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Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ana.10312openalex-snapshot

Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress–induced death of motor neurons in amyotrophic lateral sclerosis

inferredcites →https://doi.org/10.1002/ana.1252openalex-snapshot

Disease mechanisms revealed by transcription profiling in SOD1‐G93A transgenic mouse spinal cord

inferredcites →https://doi.org/10.1002/ana.410160105openalex-snapshot

Clinical and genetic variations in the syndrome of adult GM2 gangliodosis resulting from hexosaminidase a deficiency

inferredcites →https://doi.org/10.1002/ana.410170413openalex-snapshot

Motor neuron disease and adult hexosaminidase a deficiency in two families: Evidence for multisystem degeneration

inferredcites →https://doi.org/10.1002/ana.410180111openalex-snapshot

Ganglioside patterns in amyotrophic lateral sclerosis brain regions

inferredcites →https://doi.org/10.1002/ana.410270517openalex-snapshot

Polyclonal IgM anti‐GM1 ganglioside antibody in patients with motor neuron disease and variants

inferredcites →https://doi.org/10.1002/ana.410400105openalex-snapshot

Cerebrovascular complications of Fabry's disease

inferredcites →https://doi.org/10.1002/jnr.490120209openalex-snapshot

Gangliosides of human spinal cord: Aberrant composition of cords from patients with amyotrophic lateral sclerosis

inferredcites →https://doi.org/10.1002/jnr.490380305openalex-snapshot

Differentiation of oligodendrocytes cultured from developing rat brain is enhanced by exogenous GM3 ganglioside

inferredcites →https://doi.org/10.1016/j.ajhg.2012.05.001openalex-snapshot

Spinal Muscular Atrophy Associated with Progressive Myoclonic Epilepsy Is Caused by Mutations in ASAH1

inferredcites →https://doi.org/10.1016/j.ajhg.2012.11.021openalex-snapshot

Loss of Function of Glucocerebrosidase GBA2 Is Responsible for Motor Neuron Defects in Hereditary Spastic Paraplegia

inferredcites →https://doi.org/10.1016/j.ajhg.2013.05.006openalex-snapshot

Alteration of Ganglioside Biosynthesis Responsible for Complex Hereditary Spastic Paraplegia

inferredcites →https://doi.org/10.1016/j.bbagen.2007.08.010openalex-snapshot

The Yin and Yang of lactosylceramide metabolism: Implications in cell function

inferredcites →https://doi.org/10.1016/j.bbalip.2013.06.001openalex-snapshot

New insights on glucosylated lipids: Metabolism and functions

inferredcites →https://doi.org/10.1016/j.neuron.2013.12.009openalex-snapshot

Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration

inferredcites →https://doi.org/10.1016/j.neuron.2014.01.011openalex-snapshot

Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

inferredcites →https://doi.org/10.1016/j.neuron.2014.01.013openalex-snapshot

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

inferredcites →https://doi.org/10.1016/j.stem.2014.03.004openalex-snapshot

Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1

inferredcites →https://doi.org/10.1016/j.ymgme.2007.04.001openalex-snapshot

A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease

inferredcites →https://doi.org/10.1016/s0074-7742(09)85022-8openalex-snapshot

Chapter 22 Neurotrophic and Neuroprotective Actions of an Enhancer of Ganglioside Biosynthesis

inferredcites →https://doi.org/10.1038/85879openalex-snapshot

Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I

inferredcites →https://doi.org/10.1038/nbt.1957openalex-snapshot

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

inferredcites →https://doi.org/10.1038/nn.3357openalex-snapshot

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

inferredcites →https://doi.org/10.1038/nn.3584openalex-snapshot

State of play in amyotrophic lateral sclerosis genetics

inferredcites →https://doi.org/10.1038/nn2073openalex-snapshot

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

inferredcites →https://doi.org/10.1038/sj.sc.3101232openalex-snapshot

Ganglioside patterns in human spinal cord

inferredcites →https://doi.org/10.1073/pnas.0607721104openalex-snapshot

A missense mutation in the 3-ketodihydrosphingosine reductase FVT1 as candidate causal mutation for bovine spinal muscular atrophy

