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Toward personalized cognitive diagnostics of at-genetic-risk Alzheimer’s disease

https://doi.org/10.1073/pnas.1901600116
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
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Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease
inferredcites →https://doi.org/10.1007/s10508-015-0497-1openalex-snapshot
Sex, but not Apolipoprotein E Polymorphism, Differences in Spatial Performance in Young Adults
inferredcites →https://doi.org/10.1016/0306-4522(79)90015-0openalex-snapshot
The hippocampus as a cognitive map
inferredcites →https://doi.org/10.1016/j.arr.2012.04.007openalex-snapshot
Spatial navigation in normal aging and the prodromal stage of Alzheimer's disease: Insights from imaging and behavioral studies
inferredcites →https://doi.org/10.1016/j.bbr.2016.03.052openalex-snapshot
Real-space path integration is impaired in Alzheimer’s disease and mild cognitive impairment
inferredcites →https://doi.org/10.1016/j.cobeha.2014.08.005openalex-snapshot
Neural systems supporting navigation
inferredcites →https://doi.org/10.1016/j.cortex.2015.03.016openalex-snapshot
Lost in spatial translation – A novel tool to objectively assess spatial disorientation in Alzheimer's disease and frontotemporal dementia
inferredcites →https://doi.org/10.1016/j.cub.2018.06.009openalex-snapshot
Global Determinants of Navigation Ability
inferredcites →https://doi.org/10.1016/j.jalz.2016.08.004openalex-snapshot
Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative
inferredcites →https://doi.org/10.1016/j.mehy.2012.12.031openalex-snapshot
Getting lost in Alzheimer’s disease: A break in the mental frame syncing
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2018.06.012openalex-snapshot
Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation, and late-life activities
inferredcites →https://doi.org/10.1016/j.neuroimage.2017.07.031openalex-snapshot
Sex-linked association between cortical scene selectivity and navigational ability
inferredcites →https://doi.org/10.1016/j.neuron.2015.03.039openalex-snapshot
Environmental Boundaries as an Error Correction Mechanism for Grid Cells
inferredcites →https://doi.org/10.1016/j.neuron.2017.06.037openalex-snapshot
The Aging Navigational System
inferredcites →https://doi.org/10.1016/j.neuroscience.2007.03.005openalex-snapshot
Effects of sex and APOE ε4 on object recognition and spatial navigation in the elderly
inferredcites →https://doi.org/10.1016/j.nicl.2017.03.016openalex-snapshot
Family history and APOE4 risk for Alzheimer's disease impact the neural correlates of episodic memory by early midlife
inferredcites →https://doi.org/10.1016/j.yhbeh.2004.11.013openalex-snapshot
Virtual navigation in humans: the impact of age, sex, and hormones on place learning
inferredcites →https://doi.org/10.1016/s0166-4328(98)00019-9openalex-snapshot
A characterization of performance by men and women in a virtual Morris water task:
inferredcites →https://doi.org/10.1016/s1474-4422(14)70090-0openalex-snapshot
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
inferredcites →https://doi.org/10.1016/s1474-4422(16)30123-5openalex-snapshot
Gaming for dementia research: a quest to save the brain
inferredcites →https://doi.org/10.1017/s1041610216001496openalex-snapshot
Addenbrooke's cognitive examination III: diagnostic utility for mild cognitive impairment and dementia and correlation with standardized neuropsychological tests
inferredcites →https://doi.org/10.1037//0735-7044.110.6.1309openalex-snapshot
Sex differences in performance in the Morris water maze and the effects of initial nonstationary hidden platform training.
inferredcites →https://doi.org/10.1037/0033-295x.114.2.340openalex-snapshot
Remembering the past and imagining the future: A neural model of spatial memory and imagery.
inferredcites →https://doi.org/10.1037/neu0000072openalex-snapshot
APOE and spatial navigation in amnestic MCI: Results from a computer-based test.
inferredcites →https://doi.org/10.1037/neu0000147openalex-snapshot
Association of the apolipoprotein E genotype with memory performance and executive functioning in cognitively intact elderly.
inferredcites →https://doi.org/10.1038/nature19323openalex-snapshot
The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
inferredcites →https://doi.org/10.1038/nn.4656openalex-snapshot
The cognitive map in humans: spatial navigation and beyond
inferredcites →https://doi.org/10.1038/nprot.2006.115openalex-snapshot
Clinical and empirical applications of the Rey–Osterrieth Complex Figure Test
inferredcites →https://doi.org/10.1038/s41582-018-0031-xopenalex-snapshot
Spatial navigation deficits — overlooked cognitive marker for preclinical Alzheimer disease?
