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Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Measurement of Phagocytic Engulfment of Apoptotic Cells by Macrophages Using pHrodo Succinimidyl Ester

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Evidence for Normal Aging of the Septo-Hippocampal Cholinergic System in apoE (−/−) Mice but Impaired Clearance of Axonal Degeneration Products Following Injury

inferredcites →https://doi.org/10.1006/exnr.2001.7715openalex-snapshot

Behavioral Phenotyping of GFAP-ApoE3 and -ApoE4 Transgenic Mice: ApoE4 Mice Show Profound Working Memory Impairments in the Absence of Alzheimer's-like Neuropathology

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The Double-Edged Flower: Roles of Complement Protein C1q in Neurodegenerative Diseases

inferredcites →https://doi.org/10.1016/j.bbr.2008.05.008openalex-snapshot

Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks

inferredcites →https://doi.org/10.1016/j.cell.2007.10.036openalex-snapshot

The Classical Complement Cascade Mediates CNS Synapse Elimination

inferredcites →https://doi.org/10.1016/j.cell.2016.03.022openalex-snapshot

Whole-Genome Sequencing of a Healthy Aging Cohort

inferredcites →https://doi.org/10.1016/j.cell.2016.04.001openalex-snapshot

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

inferredcites →https://doi.org/10.1016/j.jim.2014.06.008openalex-snapshot

An improved flow cytometry assay to monitor phagosome acidification

inferredcites →https://doi.org/10.1016/j.neuron.2011.07.022openalex-snapshot

Development of a Method for the Purification and Culture of Rodent Astrocytes

inferredcites →https://doi.org/10.1016/j.neuron.2012.03.026openalex-snapshot

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

inferredcites →https://doi.org/10.1016/j.neuron.2012.10.015openalex-snapshot

Genetic Dissection of TAM Receptor-Ligand Interaction in Retinal Pigment Epithelial Cell Phagocytosis

inferredcites →https://doi.org/10.1016/s0021-9258(17)31529-6openalex-snapshot

Isoform-specific binding of apolipoprotein E to beta-amyloid.

inferredcites →https://doi.org/10.1016/s0021-9258(18)34756-2openalex-snapshot

Micellar complexes of human apolipoprotein A-I with phosphatidylcholines and cholesterol prepared from cholate-lipid dispersions.

inferredcites →https://doi.org/10.1021/bi036305iopenalex-snapshot

Apolipoprotein E Enhances Hepatic Lipase-Mediated Hydrolysis of Reconstituted High-Density Lipoprotein Phospholipid and Triacylglycerol in an Isoform-Dependent Manner

inferredcites →https://doi.org/10.1038/35006162openalex-snapshot

Fluctuations caught in the act

inferredcites →https://doi.org/10.1038/35006165openalex-snapshot

Apolipoprotein E and cognitive performance

inferredcites →https://doi.org/10.1038/nature12776openalex-snapshot

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

inferredcites →https://doi.org/10.1038/nature17630openalex-snapshot

TAM receptors regulate multiple features of microglial physiology

inferredcites →https://doi.org/10.1038/ng0694-180openalex-snapshot

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

inferredcites →https://doi.org/10.1038/ni.3253openalex-snapshot

Phagocytosis of apoptotic cells in homeostasis

inferredcites →https://doi.org/10.1038/nm1058openalex-snapshot

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides

inferredcites →https://doi.org/10.1038/nprot.2008.171openalex-snapshot

A rapid Percoll gradient procedure for preparation of synaptosomes

inferredcites →https://doi.org/10.1038/nrneurol.2015.225openalex-snapshot

Tau and neurodegenerative disease: the story so far

inferredcites →https://doi.org/10.1073/pnas.0409072102openalex-snapshot

Gene delivery of human apolipoprotein E alters brain Aβ burden in a mouse model of Alzheimer's disease

inferredcites →https://doi.org/10.1073/pnas.050004797openalex-snapshot

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

inferredcites →https://doi.org/10.1073/pnas.1220484110openalex-snapshot

ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

inferredcites →https://doi.org/10.1073/pnas.95.18.10914openalex-snapshot

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females

inferredcites →https://doi.org/10.1074/jbc.270.16.9039openalex-snapshot

Purification of Apolipoprotein E Attenuates Isoform-specific Binding to β-Amyloid

inferredcites →https://doi.org/10.1083/jcb.85.3.890openalex-snapshot

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

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Cellular Catabolism of Lipid Poor Apolipoprotein E via Cell Surface LDL Receptor-Related Protein

