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Piezo1, a mechanically activated ion channel, is required for vascular development in mice

https://doi.org/10.1073/pnas.1409233111
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/gene.10152openalex-snapshot
What cardiovascular defect does my prenatal mouse mutant have, and why?
inferredcites →https://doi.org/10.1007/bf00190388openalex-snapshot
Digital particle image velocimetry
inferredcites →https://doi.org/10.1007/s00249-008-0318-8openalex-snapshot
The mechano-gated K2P channel TREK-1
inferredcites →https://doi.org/10.1007/s00424-005-1424-4openalex-snapshot
The mechanosensitive nature of TRPV channels
inferredcites →https://doi.org/10.1007/s12013-011-9158-8openalex-snapshot
Fluid Dynamics of Heart Development
inferredcites →https://doi.org/10.1016/j.cell.2009.09.010openalex-snapshot
Mechanotransduction by Hair Cells: Models, Molecules, and Mechanisms
inferredcites →https://doi.org/10.1016/j.cell.2014.02.026openalex-snapshot
Merkel Cells Transduce and Encode Tactile Stimuli to Drive Aβ-Afferent Impulses
inferredcites →https://doi.org/10.1016/j.conb.2009.07.008openalex-snapshot
Mammalian somatosensory mechanotransduction
inferredcites →https://doi.org/10.1016/j.devcel.2005.12.006openalex-snapshot
Mechanisms of Mechanotransduction
inferredcites →https://doi.org/10.1016/j.neuron.2012.04.023openalex-snapshot
How We Feel: Ion Channel Partnerships that Detect Mechanical Inputs and Give Rise to Touch and Pain Perception
inferredcites →https://doi.org/10.1016/j.tins.2012.04.002openalex-snapshot
Sensing pressure with ion channels
inferredcites →https://doi.org/10.1016/s0006-3495(79)85267-4openalex-snapshot
Response latency of vertebrate hair cells
inferredcites →https://doi.org/10.1038/35065539openalex-snapshot
Defining brain wiring patterns and mechanisms through gene trapping in mice
inferredcites →https://doi.org/10.1038/embor.2013.170openalex-snapshot
Piezo1‐dependent stretch‐activated channels are inhibited by Polycystin‐2 in renal tubular epithelial cells
inferredcites →https://doi.org/10.1038/nature01282openalex-snapshot
Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis
inferredcites →https://doi.org/10.1038/nature03952openalex-snapshot
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
inferredcites →https://doi.org/10.1038/nature06254openalex-snapshot
Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch
inferredcites →https://doi.org/10.1038/nature10316openalex-snapshot
Dynamic molecular processes mediate cellular mechanotransduction
inferredcites →https://doi.org/10.1038/nature10801openalex-snapshot
The role of Drosophila Piezo in mechanical nociception
inferredcites →https://doi.org/10.1038/nature10812openalex-snapshot
Piezo proteins are pore-forming subunits of mechanically activated channels
inferredcites →https://doi.org/10.1038/nature11685openalex-snapshot
Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation
inferredcites →https://doi.org/10.1038/nature13250openalex-snapshot
Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors
inferredcites →https://doi.org/10.1038/nature13251openalex-snapshot
Piezo2 is required for Merkel-cell mechanotransduction
inferredcites →https://doi.org/10.1038/ncomms2899openalex-snapshot
Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels
inferredcites →https://doi.org/10.1038/nm1338openalex-snapshot
Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice
inferredcites →https://doi.org/10.1038/nn1362openalex-snapshot
The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals
inferredcites →https://doi.org/10.1038/nrm2595openalex-snapshot
Neurosensory mechanotransduction
inferredcites →https://doi.org/10.1038/nrm2596openalex-snapshot
Mechanotransduction in vascular physiology and atherogenesis
inferredcites →https://doi.org/10.1038/nrm2597openalex-snapshot
Mechanotransduction gone awry
inferredcites →https://doi.org/10.1038/nrn2993openalex-snapshot
Molecular mechanisms of mechanotransduction in mammalian sensory neurons
inferredcites →https://doi.org/10.1073/pnas.0407474101openalex-snapshot
The role of the glycocalyx in reorganization of the actin cytoskeleton under fluid shear stress: A “bumper-car” model
inferredcites →https://doi.org/10.1073/pnas.1221400110openalex-snapshot
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis
inferredcites →https://doi.org/10.1093/emboj/17.15.4283openalex-snapshot
A mammalian two pore domain mechano‐gated S‐like K+ channel
inferredcites →https://doi.org/10.1097/moh.0b013e3282fa7445openalex-snapshot
Rho signaling and mechanical control of vascular development
inferredcites →https://doi.org/10.1097/moh.0b013e32835f6870openalex-snapshot
Disorders of red cell volume regulation
inferredcites →https://doi.org/10.1111/j.1549-8719.2010.00025.xopenalex-snapshot
The Effects of Hemodynamic Force on Embryonic Development
inferredcites →https://doi.org/10.1113/jphysiol.1984.sp015317openalex-snapshot
Stretch‐activated single ion channel currents in tissue‐cultured embryonic chick skeletal muscle.
