On the public citation graph

Mesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesis

https://doi.org/10.1073/pnas.1805683115
0 signed · 90 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.
Claim with ORCID
Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.
See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ijc.29210openalex-snapshot
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
inferredcites →https://doi.org/10.1002/ijc.29716openalex-snapshot
Blockade of MK 2 is protective in inflammation‐associated colorectal cancer development
inferredcites →https://doi.org/10.1002/j.1460-2075.1992.tb05492.xopenalex-snapshot
MAPKAP kinase‐2; a novel protein kinase activated by mitogen‐activated protein kinase.
inferredcites →https://doi.org/10.1002/jcb.21154openalex-snapshot
Smooth muscle α‐actin expression and myofibroblast differentiation by TGFβ are dependent upon MK2
inferredcites →https://doi.org/10.1002/path.4103openalex-snapshot
From sentinel cells to inflammatory culprits: cancer‐associated fibroblasts in tumour‐related inflammation
inferredcites →https://doi.org/10.1007/s00018-009-0086-3openalex-snapshot
Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology
inferredcites →https://doi.org/10.1016/0092-8674(90)90186-iopenalex-snapshot
A genetic model for colorectal tumorigenesis
inferredcites →https://doi.org/10.1016/j.bbamcr.2007.03.010openalex-snapshot
p38 MAP-Kinases pathway regulation, function and role in human diseases
inferredcites →https://doi.org/10.1016/j.ccr.2014.02.019openalex-snapshot
Dual Function of p38α MAPK in Colon Cancer: Suppression of Colitis-Associated Tumor Initiation but Requirement for Cancer Cell Survival
inferredcites →https://doi.org/10.1016/j.molcel.2005.01.005openalex-snapshot
MAPKAP Kinase-2
inferredcites →https://doi.org/10.1016/j.surg.2012.05.009openalex-snapshot
Deletion of p38-alpha mitogen-activated protein kinase within the intestinal epithelium promotes colon tumorigenesis
inferredcites →https://doi.org/10.1016/s0092-8674(03)00002-3openalex-snapshot
Twist Regulates Cytokine Gene Expression through a Negative Feedback Loop that Represses NF-κB Activity
inferredcites →https://doi.org/10.1021/jm0611004openalex-snapshot
Pyrrolopyridine Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK-2)
inferredcites →https://doi.org/10.1023/a:1008942828960openalex-snapshot
Conditional gene targeting in macrophages and granulocytes using LysMcre mice
inferredcites →https://doi.org/10.1038/10061openalex-snapshot
MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis
inferredcites →https://doi.org/10.1038/359235a0openalex-snapshot
APC mutations occur early during colorectal tumorigenesis
inferredcites →https://doi.org/10.1038/cdd.2009.36openalex-snapshot
p38α blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1α- to FoxO-dependent transcription
inferredcites →https://doi.org/10.1038/labinvest.2012.177openalex-snapshot
Inhibition of p38/Mk2 signaling pathway improves the anti-inflammatory effect of WIN55 on mouse experimental colitis
inferredcites →https://doi.org/10.1038/nprot.2007.41openalex-snapshot
Chemically induced mouse models of intestinal inflammation
inferredcites →https://doi.org/10.1038/nrd2829openalex-snapshot
Targeting innate immunity protein kinase signalling in inflammation
inferredcites →https://doi.org/10.1038/sj.emboj.7600973openalex-snapshot
MAPKAPK‐2‐mediated LIM‐kinase activation is critical for VEGF‐induced actin remodeling and cell migration
inferredcites →https://doi.org/10.1038/sj.onc.1209337openalex-snapshot
MAPKAPK2 and HSP27 are downstream effectors of p38 MAP kinase-mediated matrix metalloproteinase type 2 activation and cell invasion in human prostate cancer
inferredcites →https://doi.org/10.1053/j.gastro.2010.01.058openalex-snapshot
Inflammation and Colon Cancer
inferredcites →https://doi.org/10.1074/jbc.m204935200openalex-snapshot
cis Elements of the Villin Gene Control Expression in Restricted Domains of the Vertical (Crypt) and Horizontal (Duodenum, Cecum) Axes of the Intestine
inferredcites →https://doi.org/10.1074/jbc.m205863200openalex-snapshot
Cytoskeletal Changes in Hypoxic Pulmonary Endothelial Cells Are Dependent on MAPK-activated Protein Kinase MK2