inferredcites →https://doi.org/10.1038/s41582-018-0032-9openalex-snapshot
Sex differences in Alzheimer disease — the gateway to precision medicine
inferredcites →https://doi.org/10.1038/s41586-018-0102-6openalex-snapshot
Vector-based navigation using grid-like representations in artificial agents
inferredcites →https://doi.org/10.1056/nejm199603213341202openalex-snapshot
Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E
inferredcites →https://doi.org/10.1056/nejmoa1312889openalex-snapshot
Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
inferredcites →https://doi.org/10.1073/pnas.97.21.11661openalex-snapshot
Genetics and visual attention: Selective deficits in healthy adult carriers of the ɛ4 allele of the apolipoprotein E gene
inferredcites →https://doi.org/10.1080/13825585.2015.1041449openalex-snapshot
Age- and education-adjusted normative data for the Montreal Cognitive Assessment (MoCA) in older adults age 70–99
inferredcites →https://doi.org/10.1080/17588928.2013.831820openalex-snapshot
Relationship of cognitive reserve and APOE status to the emergence of clinical symptoms in preclinical Alzheimer’s disease
inferredcites →https://doi.org/10.1093/brain/awv236openalex-snapshot
The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease
inferredcites →https://doi.org/10.1093/brain/aww353openalex-snapshot
Alzheimer's disease: time to focus on the brain, not just molecules
inferredcites →https://doi.org/10.1097/nen.0b013e31825018f7openalex-snapshot
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
inferredcites →https://doi.org/10.1098/rstb.2012.0510openalex-snapshot
Space in the brain: how the hippocampal formation supports spatial cognition
inferredcites →https://doi.org/10.1126/science.8346443openalex-snapshot
Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
inferredcites →https://doi.org/10.1126/science.aac8128openalex-snapshot
Reduced grid-cell–like representations in adults at genetic risk for Alzheimer’s disease
inferredcites →https://doi.org/10.1177/0956797614567339openalex-snapshot
When Does Cognitive Functioning Peak? The Asynchronous Rise and Fall of Different Cognitive Abilities Across the Life Span
inferredcites →https://doi.org/10.1203/pdr.0b013e3181cb8e68openalex-snapshot
Apolipoprotein E4 and Sex Affect Neurobehavioral Performance in Primary School Children
inferredcites →https://doi.org/10.1212/01.wnl.0000271376.19515.c6openalex-snapshot
Spatial cognition and the human navigation network in AD and MCI
inferredcites →https://doi.org/10.1212/wnl.0000000000003322openalex-snapshot
Presymptomatic cortical thinning in familial Alzheimer disease
inferredcites →https://doi.org/10.1212/wnl.0000000000004425openalex-snapshot
Sex differences in Alzheimer risk
inferredcites →https://doi.org/10.1371/journal.pone.0213272openalex-snapshot
Virtual navigation tested on a mobile app is predictive of real-world wayfinding navigation performance
inferredcites →https://doi.org/10.2147/clep.s37929openalex-snapshot
Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences
inferredcites →https://doi.org/10.2174/1567205013666160401115127openalex-snapshot
Alzheimer's Disease Genetic Risk Factor APOE-ε4 Also Affects Normal Brain Function
inferredcites →https://doi.org/10.3233/jad-150855openalex-snapshot
Spatial Navigation in Preclinical Alzheimer’s Disease
inferredcites →https://doi.org/10.3233/jad-160592openalex-snapshot
Egocentric versus Allocentric Spatial Memory in Behavioral Variant Frontotemporal Dementia and Alzheimer’s Disease
inferredcites →https://doi.org/10.3389/fnagi.2015.00088openalex-snapshot
Detecting early egocentric and allocentric impairments deficits in Alzheimer’s disease: an experimental study with virtual reality
inferredcites →https://doi.org/10.3389/fnbeh.2014.00089openalex-snapshot
Neural Correlates of Spatial Navigation Changes in Mild Cognitive Impairment and Alzheimer’s Disease

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.2139/ssrn.4604386openalex-extracted
TSMC-Net: A Cognitive Navigation State Classification Model Based on EEG Signals
inferred← citeshttps://doi.org/10.1001/jamaneurol.2023.1067openalex-snapshot
Comparison of Group-Level and Individualized Brain Regions for Measuring Change in Longitudinal Tau Positron Emission Tomography in Alzheimer Disease
inferred← citeshttps://doi.org/10.1002/acn3.50940openalex-snapshot
A unified brain system of orientation and its disruption in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1002/alz.13391openalex-snapshot
Artificial intelligence for dementia—Applied models and digital health
inferred← citeshttps://doi.org/10.1002/alz.13716openalex-snapshot
Early detection of diseases causing dementia using digital navigation and gait measures: A systematic review of evidence
inferred← citeshttps://doi.org/10.1002/alz.13733openalex-snapshot
Entorhinal‐based path integration selectively predicts midlife risk of Alzheimer's disease
inferred← citeshttps://doi.org/10.1002/alz.70245openalex-snapshot
Impact of APOE4‐related dementia risk in underrepresented groups from the All of Us research program
inferred← citeshttps://doi.org/10.1002/ctm2.928openalex-snapshot
How the environment shapes our ability to navigate
inferred← citeshttps://doi.org/10.1002/dad2.12208openalex-snapshot
A profile of brain reserve in adults at genetic risk of Alzheimer's disease
inferred← citeshttps://doi.org/10.1002/dad2.12217openalex-snapshot
Current advances in digital cognitive assessment for preclinical Alzheimer's disease
inferred← citeshttps://doi.org/10.1002/hbm.26623openalex-snapshot
Lost in space(s): Multimodal neuroimaging of disorientation along the Alzheimer's disease continuum
inferred← citeshttps://doi.org/10.1002/wcs.1549openalex-snapshot
Reframing spatial frames of reference: What can aging tell us about egocentric and allocentric navigation?