inferredcites →https://doi.org/10.1126/science.1193270openalex-snapshot
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
inferredcites →https://doi.org/10.1126/science.287.5461.2229openalex-snapshot
A Drosophila Mechanosensory Transduction Channel
inferredcites →https://doi.org/10.1146/annurev.biophys.37.032807.125836openalex-snapshot
Eukaryotic Mechanosensitive Channels
inferredcites →https://doi.org/10.1152/ajpheart.01047.2006openalex-snapshot
Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell
inferredcites →https://doi.org/10.1152/physrev.1995.75.3.519openalex-snapshot
Flow-mediated endothelial mechanotransduction
inferredcites →https://doi.org/10.1159/000356667openalex-snapshot
Calcium's Role in Mechanotransduction during Muscle Development
inferredcites →https://doi.org/10.1161/circresaha.108.192765openalex-snapshot
Ciliary Polycystin-2 Is a Mechanosensitive Calcium Channel Involved in Nitric Oxide Signaling Cascades
inferredcites →https://doi.org/10.1182/blood-2002-08-2531openalex-snapshot
Circulation is established in a stepwise pattern in the mammalian embryo
inferredcites →https://doi.org/10.1242/dev.00831openalex-snapshot
Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis
inferredcites →https://doi.org/10.1242/dev.00929openalex-snapshot
Flow regulates arterial-venous differentiation in the chick embryo yolk sac
inferredcites →https://doi.org/10.1242/dev.02883openalex-snapshot
Vascular remodeling of the mouse yolk sac requires hemodynamic force
inferredcites →https://doi.org/10.1371/journal.pone.0002853openalex-snapshot
Three-Dimensional Analysis of Vascular Development in the Mouse Embryo
inferredcites →https://doi.org/10.1371/journal.pone.0024338openalex-snapshot
JNK2 Promotes Endothelial Cell Alignment under Flow
inferredcites →https://doi.org/10.1523/jneurosci.0522-13.2013openalex-snapshot
piezo2bRegulates Vertebrate Light Touch Response
inferredcites →https://doi.org/10.2144/000112034openalex-snapshot
Clearing and Photography of Whole Mount X-Gal Stained Mouse Embryos

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Oscillatory cortical forces promote three dimensional mesenchymal cell intercalations to shape the mandibular arch
inferred← citeshttps://doi.org/10.2139/ssrn.3804753openalex-extracted
Mechanosensitive Piezo1 Mediates Bone Fracture Repair by Promoting Angiogenesis Through Notch Signaling
inferred← citeshttps://doi.org/10.2139/ssrn.4154102openalex-extracted
Targeting PIEZO1 Refines Macrophage Function in Atherosclerosis
inferred← citeshttps://doi.org/10.2139/ssrn.4574779openalex-extracted
Exome Sequencing Identifies Genetic Variants in Patients with Varicose Veins
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Remotely Actuated Magnetic Nanocarpets for Bone Tissue Engineering: Non‐Invasive Modulation of Mechanosensitive Ion Channels for Enhanced Osteogenesis
inferred← citeshttps://doi.org/10.1002/adfm.202529076openalex-snapshot
MagPiezo: A Magnetogenetic Platform for Remote Activation of Endogenous Piezo1 Channels in Endothelial Cells
inferred← citeshttps://doi.org/10.1002/adhm.202402167openalex-snapshot
Force versus Response: Methods for Activating and Characterizing Mechanosensitive Ion Channels and GPCRs
inferred← citeshttps://doi.org/10.1002/adma.201808050openalex-snapshot
Mechanically Defined Microenvironment Promotes Stabilization of Microvasculature, Which Correlates with the Enrichment of a Novel Piezo‐1+ Population of Circulating CD11b+/CD115+ Monocytes
inferred← citeshttps://doi.org/10.1002/advs.202105809openalex-snapshot
Acoustofluidic Stimulation of Functional Immune Cells in a Microreactor
inferred← citeshttps://doi.org/10.1002/advs.202206190openalex-snapshot
Light‐Induced Nanoscale Deformation in Azobenzene Thin Film Triggers Rapid Intracellular Ca 2+ Increase via Mechanosensitive Cation Channels
inferred← citeshttps://doi.org/10.1002/advs.202303367openalex-snapshot
Spatial Mechano‐Signaling Regulation of GTPases through Non‐Degradative Ubiquitination
inferred← citeshttps://doi.org/10.1002/advs.202509715openalex-snapshot
Magnetic Fe 3 O 4 Nanoparticles Modified Hydroxyapatite Whisker: A Novel Framework with Superior Osteogenic Efficacy
inferred← citeshttps://doi.org/10.1002/advs.202511774openalex-snapshot
PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity
inferred← citeshttps://doi.org/10.1002/ajh.24929openalex-snapshot
Hereditary stomatocytosis: An underdiagnosed condition
inferred← citeshttps://doi.org/10.1002/ajh.25008openalex-snapshot
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Veins and Arteries Build Hierarchical Branching Patterns Differently: Bottom‐Up versus Top‐Down
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inferred← citeshttps://doi.org/10.1002/cm.21652openalex-snapshot
Early events in endothelial flow sensing
inferred← citeshttps://doi.org/10.1002/cns.70715openalex-snapshot
High Shear Stress‐Induced Endothelial Piezo1 Downregulation Promotes Intracranial Aneurysm Formation via the PDGF ‐ BB / PDGFRβ Paracrine Signaling Pathway
inferred← citeshttps://doi.org/10.1002/cph4.70256openalex-snapshot
Neuro‐Immune Interaction: A New Therapeutic Target for Cardiovascular Diseases
inferred← citeshttps://doi.org/10.1002/cphy.c230005openalex-snapshot
Mechanosensing in Metabolism
inferred← citeshttps://doi.org/10.1002/dvdy.401openalex-snapshot
Emerging role of Piezo ion channels in cardiovascular development
inferred← citeshttps://doi.org/10.1002/dvg.23476openalex-snapshot
Generation of Piezo1‐CreER transgenic mice for visualization and lineage tracing of mechanical force responsive cells in vivo
inferred← citeshttps://doi.org/10.1002/glia.24251openalex-snapshot
Piezo channels contribute to the regulation of myelination in Schwann cells
inferred← citeshttps://doi.org/10.1002/glia.24334openalex-snapshot
Mechanosensitive channel Piezo1 is an essential regulator in cell cycle progression of optic nerve head astrocytes
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2023.tb00284.xopenalex-snapshot
Mechanosensitive Channels in Lung Health and Disease
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2024.tb00289.xopenalex-snapshot
Mechanosensing in Metabolism
inferred← citeshttps://doi.org/10.1002/jcp.30056openalex-snapshot
Analyzing the shear‐induced sensitization of mechanosensitive ion channel Piezo‐1 in human aortic endothelial cells
inferred← citeshttps://doi.org/10.1002/jcp.30470openalex-snapshot
Novel insights for the role of nitric oxide in placental vascular function during and beyond pregnancy
inferred← citeshttps://doi.org/10.1002/jcp.30623openalex-snapshot
Biphasic effect of mechanical stress on lymphocyte activation
inferred← citeshttps://doi.org/10.1002/jcp.30656openalex-snapshot
Piezo1 controls cell volume and migration by modulating swelling‐activated chloride current through Ca 2+ influx
inferred← citeshttps://doi.org/10.1002/jcp.30958openalex-snapshot
Signaling mechanisms in red blood cells: A view through the protein phosphorylation and deformability
inferred← citeshttps://doi.org/10.1002/jcp.31001openalex-snapshot
Regulation of PIEZO1 channels by lipids and the structural components of extracellular matrix/cell cytoskeleton
inferred← citeshttps://doi.org/10.1002/jcp.70036openalex-snapshot
Piezo1 Is Related to the Enamel Matrix Formation in Mouse Tooth Germ Development
inferred← citeshttps://doi.org/10.1002/jev2.70375openalex-snapshot
Shear Stress‐Stimulated Trafficking of Endothelial Piezo1 to Splenic Capsule Boosts Spleen Contraction and Exercise Endurance
inferred← citeshttps://doi.org/10.1002/jex2.70182openalex-snapshot
Engineering Piezo1‐Mediated Calcium Signalling for Enhanced Extracellular Vesicle Biogenesis and Cargo Loading
inferred← citeshttps://doi.org/10.1002/pd.6451openalex-snapshot
PIEZO1 is the most common monogenic etiology of non‐immune hydrops fetalis detected by prenatal exome sequencing
inferred← citeshttps://doi.org/10.1002/prot.25384openalex-snapshot
Investigating the structural dynamics of the PIEZO1 channel activation and inactivation by coarse‐grained modeling
inferred← citeshttps://doi.org/10.1002/pul2.70371openalex-snapshot
Functional Role of Piezo1 in Regulating Whole‐Lung Vascular Reactivity
inferred← citeshttps://doi.org/10.1002/smll.202103466openalex-snapshot
Generation, Transmission, and Regulation of Mechanical Forces in Embryonic Morphogenesis
inferred← citeshttps://doi.org/10.1002/wdev.363openalex-snapshot
Postnatal development of cerebrovascular structure and the neurogliovascular unit
inferred← citeshttps://doi.org/10.1007/112_2015_26openalex-snapshot
The Piezo Mechanosensitive Ion Channels: May the Force Be with You!