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Alzheimer's Disease Is a Synaptic Failure

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Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

inferredcites →https://doi.org/10.1126/science.8346443openalex-snapshot

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

inferredcites →https://doi.org/10.1126/science.aad8373openalex-snapshot

Complement and microglia mediate early synapse loss in Alzheimer mouse models

inferredcites →https://doi.org/10.1126/scitranslmed.3002156openalex-snapshot

Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance

inferredcites →https://doi.org/10.1159/000337230openalex-snapshot

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

inferredcites →https://doi.org/10.1172/jci44646openalex-snapshot

Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma

inferredcites →https://doi.org/10.1186/1750-1326-8-13openalex-snapshot

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

inferredcites →https://doi.org/10.1194/jlr.m500114-jlr200openalex-snapshot

The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor

inferredcites →https://doi.org/10.1242/jcs.040717openalex-snapshot

Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis

inferredcites →https://doi.org/10.14348/molcells.2014.0248openalex-snapshot

Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms

inferredcites →https://doi.org/10.1523/jneurosci.1333-13.2013openalex-snapshot

A Dramatic Increase of C1q Protein in the CNS during Normal Aging

inferredcites →https://doi.org/10.1523/jneurosci.4026-09.2009openalex-snapshot

ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical NeuronsIn Vivo

inferredcites →https://doi.org/10.1523/jneurosci.4178-07.2008openalex-snapshot

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

inferredcites →https://doi.org/10.2144/000112001openalex-snapshot

High-Throughput Phagocytosis Assay Utilizing a pH-Sensitive Fluorescent Dye

inferredcites →https://doi.org/10.4049/jimmunol.172.4.2177openalex-snapshot

A Novel Role for an Insect Apolipoprotein (Apolipophorin III) in β-1,3-Glucan Pattern Recognition and Cellular Encapsulation Reactions

inferredcites →https://doi.org/10.4049/jimmunol.173.10.6366openalex-snapshot

Apolipoprotein E Modulates Clearance of Apoptotic Bodies In Vitro and In Vivo, Resulting in a Systemic Proinflammatory State in Apolipoprotein E-Deficient Mice

inferredcites →https://doi.org/10.7554/elife.03385openalex-snapshot

Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

inferredcites →https://doi.org/10.7554/elife.03498openalex-snapshot

Myosin VIII associates with microtubule ends and together with actin plays a role in guiding plant cell division

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Retinal dysfunction in APOE4 knock‐in mouse model of Alzheimer's disease

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Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network

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As a Potential Therapeutic Target, C1q Induces Synapse Loss Via Inflammasome-activating Apoptotic and Mitochondria Impairment Mechanisms in Alzheimer’s Disease

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References

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In vitro models for human neuroglia

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A Neuroinflammatory View of Alzheimer’s Disease

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Complement as a powerful “influencer” in the brain during development, adulthood and neurological disorders

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Apolipoprotein E4 and synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic implications

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Untangling Genetic Risk for Alzheimer’s Disease

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Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer’s Disease-like Pathology

inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112196openalex-snapshot

APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge

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Multi-functionalized chitosan-Extracellular vesicles nanohybrid system for intranasal delivery of pApoE2 to attenuate age-related inflammation

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Complement therapeutics in neurodegenerative diseases

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Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease

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The roles of astrocytic phagocytosis in maintaining homeostasis of brains

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Aβ-oligomer uptake and the resulting inflammatory response in adult human astrocytes are precluded by an anti-Aβ single chain variable fragment in combination with an apoE mimetic peptide

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Astrocytes initiate autophagic flux and maintain cell viability after internalizing non-active native extracellular α-synuclein

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Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer’s disease (AD) risk

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What are activated and reactive glia and what is their role in neurodegeneration?

