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Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Effect of Oncogene Transformation of Rat Embryo Cells on Cellular Oxygen Consumption and Glycolysis
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Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides
inferredcites →https://doi.org/10.1016/j.cell.2004.06.028openalex-snapshot
Single Cell Profiling of Potentiated Phospho-Protein Networks in Cancer Cells
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Activation of Ras cascade increases the mitochondrial enzyme content of respiratory competent yeast
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A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth
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Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells
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Glucose-Induced Stimulation of the Ras-cAMP Pathway in Yeast Leads to Multiple Phosphorylations and Activation of 6-Phosphofructo-2-kinase
inferredcites →https://doi.org/10.1023/a:1006859115450openalex-snapshot
Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides
inferredcites →https://doi.org/10.1038/22780openalex-snapshot
Creation of human tumour cells with defined genetic elements
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Metabolite profiling for plant functional genomics
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PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
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Bcl-xL and Akt cooperate to promote leukemogenesis in vivo
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Cloning, characterization and mapping of the human ATP5E gene, identification of pseudogene ATP5EP1, and definition of the ATP5E motif
inferredcites →https://doi.org/10.1073/pnas.97.26.14766openalex-snapshot
Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F 0 F 1 -ATPase
inferredcites →https://doi.org/10.1074/jbc.273.40.26187openalex-snapshot
An Unusual High-K Hexokinase Is Expressed in the mhAT3F Hepatoma Cell Line
inferredcites →https://doi.org/10.1074/jbc.m202487200openalex-snapshot
Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis
inferredcites →https://doi.org/10.1074/jbc.m308439200openalex-snapshot
Deficiency of the Nrf1 and Nrf2 Transcription Factors Results in Early Embryonic Lethality and Severe Oxidative Stress
inferredcites →https://doi.org/10.1093/carcin/bgh113openalex-snapshot
The bioenergetic signature of lung adenocarcinomas is a molecular marker of cancer diagnosis and prognosis
inferredcites →https://doi.org/10.1126/science.124.3215.269openalex-snapshot
On Respiratory Impairment in Cancer Cells
inferredcites →https://doi.org/10.1126/science.3103217openalex-snapshot
Elevated Levels of Glucose Transport and Transporter Messenger RNA Are Induced by ras or src Oncogenes
inferredcites →https://doi.org/10.1152/japplphysiol.00765.2003openalex-snapshot
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inferredcites →https://doi.org/10.1158/0008-5472.can-03-1101openalex-snapshot
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inferredcites →https://doi.org/10.1158/0008-5472.can-03-2904openalex-snapshot
Akt Stimulates Aerobic Glycolysis in Cancer Cells
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Activation of Antioxidant Pathways in Ras-Mediated Oncogenic Transformation of Human Surface Ovarian Epithelial Cells Revealed by Functional Proteomics and Mass Spectrometry
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Homeostatic functions of the p53 tumor suppressor: Regulation of energy metabolism and antioxidant defense
inferred← citeshttps://doi.org/10.1016/j.semcancer.2012.02.009openalex-snapshot
Tumor metabolism as modulator of immune response and tumor progression
inferred← citeshttps://doi.org/10.1016/j.semcancer.2022.12.001openalex-snapshot
Targeting lactate metabolism for cancer immunotherapy - a matter of precision
inferred← citeshttps://doi.org/10.1016/j.semcdb.2012.01.007openalex-snapshot
The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer
inferred← citeshttps://doi.org/10.1016/j.semcdb.2019.05.019openalex-snapshot