inferred← citeshttps://doi.org/10.1007/112_2020_32openalex-snapshot
Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues
inferred← citeshttps://doi.org/10.1007/164_2019_336openalex-snapshot
Ion Channel Pharmacology for Pain Modulation
inferred← citeshttps://doi.org/10.1007/978-1-0716-5360-9_19openalex-snapshot
Direct Observation and Measurement of Membrane Tension in Xenopus laevis Animal Cap Explants Using the Mechanosensitive Dye, Flipper-TR
inferred← citeshttps://doi.org/10.1007/978-3-030-46725-8_6openalex-snapshot
Role of Biomechanical Stress and Mechanosensitive miRNAs in Calcific Aortic Valve Disease
inferred← citeshttps://doi.org/10.1007/978-3-030-63164-2_13openalex-snapshot
Exploitation of Vascular Mechanobiology for Therapy Innovations
inferred← citeshttps://doi.org/10.1007/978-3-030-63164-2_5openalex-snapshot
GPCRs Under Flow and Pressure
inferred← citeshttps://doi.org/10.1007/978-3-030-63164-2_6openalex-snapshot
Hemodynamic Control of Endothelial Cell Fates in Development
inferred← citeshttps://doi.org/10.1007/978-3-031-23965-6_2openalex-snapshot
Mechanotransduction in Heart Development
inferred← citeshttps://doi.org/10.1007/978-3-031-45379-3_5openalex-snapshot
The Physical Factors Involved in Cancer Progression
inferred← citeshttps://doi.org/10.1007/978-3-032-19509-8_3openalex-snapshot
PIEZO1 in Immune Cells: From Force to Function
inferred← citeshttps://doi.org/10.1007/978-3-032-22637-2_5openalex-snapshot
Biophysical Considerations in Cell Fusion
inferred← citeshttps://doi.org/10.1007/978-3-319-18705-1_7openalex-snapshot
TRP Channels and Mechanical Transduction
inferred← citeshttps://doi.org/10.1007/978-3-319-41523-9_10openalex-snapshot
Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors
inferred← citeshttps://doi.org/10.1007/978-3-319-57732-6_24openalex-snapshot
Cardiovascular and Hemostatic Disorders: SOCE in Cardiovascular Cells: Emerging Targets for Therapeutic Intervention
inferred← citeshttps://doi.org/10.1007/978-4-431-54801-0_15openalex-snapshot
Innovation of Vascular Engineering by Mechanomedicine
inferred← citeshttps://doi.org/10.1007/978-981-10-6244-5_4openalex-snapshot
Principles of Mechanosensing at the Membrane Interface
inferred← citeshttps://doi.org/10.1007/978-981-16-4254-8_3openalex-snapshot
Ion Channels in Biophysics and Physiology: Methods & Challenges to Study Mechanosensitive Ion Channels
inferred← citeshttps://doi.org/10.1007/978-981-16-6206-5_14openalex-snapshot
Genetic Association in Lower Limb Swelling
inferred← citeshttps://doi.org/10.1007/978-981-96-7448-0_1-1openalex-snapshot
Piezo Channels: Roles in Craniofacial Development and Dentistry
inferred← citeshttps://doi.org/10.1007/978-981-99-0846-2_46-1openalex-snapshot
The Role of Stem Cells in Exercise-Enhanced Organogenesis and Regeneration
inferred← citeshttps://doi.org/10.1007/978-981-99-7119-0_46openalex-snapshot
The Role of Stem Cells in Exercise-Enhanced Organogenesis and Regeneration
inferred← citeshttps://doi.org/10.1007/s00018-015-1885-3openalex-snapshot
Blood flow mechanics in cardiovascular development
inferred← citeshttps://doi.org/10.1007/s00018-015-2018-8openalex-snapshot
Shear stress mediates exocytosis of functional TRPV4 channels in endothelial cells
inferred← citeshttps://doi.org/10.1007/s00018-024-05159-6openalex-snapshot
High-content method for mechanosignaling studies using IsoStretcher technology and quantitative Ca2+ imaging applied to Piezo1 in cardiac HL-1 cells
inferred← citeshttps://doi.org/10.1007/s00018-024-05372-3openalex-snapshot
PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis
inferred← citeshttps://doi.org/10.1007/s00018-025-05804-8openalex-snapshot
Piezo1 disrupts blood–brain barrier via CaMKII/Nrf2 in ischemic stroke
inferred← citeshttps://doi.org/10.1007/s00018-025-06026-8openalex-snapshot
Talin1 modulates the Piezo1–YAP axis to regulate endothelial cell inflammation and atherosclerosis
inferred← citeshttps://doi.org/10.1007/s00246-014-1061-9openalex-snapshot
Fontan Hepatic Fibrosis and Pulmonary Vascular Development
inferred← citeshttps://doi.org/10.1007/s00277-020-03955-1openalex-snapshot
Mechanosensitive Piezo1 ion channel protein (PIEZO1 gene): update and extended mutation analysis of hereditary xerocytosis in India
inferred← citeshttps://doi.org/10.1007/s00418-023-02181-wopenalex-snapshot
Developmental function of Piezo1 in mouse submandibular gland morphogenesis
inferred← citeshttps://doi.org/10.1007/s00424-014-1578-zopenalex-snapshot
Piezo channels: from structure to function
inferred← citeshttps://doi.org/10.1007/s00424-016-1811-zopenalex-snapshot
Piezo1-dependent regulation of urinary osmolarity
inferred← citeshttps://doi.org/10.1007/s00424-020-02369-2openalex-snapshot
It takes more than two to tango: mechanosignaling of the endothelial surface
inferred← citeshttps://doi.org/10.1007/s00424-022-02667-xopenalex-snapshot
Nobel somatosensations and pain
inferred← citeshttps://doi.org/10.1007/s00424-024-02951-yopenalex-snapshot
Piezo1, the new actor in cell volume regulation
inferred← citeshttps://doi.org/10.1007/s00424-024-02983-4openalex-snapshot
Alteration of Piezo1 signaling in type 2 diabetic mice: focus on endothelium and BKCa channel
inferred← citeshttps://doi.org/10.1007/s00429-024-02759-7openalex-snapshot
Expression patterns of Piezo1 in the developing mouse forebrain
inferred← citeshttps://doi.org/10.1007/s00432-020-03179-wopenalex-snapshot
The function of Piezo1 in colon cancer metastasis and its potential regulatory mechanism
inferred← citeshttps://doi.org/10.1007/s00441-018-2926-7openalex-snapshot
Piezo proteins: incidence and abundance in the enteric nervous system. Is there a link with mechanosensitivity?