inferredcites →https://doi.org/10.1073/pnas.0702230104openalex-snapshot

Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons

inferredcites →https://doi.org/10.1073/pnas.1308421110openalex-snapshot

Metabolic signatures of amyotrophic lateral sclerosis reveal insights into disease pathogenesis

inferredcites →https://doi.org/10.1073/pnas.96.13.7532openalex-snapshot

Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects

inferredcites →https://doi.org/10.1074/jbc.m302211200openalex-snapshot

Ganglioside GM3 Inhibits Matrix Metalloproteinase-9 Activation and Disrupts Its Association with Integrin

inferredcites →https://doi.org/10.1074/jbc.m400444200openalex-snapshot

Drosophila Glucosylceramide Synthase

inferredcites →https://doi.org/10.1074/jbc.r111.254359openalex-snapshot

Many Ceramides

inferredcites →https://doi.org/10.1093/brain/awq345openalex-snapshot

Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis

inferredcites →https://doi.org/10.1093/brain/awr193openalex-snapshot

Dysregulation of astrocyte–motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis

inferredcites →https://doi.org/10.1093/glycob/8.9.885openalex-snapshot

Variations among cell lines in the synthesis of sphingolipids in de novo and recycling pathways

inferredcites →https://doi.org/10.1096/fj.11-190819openalex-snapshot

Disease progression in a mouse model of amyotrophic lateral sclerosis: the influence of chronic stress and corticosterone

inferredcites →https://doi.org/10.1111/j.1471-4159.2007.04822.xopenalex-snapshot

Lactosylceramide: a lipid second messenger in neuroinflammatory disease

inferredcites →https://doi.org/10.1111/j.1471-4159.2010.07067.xopenalex-snapshot

Gangliosides are essential in the protection of inflammation and neurodegeneration via maintenance of lipid rafts: elucidation by a series of ganglioside‐deficient mutant mice

inferredcites →https://doi.org/10.1126/science.178.4065.1100openalex-snapshot

Ceramidase Deficiency in Farber's Disease (Lipogranulomatosis)

inferredcites →https://doi.org/10.1134/s0006297909030018openalex-snapshot

Ganglioside GM3 and its biological functions

inferredcites →https://doi.org/10.1136/jnnp.56.4.361openalex-snapshot

A characteristic ganglioside antibody pattern in the CSF of patients with amyotrophic lateral sclerosis.

inferredcites →https://doi.org/10.1161/01.res.0000185327.45463.a8openalex-snapshot

Novel Role of Lactosylceramide in Vascular Endothelial Growth Factor–Mediated Angiogenesis in Human Endothelial Cells

inferredcites →https://doi.org/10.1172/jci16450openalex-snapshot

Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis

inferredcites →https://doi.org/10.1172/jci200216450openalex-snapshot

Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis

inferredcites →https://doi.org/10.1177/08830738030180090201openalex-snapshot

Globoid Cell Leukodystrophy (Krabbe's Disease): Update

inferredcites →https://doi.org/10.1194/jlr.r3000020-jlr200openalex-snapshot

Regulation of ganglioside biosynthesis in the nervous system

inferredcites →https://doi.org/10.1371/journal.pbio.1001506openalex-snapshot

Neuronal Expression of Glucosylceramide Synthase in Central Nervous System Regulates Body Weight and Energy Homeostasis

inferredcites →https://doi.org/10.1371/journal.pone.0043310openalex-snapshot

Systemic Delivery of a Glucosylceramide Synthase Inhibitor Reduces CNS Substrates and Increases Lifespan in a Mouse Model of Type 2 Gaucher Disease

inferredcites →https://doi.org/10.2337/db06-0719openalex-snapshot

Inhibiting Glycosphingolipid Synthesis Improves Glycemic Control and Insulin Sensitivity in Animal Models of Type 2 Diabetes

