On the public citation graph

DNA polymerase ε and δ proofreading suppress discrete mutator and cancer phenotypes in mice

0 signed · 262 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/humu.20047openalex-snapshot

Structural and functional analysis of mutations at the human hypoxanthine phosphoribosyl transferase (HPRT1) locus

inferredcites →https://doi.org/10.1002/j.1460-2075.1991.tb07751.xopenalex-snapshot

The 3′ to 5′ exonuclease activity located in the DNA polymerase delta subunit of Saccharomyces cerevisiae is required for accurate replication.

inferredcites →https://doi.org/10.1002/j.1460-2075.1993.tb05790.xopenalex-snapshot

Pathway correcting DNA replication errors in Saccharomyces cerevisiae.

inferredcites →https://doi.org/10.1006/jmbi.2000.3744openalex-snapshot

Evidence from mutational specificity studies that yeast DNA polymerases δ and ϵ replicate different DNA strands at an intracellular replication fork 1 1Edited by A. R. Fersht

inferredcites →https://doi.org/10.1007/bf00280418openalex-snapshot

The 3′ → 5′ exonucleases of both DNA polymerases δ and ε participate in correcting errors of DNA replication in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1016/0092-8674(89)90883-0openalex-snapshot

A conserved 3′→5′ exonuclease active site in prokaryotic and eukaryotic DNA polymerases

inferredcites →https://doi.org/10.1016/j.molcel.2008.02.022openalex-snapshot

Division of Labor at the Eukaryotic Replication Fork

inferredcites →https://doi.org/10.1016/j.tcb.2008.08.005openalex-snapshot

Dividing the workload at a eukaryotic replication fork

inferredcites →https://doi.org/10.1016/s0027-5107(97)00248-0openalex-snapshot

Comparison between in vivo mutagenicity and carcinogenicity in multiple organs by benzo[a]pyrene in the lacZ transgenic mouse (Muta™Mouse)

inferredcites →https://doi.org/10.1016/s0027-5107(98)00032-3openalex-snapshot

No direct correlation between mutant frequencies and cancer incidence induced by MeIQ in various organs of Big Blue® mice

inferredcites →https://doi.org/10.1016/s0074-7696(06)55002-8openalex-snapshot

Roles of DNA Polymerases in Replication, Repair, and Recombination in Eukaryotes

inferredcites →https://doi.org/10.1016/s0079-6603(08)00004-4openalex-snapshot

DNA Polymerase ε: A Polymerase of Unusual Size (and Complexity)

inferredcites →https://doi.org/10.1016/s1471-4914(02)02359-6openalex-snapshot

Mouse models for human DNA mismatch-repair gene defects

inferredcites →https://doi.org/10.1021/cr0404794openalex-snapshot

DNA Mismatch Repair: Functions and Mechanisms

inferredcites →https://doi.org/10.1038/362709a0openalex-snapshot

Instability and decay of the primary structure of DNA

inferredcites →https://doi.org/10.1038/88963openalex-snapshot

Defective DNA polymerase-δ proofreading causes cancer susceptibility in mice

inferredcites →https://doi.org/10.1038/cr.2008.4openalex-snapshot

The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases

inferredcites →https://doi.org/10.1038/nrm804openalex-snapshot

The 3′–5′ exonucleases

inferredcites →https://doi.org/10.1042/0264-6021:3560685openalex-snapshot

Structural similarities of Na,K-ATPase and SERCA, the Ca2+-ATPase of the sarcoplasmic reticulum

inferredcites →https://doi.org/10.1073/pnas.0607057103openalex-snapshot

Human cancers express a mutator phenotype

inferredcites →https://doi.org/10.1073/pnas.232340999openalex-snapshot

High incidence of epithelial cancers in mice deficient for DNA polymerase δ proofreading

inferredcites →https://doi.org/10.1073/pnas.88.21.9473openalex-snapshot

Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity.

inferredcites →https://doi.org/10.1073/pnas.93.17.9073openalex-snapshot

Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage lambda transgene target.

inferredcites →https://doi.org/10.1073/pnas.94.7.3122openalex-snapshot

Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2

inferredcites →https://doi.org/10.1074/jbc.m110615200openalex-snapshot

Human DNA Polymerase ε Colocalizes with Proliferating Cell Nuclear Antigen and DNA Replication Late, but Not Early, in S Phase

inferredcites →https://doi.org/10.1080/10409230590935433openalex-snapshot

DNA Polymerases that Propagate the Eukaryotic DNA Replication Fork

inferredcites →https://doi.org/10.1093/carcin/bgl079openalex-snapshot

Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6

inferredcites →https://doi.org/10.1093/genetics/142.3.717openalex-snapshot

3′ → 5′ Exonucleases of DNA Polymerases ϵ and δ Correct Base Analog Induced DNA Replication Errors on Opposite DNA Strands in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1093/genetics/148.4.1667openalex-snapshot

