026/973206300200140openalex-snapshot

Insights into amyloid precursor protein target through PPI network analysis

inferred← citeshttps://doi.org/10.6084/m9.figshare.22603612openalex-snapshot

Additional file 1 of Hippocampus-centred grey matter covariance networks predict the development and reversion of mild cognitive impairment

inferred← citeshttps://doi.org/10.61173/2hyvmr05openalex-snapshot

ApoE Proteins and the Pathogenesis of Alzheimer‘s Disease and Its Early Diagnosis Progress

inferred← citeshttps://doi.org/10.64898/2026.03.25.26349329openalex-snapshot

Peripheral Mitochondrial Energetics are Associated with Cortical Neurophysiological Alterations in Alzheimer’s Disease

inferred← citeshttps://doi.org/10.64898/2026.04.04.26350158openalex-snapshot

Shared Genetic Architecture Between Kidney Function and Alzheimer Disease Across Ancestries

inferred← citeshttps://doi.org/10.70389/pjs.100042openalex-snapshot

Insights into the Pathogenesis of Alzheimer’s Disease for Better Therapeutics

inferred← citeshttps://doi.org/10.70675/d1e7c169zb2c9z42b9zad9az534dad0570d3openalex-snapshot

Évaluation des effets mitochondriaux, génétiques et comportementaux de l’irradiation du système nerveux avec un microfaisceau de protons chez le nématode C. elegans

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