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3245222openalex-extracted

Mutations in the Glycosyltransferase Domain of GLT8D1 Cause Amyotrophic Lateral Sclerosis

inferred← citeshttps://doi.org/10.1002/047167849x.bio115openalex-snapshot

Lipids in Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.1002/2211-5463.13727openalex-snapshot

GM1 ganglioside exerts protective effects against glutamate‐excitotoxicity via its oligosaccharide in wild‐type and amyotrophic lateral sclerosis motor neurons

inferred← citeshttps://doi.org/10.1002/acn3.52013openalex-snapshot

SPTLC2 variants are associated with early‐onset ALS and FTD due to aberrant sphingolipid synthesis

inferred← citeshttps://doi.org/10.1002/advs.202514128openalex-snapshot

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

inferred← citeshttps://doi.org/10.1002/ana.27208openalex-snapshot

Longitudinal Metabolomics in Amyotrophic Lateral Sclerosis Implicates Impaired Lipid Metabolism

inferred← citeshttps://doi.org/10.1002/glia.24622openalex-snapshot

Towards an integrated approach for understanding glia in Amyotrophic Lateral Sclerosis

inferred← citeshttps://doi.org/10.1007/978-3-030-21735-8_18openalex-snapshot

Overview of Lipid Biomarkers in Amyotrophic Lateral Sclerosis (ALS)

inferred← citeshttps://doi.org/10.1007/978-3-031-12390-0_13openalex-snapshot

Gangliosides in Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.1007/978-3-032-16833-7_17openalex-snapshot

The Role of the Golgi Apparatus in Neurodegeneration

inferred← citeshttps://doi.org/10.1007/s00109-024-02419-7openalex-snapshot

Evidence for alterations in lipid profiles and biophysical properties of lipid rafts from spinal cord in sporadic amyotrophic lateral sclerosis

inferred← citeshttps://doi.org/10.1007/s00415-016-8168-2openalex-snapshot

Cognition and eating behavior in amyotrophic lateral sclerosis: effect on survival

inferred← citeshttps://doi.org/10.1007/s10072-024-07581-xopenalex-snapshot

The presence and clinical significance of autoantibodies in amyotrophic lateral sclerosis: a narrative review

inferred← citeshttps://doi.org/10.1007/s12017-021-08646-2openalex-snapshot

Sphingolipids as Regulators of Neuro-Inflammation and NADPH Oxidase 2

inferred← citeshttps://doi.org/10.1007/s12035-018-1448-3openalex-snapshot

The Role of Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders

inferred← citeshttps://doi.org/10.1007/s12035-019-1484-7openalex-snapshot

Metabo-lipidomics of Fibroblasts and Mitochondrial-Endoplasmic Reticulum Extracts from ALS Patients Shows Alterations in Purine, Pyrimidine, Energetic, and Phospholipid Metabolisms

inferred← citeshttps://doi.org/10.1007/s12035-020-02217-5openalex-snapshot

Perilipin 4 Protein: an Impending Target for Amyotrophic Lateral Sclerosis

inferred← citeshttps://doi.org/10.1016/b978-0-443-16156-8.00007-9openalex-snapshot

Glycosphingolipids and central nervous system–related diseases

inferred← citeshttps://doi.org/10.1016/j.addr.2020.06.028openalex-snapshot

Bioactive lipids, inflammation and chronic diseases

inferred← citeshttps://doi.org/10.1016/j.celrep.2019.02.006openalex-snapshot

Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis

inferred← citeshttps://doi.org/10.1016/j.chroma.2022.463124openalex-snapshot

Development and application of a fast ultra-high performance liquid chromatography-trapped ion mobility mass spectrometry method for untargeted lipidomics

inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.04.006openalex-snapshot

Synthesis and biological evaluation of neoglycosphingolipids

inferred← citeshttps://doi.org/10.1016/j.ejphar.2020.173446openalex-snapshot

Drug repositioning in neurodegeneration: An overview of the use of ambroxol in neurodegenerative diseases

inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113258openalex-snapshot

The riddle of sphingolipid structure-function relationship in the nervous system

inferred← citeshttps://doi.org/10.1016/j.jid.2016.09.028openalex-snapshot

Ganglioside GM3 Mediates Glucose-Induced Suppression of IGF-1 Receptor–Rac1 Activation to Inhibit Keratinocyte Motility

inferred← citeshttps://doi.org/10.1016/j.jmb.2016.10.027openalex-snapshot

Glycolipids and Lectins in Endocytic Uptake Processes

inferred← citeshttps://doi.org/10.1016/j.jns.2026.126039openalex-snapshot

Association of anti-glycolipid IgG with respiratory function decline in amyotrophic lateral sclerosis

inferred← citeshttps://doi.org/10.1016/j.jpha.2023.04.003openalex-snapshot

Dissecting the brain with spatially resolved multi-omics

inferred← citeshttps://doi.org/10.1016/j.matbio.2020.11.005openalex-snapshot

When lipid homeostasis runs havoc: Lipotoxicity links lysosomal dysfunction to autophagy

inferred← citeshttps://doi.org/10.1016/j.nbd.2021.105360openalex-snapshot

Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis

inferred← citeshttps://doi.org/10.1016/j.nbd.2025.106798openalex-snapshot

Elevation of ganglioside degradation pathway drives GM2 and GM3 within amyloid plaques in a transgenic mouse model of Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.nbd.2025.106851openalex-snapshot

Glycosphingolipids in neurodegeneration – Molecular mechanisms, cellular roles, and therapeutic perspectives

inferred← citeshttps://doi.org/10.1016/j.nbd.2026.107630openalex-snapshot

TDP-43 and ALS - what's wrong with my membranes?

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2019.12.029openalex-snapshot

Glycosphingolipid Biosynthesis Pathway in the Spinal Cord and Dorsal Root Ganglia During Inflammatory Pain: Early and Late Changes in Expression Patterns of Glycosyltransferase Genes

inferred← citeshttps://doi.org/10.1016/j.pharmr.2026.100113openalex-snapshot

Links between COVID-19, long COVID, and neurodegeneration: The role of glycosphingolipids

inferred← citeshttps://doi.org/10.1016/j.semcdb.2020.08.012openalex-snapshot

The role of lipids in the central nervous system and their pathological implications in amyotrophic lateral sclerosis

inferred← citeshttps://doi.org/10.1016/j.semcdb.2020.10.008openalex-snapshot

Sphingolipids metabolism alteration in the central nervous system: Amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases

inferred← citeshttps://doi.org/10.1016/j.semcdb.2021.02.002openalex-snapshot

The Mitochondrial-associated ER membrane (MAM) compartment and its dysregulation in Amyotrophic Lateral Sclerosis (ALS)

inferred← citeshttps://doi.org/10.1016/j.tibs.2026.05.009openalex-snapshot

Glycosphingolipids in cell identity: Biosynthesis, functions, and emerging tools

inferred← citeshttps://doi.org/10.1016/j.ymgmr.2019.100540openalex-snapshot

A case of motor neuron involvement in Gaucher disease

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Treatment with THI, an inhibitor of sphingosine-1-phosphate lyase, modulates glycosphingolipid metabolism and results therapeutically effective in experimental models of Huntington’s disease

inferred← citeshttps://doi.org/10.1021/acs.analchem.1c02546openalex-snapshot

Tear-Based Vibrational Spectroscopy Applied to Amyotrophic Lateral Sclerosis

inferred← citeshttps://doi.org/10.1021/acsinfocus.7e7027openalex-snapshot

Carbohydrate Synthesis

inferred← citeshttps://doi.org/10.1038/nrneurol.2016.172openalex-snapshot

Guillain–Barré syndrome: a century of progress

inferred← citeshttps://doi.org/10.1038/s41576-023-00592-yopenalex-snapshot

Amyotrophic lateral sclerosis: translating genetic discoveries into therapies

inferred← citeshttps://doi.org/10.1038/s41591-021-01346-1openalex-snapshot

Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis

inferred← citeshttps://doi.org/10.1038/s41593-021-00944-zopenalex-snapshot

Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS

inferred← citeshttps://doi.org/10.1038/s41598-017-05313-0openalex-snapshot

Inhibition of β-Glucocerebrosidase Activity Preserves Motor Unit Integrity in a Mouse Model of Amyotrophic Lateral Sclerosis