inferred← citeshttps://doi.org/10.1007/s10409-025-25609-xopenalex-snapshot
Mechanobiological response of osteocyte PIEZO1 to induced piezoelectricity of bone matrix
inferred← citeshttps://doi.org/10.1007/s10522-016-9675-3openalex-snapshot
Different transcriptional profiling between senescent and non-senescent human coronary artery endothelial cells (HCAECs) by Omeprazole and Lansoprazole treatment
inferred← citeshttps://doi.org/10.1007/s10753-024-02234-9openalex-snapshot
Piezo1-Induced Nasal Epithelial Barrier Dysfunction in Allergic Rhinitis
inferred← citeshttps://doi.org/10.1007/s11010-024-05000-5openalex-snapshot
The mechanisms of exercise improving cardiovascular function by stimulating Piezo1 and TRP ion channels: a systemic review
inferred← citeshttps://doi.org/10.1007/s11033-025-10969-3openalex-snapshot
Piezo1 in heart failure: A new perspective from cytomechanical sensing to diverse cellular pathways
inferred← citeshttps://doi.org/10.1007/s11033-025-11114-wopenalex-snapshot
PIEZO1: a mechanosensitive ion channel in the pathogenesis and pharmacotherapy of diabetic neuropathy
inferred← citeshttps://doi.org/10.1007/s11255-026-05233-xopenalex-snapshot
The extracellular matrix Piezo1 feedback loop drives renal fibrosis through compartment-specific mechanotransduction
inferred← citeshttps://doi.org/10.1007/s11886-025-02278-9openalex-snapshot
Alteration of Essential Cell Function by Ultrasound-Targeted Microbubble Cavitation
inferred← citeshttps://doi.org/10.1007/s11906-020-1016-xopenalex-snapshot
Mechanisms of Synergistic Interactions of Diabetes and Hypertension in Chronic Kidney Disease: Role of Mitochondrial Dysfunction and ER Stress
inferred← citeshttps://doi.org/10.1007/s12079-020-00576-1openalex-snapshot
Biomechanical signal communication in vascular smooth muscle cells
inferred← citeshttps://doi.org/10.1007/s12551-021-00847-0openalex-snapshot
Computational studies of Piezo1 yield insights into key lipid–protein interactions, channel activation, and agonist binding
inferred← citeshttps://doi.org/10.1007/s12551-024-01246-xopenalex-snapshot
Biological sensing of fluid flow—lessons from PIEZO1
inferred← citeshttps://doi.org/10.1007/s12551-025-01379-7openalex-snapshot
Magneto-mechanics in mechanobiology: enabling remote force transmission to cells and extracellular matrix
inferred← citeshttps://doi.org/10.1007/s13577-022-00738-wopenalex-snapshot
The Piezo1 ion channel in glaucoma: a new perspective on mechanical stress
inferred← citeshttps://doi.org/10.1007/s13577-022-00853-8openalex-snapshot
Piezo protein determines stem cell fate by transmitting mechanical signals
inferred← citeshttps://doi.org/10.1007/s13577-024-01035-4openalex-snapshot
Role of mechanically-sensitive cation channels Piezo1 and TRPV4 in trabecular meshwork cell mechanotransduction
inferred← citeshttps://doi.org/10.1007/s13679-026-00754-zopenalex-snapshot
PIEZO Channels in Metabolism and Metabolic Diseases: Research Advances and Therapeutic Strategies
inferred← citeshttps://doi.org/10.1007/s40139-016-0117-3openalex-snapshot
Fluid Mechanics as a Driver of Tissue-Scale Mechanical Signaling in Organogenesis
inferred← citeshttps://doi.org/10.1007/s40778-020-00172-4openalex-snapshot
Mechanoregulation in Hematopoiesis and Hematologic Disorders
inferred← citeshttps://doi.org/10.1007/s40883-022-00264-zopenalex-snapshot
Molecular Circuit Discovery for Mechanobiology of Cardiovascular Disease
inferred← citeshttps://doi.org/10.1007/s42452-026-08291-zopenalex-snapshot
Piezo1 mediates oscillatory shear stress-induced endothelial-to-mesenchymal transition through the AP-1 and KLF2 regulatory pathways in mitral regurgitation
inferred← citeshttps://doi.org/10.1016/b978-0-12-809633-8.08094-8openalex-snapshot
Mechanosensory Transduction: Focus on Ion Channels ☆
inferred← citeshttps://doi.org/10.1016/b978-0-12-812532-8.00008-2openalex-snapshot
Genetic Disorders of the Lymphatic System
inferred← citeshttps://doi.org/10.1016/b978-0-12-817195-0.00001-9openalex-snapshot
Biomechanical regulation of endothelial function in atherosclerosis
inferred← citeshttps://doi.org/10.1016/b978-0-12-817195-0.00002-0openalex-snapshot
Molecular mechanisms of the vascular responses to hemodynamic forces
inferred← citeshttps://doi.org/10.1016/b978-0-323-90195-6.00019-xopenalex-snapshot
Extracellular matrix–dependent mechanosensing and mechanotransduction
inferred← citeshttps://doi.org/10.1016/b978-0-323-95262-0.00014-0openalex-snapshot
Liver fibrosis
inferred← citeshttps://doi.org/10.1016/b978-0-323-99742-3.00016-3openalex-snapshot
Magnetic nanomaterials for minimally invasive neuromodulation