inferred← citeshttps://doi.org/10.1002/wcs.70034openalex-snapshot
What Counts as an Environment in Memory Research? Conceptualizing Environment Across Memory Traditions
inferred← citeshttps://doi.org/10.1007/978-3-030-60149-2_45openalex-snapshot
The Relationship Between the Seniors’ Appraisal of Cognitive-Training Games and Game-Related Stress Is Complex: A Mixed-Methods Study
inferred← citeshttps://doi.org/10.1007/978-3-030-78111-8_1openalex-snapshot
The Belief in Health Benefits of Digital Play Modulates Physiological Responses to Games: A Repeated-Measures Quantitative Study of Game Stress in Older Adults Playing Different Game Genres
inferred← citeshttps://doi.org/10.1007/978-3-031-34866-2_31openalex-snapshot
From a Research Centre to a Mall: Bringing Virtual Reality and Digital Playing to a Living Lab for Community Dwelling Older Adults
inferred← citeshttps://doi.org/10.1007/978-3-031-47658-7_12openalex-snapshot
A Theory-of-mind Game for the Early Detection of Frontotemporal Dementia
inferred← citeshttps://doi.org/10.1007/978-3-032-20563-6_14openalex-snapshot
How Do Aging and Neurodegenerative Diseases Affect Spatial Navigation at the Behavioral Level?
inferred← citeshttps://doi.org/10.1007/978-981-33-6549-0_11openalex-snapshot
Modeling the Self-navigation Behavior of Patients with Alzheimer’s Disease in Virtual Reality
inferred← citeshttps://doi.org/10.1007/s00415-025-13151-8openalex-snapshot
Spatial navigation deficits in early Alzheimer’s disease: the role of biomarkers and APOE genotype
inferred← citeshttps://doi.org/10.1007/s10339-021-01031-8openalex-snapshot
Ageing- and dementia-friendly design: theory and evidence from cognitive psychology, neuropsychology and environmental psychology can contribute to design guidelines that minimise spatial disorientation
inferred← citeshttps://doi.org/10.1007/s11065-024-09633-7openalex-snapshot
Virtual Reality and Serious Videogame-Based Instruments for Assessing Spatial Navigation in Alzheimer’s Disease: A Systematic Review of Psychometric Properties
inferred← citeshttps://doi.org/10.1007/s40869-020-00103-7openalex-snapshot
For Whom the Games Toll: A Qualitative and Intergenerational Evaluation of What is Serious in Games for Older Adults
inferred← citeshttps://doi.org/10.1007/s43681-025-00673-0openalex-snapshot
Harnessing artificial intelligence in Alzheimer's disease management: navigating ethical challenges in AI
inferred← citeshttps://doi.org/10.1016/b978-0-12-822240-9.00006-5openalex-snapshot
Opportunities arising from the tech revolution
inferred← citeshttps://doi.org/10.1016/b978-0-12-822240-9.00009-0openalex-snapshot
Advances in cognitive testing
inferred← citeshttps://doi.org/10.1016/b978-0-443-15754-7.00042-0openalex-snapshot
Visual memory for natural scenes
inferred← citeshttps://doi.org/10.1016/j.arr.2020.101020openalex-snapshot
How age relates to spatial navigation performance: Functional and methodological considerations
inferred← citeshttps://doi.org/10.1016/j.cccb.2022.100155openalex-snapshot
Spatial orientation – a stable marker for vascular cognitive impairment?