inferredcites →https://doi.org/10.1074/jbc.m507209200openalex-snapshot
Blocking Tumor Cell Migration and Invasion with Biphenyl Isoxazole Derivative KRIBB3, a Synthetic Molecule That Inhibits Hsp27 Phosphorylation
inferredcites →https://doi.org/10.1074/jbc.m610987200openalex-snapshot
Heat Shock Protein 27 Functions in Inflammatory Gene Expression and Transforming Growth Factor-β-activated Kinase-1 (TAK1)-mediated Signaling
inferredcites →https://doi.org/10.1093/carcin/bgp238openalex-snapshot
MK2 regulates the early stages of skin tumor promotion
inferredcites →https://doi.org/10.1093/nar/23.24.5080openalex-snapshot
Acre-transgenic mouse strain for the ubiquitous deletion ofloxP-flanked gene segments including deletion in germ cells
inferredcites →https://doi.org/10.1111/febs.13250openalex-snapshot
Roles of p38α mitogen‐activated protein kinase in mouse models of inflammatory diseases and cancer
inferredcites →https://doi.org/10.1111/j.1365-2613.2006.00477.xopenalex-snapshot
Developmental abnormalities in multiple proliferative tissues of ApcMin/+ mice
inferredcites →https://doi.org/10.1124/jpet.110.166173openalex-snapshot
A Benzothiophene Inhibitor of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Inhibits Tumor Necrosis Factor α Production and Has Oral Anti-Inflammatory Efficacy in Acute and Chronic Models of Inflammation
inferredcites →https://doi.org/10.1124/mol.113.090365openalex-snapshot
Mitogen-Activated Protein Kinase–Activated Protein Kinase 2 in Neuroinflammation, Heat Shock Protein 27 Phosphorylation, and Cell Cycle: Role and Targeting
inferredcites →https://doi.org/10.1126/science.1260825openalex-snapshot
Variation in cancer risk among tissues can be explained by the number of stem cell divisions
inferredcites →https://doi.org/10.1126/science.2296722openalex-snapshot
A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse
inferredcites →https://doi.org/10.1128/mcb.22.13.4827-4835.2002openalex-snapshot
Distinct Cellular Functions of MK2
inferredcites →https://doi.org/10.1152/ajplung.00339.2011openalex-snapshot
MK2 posttranscriptionally regulates TNF-α-induced expression of ICAM-1 and IL-8 via tristetraprolin in human pulmonary microvascular endothelial cells
inferredcites →https://doi.org/10.1158/0008-5472.can-09-2918openalex-snapshot
p38 Mitogen-Activated Protein Kinase–Driven MAPKAPK2 Regulates Invasion of Bladder Cancer by Modulation of MMP-2 and MMP-9 Activity
inferredcites →https://doi.org/10.1161/atvbaha.111.243477openalex-snapshot
Interleukin-1 Assembles a Proangiogenic Signaling Module Consisting of Caveolin-1, Tumor Necrosis Factor Receptor–Associated Factor 6, p38–Mitogen-Activated Protein Kinase (MAPK), and MAPK-Activated Protein Kinase 2 in Endothelial Cells
inferredcites →https://doi.org/10.1165/rcmb.2007-0077ocopenalex-snapshot
Lack of MK2 Inhibits Myofibroblast Formation and Exacerbates Pulmonary Fibrosis
inferredcites →https://doi.org/10.1177/1947601912462718openalex-snapshot
MK2 Regulates Ras Oncogenesis through Stimulating ROS Production
inferredcites →https://doi.org/10.1186/s13221-016-0038-2openalex-snapshot
Normal endothelial but impaired arterial development in MAP-Kinase activated protein kinase 2 (MK2) deficient mice
inferredcites →https://doi.org/10.1242/jcs.114.4.671openalex-snapshot
Tie-1-directed expression of Cre recombinase in endothelial cells of embryoid bodies and transgenic mice
inferredcites →https://doi.org/10.1371/journal.pone.0120724openalex-snapshot
Stromal Expression of Heat-Shock Protein 27 Is Associated with Worse Clinical Outcome in Patients with Colorectal Cancer Lung Metastases
inferredcites →https://doi.org/10.1371/journal.pone.0148998openalex-snapshot
Heat Shock Protein 27 Plays a Pivotal Role in Myofibroblast Differentiation and in the Development of Bleomycin-Induced Pulmonary Fibrosis
inferredcites →https://doi.org/10.18632/oncotarget.3816openalex-snapshot
Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors
inferredcites →https://doi.org/10.2174/1568026054985911openalex-snapshot
Potential Adverse Effects Associated with Inhibition of p38α/β MAP Kinases
inferredcites →https://doi.org/10.3389/fgene.2014.00346openalex-snapshot
Heat shock protein 27 phosphorylation state is associated with cancer progression