inferred← citeshttps://doi.org/10.1016/bs.acr.2022.01.001openalex-snapshot
Molecular sensors for detection of tumor-stroma crosstalk
inferred← citeshttps://doi.org/10.1016/bs.ctdb.2018.12.009openalex-snapshot
Fluid forces shape the embryonic heart: Insights from zebrafish
inferred← citeshttps://doi.org/10.1016/bs.ctdb.2022.02.013openalex-snapshot
Plumbing our organs: Lessons from vascular development to instruct lab generated tissues
inferred← citeshttps://doi.org/10.1016/bs.ctdb.2024.02.001openalex-snapshot
Vascular development, remodeling and maturation
inferred← citeshttps://doi.org/10.1016/bs.ctm.2016.10.001openalex-snapshot
The Structural Basis for Sensing by the Piezo1 Protein
inferred← citeshttps://doi.org/10.1016/bs.ctm.2016.10.002openalex-snapshot
Regulation of Piezo Channels by Cellular Signaling Pathways
inferred← citeshttps://doi.org/10.1016/bs.ctm.2016.11.001openalex-snapshot
Piezo1 Channels in Vascular Development and the Sensing of Shear Stress
inferred← citeshttps://doi.org/10.1016/bs.ctm.2016.11.003openalex-snapshot
Mechanosensitive Piezo Channels in the Gastrointestinal Tract
inferred← citeshttps://doi.org/10.1016/bs.ctm.2016.11.004openalex-snapshot
The Kinetics and the Permeation Properties of Piezo Channels
inferred← citeshttps://doi.org/10.1016/bs.ctm.2016.11.005openalex-snapshot
A Microfluidic Approach for Studying Piezo Channels
inferred← citeshttps://doi.org/10.1016/bs.ctm.2016.11.006openalex-snapshot
In Touch With the Mechanosensitive Piezo Channels
inferred← citeshttps://doi.org/10.1016/bs.ctm.2016.11.007openalex-snapshot
A Tour de Force
inferred← citeshttps://doi.org/10.1016/bs.ctm.2017.01.001openalex-snapshot
Genetic Diseases of PIEZO1 and PIEZO2 Dysfunction
inferred← citeshttps://doi.org/10.1016/bs.ctm.2020.01.005openalex-snapshot
Ion channels in capillary endothelium
inferred← citeshttps://doi.org/10.1016/bs.ctm.2020.02.002openalex-snapshot
Endothelial inwardly-rectifying K+ channels as a key component of shear stress-induced mechanotransduction
inferred← citeshttps://doi.org/10.1016/bs.ctm.2021.07.001openalex-snapshot
Cardiovascular mechanosensitive ion channels—Translating physical forces into physiological responses
inferred← citeshttps://doi.org/10.1016/bs.mie.2020.12.024openalex-snapshot
Stretch and poke stimulation for characterizing mechanically activated ion channels
inferred← citeshttps://doi.org/10.1016/j.actbio.2024.12.034openalex-snapshot
PIEZO1-mediated mechanotransduction regulates collagen synthesis on nanostructured 2D and 3D models of fibrosis
inferred← citeshttps://doi.org/10.1016/j.ajpath.2024.10.007openalex-snapshot
The mRNA Stability of PIEZO1, Regulated by Methyltransferase-Like 3 via N6-Methylation of Adenosine Modification in a YT521-B Homology Domain Family 2–Dependent Manner, Facilitates the Progression of Diabetic Retinopathy
inferred← citeshttps://doi.org/10.1016/j.archoralbio.2024.105963openalex-snapshot
The role of the Piezo1 channel in osteoblasts under cyclic stretching: A study on osteogenic and osteoclast factors
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2016.03.007openalex-snapshot
Vascular endothelium – Gatekeeper of vessel health
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2025.120553openalex-snapshot
Mechanisms of matrix stiffness affecting calcific aortic valve disease by regulating Piezo1
inferred← citeshttps://doi.org/10.1016/j.avsg.2018.04.030openalex-snapshot
Mechanisms Underlying Atheroma Induction: The Roles of Mechanotransduction, Vascular Wall Cells, and Blood Cells
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2015.11.014openalex-snapshot
Hemodynamics driven cardiac valve morphogenesis
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2016.03.004openalex-snapshot
Interplay between cardiac function and heart development
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2019.02.016openalex-snapshot
An element for development: Calcium signaling in mammalian reproduction and development
inferred← citeshttps://doi.org/10.1016/j.bbrc.2018.02.058openalex-snapshot
Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation
inferred← citeshttps://doi.org/10.1016/j.bbrc.2019.08.078openalex-snapshot
Activation of Piezo1 mechanosensitive ion channel in HEK293T cells by 30 MHz vertically deployed surface acoustic waves
inferred← citeshttps://doi.org/10.1016/j.bbrc.2022.11.060openalex-snapshot
Piezo1 in endothelial cells is involved in vitamin D-induced vascular calcification
inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.151135openalex-snapshot
PIEZO1-mediated calcium influx transiently alters nuclear mechanical properties via actin remodeling in chondrocytes