inferred← citeshttps://doi.org/10.1038/s41598-017-17389-9openalex-snapshot

Lipidomics Reveals Cerebrospinal-Fluid Signatures of ALS

inferred← citeshttps://doi.org/10.1038/s41598-019-48059-7openalex-snapshot

Alterations in lipid metabolism of spinal cord linked to amyotrophic lateral sclerosis

inferred← citeshttps://doi.org/10.1038/s42003-024-07231-0openalex-snapshot

Unravelling neuronal and glial differences in ceramide composition, synthesis, and sensitivity to toxicity

inferred← citeshttps://doi.org/10.1051/medsci/2020071openalex-snapshot

Potentiel thérapeutique de l’ambroxol contre les maladies du motoneurone

inferred← citeshttps://doi.org/10.1073/pnas.1913956117openalex-snapshot

Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration

inferred← citeshttps://doi.org/10.1080/21678421.2021.1985790openalex-snapshot

Theme 04 - IN VIVO EXPERIMETAL MODELS

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Myelin Lipid Alterations in Neurodegenerative Diseases: Landscape and Pathogenic Implications

inferred← citeshttps://doi.org/10.1093/brain/awac025openalex-snapshot

Metabolomics identifies shared lipid pathways in independent amyotrophic lateral sclerosis cohorts

inferred← citeshttps://doi.org/10.1093/brain/awz358openalex-snapshot

Disrupted glycosylation of lipids and proteins is a cause of neurodegeneration

inferred← citeshttps://doi.org/10.1093/braincomms/fcab143openalex-snapshot

Lipidomic traits of plasma and cerebrospinal fluid in amyotrophic lateral sclerosis correlate with disease progression

inferred← citeshttps://doi.org/10.1093/hmg/ddv439openalex-snapshot

Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase

inferred← citeshttps://doi.org/10.1093/med/9780197549469.003.0055openalex-snapshot

Treating Lafora Disease with an Antibody-Enzyme Fusion

inferred← citeshttps://doi.org/10.1093/oxfordhb/9780190932183.013.14openalex-snapshot

Mitochondria and Energy Metabolism in the Pathogenesis and Therapy of Amyotrophic Lateral Sclerosis

inferred← citeshttps://doi.org/10.1101/2022.06.28.497990openalex-snapshot

GLT8D1 mutations cause amyotrophic lateral sclerosis via disruption of neurotrophin signalling within membrane lipid rafts

inferred← citeshttps://doi.org/10.1101/2022.08.30.505901openalex-snapshot

Profound lipid dysregulation in mutant TDP-43 mice is ameliorated by the glucocerebrosidase 2 inhibitor ambroxol

inferred← citeshttps://doi.org/10.1101/2025.03.21.25324430openalex-snapshot

Plasma gangliosides correlate with disease stages and symptom severity in Huntington’s disease carriers

inferred← citeshttps://doi.org/10.1101/605998openalex-snapshot

A multi-omic analysis of optineurin proteinopathy in a yeast model suggests the involvement of lipid metabolism in Amyotrophic Lateral Sclerosis

inferred← citeshttps://doi.org/10.1101/682526openalex-snapshot

Nuclear lipidome is altered in amyotrophic lateral sclerosis: a preliminary study

inferred← citeshttps://doi.org/10.1111/jnc.15906openalex-snapshot

Glycogen accumulation modulates life span in a mouse model of amyotrophic lateral sclerosis

inferred← citeshttps://doi.org/10.1126/science.aav9776openalex-snapshot

Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis

inferred← citeshttps://doi.org/10.1134/s1068162021050277openalex-snapshot

The Role of Sphingosine-1-Phosphate in Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.1136/jnnp-2020-323611openalex-snapshot