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Astroglia-specific contributions to the regulation of synapses, cognition and behaviour

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Increased posterior default mode network activity and structural connectivity in young adult APOE-ε4 carriers: a multimodal imaging investigation

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Microglial efferocytosis: Diving into the Alzheimer’s disease gene pool

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Exploring the dual character of metformin in Alzheimer's disease

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Astrocytic synapse engulfment is differentially controlled by APOE genotype

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Possible positive effect of the APOE ε2 allele on cognition in early to mid-adult life

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Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice

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The role of genetic risk factors of Alzheimer's disease in synaptic dysfunction

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ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease

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Complement-mediated synapse loss in Alzheimer’s disease: mechanisms and involvement of risk factors

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Tract-specific differences in white matter microstructure between young adult APOE ε4 carriers and non-carriers: A replication and extension study

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APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches

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Antineuroinflammatory therapy: potential treatment for autism spectrum disorder by inhibiting glial activation and restoring synaptic function

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Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders

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Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease

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The synapse as a treatment avenue for Alzheimer’s Disease

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APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline

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Knowing the enemy: strategic targeting of complement to treat Alzheimer disease

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Microglial phagocytosis in Alzheimer disease

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Rodent models for Alzheimer disease

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Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

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Cell type-specific roles of APOE4 in Alzheimer disease

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Accurate and efficient integrative reference-informed spatial domain detection for spatial transcriptomics

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Synaptic pruning through glial synapse engulfment upon motor learning

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Single cell RNA sequencing confirms retinal microglia activation associated with early onset retinal degeneration

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Lifelong absence of microglia alters hippocampal glutamatergic networks but not synapse and spine density

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Clonal hematopoiesis as the intersection between genetics and resilience in Alzheimer’s disease

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The role of APOE4 in Alzheimer’s disease: strategies for future therapeutic interventions

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Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH

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CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness

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Identification of the abnormalities in astrocytic functions as potential drug targets for neurodegenerative disease

inferred← citeshttps://doi.org/10.1083/jcb.201709069openalex-snapshot

Microglia in Alzheimer’s disease

inferred← citeshttps://doi.org/10.1084/jem.20171265openalex-snapshot

ApoE facilitates the microglial response to amyloid plaque pathology

inferred← citeshttps://doi.org/10.1093/brain/awaf429openalex-snapshot

Differential selectivity of microglia and astrocytes in HIV-1 gp120-induced synaptic pruning

inferred← citeshttps://doi.org/10.1093/braincomms/fcac135openalex-snapshot

Astrocytic function is associated with both amyloid-β and tau pathology in non-demented APOE ϵ4 carriers

inferred← citeshttps://doi.org/10.1093/braincomms/fcac286openalex-snapshot

Distinct brain pathologies associated with Alzheimer’s disease biomarker-related phospho-tau 181 and phospho-tau 217 in App knock-in mouse models of amyloid-β amyloidosis

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Enriched Environment Alleviate AD Pathological Progression by Reducing Microglia Complement Signaling in Aged Male APP / PS1 Mice

inferred← citeshttps://doi.org/10.1097/mol.0000000000000383openalex-snapshot

Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease

inferred← citeshttps://doi.org/10.1101/2023.04.19.537428openalex-snapshot

Upregulated NF-κB pathway proteins may underlie APOE44 associated astrocyte phenotypes in sporadic Alzheimer’s disease

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Apolipoprotein E ε4 exacerbates microglia-mediated complement-dependent synapse loss caused by neuronal Tpk deficiency

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SORLA upregulation suppresses global pathological effects in aged tauopathy mouse brain

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Axon Regeneration and Functional Recovery after Spinal Cord Injury is Enhanced by Allele-Specific ApoE Neuronal Action through LRP8

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Glia Development and Function in the NematodeCaenorhabditis elegans

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Glia in Neurodegenerative Disease

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Alzheimer's disease phenotype based upon the carrier status of the apolipoprotein E ɛ4 allele