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117505openalex-snapshot
Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged APP knock-in mice
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117971openalex-snapshot
Navigation strategies predict spatial memory and hippocampal recruitment
inferred← citeshttps://doi.org/10.1016/j.chb.2024.108349openalex-snapshot
Detecting cognitive impairment through an age-friendly serious game: The development and usability of the Spatial Performance Assessment for Cognitive Evaluation (SPACE)
inferred← citeshttps://doi.org/10.1016/j.cobeha.2020.01.011openalex-snapshot
Infusing cognitive neuroscience into the clinical neuropsychology of memory
inferred← citeshttps://doi.org/10.1016/j.cortex.2024.05.006openalex-snapshot
The effect of apolipoprotein E genotype on spatial processing in humans: A meta-analysis and systematic review
inferred← citeshttps://doi.org/10.1016/j.cortex.2025.02.003openalex-snapshot
A cognitive–motor framework for spatial navigation in aging and early-stage Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.cub.2022.06.090openalex-snapshot
Predictive maps in rats and humans for spatial navigation
inferred← citeshttps://doi.org/10.1016/j.cub.2023.04.065openalex-snapshot
Grid cell disruption in a mouse model of early Alzheimer’s disease reflects reduced integration of self-motion cues
inferred← citeshttps://doi.org/10.1016/j.isci.2024.109832openalex-snapshot
Spatial navigation questionnaires as a supportive diagnostic tool in early Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.isci.2024.109977openalex-snapshot
Combining patient-lesion and big data approaches to reveal hippocampal contributions to spatial memory and navigation
inferred← citeshttps://doi.org/10.1016/j.isci.2025.113441openalex-snapshot
Separable cognitive and motor decline tracked across adult life-span for goal-directed navigation
inferred← citeshttps://doi.org/10.1016/j.isci.2026.116909openalex-snapshot
Generating and analyzing personality questionnaires using large language models
inferred← citeshttps://doi.org/10.1016/j.jalz.2019.08.195openalex-snapshot
Brain imaging measurements of fibrillar amyloid‐β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele
inferred← citeshttps://doi.org/10.1016/j.jenvp.2024.102296openalex-snapshot
Video gaming, but not reliance on GPS, is associated with spatial navigation performance
inferred← citeshttps://doi.org/10.1016/j.jml.2023.104472openalex-snapshot
Moving experimental psychology online: How to obtain high quality data when we can’t see our participants
inferred← citeshttps://doi.org/10.1016/j.mlwa.2022.100419openalex-snapshot
Who believes they are good navigators? A machine learning pipeline highlights the impact of gender, commuting time, and education
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2021.05.005openalex-snapshot
Anxiety and Alzheimer’s disease: Behavioral analysis and neural basis in rodent models of Alzheimer’s-related neuropathology
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2025.106379openalex-snapshot
The complementary role of egocentric and allocentric spatial navigation tasks for the diagnosis of Alzheimer’s disease: A diagnostic meta-analysis
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2020.02.007openalex-snapshot
Functional connectivity between the entorhinal and posterior cingulate cortices underpins navigation discrepancies in at-risk Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2023.06.016openalex-snapshot
Spatial cognition is associated with levels of phosphorylated-tau and β-amyloid in clinically normal older adults
inferred← citeshttps://doi.org/10.1016/j.neuroimage.2026.122142openalex-snapshot
Advancing multimodal neuroimaging: Explainable and responsible AI for early dementia detection
inferred← citeshttps://doi.org/10.1016/j.neurol.2025.06.017openalex-snapshot
Digital health in presymptomatic diseases
inferred← citeshttps://doi.org/10.1016/j.neuropsychologia.2026.109517openalex-snapshot
Aphantasia is associated with spatial memory and navigation difficulties in complex virtual environments
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2024.102569openalex-snapshot
Grid codes underlie multiple cognitive maps in the human brain
inferred← citeshttps://doi.org/10.1016/j.tins.2026.08.005openalex-snapshot
Spatial navigation and the basal forebrain in Alzheimer’s disease and other neurodegenerative diseases
inferred← citeshttps://doi.org/10.1016/j.xcrm.2023.101379openalex-snapshot
Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer’s disease
inferred← citeshttps://doi.org/10.1017/9781108671408openalex-snapshot
Smartphones within Psychological Science
inferred← citeshttps://doi.org/10.1017/9781108671408.001openalex-snapshot
Preface
inferred← citeshttps://doi.org/10.1017/9781108671408.002openalex-snapshot
Introduction
inferred← citeshttps://doi.org/10.1017/9781108671408.003openalex-snapshot
Smartphone Usage
inferred← citeshttps://doi.org/10.1017/9781108671408.004openalex-snapshot
Health and Behaviour Change