Untargeted metabolomics yields insight into ALS disease mechanisms

inferred← citeshttps://doi.org/10.1152/physrev.00004.2024openalex-snapshot

Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives

inferred← citeshttps://doi.org/10.1155/2015/120748openalex-snapshot

Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans

inferred← citeshttps://doi.org/10.1155/2024/4530255openalex-snapshot

Gangliosides as Therapeutic Targets for Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.11606/t.46.2018.tde-20072018-085559openalex-snapshot

Eventos redox na biologia dos lipídios: modificação de tióis e alterações do lipidoma em ALS

inferred← citeshttps://doi.org/10.11606/t.46.2019.tde-24102019-110456openalex-snapshot

Exploring the role of lipids in protein modification and amyotrophic lateral sclerosis

inferred← citeshttps://doi.org/10.1177/1759091419884859openalex-snapshot

Intracerebroventricular Infusion of Gangliosides Augments the Adult Neural Stem Cell Pool in Mouse Brain

inferred← citeshttps://doi.org/10.1186/s13024-018-0294-0openalex-snapshot

Disease-modifying effects of metabolic perturbations in ALS/FTLD

inferred← citeshttps://doi.org/10.1186/s13195-022-00966-0openalex-snapshot

Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer’s disease

inferred← citeshttps://doi.org/10.1186/s40035-022-00322-0openalex-snapshot

Deciphering lipid dysregulation in ALS: from mechanisms to translational medicine

inferred← citeshttps://doi.org/10.1186/s40035-025-00477-6openalex-snapshot

Gene therapy breakthroughs in ALS: a beacon of hope for 20% of ALS patients

inferred← citeshttps://doi.org/10.1242/dmm.050206openalex-snapshot

Glycosphingolipids are linked to elevated neurotransmission and neurodegeneration in a Drosophila model of Niemann Pick type C

inferred← citeshttps://doi.org/10.1371/journal.pone.0198116openalex-snapshot

A pharmaco-metabolomics approach in a clinical trial of ALS: Identification of predictive markers of progression

inferred← citeshttps://doi.org/10.1371/journal.pone.0230499openalex-snapshot

Targeting glycosphingolipid metabolism as a potential therapeutic approach for treating disease in female MRL/lpr lupus mice

inferred← citeshttps://doi.org/10.1371/journal.pone.0268159openalex-snapshot

A molecular view of amyotrophic lateral sclerosis through the lens of interaction network modules

inferred← citeshttps://doi.org/10.1371/journal.pone.0271360openalex-snapshot

Human iPSC-derived astrocytes generated from donors with globoid cell leukodystrophy display phenotypes associated with disease

inferred← citeshttps://doi.org/10.1523/jneurosci.1388-20.2020openalex-snapshot

Neutral Lipid Cacostasis Contributes to Disease Pathogenesis in Amyotrophic Lateral Sclerosis

inferred← citeshttps://doi.org/10.21203/rs.3.rs-5182325/v1openalex-snapshot

Simple gangliosides co-localize with amyloid plaques and increase with age in a transgenic mouse model of Alzheimer’s disease

inferred← citeshttps://doi.org/10.21203/rs.3.rs-656827/v1openalex-snapshot

A Molecular View of Amyotrophic Lateral Sclerosis Through the Lens of Interaction Network Modules

inferred← citeshttps://doi.org/10.21203/rs.3.rs-656827/v2openalex-snapshot

A Molecular View of Amyotrophic Lateral Sclerosis Through the Lens of Interaction Network Modules

inferred← citeshttps://doi.org/10.2169/internalmedicine.6168-20openalex-snapshot

Sporadic Amyotrophic Lateral Sclerosis Due to a FUS P525L Mutation with Asymmetric Muscle Weakness and Anti-ganglioside Antibodies

inferred← citeshttps://doi.org/10.3233/jad-170660openalex-snapshot

Lipid Metabolism and Survival Across the Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Spectrum: Relationships to Eating Behavior and Cognition

inferred← citeshttps://doi.org/10.3233/jpd-202310openalex-snapshot

Cerebrospinal Fluid Profiles in Parkinson’s Disease: No Accumulation of Glucosylceramide, but Significant Downregulation of Active Complement C5 Fragment