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Phenotypic heterogeneity of astrocytes in motor neuron disease

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Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease

inferred← citeshttps://doi.org/10.1111/febs.15878openalex-snapshot

Instructive roles of astrocytes in hippocampal synaptic plasticity: neuronal activity‐dependent regulatory mechanisms

inferred← citeshttps://doi.org/10.1111/jnc.14486openalex-snapshot

Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlc1‐over‐expressing mice

inferred← citeshttps://doi.org/10.1111/jnc.15327openalex-snapshot

Microglial phagocytosis of neurons in neurodegeneration, and its regulation

inferred← citeshttps://doi.org/10.1111/jnc.15994openalex-snapshot

Myelination‐ and migration‐associated genes are downregulated after phagocytosis in cultured oligodendrocyte precursor cells

inferred← citeshttps://doi.org/10.1111/joim.12759openalex-snapshot

Targeting Alzheimer's disease with gene and cell therapies

inferred← citeshttps://doi.org/10.1111/joim.12838openalex-snapshot

Connecting the brain cholesterol and renin–angiotensin systems: potential role of statins and RAS ‐modifying medications in dementia

inferred← citeshttps://doi.org/10.1111/nan.12529openalex-snapshot

Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease

inferred← citeshttps://doi.org/10.1124/pharmrev.120.000031openalex-snapshot

Cognitive Impairment in Older Adults and Therapeutic Strategies

inferred← citeshttps://doi.org/10.1126/sciadv.aed6825openalex-snapshot

SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain

inferred← citeshttps://doi.org/10.1126/science.abb8587openalex-snapshot

Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases

inferred← citeshttps://doi.org/10.1126/scitranslmed.aaf6295openalex-snapshot

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

inferred← citeshttps://doi.org/10.1134/s0022093021060016openalex-snapshot

Metabolic Plasticity of Astrocytes

inferred← citeshttps://doi.org/10.1146/annurev-pathmechdis-030421-112756openalex-snapshot

Apolipoprotein E and Alzheimer's Disease: Findings, Hypotheses, and Potential Mechanisms

inferred← citeshttps://doi.org/10.1155/2018/2530414openalex-snapshot

Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer’s Disease

inferred← citeshttps://doi.org/10.1161/atvbaha.126.324590openalex-snapshot

Cell-to-Cell Signaling Networks at the Blood-Brain Barrier in Health and Disease

inferred← citeshttps://doi.org/10.1177/02698811221147151openalex-snapshot

Neurostructural and neurocognitive correlates of APOE ε4 in youth bipolar disorder

inferred← citeshttps://doi.org/10.1177/1073858420945964openalex-snapshot

Dendritic Spines: Mediators of Cognitive Resilience in Aging and Alzheimer’s Disease

inferred← citeshttps://doi.org/10.1177/10738584261445356openalex-snapshot

Perisynaptic Astrocytic Processes as Communication Hubs and Early Sites of Dysfunction

inferred← citeshttps://doi.org/10.1177/1352458518760715openalex-snapshot

Convergent effects of a functional C3 variant on brain atrophy, demyelination, and cognitive impairment in multiple sclerosis

inferred← citeshttps://doi.org/10.1177/13872877251322808openalex-snapshot

Associations between plasma complement C1q and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact adults: The CABLE study

inferred← citeshttps://doi.org/10.1177/13872877251389965openalex-snapshot

Alzheimer's disease pathogenesis and the role of APOE ε4 in remodeling functional gradients of the default mode network

inferred← citeshttps://doi.org/10.1177/20406223221081605openalex-snapshot

Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer’s disease?