3D gastrointestinal models and organoids to study metabolism in human colon cancer
inferred← citeshttps://doi.org/10.1016/j.tem.2014.03.006openalex-snapshot
G protein-coupled receptors and the regulation of autophagy
inferred← citeshttps://doi.org/10.1016/j.tig.2014.11.002openalex-snapshot
Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery
inferred← citeshttps://doi.org/10.1016/j.yexcr.2009.06.024openalex-snapshot
Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply
inferred← citeshttps://doi.org/10.1016/j.yexcr.2015.04.007openalex-snapshot
The progression from a lower to a higher invasive stage of bladder cancer is associated with severe alterations in glucose and pyruvate metabolism
inferred← citeshttps://doi.org/10.1016/j.yexmp.2009.01.003openalex-snapshot
Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer
inferred← citeshttps://doi.org/10.1016/j.yexmp.2009.01.011openalex-snapshot
Structure-based drug design: From nucleic acid to membrane protein targets
inferred← citeshttps://doi.org/10.1016/s0140-6736(06)68228-7openalex-snapshot
Cancer's sweet tooth: the Janus effect of glucose metabolism in tumorigenesis
inferred← citeshttps://doi.org/10.1021/acs.analchem.2c00680openalex-snapshot
Bioorthogonal Light-Up Fluorescent Probe Enables Wash-Free Real-Time Dynamic Monitoring of Cellular Glucose Uptake
inferred← citeshttps://doi.org/10.1021/cb600143jopenalex-snapshot
Mechanistic Basis for Therapeutic Targeting of the Mitochondrial F1Fo-ATPase
inferred← citeshttps://doi.org/10.1021/cb900271ropenalex-snapshot
Exploring Disease through Metabolomics
inferred← citeshttps://doi.org/10.1021/pr100774fopenalex-snapshot
Targeted Proteomic Analysis of Glycolysis in Cancer Cells
inferred← citeshttps://doi.org/10.1038/cr.2011.145openalex-snapshot
K-rasG12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis
inferred← citeshttps://doi.org/10.1038/embor.2013.72openalex-snapshot
Degradation of IF1 controls energy metabolism during osteogenic differentiation of stem cells
inferred← citeshttps://doi.org/10.1038/msb.2011.56openalex-snapshot
Oncogenic K‐Ras decouples glucose and glutamine metabolism to support cancer cell growth
inferred← citeshttps://doi.org/10.1038/nbt0910-904openalex-snapshot
Towards patient-based cancer therapeutics
inferred← citeshttps://doi.org/10.1038/nbt1387openalex-snapshot
Large-scale chemical dissection of mitochondrial function
inferred← citeshttps://doi.org/10.1038/nchembio0705-64openalex-snapshot
Small molecules: the missing link in the central dogma
inferred← citeshttps://doi.org/10.1038/nrc2468openalex-snapshot
Hypoxia, HIF1 and glucose metabolism in the solid tumour
inferred← citeshttps://doi.org/10.1038/nrc3038openalex-snapshot
Otto Warburg's contributions to current concepts of cancer metabolism
inferred← citeshttps://doi.org/10.1038/nrc3106openalex-snapshot
RAS oncogenes: weaving a tumorigenic web
inferred← citeshttps://doi.org/10.1038/onc.2009.229openalex-snapshot
Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth
inferred← citeshttps://doi.org/10.1038/onc.2009.358openalex-snapshot
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
inferred← citeshttps://doi.org/10.1038/onc.2010.182openalex-snapshot
Metabolism and proliferation share common regulatory pathways in cancer cells
inferred← citeshttps://doi.org/10.1038/onc.2012.50openalex-snapshot
Oncogenic K-ras expression is associated with derangement of the cAMP/PKA pathway and forskolin-reversible alterations of mitochondrial dynamics and respiration
inferred← citeshttps://doi.org/10.1038/onc.2012.6openalex-snapshot
Targeting tumor cell metabolism with statins
inferred← citeshttps://doi.org/10.1038/onc.2013.463openalex-snapshot
Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch
inferred← citeshttps://doi.org/10.1038/s41388-020-1276-6openalex-snapshot
Genome remodeling upon mesenchymal tumor cell fusion contributes to tumor progression and metastatic spread
inferred← citeshttps://doi.org/10.1038/s41416-023-02568-5openalex-snapshot
Mitochondrial DNA copy number plays opposing roles in T-lymphocyte infiltration of colorectal cancer based on mismatch repair status: new directions for immunotherapy?