inferred← citeshttps://doi.org/10.3389/fcell.2019.00075openalex-snapshot

Golgi Complex Dynamics and Its Implication in Prevalent Neurological Disorders

inferred← citeshttps://doi.org/10.3389/fcimb.2022.1011378openalex-snapshot

Clonorchis sinensis infection induces hepatobiliary injury via disturbing sphingolipid metabolism and activating sphingosine 1-phosphate receptor 2

inferred← citeshttps://doi.org/10.3389/fnagi.2020.595751openalex-snapshot

Satellite Glial Cells of the Dorsal Root Ganglion: A New “Guest/Physiopathological Target” in ALS

inferred← citeshttps://doi.org/10.3389/fneur.2019.00859openalex-snapshot

Gangliosides: Treatment Avenues in Neurodegenerative Disease

inferred← citeshttps://doi.org/10.3389/fneur.2020.00437openalex-snapshot

Exploring Sphingolipid Implications in Neurodegeneration

inferred← citeshttps://doi.org/10.3389/fnins.2020.00074openalex-snapshot

Lipids in the Physiopathology of Hereditary Spastic Paraplegias

inferred← citeshttps://doi.org/10.3389/fnins.2020.572965openalex-snapshot

Gangliosides in the Brain: Physiology, Pathophysiology and Therapeutic Applications

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Antibody-Based Therapeutic Interventions for Amyotrophic Lateral Sclerosis: A Systematic Literature Review

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Sphingolipids in neurodegenerative diseases

inferred← citeshttps://doi.org/10.3389/fnmol.2017.00356openalex-snapshot

Lipid Involvement in Neurodegenerative Diseases of the Motor System: Insights from Lysosomal Storage Diseases

inferred← citeshttps://doi.org/10.3389/fnmol.2017.00433openalex-snapshot

Sphingolipid Metabolism Is Dysregulated at Transcriptomic and Metabolic Levels in the Spinal Cord of an Animal Model of Amyotrophic Lateral Sclerosis

inferred← citeshttps://doi.org/10.3389/fnmol.2018.00010openalex-snapshot

Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease

inferred← citeshttps://doi.org/10.3389/fphar.2019.00883openalex-snapshot

Ambroxol Hydrochloride Improves Motor Functions and Extends Survival in a Mouse Model of Familial Amyotrophic Lateral Sclerosis

inferred← citeshttps://doi.org/10.3389/fphar.2021.653842openalex-snapshot

Ganglioside GM1 Targets Astrocytes to Stimulate Cerebral Energy Metabolism

inferred← citeshttps://doi.org/10.3389/fphar.2021.768023openalex-snapshot

Current Drug Repurposing Strategies for Rare Neurodegenerative Disorders

inferred← citeshttps://doi.org/10.3389/fphys.2026.1773221openalex-snapshot

Proteograph™-based proteome and sphingolipidome analyses identified novel serum biomarkers to monitor astronauts’ health in spaceflight

inferred← citeshttps://doi.org/10.3390/app13179922openalex-snapshot

Assessing Glycosphingolipid Profiles in Human Health and Disease Using Non-Imaging MALDI Mass Spectrometry

inferred← citeshttps://doi.org/10.3390/biom12101434openalex-snapshot

Aberrant Ganglioside Functions to Underpin Dysregulated Myelination, Insulin Signalling, and Cytokine Expression: Is There a Link and a Room for Therapy?