inferred← citeshttps://doi.org/10.1186/s12883-024-03611-5openalex-snapshot

Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers

inferred← citeshttps://doi.org/10.1186/s12916-019-1299-4openalex-snapshot

ApoE4: an emerging therapeutic target for Alzheimer’s disease

inferred← citeshttps://doi.org/10.1186/s12974-020-02024-8openalex-snapshot

The good, the bad, and the opportunities of the complement system in neurodegenerative disease

inferred← citeshttps://doi.org/10.1186/s12974-020-1719-6openalex-snapshot

The synthetic steroid tibolone exerts sex-specific regulation of astrocyte phagocytosis under basal conditions and after an inflammatory challenge

inferred← citeshttps://doi.org/10.1186/s13024-016-0139-7openalex-snapshot

3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish”

inferred← citeshttps://doi.org/10.1186/s13024-017-0192-xopenalex-snapshot

Glial contributions to neurodegeneration in tauopathies

inferred← citeshttps://doi.org/10.1186/s13024-020-00412-5openalex-snapshot

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease

inferred← citeshttps://doi.org/10.1186/s13024-020-00413-4openalex-snapshot

APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease

inferred← citeshttps://doi.org/10.1186/s13024-025-00870-9openalex-snapshot

Glial phagocytosis for synapse and toxic proteins in neurodegenerative diseases

inferred← citeshttps://doi.org/10.1186/s13024-025-00916-yopenalex-snapshot

The complement cascade in Alzheimer’s disease: modern implications of an ancient immune protagonist

inferred← citeshttps://doi.org/10.1186/s13041-017-0321-zopenalex-snapshot

HIV-associated synaptic degeneration

inferred← citeshttps://doi.org/10.1186/s13195-017-0293-3openalex-snapshot

Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer’s disease

inferred← citeshttps://doi.org/10.1186/s13195-019-0475-2openalex-snapshot

Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease

inferred← citeshttps://doi.org/10.1186/s13195-020-00628-zopenalex-snapshot

APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease

inferred← citeshttps://doi.org/10.1186/s13195-020-00705-3openalex-snapshot

Behavioral, neuromorphological, and neurobiochemical effects induced by omega-3 fatty acids following basal forebrain cholinergic depletion in aged mice

inferred← citeshttps://doi.org/10.1186/s40478-019-0754-yopenalex-snapshot

Intersection of pathological tau and microglia at the synapse

inferred← citeshttps://doi.org/10.1212/wnl.0000000000005807openalex-snapshot

Glutamatergic synaptic plasticity and dysfunction in Alzheimer disease

inferred← citeshttps://doi.org/10.1212/wnl.0000000000007323openalex-snapshot

KLOTHO heterozygosity attenuates APOE4 -related amyloid burden in preclinical AD

inferred← citeshttps://doi.org/10.1212/wnl.0000000000011883openalex-snapshot

Association of APOE Genotype With Heterogeneity of Cognitive Decline Rate in Alzheimer Disease

inferred← citeshttps://doi.org/10.1254/fpj.23004openalex-snapshot

Synaptic phagocytosis by multiple glial cell types

inferred← citeshttps://doi.org/10.12677/acm.2021.1112901openalex-snapshot

Research Progress of Microglia Related Role in Alzheimer’s Disease

inferred← citeshttps://doi.org/10.12703/r/10-19openalex-snapshot

Insight into the role of phosphatidylserine in complement-mediated synapse loss in Alzheimer’s disease

inferred← citeshttps://doi.org/10.13023/etd.2021.097openalex-snapshot

EXAMINING HUMAN APOE GENOTYPE AND SEX AS MODULATORS OF RESPIRATORY PLASTICITY IN THE PRESENCE AND ABSENCE OF SPINAL CORD INJURY

inferred← citeshttps://doi.org/10.1371/journal.pcbi.1011290openalex-snapshot

Investigating the ability of astrocytes to drive neural network synchrony

inferred← citeshttps://doi.org/10.1371/journal.pone.0194661openalex-snapshot

Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion

inferred← citeshttps://doi.org/10.1371/journal.pone.0229240openalex-snapshot

Apolipoprotein E regulates the maturation of injury-induced adult-born hippocampal neurons following traumatic brain injury

inferred← citeshttps://doi.org/10.14348/molcells.2019.0200openalex-snapshot

ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer's Disease.