inferred← citeshttps://doi.org/10.1016/j.bcmd.2020.102413openalex-snapshot
Heterogeneous phenotype of Hereditary Xerocytosis in association with PIEZO1 variants
inferred← citeshttps://doi.org/10.1016/j.bcmd.2021.102619openalex-snapshot
Trpv1 and Trpa1 are not essential for Psickle-like activity in red cells of the SAD mouse model of sickle cell disease
inferred← citeshttps://doi.org/10.1016/j.bcp.2018.10.023openalex-snapshot
Fluid shear stress sensing in vascular homeostasis and remodeling: Towards the development of innovative pharmacological approaches to treat vascular dysfunction
inferred← citeshttps://doi.org/10.1016/j.bcp.2019.08.013openalex-snapshot
Using Yoda-1 to mimic laminar flow in vitro: A tool to simplify drug testing
inferred← citeshttps://doi.org/10.1016/j.bcp.2022.115290openalex-snapshot
Endothelial mechanosensing: A forgotten target to treat vascular remodeling in hypertension?
inferred← citeshttps://doi.org/10.1016/j.bioadv.2023.213516openalex-snapshot
Mechanical activation of lung epithelial cells through the ion channel Piezo1 activates the metalloproteinases ADAM10 and ADAM17 and promotes growth factor and adhesion molecule release
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2018.05.058openalex-snapshot
Extracellular fluid viscosity enhances liver cancer cell mechanosensing and migration
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2019.01.010openalex-snapshot
Role of nuclear mechanosensitivity in determining cellular responses to forces and biomaterials
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2020.120283openalex-snapshot
Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel
inferred← citeshttps://doi.org/10.1016/j.biopha.2021.111692openalex-snapshot
Piezo-type mechanosensitive ion channel component 1 (Piezo1) in human cancer
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.114151openalex-snapshot
Endothelial GLUTs and vascular biology
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.114198openalex-snapshot
Effects of shear stress on vascular endothelial functions in atherosclerosis and potential therapeutic approaches
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115343openalex-snapshot
Barasertib impedes chondrocyte senescence and alleviates osteoarthritis by mitigating the destabilization of heterochromatin induced by AURKB
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.116545openalex-snapshot
Mechanical stress induced mitochondrial dysfunction in cardiovascular diseases: Novel mechanisms and therapeutic targets
inferred← citeshttps://doi.org/10.1016/j.bone.2020.115247openalex-snapshot
Identification of PIEZO1 polymorphisms for human bone mineral density
inferred← citeshttps://doi.org/10.1016/j.bpj.2016.12.009openalex-snapshot
Signatures of Mechanosensitive Gating
inferred← citeshttps://doi.org/10.1016/j.bpj.2017.10.035openalex-snapshot
Mechanical Transduction and the Dark Energy of Biology
inferred← citeshttps://doi.org/10.1016/j.bpj.2018.11.2049openalex-snapshot
Myosin-II Mediated Traction Forces Evoke Localized Piezo1 Ca2+ Flickers
inferred← citeshttps://doi.org/10.1016/j.bpj.2020.07.043openalex-snapshot
Piezo1 Forms Specific, Functionally Important Interactions with Phosphoinositides and Cholesterol
inferred← citeshttps://doi.org/10.1016/j.bpj.2020.11.2274openalex-snapshot
Mechanical Activation of MscL Revealed by a Locally Distributed Tension Molecular Dynamics Approach
inferred← citeshttps://doi.org/10.1016/j.bpj.2021.02.003openalex-snapshot
Modeling of full-length Piezo1 suggests importance of the proximal N-terminus for dome structure
inferred← citeshttps://doi.org/10.1016/j.bpj.2021.02.006openalex-snapshot
Molecular dynamics simulations of Piezo1 channel opening by increases in membrane tension
inferred← citeshttps://doi.org/10.1016/j.bpj.2024.12.025openalex-snapshot
Amyloid beta Aβ1-40 activates Piezo1 channels in brain capillary endothelial cells
inferred← citeshttps://doi.org/10.1016/j.bpj.2025.01.010openalex-snapshot
Single-particle tracking reveals heterogeneous PIEZO1 diffusion
inferred← citeshttps://doi.org/10.1016/j.bpj.2025.03.021openalex-snapshot
Flow-sensitive ion channels in vascular endothelial cells: Mechanisms of activation and roles in mechanotransduction
inferred← citeshttps://doi.org/10.1016/j.burns.2026.108078openalex-snapshot
Piezo1/2 in fibrosis: Cell-type-specific roles, organ-specific pathogenesis, and therapeutic implications
inferred← citeshttps://doi.org/10.1016/j.cdev.2021.203683openalex-snapshot
Mechanosensitive ion channels in cell migration
inferred← citeshttps://doi.org/10.1016/j.cdev.2021.203730openalex-snapshot
Reprint of: Mechanosensitive ion channels in cell migration