Rates of Spontaneous Mutation

inferredcites →https://doi.org/10.1111/j.1742-4658.2006.05310.xopenalex-snapshot

Distinctive activities of DNA polymerases during human DNA replication

inferredcites →https://doi.org/10.1126/science.1144067openalex-snapshot

Yeast DNA Polymerase ε Participates in Leading-Strand DNA Replication

inferredcites →https://doi.org/10.1128/9781555816704openalex-snapshot

DNA Repair and Mutagenesis

inferredcites →https://doi.org/10.1128/mcb.19.3.2000openalex-snapshot

The 3′→5′ Exonucleases of DNA Polymerases δ and ɛ and the 5′→3′ Exonuclease Exo1 Have Major Roles in Postreplication Mutation Avoidance in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1146/annurev.biochem.73.011303.073859openalex-snapshot

CELLULAR DNA REPLICASES: Components and Dynamics at the Replication Fork

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3974793openalex-extracted

inferred← citeshttps://doi.org/10.1001/jamanetworkopen.2023.51906openalex-snapshot

Race, Prevalence of POLE and POLD1 Alterations, and Survival Among Patients With Endometrial Cancer

inferred← citeshttps://doi.org/10.1001/jamaoncol.2020.0065openalex-snapshot

Evaluation of POLE/POLD1 Variants as Potential Biomarkers for Immune Checkpoint Inhibitor Treatment Outcomes

inferred← citeshttps://doi.org/10.1002/1873-3468.15070openalex-snapshot

p12 isoform‐2 is a regulatory subunit of human DNA polymerase delta and is dysregulated in various cancers

inferred← citeshttps://doi.org/10.1002/cam4.1245openalex-snapshot

POLE somatic mutations in advanced colorectal cancer

inferred← citeshttps://doi.org/10.1002/cam4.305openalex-snapshot

Mutations in POLE and survival of colorectal cancer patients – link to disease stage and treatment

inferred← citeshttps://doi.org/10.1002/cncr.29046openalex-snapshot

Polymerase ɛ ( POLE ) mutations in endometrial cancer: Clinical outcomes and implications for L ynch syndrome testing

inferred← citeshttps://doi.org/10.1002/cncr.29057openalex-snapshot

POLE mutations as an alternative pathway for microsatellite instability in endometrial cancer: Implications for L ynch syndrome testing

inferred← citeshttps://doi.org/10.1002/em.21731openalex-snapshot

Mouse models of DNA polymerases

inferred← citeshttps://doi.org/10.1002/em.21735openalex-snapshot

Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools

inferred← citeshttps://doi.org/10.1002/em.21745openalex-snapshot

DNA polymerase delta in dna replication and genome maintenance

inferred← citeshttps://doi.org/10.1002/iub.1276openalex-snapshot

DNA polymerase ε and its roles in genome stability

inferred← citeshttps://doi.org/10.1002/path.4185openalex-snapshot

Germline and somatic polymerase ϵ and δ mutations define a new class of hypermutated colorectal and endometrial cancers

inferred← citeshttps://doi.org/10.1007/7631_2015_1openalex-snapshot

Future Directions and New Targets in Endometrial Cancer

inferred← citeshttps://doi.org/10.1007/978-3-642-39796-7_2openalex-snapshot

Eukaryotic Replicative DNA Polymerases

inferred← citeshttps://doi.org/10.1007/978-3-642-39796-7_3openalex-snapshot

DNA Repair Polymerases

inferred← citeshttps://doi.org/10.1007/978-94-007-4572-8_12openalex-snapshot

Structure and Function of Eukaryotic DNA Polymerase δ

inferred← citeshttps://doi.org/10.1007/978-981-15-1067-0_6openalex-snapshot

Genomic Instability and Cancer Metastasis

inferred← citeshttps://doi.org/10.1007/s00203-024-04214-xopenalex-snapshot

Site directed mutagenesis reveals functional importance of conserved amino acid residues within the N-terminal domain of Dpb2 in budding yeast

inferred← citeshttps://doi.org/10.1007/s00285-024-02134-4openalex-snapshot

Error-induced extinction in a multi-type critical birth–death process

inferred← citeshttps://doi.org/10.1007/s00294-018-0820-1openalex-snapshot

Fidelity of DNA replication—a matter of proofreading

inferred← citeshttps://doi.org/10.1007/s10555-013-9426-8openalex-snapshot

Do mutator mutations fuel tumorigenesis?