inferred← citeshttps://doi.org/10.3390/biom13050863openalex-snapshot

Evidence of Metabolic Dysfunction in Amyotrophic Lateral Sclerosis (ALS) Patients and Animal Models

inferred← citeshttps://doi.org/10.3390/biomedicines10051105openalex-snapshot

Lipid Metabolic Alterations in the ALS–FTD Spectrum of Disorders

inferred← citeshttps://doi.org/10.3390/biomedicines9091080openalex-snapshot

Storage of Mutant Human SOD1 in Non-Neural Cells from the Type-1 Amyotrophic Lateral Sclerosis ratG93A Model Correlated with the Lysosomes’ Dysfunction

inferred← citeshttps://doi.org/10.3390/biomedicines9121944openalex-snapshot

Altered Metabolic Profiles of the Plasma of Patients with Amyotrophic Lateral Sclerosis

inferred← citeshttps://doi.org/10.3390/cells14211734openalex-snapshot

Does Amyotrophic Lateral Sclerosis (ALS) Have Metabolic Causes from Human Evolution?

inferred← citeshttps://doi.org/10.3390/cimb47121003openalex-snapshot

Evaluating the CRP Interactome: Insights into Possible Novel Roles in Cellular Signaling and Tumorigenicity

inferred← citeshttps://doi.org/10.3390/dna6030040openalex-snapshot

Sphingolipid Regulation of Genome Stability: Stress Signaling, Chromatin Control, and Organelle Dysfunction

inferred← citeshttps://doi.org/10.3390/ijms22147353openalex-snapshot

Novelty of Sphingolipids in the Central Nervous System Physiology and Disease: Focusing on the Sphingolipid Hypothesis of Neuroinflammation and Neurodegeneration

inferred← citeshttps://doi.org/10.3390/ijms22179553openalex-snapshot

A Transcriptomic Meta-Analysis Shows Lipid Metabolism Dysregulation as an Early Pathological Mechanism in the Spinal Cord of SOD1 Mice

inferred← citeshttps://doi.org/10.3390/ijms222011224openalex-snapshot

Histone Deacetylase Inhibition Regulates Lipid Homeostasis in a Mouse Model of Amyotrophic Lateral Sclerosis

inferred← citeshttps://doi.org/10.3390/ijms23105330openalex-snapshot

Sphingolipid Players in Multiple Sclerosis: Their Influence on the Initiation and Course of the Disease

inferred← citeshttps://doi.org/10.3390/ijms23147806openalex-snapshot

Ceramide and Sphingosine-1-Phosphate in Neurodegenerative Disorders and Their Potential Involvement in Therapy

inferred← citeshttps://doi.org/10.3390/ijms23158082openalex-snapshot

Ceramide/Sphingosine 1-Phosphate Axis as a Key Target for Diagnosis and Treatment in Alzheimer’s Disease and Other Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.3390/ijms24076180openalex-snapshot

Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration

inferred← citeshttps://doi.org/10.3390/ijms24119558openalex-snapshot

Ganglioside GM1 and the Central Nervous System

inferred← citeshttps://doi.org/10.3390/ijms25010131openalex-snapshot

Lipids as Emerging Biomarkers in Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.3390/ijms25168583openalex-snapshot

Glutamate, Gangliosides, and the Synapse: Electrostatics at Work in the Brain

inferred← citeshttps://doi.org/10.3390/ijms252211962openalex-snapshot

Mechanistic and Therapeutic Implications of Protein and Lipid Sialylation in Human Diseases

inferred← citeshttps://doi.org/10.3390/jpm12091418openalex-snapshot

The Role of Sphingomyelin and Ceramide in Motor Neuron Diseases

inferred← citeshttps://doi.org/10.3390/life13020510openalex-snapshot

Involvement of Lipids in the Pathogenesis of Amyotrophic Lateral Sclerosis

inferred← citeshttps://doi.org/10.3390/metabo15040282openalex-snapshot

Lipid Metabolism and Statin Therapy in Neurodegenerative Diseases: An Endocrine View

inferred← citeshttps://doi.org/10.3892/ijmm.2025.5580openalex-snapshot

Lipid metabolism in microglia: Emerging mechanisms and therapeutic opportunities for neurodegenerative diseases (Review)

inferred← citeshttps://doi.org/10.4103/1673-5374.343890openalex-snapshot

Gangliosides in nervous system development, regeneration, and pathologies

inferred← citeshttps://doi.org/10.6084/m9.figshare.19106114openalex-snapshot

Additional file 5 of Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer’s disease

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