inferred← citeshttps://doi.org/10.1017/9781108671408.005openalex-snapshot
Social Interaction and Interpersonal Relationships
inferred← citeshttps://doi.org/10.1017/9781108671408.006openalex-snapshot
Personality and Individual Differences
inferred← citeshttps://doi.org/10.1017/9781108671408.007openalex-snapshot
Cognition
inferred← citeshttps://doi.org/10.1017/9781108671408.008openalex-snapshot
Safety and Security
inferred← citeshttps://doi.org/10.1017/9781108671408.009openalex-snapshot
Conclusion
inferred← citeshttps://doi.org/10.1017/9781108671408.010openalex-snapshot
Index
inferred← citeshttps://doi.org/10.1017/s0144686x23000612openalex-snapshot
Experiences of age-related declining navigation abilities and impact on use of outdoor environments: a qualitative study of young-old adults with self-reported memory difficulties
inferred← citeshttps://doi.org/10.1017/s1355617721000655openalex-snapshot
Two Immersive Virtual Reality Tasks for the Assessment of Spatial Orientation in Older Adults with and Without Cognitive Impairment: Concurrent Validity, Group Comparison, and Accuracy Results
inferred← citeshttps://doi.org/10.1038/s41386-019-0595-1openalex-snapshot
Polygenic risk for Alzheimer's disease shapes hippocampal scene-selectivity
inferred← citeshttps://doi.org/10.1038/s41398-022-02237-wopenalex-snapshot
Developments in scalable strategies for detecting early markers of cognitive decline
inferred← citeshttps://doi.org/10.1038/s41467-025-67012-zopenalex-snapshot
Graded encoding of spatial novelty scales in the human brain
inferred← citeshttps://doi.org/10.1038/s41562-024-01878-9openalex-snapshot
Using games to understand the mind
inferred← citeshttps://doi.org/10.1038/s41586-022-04486-7openalex-snapshot
Entropy of city street networks linked to future spatial navigation ability
inferred← citeshttps://doi.org/10.1038/s41598-020-66114-6openalex-snapshot
Short-term memory advantage for brief durations in human APOE ε4 carriers
inferred← citeshttps://doi.org/10.1038/s41598-022-06899-wopenalex-snapshot
Machine learning detects altered spatial navigation features in outdoor behaviour of Alzheimer’s disease patients
inferred← citeshttps://doi.org/10.1038/s41598-022-17634-wopenalex-snapshot
Predicting real world spatial disorientation in Alzheimer’s disease patients using virtual reality navigation tests
inferred← citeshttps://doi.org/10.1038/s41598-022-18415-1openalex-snapshot
Task-dependent learning and memory deficits in the TgF344-AD rat model of Alzheimer’s disease: three key timepoints through middle-age in females
inferred← citeshttps://doi.org/10.1038/s42003-026-10707-wopenalex-snapshot
Feature-specific environmental contributions to human cortical architecture revealed by twin brainprints
inferred← citeshttps://doi.org/10.1038/s43856-026-01484-yopenalex-snapshot
Spatial navigation as a digital marker for clinically differentiating cognitive impairment severity
inferred← citeshttps://doi.org/10.1038/s44159-026-00544-3openalex-snapshot
Determinants of individual navigation ability
inferred← citeshttps://doi.org/10.1038/s44271-023-00031-yopenalex-snapshot
Using smartphones to optimise and scale-up the assessment of model-based planning
inferred← citeshttps://doi.org/10.1055/s-0041-1741495openalex-snapshot
Digital Phenotyping in Clinical Neurology
inferred← citeshttps://doi.org/10.1073/pnas.2319952121openalex-snapshot
Spatial memory and hippocampal remapping: Who will age well?
inferred← citeshttps://doi.org/10.1080/13803395.2023.2167942openalex-snapshot
Predicting conversion of patients with Mild Cognitive Impairment to Alzheimer’s disease using bedside cognitive assessments
inferred← citeshttps://doi.org/10.1080/13875868.2020.1830993openalex-snapshot
Computer models of saliency alone fail to predict subjective visual attention to landmarks during observed navigation
inferred← citeshttps://doi.org/10.1080/13875868.2024.2319735openalex-snapshot
Individuals learning to drive solo before age 18 have superior spatial navigation ability compared with those who learn later
inferred← citeshttps://doi.org/10.1093/braincomms/fcab085openalex-snapshot
APOE ε4 alters associations between docosahexaenoic acid and preclinical markers of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1093/braincomms/fcab087openalex-snapshot
Memory precision of object-location binding is unimpaired in APOE ε4-carriers with spatial navigation deficits
inferred← citeshttps://doi.org/10.1093/braincomms/fcag375openalex-snapshot
Episodic memory retrieval with increasing task demand: associations with age, APOE4 genotype, and Alzheimer’s disease pathology
inferred← citeshttps://doi.org/10.1097/wad.0000000000000487openalex-snapshot
Limited Longitudinal Change in Self-reported Spatial Navigation Ability in Preclinical Alzheimer Disease
inferred← citeshttps://doi.org/10.1101/2020.01.23.917211openalex-snapshot
Entropy of city street networks linked to future spatial navigation ability
inferred← citeshttps://doi.org/10.1101/2023.01.31.526473openalex-snapshot