inferred← citeshttps://doi.org/10.1007/s10689-015-9803-2openalex-snapshot

A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine

inferred← citeshttps://doi.org/10.1007/s10689-015-9826-8openalex-snapshot

POLE mutations in families predisposed to cutaneous melanoma

inferred← citeshttps://doi.org/10.1007/s11357-024-01113-3openalex-snapshot

Somatic mutations in aging and disease

inferred← citeshttps://doi.org/10.1007/s12029-023-00927-2openalex-snapshot

Immune Checkpoint Inhibitors in pMMR/MSS Colorectal Cancer

inferred← citeshttps://doi.org/10.1007/s12672-025-03652-3openalex-snapshot

Endometrial cancer: from clinical reality to molecular treatment

inferred← citeshttps://doi.org/10.1016/b978-0-12-397933-9.00025-4openalex-snapshot

Immune Deficiencies Caused by B Cell Defects

inferred← citeshttps://doi.org/10.1016/b978-0-12-803309-8.00017-3openalex-snapshot

Base Excision Repair and Nucleotide Excision Repair

inferred← citeshttps://doi.org/10.1016/b978-0-323-85679-9.00017-9openalex-snapshot

Base excision repair and nucleotide excision repair

inferred← citeshttps://doi.org/10.1016/bs.acr.2021.03.003openalex-snapshot

Unraveling the genomic landscape of colorectal cancer through mutational signatures

inferred← citeshttps://doi.org/10.1016/j.annonc.2024.03.009openalex-snapshot

Immune checkpoint inhibitors for POLE or POLD1 proofreading-deficient metastatic colorectal cancer

inferred← citeshttps://doi.org/10.1016/j.arr.2024.102268openalex-snapshot

Somatic mutations in human ageing: New insights from DNA sequencing and inherited mutations

inferred← citeshttps://doi.org/10.1016/j.cbpa.2011.07.025openalex-snapshot

Balancing eukaryotic replication asymmetry with replication fidelity

inferred← citeshttps://doi.org/10.1016/j.cell.2017.09.048openalex-snapshot

Comprehensive Analysis of Hypermutation in Human Cancer

inferred← citeshttps://doi.org/10.1016/j.dld.2018.02.009openalex-snapshot

Early onset sporadic colorectal cancer: Worrisome trends and oncogenic features

inferred← citeshttps://doi.org/10.1016/j.dnarep.2011.02.003openalex-snapshot

The in vitro fidelity of yeast DNA polymerase δ and polymerase ɛ holoenzymes during dinucleotide microsatellite DNA synthesis

inferred← citeshttps://doi.org/10.1016/j.dnarep.2013.08.012openalex-snapshot

Human Pol ɛ-dependent replication errors and the influence of mismatch repair on their correction

inferred← citeshttps://doi.org/10.1016/j.dnarep.2015.04.006openalex-snapshot

Quantifying the contributions of base selectivity, proofreading and mismatch repair to nuclear DNA replication in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1016/j.dnarep.2015.11.020openalex-snapshot

Non-canonical actions of mismatch repair

inferred← citeshttps://doi.org/10.1016/j.dnarep.2017.06.003openalex-snapshot

Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy

inferred← citeshttps://doi.org/10.1016/j.dnarep.2017.11.005openalex-snapshot

DNA Replication and associated repair pathways are involved in the mutagenesis of methylated cytosine

inferred← citeshttps://doi.org/10.1016/j.dnarep.2019.02.007openalex-snapshot

POLE proofreading defects: Contributions to mutagenesis and cancer

inferred← citeshttps://doi.org/10.1016/j.dnarep.2024.103694openalex-snapshot

The mutagenic consequences of defective DNA repair

inferred← citeshttps://doi.org/10.1016/j.dnarep.2025.103885openalex-snapshot

Proofreading exonuclease activities of Polδ and Polε differentially contribute to the removal of chain-terminating nucleoside analogs

inferred← citeshttps://doi.org/10.1016/j.gde.2013.12.005openalex-snapshot

Replicative DNA polymerase mutations in cancer

inferred← citeshttps://doi.org/10.1016/j.gene.2016.06.031openalex-snapshot

POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies

inferred← citeshttps://doi.org/10.1016/j.gore.2015.01.005openalex-snapshot

Improved survival of patients with hypermutation in uterine serous carcinoma

inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e28044openalex-snapshot

Single base substitution signatures 17a, 17b, and 40 are induced by γ-ray irradiation in association with increased reactive oxidative species

inferred← citeshttps://doi.org/10.1016/j.jbc.2023.104705openalex-snapshot

Genome-wide contributions of the MutSα- and MutSβ-dependent DNA mismatch repair pathways to the maintenance of genetic stability in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1016/j.jmoldx.2025.12.004openalex-snapshot

Phenotypic POLE Variant Classification Identifies Patients Who May Have Favorable Prognosis and Benefit from Immunotherapy

inferred← citeshttps://doi.org/10.1016/j.mad.2011.10.009openalex-snapshot

Somatic mutations in aging, cancer and neurodegeneration

inferred← citeshttps://doi.org/10.1016/j.matbio.2013.05.001openalex-snapshot

Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype

inferred← citeshttps://doi.org/10.1016/j.molcel.2016.05.003openalex-snapshot

DNA Replication—A Matter of Fidelity

inferred← citeshttps://doi.org/10.1016/j.molcel.2020.05.012openalex-snapshot

POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status

inferred← citeshttps://doi.org/10.1016/j.molmed.2023.04.002openalex-snapshot

Mitigating age-related somatic mutation burden

inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2012.07.003openalex-snapshot