inferred← citeshttps://doi.org/10.1038/s41598-017-04366-5openalex-snapshot
Lactate dehydrogenase A promotes the invasion and proliferation of pituitary adenoma
inferred← citeshttps://doi.org/10.1038/s42003-018-0111-xopenalex-snapshot
A framework for large-scale metabolome drug profiling links coenzyme A metabolism to the toxicity of anti-cancer drug dichloroacetate
inferred← citeshttps://doi.org/10.1038/s42003-026-11151-6openalex-snapshot
Cancer-derived lactic acid as a potential upstream contributor to tumor hypoxia
inferred← citeshttps://doi.org/10.1038/sigtrans.2016.47openalex-snapshot
Central role of lactate and proton in cancer cell resistance to glucose deprivation and its clinical translation
inferred← citeshttps://doi.org/10.1038/sj.bjc.6602962openalex-snapshot
Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted
inferred← citeshttps://doi.org/10.1038/sj.jid.5701107openalex-snapshot
Human Skin Keloid Fibroblasts Display Bioenergetics of Cancer Cells
inferred← citeshttps://doi.org/10.1038/sj.onc.1209097openalex-snapshot
Akt-dependent transformation: there is more to growth than just surviving
inferred← citeshttps://doi.org/10.1038/sj.onc.1209528openalex-snapshot
Ras-dependent carbon metabolism and transformation in mouse fibroblasts
inferred← citeshttps://doi.org/10.1038/sj.onc.1209597openalex-snapshot
Glycolysis inhibition for anticancer treatment
inferred← citeshttps://doi.org/10.1038/sj.onc.1209598openalex-snapshot
Mitochondria as therapeutic targets for cancer chemotherapy
inferred← citeshttps://doi.org/10.1038/sj.onc.1209709openalex-snapshot
Ras transformation requires metabolic control by 6-phosphofructo-2-kinase
inferred← citeshttps://doi.org/10.1038/sj.onc.1210583openalex-snapshot
The field of cancer research: an indicator of present transformations in biology
inferred← citeshttps://doi.org/10.1038/srep22788openalex-snapshot
Insulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function
inferred← citeshttps://doi.org/10.1039/c0mb00309copenalex-snapshot
Tracking cellular metabolomics in lipoapoptosis- and steatosis-developing liver cells
inferred← citeshttps://doi.org/10.1039/c2ay25046bopenalex-snapshot
Comparison of extraction conditions and normalization approaches for cellular metabolomics of adherent growing cells with GC-MS
inferred← citeshttps://doi.org/10.1051/jbio/2020014openalex-snapshot
Le régime cétogène : une stratégie alimentaire efficace en complément des traitements contre le cancer ?
inferred← citeshttps://doi.org/10.1053/j.gastro.2012.07.115openalex-snapshot
Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism
inferred← citeshttps://doi.org/10.1073/pnas.0605080104openalex-snapshot
Alterations of cellular bioenergetics in pulmonary artery endothelial cells
inferred← citeshttps://doi.org/10.1073/pnas.0700690104openalex-snapshot
Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production
inferred← citeshttps://doi.org/10.1073/pnas.0807581105openalex-snapshot
Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP + , or paraquat
inferred← citeshttps://doi.org/10.1073/pnas.1004882107openalex-snapshot
Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells
inferred← citeshttps://doi.org/10.1073/pnas.1104943108openalex-snapshot
Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms
inferred← citeshttps://doi.org/10.1074/jbc.m109.049478openalex-snapshot
Effect of Anaplerotic Fluxes and Amino Acid Availability on Hepatic Lipoapoptosis
inferred← citeshttps://doi.org/10.1074/jbc.m116.740209openalex-snapshot
TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer
inferred← citeshttps://doi.org/10.1074/jbc.m511064200openalex-snapshot
Induction of Oxidative Metabolism by Mitochondrial Frataxin Inhibits Cancer Growth
inferred← citeshttps://doi.org/10.1074/mcp.m111.015214openalex-snapshot
Quantitative Analysis of Energy Metabolic Pathways in MCF-7 Breast Cancer Cells by Selected Reaction Monitoring Assay
inferred← citeshttps://doi.org/10.1080/01635581.2015.1085584openalex-snapshot
The Effect of Silencing HIF-1α Gene in BxPC-3 Cell Line on Glycolysis-Related Gene Expression, Cell Growth, Invasion, and Apoptosis
inferred← citeshttps://doi.org/10.1080/15384101.2016.1215387openalex-snapshot
Transformation by different oncogenes relies on specific metabolic adaptations
inferred← citeshttps://doi.org/10.1080/17590914.2024.2422268openalex-snapshot
Amino Acid and Glucose Fermentation Maintain ATP Content in Mouse and Human Malignant Glioma Cells
inferred← citeshttps://doi.org/10.1083/jcb.200703099openalex-snapshot
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
inferred← citeshttps://doi.org/10.1088/0951-7715/23/1/r01openalex-snapshot
Nonlinear modelling of cancer: bridging the gap between cells and tumours
inferred← citeshttps://doi.org/10.1089/ars.2012.4883openalex-snapshot
Mitochondria-Mediated Energy Adaption in Cancer: The H + -ATP Synthase-Geared Switch of Metabolism in Human Tumors
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