Path integration selectively predicts midlife risk of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1101/2023.03.30.534904openalex-snapshot
Handedness and its association with education and spatial navigation assessed in over 400,000 participants across 41 countries
inferred← citeshttps://doi.org/10.1101/2023.09.11.556925openalex-snapshot
Modeling the impact of genotype, age, sex, and continuous navigation on pathway integration performance
inferred← citeshttps://doi.org/10.1101/2023.09.26.559011openalex-snapshot
Individuals learning to drive solo before age 18 have superior spatial navigation ability compared with those who learn later
inferred← citeshttps://doi.org/10.1101/2023.10.01.23296035openalex-snapshot
Geometry of navigation identifies genetic-risk and clinical Alzheimer’s disease
inferred← citeshttps://doi.org/10.1101/2024.10.12.24315402openalex-snapshot
Beyond Traditional Assessments of Cognitive Status: Exploring the Potential of Spatial Navigation Tasks
inferred← citeshttps://doi.org/10.1101/2024.10.31.620595openalex-snapshot
London taxi drivers leverage regional boundaries to optimise route choices and improve their navigation skill across three decades
inferred← citeshttps://doi.org/10.1101/2024.11.26.624990openalex-snapshot
Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged App NL-G-F mice
inferred← citeshttps://doi.org/10.1101/2025.06.05.25329079openalex-snapshot
Spatial Navigation as a Digital Marker for Clinically Differentiating Cognitive Impairment Severity
inferred← citeshttps://doi.org/10.1101/771170openalex-snapshot
Functional connectivity between the entorhinal and posterior cingulate cortices associated with navigation impairment following path integration in at-genetic-risk Alzheimer’s disease
inferred← citeshttps://doi.org/10.1109/gcce53005.2021.9622005openalex-snapshot
Toward a PCG-driven 3D Game for Preclinical Detection of Dementia
inferred← citeshttps://doi.org/10.1109/gem56474.2022.10017770openalex-snapshot
User Friendly Minecraft Mod for Early Detection of Alzheimer's Disease in Young Adults
inferred← citeshttps://doi.org/10.1109/vrw62533.2024.00405openalex-snapshot
Immersive Behavioral Therapy for Phobia Treatment in Individuals with Intellectual Disabilities
inferred← citeshttps://doi.org/10.1111/cogs.13308openalex-snapshot
Measuring Cognitive Abilities in the Wild: Validating a Population‐Scale Game‐Based Cognitive Assessment
inferred← citeshttps://doi.org/10.1111/ene.15657openalex-snapshot
The APOE4 effect: structural brain differences in Alzheimer's disease according to the age at symptom onset
inferred← citeshttps://doi.org/10.1111/tops.12590openalex-snapshot
Explaining World‐Wide Variation in Navigation Ability from Millions of People: Citizen Science Project Sea Hero Quest
inferred← citeshttps://doi.org/10.1126/sciadv.aba1394openalex-snapshot
Unmasking selective path integration deficits in Alzheimer’s disease risk carriers
inferred← citeshttps://doi.org/10.1126/sciadv.adn3268openalex-snapshot
Architectural styles of curiosity in global Wikipedia mobile app readership
inferred← citeshttps://doi.org/10.1136/bmjopen-2020-042823openalex-snapshot
Feasibility and acceptability of a multi-domain intervention to increase Mediterranean diet adherence and physical activity in older UK adults at risk of dementia: protocol for the MedEx-UK randomised controlled trial
inferred← citeshttps://doi.org/10.1145/3484824.3484886openalex-snapshot
Alzheimer's Disease
inferred← citeshttps://doi.org/10.1145/3544549.3583828openalex-snapshot
The Spatial Performance Assessment for Cognitive Evaluation (SPACE): A Novel Game for the Early Detection of Cognitive Impairment
inferred← citeshttps://doi.org/10.1146/annurev-neuro-101220-014053openalex-snapshot
Smartphones and the Neuroscience of Mental Health
inferred← citeshttps://doi.org/10.11606/t.5.2020.tde-15092021-155025openalex-snapshot
Avaliação da orientação espacial em um ambiente de realidade virtual em pacientes com comprometimento cognitivo leve
inferred← citeshttps://doi.org/10.1162/jocn_a_01956openalex-snapshot
Landmark-dependent Navigation Strategy Declines across the Human Life-Span: Evidence from Over 37,000 Participants
inferred← citeshttps://doi.org/10.1177/08919887231195227openalex-snapshot
Effects of Sport Stacking on Cognition in Patients With Mild Alzheimer’s Disease and MCI: Preliminary Findings of Randomized Controlled Trial
inferred← citeshttps://doi.org/10.1177/1073191120985612openalex-snapshot
Construct and Predictive Validity of an Assessment Game to Measure Honesty–Humility
inferred← citeshttps://doi.org/10.1177/13872877251334781openalex-snapshot
Investigating the associations between tau and mental orientation among cognitively unimpaired individuals
inferred← citeshttps://doi.org/10.1177/1535759719857069openalex-snapshot
Epilepsy Did it Again: Memory and Model-Based Planning Studied in Patients After Epilepsy Surgery
inferred← citeshttps://doi.org/10.1177/23982128251314577openalex-snapshot
No effect of apolipoprotein E polymorphism on MRI brain activity during movie watching
inferred← citeshttps://doi.org/10.1186/s12859-022-04903-8openalex-snapshot