Aberrant DNA replication in cancer

inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2014.01.003openalex-snapshot

Frequent POLE1 p.S297F mutation in Chinese patients with ovarian endometrioid carcinoma

inferred← citeshttps://doi.org/10.1016/j.semcancer.2010.10.001openalex-snapshot

Aberrant expression of alternative DNA polymerases: A source of mutator phenotype as well as replicative stress in cancer

inferred← citeshttps://doi.org/10.1016/j.semcancer.2010.10.009openalex-snapshot

DNA replication fidelity and cancer

inferred← citeshttps://doi.org/10.1016/j.semcancer.2015.03.005openalex-snapshot

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition

inferred← citeshttps://doi.org/10.1016/j.semdp.2026.151033openalex-snapshot

The current molecular landscape of endometrial and ovarian carcinomas: insights and practical updates

inferred← citeshttps://doi.org/10.1016/j.tig.2020.12.003openalex-snapshot

Underappreciated Roles of DNA Polymerase δ in Replication Stress Survival

inferred← citeshttps://doi.org/10.1016/j.yexcr.2019.02.020openalex-snapshot

Differential genomic destabilisation in human cells with pathogenic MSH2 mutations introduced by genome editing

inferred← citeshttps://doi.org/10.1016/j.ygyno.2015.04.027openalex-snapshot

Polymerase ε (POLE) ultra-mutated tumors induce robust tumor-specific CD4+ T cell responses in endometrial cancer patients

inferred← citeshttps://doi.org/10.1016/j.ygyno.2016.11.023openalex-snapshot

Polymerase ε (POLE) ultra-mutation in uterine tumors correlates with T lymphocyte infiltration and increased resistance to platinum-based chemotherapy in vitro

inferred← citeshttps://doi.org/10.1016/j.ygyno.2016.12.015openalex-snapshot

Molecular approaches for classifying endometrial carcinoma

inferred← citeshttps://doi.org/10.1016/j.yrtph.2015.12.018openalex-snapshot

HESI/FDA workshop on immunomodulators and cancer risk assessment: Building blocks for a weight-of-evidence approach

inferred← citeshttps://doi.org/10.1038/ejhg.2010.216openalex-snapshot

Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer

inferred← citeshttps://doi.org/10.1038/gim.2015.75openalex-snapshot

POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance

inferred← citeshttps://doi.org/10.1038/ncomms5990openalex-snapshot

Phenotypic characterization of missense polymerase-δ mutations using an inducible protein-replacement system

inferred← citeshttps://doi.org/10.1038/ng.2503openalex-snapshot

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

inferred← citeshttps://doi.org/10.1038/ng.2540openalex-snapshot

The burden of faulty proofreading in colon cancer

inferred← citeshttps://doi.org/10.1038/nmeth.1781openalex-snapshot

Decoding cell lineage from acquired mutations using arbitrary deep sequencing

inferred← citeshttps://doi.org/10.1038/nrc.2015.12openalex-snapshot

A panoply of errors: polymerase proofreading domain mutations in cancer

inferred← citeshttps://doi.org/10.1038/nrc2998openalex-snapshot

DNA polymerases and cancer

inferred← citeshttps://doi.org/10.1038/nrc3063openalex-snapshot

Human cancers express mutator phenotypes: origin, consequences and targeting

inferred← citeshttps://doi.org/10.1038/nsmb.2852openalex-snapshot

Delivering nonidentical twins

inferred← citeshttps://doi.org/10.1038/onc.2013.339openalex-snapshot

Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress

inferred← citeshttps://doi.org/10.1038/s10038-019-0611-7openalex-snapshot

Development of an MSI-positive colon tumor with aberrant DNA methylation in a PPAP patient

inferred← citeshttps://doi.org/10.1038/s41431-024-01598-8openalex-snapshot

Discovery of recessive effect of human polymerase δ proofreading deficiency through mutational analysis of POLD1-mutated normal and cancer cells

inferred← citeshttps://doi.org/10.1038/s41467-018-04002-4openalex-snapshot

Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair

inferred← citeshttps://doi.org/10.1038/s41467-018-08114-9openalex-snapshot

Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε

inferred← citeshttps://doi.org/10.1038/s41568-024-00705-7openalex-snapshot

Defining clinically useful biomarkers of immune checkpoint inhibitors in solid tumours

