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Spatial Navigation as a Digital Marker for Clinically Differentiating Cognitive Impairment Severity

https://doi.org/10.1101/2025.06.05.25329079

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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2024 Alzheimer's disease facts and figures

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Neuropathological stageing of Alzheimer-related changes

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COMPUTATION OF THE CORRESPONDENCE OF GEOGRAPHICAL PATTERNS

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Spatial navigation in normal aging and the prodromal stage of Alzheimer's disease: Insights from imaging and behavioral studies

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A cognitive–motor framework for spatial navigation in aging and early-stage Alzheimer's disease

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Global Determinants of Navigation Ability

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Overestimation in angular path integration precedes Alzheimer’s dementia

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Global and regional projections of the economic burden of Alzheimer's disease and related dementias from 2019 to 2050: A value of statistical life approach

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NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease

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Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

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The Aging Navigational System

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Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission

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Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019

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Bidimensional Regression: Assessing the Configural Similarity and Accuracy of Cognitive Maps and Other Two-Dimensional Data Sets.

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Microstructure of a spatial map in the entorhinal cortex

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PENSIEVE-AI a brief cognitive test to detect cognitive impairment across diverse literacy

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Spatial navigation deficits — overlooked cognitive marker for preclinical Alzheimer disease?

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Using a Digital Neuro Signature to measure longitudinal individual-level change in Alzheimer’s disease: the Altoida large cohort study

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A scoping review of remote and unsupervised digital cognitive assessments in preclinical Alzheimer’s disease

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Designing the next-generation clinical care pathway for Alzheimer’s disease

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Towards a future where Alzheimer’s disease pathology is stopped before the onset of dementia

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Alzheimer’s disease risk reduction in clinical practice: a priority in the emerging field of preventive neurology

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Spatial navigation deficit in amnestic mild cognitive impairment

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Toward personalized cognitive diagnostics of at-genetic-risk Alzheimer’s disease

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Differentiation of mild cognitive impairment using an entorhinal cortex-based test of virtual reality navigation

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Apolipoprotein ɛ4 is Associated with Dementia and Cognitive Impairment Predominantly Due to Alzheimer’s Disease and Not with Vascular Cognitive Impairment: A Singapore-Based Cohort

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Spatial Navigation and Visuospatial Strategies in Typical and Atypical Aging

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A dissociation between object manipulation spatial ability and spatial orientation ability

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1038/s41598-026-39628-8openalex-snapshot

SPACE: A novel digital tool for assessing hippocampal structural integrity in older adults

inferred← citeshttps://doi.org/10.1186/s13195-026-02013-8openalex-snapshot

AI-enabled digital phenotyping for Alzheimer’s disease: a review of multimodal sensor integration and symptom trajectories

inferred← citeshttps://doi.org/10.3758/s13428-026-02998-yopenalex-snapshot

Beyond traditional assessments of cognitive status: Exploring the potential of spatial navigation tasks

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