Development of quantitative and continuous measure for severity degree of Alzheimer’s disease evaluated from MRI images of 761 human brains
inferred← citeshttps://doi.org/10.1186/s13195-026-02013-8openalex-snapshot
AI-enabled digital phenotyping for Alzheimer’s disease: a review of multimodal sensor integration and symptom trajectories
inferred← citeshttps://doi.org/10.1212/nxg.0000000000000506openalex-snapshot
Genetic risk for Alzheimer disease predicts hippocampal volume through the human lifespan
inferred← citeshttps://doi.org/10.1371/journal.pdig.0000613openalex-snapshot
Identifying older adults at risk for dementia based on smartphone data obtained during a wayfinding task in the real world
inferred← citeshttps://doi.org/10.1371/journal.pdig.0001521openalex-snapshot
NavegApp, a serious game for assessing spatial cognition: Diagnostic accuracy in preclinical and prodromal Alzheimer’s disease
inferred← citeshttps://doi.org/10.1371/journal.pone.0239077openalex-snapshot
Test-retest reliability of spatial navigation in adults at-risk of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1371/journal.pone.0270563openalex-snapshot
Intuitive assessment of spatial navigation beyond episodic memory: Feasibility and proof of concept in middle-aged and elderly individuals
inferred← citeshttps://doi.org/10.1371/journal.pone.0278239openalex-snapshot
Vestibular contribution to path integration deficits in ‘at-genetic-risk’ for Alzheimer’s disease
inferred← citeshttps://doi.org/10.1371/journal.pone.0282436openalex-snapshot
The use of virtual reality in screening for preclinical Alzheimer’s disease: A scoping review protocol
inferred← citeshttps://doi.org/10.1371/journal.pone.0298116openalex-snapshot
The relationship between object-based spatial ability and virtual navigation performance
inferred← citeshttps://doi.org/10.1371/journal.pone.0309006openalex-snapshot
Feasibility and reliability of online vs in-person cognitive testing in healthy older people
inferred← citeshttps://doi.org/10.1371/journal.pone.0317026openalex-snapshot
Predicting real-world navigation performance from a virtual navigation task in older adults
inferred← citeshttps://doi.org/10.1590/0004-282x20200043openalex-snapshot
Spatial orientation tasks show moderate to high accuracy for the diagnosis of mild cognitive impairment: a systematic literature review
inferred← citeshttps://doi.org/10.18573/book3openalex-snapshot
Human Computer Interaction and Emerging Technologies
inferred← citeshttps://doi.org/10.18573/book3.bopenalex-snapshot
Breaking Interaction Barriers: Monitoring Elderly in Natural Settings Exploiting Everyday Objects
inferred← citeshttps://doi.org/10.20870/ijvr.2020...3316openalex-snapshot
Interaction by gesture recognition: a tool to virtually revive the automata of the Antiquity
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1280535/v1openalex-snapshot
Distinct computational mechanisms underlying cognitive flexibility deficits in impulsivity and compulsivity
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1482938/v1openalex-snapshot
Task-dependent learning and memory deficits in the TgF344-AD rat model of Alzheimer’s disease: Three key timepoints from young adulthood to middle-age in females
inferred← citeshttps://doi.org/10.2196/66167openalex-snapshot
Digital Ergonomics of NavegApp, a Novel Serious Game for Spatial Cognition Assessment: Content Validity and Usability Study
inferred← citeshttps://doi.org/10.2196/79224openalex-snapshot
Egocentric Spatial Memory Deficit in Amnestic Mild Cognitive Impairment Revealed Through Virtual Reality: Cross-Sectional Study
inferred← citeshttps://doi.org/10.31219/osf.io/d2xs7openalex-snapshot
A Cognitive-Motor Framework for Spatial Navigation in Aging and Alzheimer’s Disease
inferred← citeshttps://doi.org/10.31234/osf.io/2fhcbopenalex-snapshot
Moving Experimental Psychology Online: How to Maintain Data Quality When We Can’t See Our Participants
inferred← citeshttps://doi.org/10.31234/osf.io/6hfrsopenalex-snapshot
Education is positively and causally linked with spatial navigation ability across the life-span
inferred← citeshttps://doi.org/10.3233/jad-215004openalex-snapshot
The Alzheimer–E. coli Axis: What Can We Learn from an Electronic Health Record Platform
inferred← citeshttps://doi.org/10.3233/jad-240347openalex-snapshot
Path Integration Detects Prodromal Alzheimer’s Disease and Predicts Cognitive Decline
inferred← citeshttps://doi.org/10.33394/jk.v8i3.5674openalex-snapshot
Teachers’ Performance Evaluation Instrument Designs in the Implementation of the New Learning Paradigm of the Merdeka Curriculum
inferred← citeshttps://doi.org/10.33830/penaanda.v1i1.4948openalex-snapshot
PEMBELAJARAN SENI RUPA BERDASARKAN PERSPEKTIF KURIKULUM MERDEKA DI SEKOLAH DASAR
inferred← citeshttps://doi.org/10.33830/penaanda.v1i2.6202openalex-snapshot
ASESMEN DIAGNOSTIK SEBAGAI PENILAIAN PEMBELAJARAN DALAM KURIKULUM MERDEKA DI SEKOLAH DASAR
inferred← citeshttps://doi.org/10.3389/fdgth.2022.916052openalex-snapshot
Enhance VR: A Multisensory Approach to Cognitive Training and Monitoring