inferred← citeshttps://doi.org/10.1038/s41568-026-00958-4openalex-snapshot

The DNA damage response and cancer immunotherapy

inferred← citeshttps://doi.org/10.1038/s41573-025-01212-6openalex-snapshot

Targeting DNA damage in ageing: towards supercharging DNA repair

inferred← citeshttps://doi.org/10.1038/s41588-021-00930-yopenalex-snapshot

Increased somatic mutation burdens in normal human cells due to defective DNA polymerases

inferred← citeshttps://doi.org/10.1038/s41588-022-01108-wopenalex-snapshot

Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity

inferred← citeshttps://doi.org/10.1038/s41588-024-01945-xopenalex-snapshot

Human DNA polymerase ε is a source of C>T mutations at CpG dinucleotides

inferred← citeshttps://doi.org/10.1038/s41594-021-00691-6openalex-snapshot

How asymmetric DNA replication achieves symmetrical fidelity

inferred← citeshttps://doi.org/10.1038/srep36971openalex-snapshot

Mutation tendency of mutator Plasmodium berghei with proofreading-deficient DNA polymerase δ

inferred← citeshttps://doi.org/10.1038/srep46535openalex-snapshot

Normally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variant

inferred← citeshttps://doi.org/10.1073/pnas.0914857107openalex-snapshot

Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases

inferred← citeshttps://doi.org/10.1073/pnas.1013048107openalex-snapshot

Differential correction of lagging-strand replication errors made by DNA polymerases α and δ

inferred← citeshttps://doi.org/10.1073/pnas.1217425110openalex-snapshot

Dual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responses

inferred← citeshttps://doi.org/10.1073/pnas.1422934112openalex-snapshot

Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity

inferred← citeshttps://doi.org/10.1073/pnas.1422948112openalex-snapshot

dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants

inferred← citeshttps://doi.org/10.1073/pnas.1507165112openalex-snapshot

Formation of interference-sensitive meiotic cross-overs requires sufficient DNA leading-strand elongation

inferred← citeshttps://doi.org/10.1073/pnas.1917624117openalex-snapshot

DNA polymerase δ proofreads errors made by DNA polymerase ε

inferred← citeshttps://doi.org/10.1073/pnas.2526551123openalex-snapshot

Polymerase ι promotes C>T substitutions in smoking models and in the platinum chemotherapy–induced SBS31 mutation signature

inferred← citeshttps://doi.org/10.1074/jbc.m110.147017openalex-snapshot

Active Site Mutations in Mammalian DNA Polymerase δ Alter Accuracy and Replication Fork Progression

inferred← citeshttps://doi.org/10.1074/jbc.m112.422733openalex-snapshot

Human DNA Polymerase ϵ Is Able to Efficiently Extend from Multiple Consecutive Ribonucleotides

inferred← citeshttps://doi.org/10.1074/jbc.m114.615278openalex-snapshot

Yeast DNA Polymerase ϵ Catalytic Core and Holoenzyme Have Comparable Catalytic Rates

inferred← citeshttps://doi.org/10.1074/jbc.ra118.003477openalex-snapshot

Impact of tobacco-specific nitrosamine–derived DNA adducts on the efficiency and fidelity of DNA replication in human cells

inferred← citeshttps://doi.org/10.1080/07853890.2025.2583543openalex-snapshot

TCGA molecular subtypes in endometriosis-associated ovarian cancer: a systematic review and meta-analysis

inferred← citeshttps://doi.org/10.1080/10409238.2020.1811630openalex-snapshot

An updated perspective on the polymerase division of labor during eukaryotic DNA replication

inferred← citeshttps://doi.org/10.1080/15384101.2017.1404208openalex-snapshot

DNA polymerase η mutational signatures are found in a variety of different types of cancer

inferred← citeshttps://doi.org/10.1080/19491034.2016.1205774openalex-snapshot

Reconstitution of a eukaryotic replisome reveals the mechanism of asymmetric distribution of DNA polymerases

inferred← citeshttps://doi.org/10.1084/jem.20121303openalex-snapshot

Polymerase ε1 mutation in a human syndrome with facial dysmorphism, immunodeficiency, livedo, and short stature (“FILS syndrome”)

inferred← citeshttps://doi.org/10.1089/crispr.2019.0006openalex-snapshot

CRISPR-Cas9 Causes Chromosomal Instability and Rearrangements in Cancer Cell Lines, Detectable by Cytogenetic Methods

inferred← citeshttps://doi.org/10.1093/database/baaf076openalex-snapshot

PolED: a manually curated database of functional studies of POLE and POLD1 variants reported in humans

inferred← citeshttps://doi.org/10.1093/femsre/fuaa038openalex-snapshot

DNA damage bypass pathways and their effect on mutagenesis in yeast

inferred← citeshttps://doi.org/10.1093/hmg/ddq175openalex-snapshot

The nucleotide composition of microsatellites impacts both replication fidelity and mismatch repair in human colorectal cells