inferred← citeshttps://doi.org/10.1016/j.cdev.2021.203735openalex-snapshot
From remodeling to quiescence: The transformation of the vascular network
inferred← citeshttps://doi.org/10.1016/j.ceb.2017.10.003openalex-snapshot
Mechanical cell competition
inferred← citeshttps://doi.org/10.1016/j.ceb.2018.05.007openalex-snapshot
The mechanobiology of zebrafish cardiac valve leaflet formation
inferred← citeshttps://doi.org/10.1016/j.ceb.2023.102216openalex-snapshot
Mechanosensitive GPCRs and ion channels in shear stress sensing
inferred← citeshttps://doi.org/10.1016/j.ceca.2019.03.007openalex-snapshot
Mechanosensitive ion channels push cancer progression
inferred← citeshttps://doi.org/10.1016/j.ceca.2021.102367openalex-snapshot
Piezo1 impairs hepatocellular tumor growth via deregulation of the MAPK-mediated YAP signaling pathway
inferred← citeshttps://doi.org/10.1016/j.ceca.2021.102431openalex-snapshot
Mechanosensitive Piezo1 in endothelial cells promotes angiogenesis to support bone fracture repair
inferred← citeshttps://doi.org/10.1016/j.ceca.2022.102571openalex-snapshot
Mechanosensitive Piezo1 channel in rat epididymal epithelial cells promotes transepithelial K+ secretion
inferred← citeshttps://doi.org/10.1016/j.cej.2023.142521openalex-snapshot
Viscosity-triggered near-infrared fluorescence nanoprobe for in vivo non-invasive diagnosis of cancer
inferred← citeshttps://doi.org/10.1016/j.cej.2025.163315openalex-snapshot
Mechanotransduction-driven immunointegration at soft-hard tissue interfaces facilitates aged bone regeneration
inferred← citeshttps://doi.org/10.1016/j.cell.2018.02.047openalex-snapshot
Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection
inferred← citeshttps://doi.org/10.1016/j.cell.2018.03.076openalex-snapshot
GPR68 Senses Flow and Is Essential for Vascular Physiology
inferred← citeshttps://doi.org/10.1016/j.cell.2019.08.049openalex-snapshot
Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels
inferred← citeshttps://doi.org/10.1016/j.cell.2020.01.033openalex-snapshot
TACAN Is an Ion Channel Involved in Sensing Mechanical Pain
inferred← citeshttps://doi.org/10.1016/j.cell.2020.06.022openalex-snapshot
RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis
inferred← citeshttps://doi.org/10.1016/j.cell.2021.01.024openalex-snapshot
A role of PIEZO1 in iron metabolism in mice and humans
inferred← citeshttps://doi.org/10.1016/j.cell.2024.04.010openalex-snapshot
Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact
inferred← citeshttps://doi.org/10.1016/j.cell.2025.02.031openalex-snapshot
Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force
inferred← citeshttps://doi.org/10.1016/j.celrep.2015.09.072openalex-snapshot
Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling
inferred← citeshttps://doi.org/10.1016/j.celrep.2017.05.079openalex-snapshot
Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels
inferred← citeshttps://doi.org/10.1016/j.celrep.2017.10.120openalex-snapshot
Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.108225openalex-snapshot
Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.109914openalex-snapshot
Patch-seq of mouse DRG neurons reveals candidate genes for specific mechanosensory functions
inferred← citeshttps://doi.org/10.1016/j.celrep.2022.110342openalex-snapshot
Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-β-catenin mechanotransduction complex
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112837openalex-snapshot
Force-induced motions of the PIEZO1 blade probed with fluorimetry
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.113128openalex-snapshot
Pannexin-1 opening in neuronal edema causes cell death but also leads to protection via increased microglia contacts
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.113652openalex-snapshot
Piezo1-dependent regulation of pericyte proliferation by blood flow during brain vascular development
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.114014openalex-snapshot
TMC7 functions as a suppressor of Piezo2 in primary sensory neurons blunting peripheral mechanotransduction
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.114334openalex-snapshot
Tentonin 3 is a pore-forming subunit of a slow inactivation mechanosensitive channel
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.114398openalex-snapshot
Piezo regulates epithelial topology and promotes precision in organ size control
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.115405openalex-snapshot
PIEZO1-dependent mode switch of neuronal migration in heterogeneous microenvironments in the developing brain
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