inferred← citeshttps://doi.org/10.3389/fdgth.2022.944753openalex-snapshot
Neuroscience from the comfort of your home: Repeated, self-administered wireless dry EEG measures brain function with high fidelity
inferred← citeshttps://doi.org/10.3389/fnagi.2024.1382801openalex-snapshot
Less spatial exploration is associated with poorer spatial memory in midlife adults
inferred← citeshttps://doi.org/10.3389/fnagi.2025.1547834openalex-snapshot
Exploring the sensitivity of episodic and spatial memory tests to healthy and pathological cognitive aging
inferred← citeshttps://doi.org/10.3389/fnagi.2026.1784911openalex-snapshot
Virtual reality-based cognitive training in mild cognitive impairment: a systematic review
inferred← citeshttps://doi.org/10.3389/fneur.2019.00594openalex-snapshot
Psychological and Cognitive Markers of Behavioral Variant Frontotemporal Dementia–A Clinical Neuropsychologist's View on Diagnostic Criteria and Beyond
inferred← citeshttps://doi.org/10.3389/fnhum.2020.00131openalex-snapshot
Path Integration Changes as a Cognitive Marker for Vascular Cognitive Impairment?—A Pilot Study
inferred← citeshttps://doi.org/10.3389/fnhum.2022.693968openalex-snapshot
A Virtual Navigation Training Promotes the Remapping of Space in Allocentric Coordinates: Evidence From Behavioral and Neuroimaging Data
inferred← citeshttps://doi.org/10.3389/fpsyg.2024.1494048openalex-snapshot
Age effect analysis of different gender groups in spatial ability test based on virtual reality technology
inferred← citeshttps://doi.org/10.3389/fpsyt.2021.574482openalex-snapshot
Feasibility of Repeated Assessment of Cognitive Function in Older Adults Using a Wireless, Mobile, Dry-EEG Headset and Tablet-Based Games
inferred← citeshttps://doi.org/10.3389/fradi.2021.731070openalex-snapshot
Expression of CRY2 Gene in the Brain Is Related to Human Navigation
inferred← citeshttps://doi.org/10.3390/brainsci11111542openalex-snapshot
Flexible Use of Spatial Frames of Reference for Object–Location Memory in Older Adults
inferred← citeshttps://doi.org/10.3390/jdad3020018openalex-snapshot
Digital Biomarkers for Early Detection of Alzheimer’s Disease: A Comprehensive Review and Bibliometric Analysis
inferred← citeshttps://doi.org/10.3390/su132111587openalex-snapshot
The Role of Big Data in Aging and Older People’s Health Research: A Systematic Review and Ecological Framework
inferred← citeshttps://doi.org/10.3724/sp.j.1042.2022.01496openalex-snapshot
Cognitive neural mechanism of boundary processing in spatial navigation
inferred← citeshttps://doi.org/10.3724/sp.j.1042.2023.01642openalex-snapshot
Individual differences in spatial navigation: A multi-scale perspective
inferred← citeshttps://doi.org/10.3724/sp.j.1042.2025.2138openalex-snapshot
面向空间导航能力的虚拟现实测验设计
inferred← citeshttps://doi.org/10.3724/sp.j.1042.2026.0191openalex-snapshot
侵入式脑机接口应用：记忆的解码与调控
inferred← citeshttps://doi.org/10.3756/artsci.20.254openalex-snapshot
Toward Early Detection of Alzheimer's Disease Using a Minecraft Mod
inferred← citeshttps://doi.org/10.3758/s13428-021-01586-6openalex-snapshot
DeFINE: Delayed feedback-based immersive navigation environment for studying goal-directed human navigation
inferred← citeshttps://doi.org/10.3758/s13428-023-02134-0openalex-snapshot
Translating spatial navigation evaluation from experimental to clinical settings: The virtual environments navigation assessment (VIENNA)
inferred← citeshttps://doi.org/10.3758/s13428-025-02616-3openalex-snapshot
The Animal-AI Environment: A virtual laboratory for comparative cognition and artificial intelligence research
inferred← citeshttps://doi.org/10.3758/s13428-026-02998-yopenalex-snapshot
Beyond traditional assessments of cognitive status: Exploring the potential of spatial navigation tasks
inferred← citeshttps://doi.org/10.3828/sfftv.2021.10openalex-snapshot
Citizens of the future
inferred← citeshttps://doi.org/10.4324/9781003416241-23openalex-snapshot
Dementia-friendly design
inferred← citeshttps://doi.org/10.5664/jcsm.9080openalex-snapshot
Effects of obstructive sleep apnea on human spatial navigational memory processing in cognitively normal older individuals
inferred← citeshttps://doi.org/10.58645/alihda.v12i1.520openalex-snapshot
Student Progress Tracing of Arabic Learning: A Qualitative Investigation of Speaking Skills Formative Evaluation in Islamic Elementary School
inferred← citeshttps://doi.org/10.6084/m9.figshare.20727661openalex-snapshot
Additional file 1 of Development of quantitative and continuous measure for severity degree of Alzheimer’s disease evaluated from MRI images of 761 human brains
inferred← citeshttps://doi.org/10.61340/cognespaadopenalex-snapshot
Cognición espacial como marcador cognitivo temprano de la enfermedad de Alzheimer: una revisión del alcance (Scoping review)
inferred← citeshttps://doi.org/10.64898/2025.12.14.693950openalex-snapshot
It’s All In The Journey: Putative Strategies Extracted from Navigation Paths Predict Spatial Memory and Hippocampal Recruitment
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