inferred← citeshttps://doi.org/10.1093/hmg/ddt131openalex-snapshot

DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer

inferred← citeshttps://doi.org/10.1093/mutage/gez049openalex-snapshot

The double-edged sword of cancer mutations: exploiting neoepitopes for the fight against cancer

inferred← citeshttps://doi.org/10.1093/nar/gkaa633openalex-snapshot

Mismatch repair and DNA polymerase δ proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ϵ variant

inferred← citeshttps://doi.org/10.1093/nar/gkac602openalex-snapshot

Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ϵ variants at low dNTP levels

inferred← citeshttps://doi.org/10.1093/nar/gkae843openalex-snapshot

Altered dNTP pools accelerate tumor formation in mice

inferred← citeshttps://doi.org/10.1093/nar/gkq1034openalex-snapshot

The high fidelity and unique error signature of human DNA polymerase

inferred← citeshttps://doi.org/10.1093/nar/gkr142openalex-snapshot

A random mutation capture assay to detect genomic point mutations in mouse tissue

inferred← citeshttps://doi.org/10.1093/nar/gkv1298openalex-snapshot

Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools

inferred← citeshttps://doi.org/10.1093/nar/gkx611openalex-snapshot

Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro

inferred← citeshttps://doi.org/10.1093/nar/gkx625openalex-snapshot

Polμ tumor variants decrease the efficiency and accuracy of NHEJ

inferred← citeshttps://doi.org/10.1093/narcan/zcad011openalex-snapshot

The hereditary N363K POLE exonuclease mutant extends PPAP tumor spectrum to glioblastomas by causing DNA damage and aneuploidy in addition to increased mismatch mutagenicity

inferred← citeshttps://doi.org/10.1093/narcan/zcad033openalex-snapshot

Replication DNA polymerases, genome instability and cancer therapies

inferred← citeshttps://doi.org/10.1093/neuonc/nov027openalex-snapshot

Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis

inferred← citeshttps://doi.org/10.1097/igc.0000000000000492openalex-snapshot

Polymerase Epsilon Exonuclease Domain Mutations in Ovarian Endometrioid Carcinoma

inferred← citeshttps://doi.org/10.1097/igc.0000000000000681openalex-snapshot

Prognostic Significance of POLE Exonuclease Domain Mutations in High-Grade Endometrioid Endometrial Cancer on Survival and Recurrence

inferred← citeshttps://doi.org/10.1097/pas.0000000000000873openalex-snapshot

Undifferentiated and Dedifferentiated Endometrial Carcinomas With POLE Exonuclease Domain Mutations Have a Favorable Prognosis

inferred← citeshttps://doi.org/10.1101/2022.01.10.475213openalex-snapshot

A Simple Bypass Assay for DNA Polymerases Shows Hypermutating Variants Associated with Cancer Show Mechanistic Differences In Vitro

inferred← citeshttps://doi.org/10.1101/2022.07.20.500591openalex-snapshot

Extended family with an inherited pathogenic variant in polymerase delta provides strong evidence for recessive effect of proofreading deficiency in human cells

inferred← citeshttps://doi.org/10.1101/2024.06.10.597960openalex-snapshot

Immune Checkpoint Blockade Delays Cancer and Extends Survival in Murine DNA Polymerase Mutator Syndromes

inferred← citeshttps://doi.org/10.1101/2024.10.09.617451openalex-snapshot

DNA Polymerase Locks Replication Fork Under Stress

inferred← citeshttps://doi.org/10.1101/2025.04.07.646990openalex-snapshot

Exploring the mechanisms of early acquired resistance to doxorubicin in melanoma spheroids

inferred← citeshttps://doi.org/10.1101/2025.09.02.673565openalex-snapshot

Reductive evolution of the DNA replication machinery in endosymbiotic fungi

inferred← citeshttps://doi.org/10.1101/gad.349431.122openalex-snapshot

DNA repair defects in cancer and therapeutic opportunities

inferred← citeshttps://doi.org/10.1101/gr.178335.114openalex-snapshot

Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition

inferred← citeshttps://doi.org/10.1101/gr.186148.114openalex-snapshot

Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice

inferred← citeshttps://doi.org/10.1101/gr.226845.117openalex-snapshot

Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers

inferred← citeshttps://doi.org/10.1101/gr.238543.118openalex-snapshot

Quantification of somatic mutation flow across individual cell division events by lineage sequencing

inferred← citeshttps://doi.org/10.1111/febs.16936openalex-snapshot

A simple bypass assay for DNA polymerases shows that cancer‐associated hypermutating variants exhibit differences in vitro

inferred← citeshttps://doi.org/10.1111/j.1525-142x.2009.00393.xopenalex-snapshot

Phylogenetic analysis of developmental and postnatal mouse cell lineages

inferred← citeshttps://doi.org/10.1111/j.1749-6632.2012.06590.xopenalex-snapshot

Implications of genetic heterogeneity in cancer

inferred← citeshttps://doi.org/10.1126/science.1191125openalex-snapshot

Increased Mutagenesis and Unique Mutation Signature Associated with Mitotic Gene Conversion

