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A Simple Bypass Assay for DNA Polymerases Shows Hypermutating Variants Associated with Cancer Show Mechanistic Differences In Vitro

https://doi.org/10.1101/2022.01.10.475213

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/j.1460-2075.1993.tb05790.xopenalex-snapshot

Pathway correcting DNA replication errors in Saccharomyces cerevisiae.

inferredcites →https://doi.org/10.1007/bf00928361openalex-snapshot

Physiological concentrations of purines and pyrimidines

inferredcites →https://doi.org/10.1007/s00294-018-0820-1openalex-snapshot

Fidelity of DNA replication—a matter of proofreading

inferredcites →https://doi.org/10.1016/j.dnarep.2017.06.003openalex-snapshot

Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy

inferredcites →https://doi.org/10.1016/j.molcel.2016.05.003openalex-snapshot

DNA Replication—A Matter of Fidelity

inferredcites →https://doi.org/10.1016/j.molcel.2020.05.012openalex-snapshot

POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status

inferredcites →https://doi.org/10.1038/nrc.2015.12openalex-snapshot

A panoply of errors: polymerase proofreading domain mutations in cancer

inferredcites →https://doi.org/10.1038/nsmb1040openalex-snapshot

Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo–electron microscopy

inferredcites →https://doi.org/10.1038/s41467-018-04002-4openalex-snapshot

Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair

inferredcites →https://doi.org/10.1038/s41467-018-08114-9openalex-snapshot

Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε

inferredcites →https://doi.org/10.1038/s41467-018-08145-2openalex-snapshot

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

inferredcites →https://doi.org/10.1038/s41467-020-14898-6openalex-snapshot

Structure of the processive human Pol δ holoenzyme

inferredcites →https://doi.org/10.1038/s41467-020-16910-5openalex-snapshot

Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome

inferredcites →https://doi.org/10.1073/pnas.0907147106openalex-snapshot

DNA polymerase ε and δ proofreading suppress discrete mutator and cancer phenotypes in mice

inferredcites →https://doi.org/10.1073/pnas.2017637117openalex-snapshot

Structure of eukaryotic DNA polymerase δ bound to the PCNA clamp while encircling DNA

inferredcites →https://doi.org/10.1074/jbc.m111.256289openalex-snapshot

Studies on Human DNA Polymerase ϵ and GINS Complex and Their Role in DNA Replication

inferredcites →https://doi.org/10.1093/nar/gkab160openalex-snapshot

Mutagenic mechanisms of cancer-associated DNA polymerase ϵ alleles

inferredcites →https://doi.org/10.1093/nar/gku1184openalex-snapshot

Significant contribution of the 3′→5′ exonuclease activity to the high fidelity of nucleotide incorporation catalyzed by human DNA polymerase ϵ

inferredcites →https://doi.org/10.1093/nar/gku1353openalex-snapshot

Switching between polymerase and exonuclease sites in DNA polymerase ε

inferredcites →https://doi.org/10.1101/gr.174789.114openalex-snapshot

Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication

inferredcites →https://doi.org/10.1146/annurev-biochem-061516-044709openalex-snapshot

Eukaryotic DNA Replication Fork

inferredcites →https://doi.org/10.1371/journal.pgen.1008572openalex-snapshot

Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer

inferredcites →https://doi.org/10.1371/journal.pgen.1009526openalex-snapshot

Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication

inferredcites →https://doi.org/10.1371/journal.pone.0094835openalex-snapshot

Crystal Structure of Yeast DNA Polymerase ε Catalytic Domain

inferredcites →https://doi.org/10.1534/g3.118.200042openalex-snapshot

Functional Analysis of Cancer-Associated DNA Polymerase ε Variants inSaccharomyces cerevisiae

inferredcites →https://doi.org/10.3390/cancers12123489openalex-snapshot

DNA Polymerases at the Eukaryotic Replication Fork Thirty Years after: Connection to Cancer

inferredcites →https://doi.org/10.3390/genes8020057openalex-snapshot

A Critical Balance: dNTPs and the Maintenance of Genome Stability

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