inferred← citeshttps://doi.org/10.1515/hsz-2019-0140openalex-snapshot

Contribution of astrocytes to metabolic dysfunction in the Alzheimer’s disease brain

inferred← citeshttps://doi.org/10.1515/jib-2017-0024openalex-snapshot

RNA-Seq Mouse Brain Regions Expression Data Analysis: Focus on ApoE Functional Network

inferred← citeshttps://doi.org/10.1515/mr-2024-0064openalex-snapshot

Immune cells in Alzheimer’s disease: insights into pathogenesis and potential therapeutic targets

inferred← citeshttps://doi.org/10.1515/revneuro-2020-0065openalex-snapshot

Patient-derived iPSCs, a reliable in vitro model for the investigation of Alzheimer’s disease

inferred← citeshttps://doi.org/10.1523/hon.010001openalex-snapshot

Ben A. Barres

inferred← citeshttps://doi.org/10.1523/jneurosci.1135-17.2017openalex-snapshot

Alzheimer's Disease and Sleep–Wake Disturbances: Amyloid, Astrocytes, and Animal Models

inferred← citeshttps://doi.org/10.1523/jneurosci.1136-17.2017openalex-snapshot

Microglia-Mediated Synapse Loss in Alzheimer's Disease

inferred← citeshttps://doi.org/10.1523/jneurosci.3442-16.2017openalex-snapshot

Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition

inferred← citeshttps://doi.org/10.15252/embj.2021110409openalex-snapshot

Astrogenesis in the murine dentate gyrus is a life‐long and dynamic process

inferred← citeshttps://doi.org/10.18632/aging.101757openalex-snapshot

Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan

inferred← citeshttps://doi.org/10.21203/rs.3.rs-580913/v1openalex-snapshot

APOEe4.Trem2*R47H Mice Show Changes in Alzheimer’s Disease-Relevant Processes in the Absence of Amyloid Plaques

inferred← citeshttps://doi.org/10.2139/ssrn.3816953openalex-snapshot

BIN1 Genetic Risk Factor for Alzheimer is Sufficient to Induce Early Structural Tract Alterations in Entorhinal-Hippocampal Area and Memory-Related Hippocampal Multi-Scale Impairments

inferred← citeshttps://doi.org/10.2147/itt.s305420openalex-snapshot

The Role of Complement in Synaptic Pruning and Neurodegeneration

inferred← citeshttps://doi.org/10.2174/0113892037326839241014054430openalex-snapshot

Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic Strategies

inferred← citeshttps://doi.org/10.2174/1570159x17666190603170511openalex-snapshot

Synaptic Elimination in Neurological Disorders

inferred← citeshttps://doi.org/10.2174/1871527319666200903161249openalex-snapshot

Decoding the Inter-Relationship between Sleep Disorders and Alzheimer’s Disease Pathogenesis

inferred← citeshttps://doi.org/10.23860/iannucci-jaclyn-2020openalex-snapshot

INVESTIGATING THE ROLE OF VASCULAR ACTIVATION IN ALZHEIMER’S DISEASE-RELATED NEUROINFLAMMATION

inferred← citeshttps://doi.org/10.26481/dis.20241211bropenalex-snapshot

Out-of-control microglia cause cognitive deficits through excessive synaptic elimination in Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3233/jad-161123openalex-snapshot

Dynamics of the Complement, Cytokine, and Chemokine Systems in the Regulation of Synaptic Function and Dysfunction Relevant to Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3233/jad-170316openalex-snapshot

Effect of APOE Genotype on Synaptic Proteins in Earlier Adult Life

inferred← citeshttps://doi.org/10.3233/jad-170819openalex-snapshot

Alzheimer’s Disease, Oligomers, and Inflammation

inferred← citeshttps://doi.org/10.3233/jad-180740openalex-snapshot

The Role of Apolipoprotein E Isoforms in Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3233/jad-200052openalex-snapshot

Fluid Biomarkers and APOE Status of Early Onset Alzheimer’s Disease Variants: A Systematic Review and Meta-Analysis

inferred← citeshttps://doi.org/10.3233/jad-200688openalex-snapshot

Simulating the Effects of Common Comedications and Genotypes on Alzheimer’s Cognitive Trajectory Using a Quantitative Systems Pharmacology Approach

inferred← citeshttps://doi.org/10.3233/jad-200747openalex-snapshot

APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid1

inferred← citeshttps://doi.org/10.3233/jad-230658openalex-snapshot

The Contributions of the Endolysosomal Compartment and Autophagy to APOE ɛ4 Allele-Mediated Increase in Alzheimer’s Disease Risk

inferred← citeshttps://doi.org/10.33540/1838openalex-snapshot

Glial Cells in Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3389/fcell.2020.548283openalex-snapshot