inferredcites →https://doi.org/10.3390/genes4020101openalex-snapshot
The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3249781openalex-extracted
Innate Sensing by Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis
inferred← citeshttps://doi.org/10.1002/advs.202416360openalex-snapshot
COPS5 Triggers Ferroptosis Defense by Stabilizing MK2 in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.1002/cam4.4452openalex-snapshot
Cancer‐associated stroma reveals prognostic biomarkers and novel insights into the tumour microenvironment of colorectal cancer and colorectal liver metastases
inferred← citeshttps://doi.org/10.1002/cbf.3454openalex-snapshot
Silencing of long noncoding RNA UCA1 inhibits colon cancer invasion, migration and epithelial‐mesenchymal transition and tumour formation by upregulating miR‐185‐5p in vitro and in vivo
inferred← citeshttps://doi.org/10.1002/ddr.70062openalex-snapshot
Evaluation of Pyrrolone‐Fused Benzosuberene MK2 Inhibitors as Promising Therapeutic Agents for HNSCC: In Vitro Efficacy, In‐Vivo Safety, and Pharmacokinetic Profiling
inferred← citeshttps://doi.org/10.1002/mc.23348openalex-snapshot
Mitogen‐activated protein kinase‐activated protein kinase‐2 (MK2) and its role in cell survival, inflammatory signaling, and migration in promoting cancer
inferred← citeshttps://doi.org/10.1002/mco2.70032openalex-snapshot
Targeting WDPF domain of Hsp27 achieves a broad spectrum of antiviral
inferred← citeshttps://doi.org/10.1007/s10142-024-01436-6openalex-snapshot
Long non-coding RNA MAGEA4-AS1 binding to p53 enhances MK2 signaling pathway and promotes the proliferation and metastasis of oral squamous cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.celrep.2018.12.072openalex-snapshot
Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.113081openalex-snapshot
The heat shock protein Hsp27 controls mitochondrial function by modulating ceramide generation
inferred← citeshttps://doi.org/10.1016/j.cytogfr.2023.12.003openalex-snapshot
Decoding the roles of heat shock proteins in liver cancer
inferred← citeshttps://doi.org/10.1016/j.jprot.2020.103886openalex-snapshot
HSP27 regulates viability and migration of cancer cell lines following irradiation
inferred← citeshttps://doi.org/10.1016/j.lfs.2019.117035openalex-snapshot
Taurine up-regulated 1 accelerates tumorigenesis of colon cancer by regulating miR-26a-5p/MMP14/p38 MAPK/Hsp27 axis in vitro and in vivo
inferred← citeshttps://doi.org/10.1016/j.lfs.2021.120075openalex-snapshot
Involvement of mitogen-activated protein kinase (MAPK)-activated protein kinase 2 (MK2) in endothelial dysfunction associated with pulmonary hypertension
inferred← citeshttps://doi.org/10.1038/s41419-020-03344-6openalex-snapshot
Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies
inferred← citeshttps://doi.org/10.1038/s41419-021-04375-3openalex-snapshot
Inhibition of DTYMK significantly restrains the growth of HCC and increases sensitivity to oxaliplatin
inferred← citeshttps://doi.org/10.1073/pnas.2505331123openalex-snapshot
Metabolic stress conditions dictate MAPKAPK2-dependent efficiency of MEK1/2 inhibition in colorectal carcinoma
inferred← citeshttps://doi.org/10.1080/07391102.2023.2265993openalex-snapshot
Novel pyrrolone-fused benzosuberene MK2 inhibitors: synthesis, pharmacophore modelling, molecular docking, and anti-cancer efficacy evaluation in HNSCC cells
inferred← citeshttps://doi.org/10.1101/2021.11.30.470656openalex-snapshot
MK2 Expression Promotes Non-Small Cell Lung Cancer Cell Death and Predicts Survival
inferred← citeshttps://doi.org/10.1101/2024.05.14.594157openalex-snapshot
CRISPR Double Knockout Library Reveals Synthetic Lethal Gene Pairs in Triple-Negative Breast Cancer
inferred← citeshttps://doi.org/10.1111/febs.70558openalex-snapshot
ACTR3 enhances the hyperproliferation of psoriatic keratinocytes by activating the TAK1 ‐ MK2 ‐ HSP27 pathway
inferred← citeshttps://doi.org/10.1111/jcmm.15273openalex-snapshot
Focal adhesion kinase is activated by microtubule‐depolymerizing agents and regulates membrane blebbing in human endothelial cells
inferred← citeshttps://doi.org/10.1146/annurev-biochem-081720-114505openalex-snapshot
MAPK-Activated Protein Kinases: Servant or Partner?