inferred← citeshttps://doi.org/10.1126/science.1211154openalex-snapshot

Aneuploidy Drives a Mutator Phenotype in Cancer

inferred← citeshttps://doi.org/10.1128/jvi.02028-21openalex-snapshot

BK Polyomavirus Requires the Mismatch Repair Pathway for DNA Damage Response Activation

inferred← citeshttps://doi.org/10.1128/spectrum.01210-25openalex-snapshot

Entamoeba histolytica “mutator” strain with a high rate of genetic mutations assists the elucidation of drug resistance mechanisms

inferred← citeshttps://doi.org/10.1134/s0006297922010023openalex-snapshot

Effect of DNA Methylation on the 3′→5′ Exonuclease Activity of Major Human Abasic Site Endonuclease APEX1

inferred← citeshttps://doi.org/10.1134/s1019331622040256openalex-snapshot

Mechanisms of Coronavirus Genome Stability As Potential Targets for Antiviral Drugs

inferred← citeshttps://doi.org/10.1136/jitc-2021-002336openalex-snapshot

Additive effects of variants of unknown significance in replication repair-associated DNA polymerase genes on mutational burden and prognosis across diverse cancers

inferred← citeshttps://doi.org/10.1146/annurev-cellbio-100616-060447openalex-snapshot

The Inherent Asymmetry of DNA Replication

inferred← citeshttps://doi.org/10.1158/0008-5472.can-10-0784openalex-snapshot

Regulation of DNA Polymerase POLD4 Influences Genomic Instability in Lung Cancer

inferred← citeshttps://doi.org/10.1158/0008-5472.can-12-3342openalex-snapshot

The Exomes of the NCI-60 Panel: A Genomic Resource for Cancer Biology and Systems Pharmacology

inferred← citeshttps://doi.org/10.1158/0008-5472.can-13-2892openalex-snapshot

A Common Cancer-Associated DNA Polymerase ϵ Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading

inferred← citeshttps://doi.org/10.1158/0008-5472.can-14-0013openalex-snapshot

Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer

inferred← citeshttps://doi.org/10.1158/0008-5472.can-20-0624openalex-snapshot

Cancers from Novel Pole -Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade

inferred← citeshttps://doi.org/10.1158/0008-5472.can-20-3241openalex-snapshot

Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer

inferred← citeshttps://doi.org/10.1158/0008-5472.can-24-2589openalex-snapshot

Immune Checkpoint Blockade Delays Cancer Development and Extends Survival in DNA Polymerase Mutator Syndromes

inferred← citeshttps://doi.org/10.1158/0008-5472.can-25-3977openalex-snapshot

Deficiency in POLE Exonuclease Causes Synthetic Lethality in Highly Aneuploid Cancer Cells

inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-15-0057openalex-snapshot

POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-15-2233openalex-snapshot

Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis

inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-15-0399openalex-snapshot

miR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB Repair

inferred← citeshttps://doi.org/10.1158/2159-8290.cd-16-0146openalex-snapshot

Personalized Oncology Meets Immunology: The Path toward Precision Immunotherapy

inferred← citeshttps://doi.org/10.1159/000455753openalex-snapshot

Fragile Genes That Are Frequently Altered in Cancer: Players Not Passengers

inferred← citeshttps://doi.org/10.1172/jci122095openalex-snapshot

Polymerase-mediated ultramutagenesis in mice produces diverse cancers with high mutational load

inferred← citeshttps://doi.org/10.1177/0192623310362249openalex-snapshot

Case Series

inferred← citeshttps://doi.org/10.1186/1471-2164-14-39openalex-snapshot

Use of somatic mutations to quantify random contributions to mouse development

inferred← citeshttps://doi.org/10.1186/s12864-023-09310-8openalex-snapshot

Candidate variants in DNA replication and repair genes in early-onset renal cell carcinoma patients referred for germline testing

inferred← citeshttps://doi.org/10.1186/s12885-016-2544-2openalex-snapshot

Changes in mitochondrial stability during the progression of the Barrett’s esophagus disease sequence

inferred← citeshttps://doi.org/10.1186/s12916-025-04611-zopenalex-snapshot

The clinical landscape of POLE-mutant colorectal cancer: a retrospective analysis of real-world outcome

inferred← citeshttps://doi.org/10.1186/s13046-022-02422-1openalex-snapshot

POLE/POLD1 mutation and tumor immunotherapy

inferred← citeshttps://doi.org/10.1186/s13073-023-01234-yopenalex-snapshot

Recommendations for the classification of germline variants in the exonuclease domain of POLE and POLD1

inferred← citeshttps://doi.org/10.1200/po-25-00382openalex-snapshot

Secondary POLE Mutation Drives Metastasis in Hereditary Breast and Ovarian Cancer: Revealing Fallopian Tube Ultramutation