The Role of Glial Mitochondria in α-Synuclein Toxicity

inferred← citeshttps://doi.org/10.3389/fimmu.2019.00790openalex-snapshot

Phagocytosis in the Brain: Homeostasis and Disease

inferred← citeshttps://doi.org/10.3389/fimmu.2021.629979openalex-snapshot

The Phagocytic Code Regulating Phagocytosis of Mammalian Cells

inferred← citeshttps://doi.org/10.3389/fnagi.2018.00114openalex-snapshot

Deciphering the Astrocyte Reaction in Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3389/fnagi.2019.00014openalex-snapshot

The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3389/fnagi.2019.00059openalex-snapshot

Astrocyte Heterogeneity: Impact to Brain Aging and Disease

inferred← citeshttps://doi.org/10.3389/fnagi.2020.00127openalex-snapshot

Commentary: Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk

inferred← citeshttps://doi.org/10.3389/fnagi.2020.00172openalex-snapshot

Age-Dependent Heterogeneity of Murine Olfactory Bulb Astrocytes

inferred← citeshttps://doi.org/10.3389/fnagi.2021.735524openalex-snapshot

Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H

inferred← citeshttps://doi.org/10.3389/fnagi.2022.954266openalex-snapshot

Reduced HGF/MET Signaling May Contribute to the Synaptic Pathology in an Alzheimer's Disease Mouse Model

inferred← citeshttps://doi.org/10.3389/fnagi.2026.1748418openalex-snapshot

Emerging pathological mechanisms of Alzheimer’s disease pathogenesis: from neuroimmune interactions to intercellular communication

inferred← citeshttps://doi.org/10.3389/fnagi.2026.1884230openalex-snapshot

Dysfunction of lipid metabolism and lysosomal capacity: at the core of microglial aging?

inferred← citeshttps://doi.org/10.3389/fncel.2019.00063openalex-snapshot

Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration

inferred← citeshttps://doi.org/10.3389/fncel.2022.899251openalex-snapshot

The Role of Astrocytes in Synapse Loss in Alzheimer's Disease: A Systematic Review

inferred← citeshttps://doi.org/10.3389/fneur.2018.01062openalex-snapshot

Rusty Microglia: Trainers of Innate Immunity in Alzheimer's Disease

inferred← citeshttps://doi.org/10.3389/fnins.2022.927256openalex-snapshot

The Role of Mesenchymal Stem Cells in Regulating Astrocytes-Related Synapse Dysfunction in Early Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3389/fnins.2024.1435082openalex-snapshot

Research progress in the mechanism of acupuncture regulating microglia in the treatment of Alzheimer’s disease

inferred← citeshttps://doi.org/10.3389/fnins.2026.1812081openalex-snapshot

Amyloid-β clearance: an astrocytic perspective

inferred← citeshttps://doi.org/10.3389/fnsyn.2023.1129036openalex-snapshot

Alzheimer’s disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression

inferred← citeshttps://doi.org/10.3389/fphys.2020.00598openalex-snapshot

Involvement of Lipids in Alzheimer’s Disease Pathology and Potential Therapies

inferred← citeshttps://doi.org/10.3390/biology12121529openalex-snapshot

The Impact of Apolipoprotein E (APOE) Epigenetics on Aging and Sporadic Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3390/brainsci14010046openalex-snapshot

Biomarkers in Alzheimer’s Disease: Are Olfactory Neuronal Precursors Useful for Antemortem Biomarker Research?

inferred← citeshttps://doi.org/10.3390/cells10030686openalex-snapshot

Microglial Pruning: Relevance for Synaptic Dysfunction in Multiple Sclerosis and Related Experimental Models

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