inferred← citeshttps://doi.org/10.1152/physiolgenomics.00155.2022openalex-snapshot
Tumor MK2 transcript levels are associated with improved response to chemotherapy and patient survival in non-small cell lung cancer
inferred← citeshttps://doi.org/10.1155/2022/2333848openalex-snapshot
HSPA12A Stimulates p38/ERK‐AP‐1 Signaling to Promote Angiogenesis and Is Required for Functional Recovery Postmyocardial Infarction
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-19-0553openalex-snapshot
Sophoridine Inhibits Human Colorectal Cancer Progression via Targeting MAPKAPK2
inferred← citeshttps://doi.org/10.1186/s13046-019-1115-1openalex-snapshot
MAPKAPK2: the master regulator of RNA-binding proteins modulates transcript stability and tumor progression
inferred← citeshttps://doi.org/10.1186/s13046-019-1167-2openalex-snapshot
MAPKAPK2 plays a crucial role in the progression of head and neck squamous cell carcinoma by regulating transcript stability
inferred← citeshttps://doi.org/10.1186/s13578-023-01139-8openalex-snapshot
Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota
inferred← citeshttps://doi.org/10.12659/msm.916619openalex-snapshot
Long Non-coding RNA Zinc Finger Antisense 1 (ZFAS1) Regulates Proliferation, Migration, Invasion, and Apoptosis by Targeting MiR-7-5p in Colorectal Cancer
inferred← citeshttps://doi.org/10.15252/embr.202052254openalex-snapshot
Promyelocytic leukemia protein targets MK2 to promote cytotoxicity
inferred← citeshttps://doi.org/10.15252/emmm.202216194openalex-snapshot
Intestinal Apc‐inactivation induces HSP25 dependency
inferred← citeshttps://doi.org/10.21203/rs.3.rs-4977046/v1openalex-snapshot
MAPKAPK2 (MK2) facilitates the epithelial-mesenchymal transition in lung adenocarcinoma through activation of the AKT/MYC signaling pathway
inferred← citeshttps://doi.org/10.26599/nr.2026.94908439openalex-snapshot
Harnessing HSPB1-targeted radiotheranostics for early diagnosis and precision therapy in colorectal cancer
inferred← citeshttps://doi.org/10.3389/fcell.2020.00630openalex-snapshot
Fibroblast Reprogramming in Gastrointestinal Cancer
inferred← citeshttps://doi.org/10.3389/fgene.2025.1615018openalex-snapshot
MK2-mediated AKT/MYC signaling activation promotes epithelial-mesenchymal transition in lung adenocarcinoma
inferred← citeshttps://doi.org/10.3389/fimmu.2020.607891openalex-snapshot
MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer
inferred← citeshttps://doi.org/10.3389/fmed.2020.00207openalex-snapshot
MK2 Is Required for Neutrophil-Derived ROS Production and Inflammatory Bowel Disease
inferred← citeshttps://doi.org/10.3390/cancers12030654openalex-snapshot
MK2 Inhibition Induces p53-Dependent Senescence in Glioblastoma Cells
inferred← citeshttps://doi.org/10.3390/cancers17233876openalex-snapshot
CRISPR-Cas9 Genome and Double-Knockout Screening to Identify Novel Therapeutic Targets for Chemoresistance in Triple-Negative Breast Cancer
inferred← citeshttps://doi.org/10.3390/ijms21061913openalex-snapshot
The p38 Pathway: From Biology to Cancer Therapy
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.