inferred← citeshttps://doi.org/10.1200/po.21.00267openalex-snapshot

Clinical and Molecular Characterization of POLE Mutations as Predictive Biomarkers of Response to Immune Checkpoint Inhibitors in Advanced Cancers

inferred← citeshttps://doi.org/10.1201/b14587-4openalex-snapshot

Genetic Instability of Cancer

inferred← citeshttps://doi.org/10.1266/ggs.18-00015openalex-snapshot

Spontaneous de novo germline mutations in humans and mice: rates, spectra, causes and consequences

inferred← citeshttps://doi.org/10.1371/annotation/db1d9553-4ebd-4015-a1cd-c483dbc0d7e5openalex-snapshot

Correction: Mutator Suppression and Escape from Replication Error–Induced Extinction in Yeast

inferred← citeshttps://doi.org/10.1371/journal.pgen.1001209openalex-snapshot

Mismatch Repair–Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase ε

inferred← citeshttps://doi.org/10.1371/journal.pgen.1002282openalex-snapshot

Mutator Suppression and Escape from Replication Error–Induced Extinction in Yeast

inferred← citeshttps://doi.org/10.1371/journal.pgen.1002680openalex-snapshot

Recombination Drives Vertebrate Genome Contraction

inferred← citeshttps://doi.org/10.1371/journal.pgen.1003016openalex-snapshot

Mismatch Repair Balances Leading and Lagging Strand DNA Replication Fidelity

inferred← citeshttps://doi.org/10.1371/journal.pgen.1003899openalex-snapshot

A Reversible Histone H3 Acetylation Cooperates with Mismatch Repair and Replicative Polymerases in Maintaining Genome Stability

inferred← citeshttps://doi.org/10.1371/journal.pgen.1005049openalex-snapshot

Replicative DNA Polymerase δ but Not ε Proofreads Errors in Cis and in Trans

inferred← citeshttps://doi.org/10.1371/journal.pgen.1005151openalex-snapshot

Volatility of Mutator Phenotypes at Single Cell Resolution

inferred← citeshttps://doi.org/10.1371/journal.pgen.1009526openalex-snapshot

Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication

inferred← citeshttps://doi.org/10.1515/bjmg-2017-0028openalex-snapshot

Detection of allelic variants of the POLE and POLD1 genes in colorectal cancer patients

inferred← citeshttps://doi.org/10.15252/embj.2019103367openalex-snapshot

Excessive excision of correct nucleotides during DNA synthesis explained by replication hurdles

inferred← citeshttps://doi.org/10.1530/ec-20-0258openalex-snapshot

POLE and POLD1 pathogenic variants in the proofreading domain in papillary thyroid cancer

inferred← citeshttps://doi.org/10.1534/g3.118.200042openalex-snapshot

Functional Analysis of Cancer-Associated DNA Polymerase ε Variants inSaccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1534/genetics.112.146910openalex-snapshot

Emergence of DNA Polymerase ε Antimutators That Escape Error-Induced Extinction in Yeast

inferred← citeshttps://doi.org/10.1534/genetics.113.160960openalex-snapshot

DNA Replication Error-Induced Extinction of Diploid Yeast

inferred← citeshttps://doi.org/10.1534/genetics.120.303333openalex-snapshot

Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells

inferred← citeshttps://doi.org/10.1534/genetics.120.303813openalex-snapshot

John W. (Jan) Drake: A Biochemical View of a Geneticist Par Excellence

inferred← citeshttps://doi.org/10.18632/oncotarget.16508openalex-snapshot

The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C)

inferred← citeshttps://doi.org/10.21037/atm-20-7553openalex-snapshot

Distinctive genomic characteristics in POLE/POLD1-mutant cancers can potentially predict beneficial clinical outcomes in patients who receive immune checkpoint inhibitor

inferred← citeshttps://doi.org/10.2174/1389200216666150812123554openalex-snapshot

Diallyl Sulfide: Potential Use in Novel Therapeutic Interventions in Alcohol, Drugs, and Disease Mediated Cellular Toxicity by Targeting Cytochrome P450 2E1

inferred← citeshttps://doi.org/10.2174/9789815080384123010007openalex-snapshot

Biology of Cancer

inferred← citeshttps://doi.org/10.26508/lsa.201900321openalex-snapshot

Human DNA polymerase delta requires an iron–sulfur cluster for high-fidelity DNA synthesis

inferred← citeshttps://doi.org/10.26508/lsa.201900323openalex-snapshot

Human DNA polymerase delta is a pentameric holoenzyme with a dimeric p12 subunit

inferred← citeshttps://doi.org/10.3103/s0027134920050124openalex-snapshot

Self-Organized Criticality in the Autowave Model of Speciation

showing the first 200 of 228

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.