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Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes

https://doi.org/10.1073/pnas.2104013118
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00412-015-0570-5openalex-snapshot
The upstreams and downstreams of H3K79 methylation by DOT1L
inferredcites →https://doi.org/10.1016/b978-0-12-800267-4.00007-9openalex-snapshot
Why Does Somatic Hypermutation by AID Require Transcription of Its Target Genes?
inferredcites →https://doi.org/10.1016/bs.ai.2015.04.002openalex-snapshot
RNA Exosome Regulates AID DNA Mutator Activity in the B Cell Genome
inferredcites →https://doi.org/10.1016/bs.ai.2016.11.002openalex-snapshot
Molecular Mechanisms of Somatic Hypermutation and Class Switch Recombination
inferredcites →https://doi.org/10.1016/j.ccr.2011.06.009openalex-snapshot
Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
inferredcites →https://doi.org/10.1016/j.cell.2010.09.017openalex-snapshot
Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5
inferredcites →https://doi.org/10.1016/j.cell.2011.01.001openalex-snapshot
The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates
inferredcites →https://doi.org/10.1016/j.cell.2014.11.013openalex-snapshot
B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity
inferredcites →https://doi.org/10.1016/j.cell.2014.11.014openalex-snapshot
Convergent Transcription at Intragenic Super-Enhancers Targets AID-Initiated Genomic Instability
inferredcites →https://doi.org/10.1016/j.cell.2015.04.034openalex-snapshot
RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity
inferredcites →https://doi.org/10.1016/j.cell.2019.02.002openalex-snapshot
Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L
inferredcites →https://doi.org/10.1016/j.celrep.2019.11.039openalex-snapshot
Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation
inferredcites →https://doi.org/10.1016/j.dnarep.2008.09.006openalex-snapshot
SHMTool: A webserver for comparative analysis of somatic hypermutation datasets
inferredcites →https://doi.org/10.1016/j.it.2020.04.009openalex-snapshot
AID in Antibody Diversification: There and Back Again
inferredcites →https://doi.org/10.1016/j.it.2020.10.011openalex-snapshot
AID in Antibody Diversification: There and Back Again
inferredcites →https://doi.org/10.1016/j.molcel.2014.05.018openalex-snapshot
Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining
inferredcites →https://doi.org/10.1016/j.molcel.2017.06.034openalex-snapshot
AID Recognizes Structured DNA for Class Switch Recombination
inferredcites →https://doi.org/10.1016/j.molcel.2017.07.020openalex-snapshot
AID Invited to the G4 Summit
inferredcites →https://doi.org/10.1016/j.molcel.2019.03.029openalex-snapshot
Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination
inferredcites →https://doi.org/10.1016/j.molimm.2019.10.002openalex-snapshot
Splicing regulator SRSF1-3 that controls somatic hypermutation of IgV genes interacts with topoisomerase 1 and AID
inferredcites →https://doi.org/10.1016/s1074-7613(00)80651-2openalex-snapshot
TdT-Accessible Breaks Are Scattered over the Immunoglobulin V Domain in a Constitutively Hypermutating B Cell Line
inferredcites →https://doi.org/10.1038/nature01760openalex-snapshot
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
inferredcites →https://doi.org/10.1038/nature02821openalex-snapshot
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
inferredcites →https://doi.org/10.1038/nature13580openalex-snapshot
Noncoding RNA transcription targets AID to divergently transcribed loci in B cells
inferredcites →https://doi.org/10.1038/nature714openalex-snapshot
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
inferredcites →https://doi.org/10.1038/ncomms5137openalex-snapshot
A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation
inferredcites →https://doi.org/10.1038/nri.2016.2openalex-snapshot
Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity
inferredcites →https://doi.org/10.1038/s41422-018-0076-9openalex-snapshot
The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes
inferredcites →https://doi.org/10.1038/s41467-018-03387-6openalex-snapshot
A licensing step links AID to transcription elongation for mutagenesis in B cells
inferredcites →https://doi.org/10.1038/s41467-019-10844-3openalex-snapshot
DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation
inferredcites →https://doi.org/10.1038/s41580-018-0010-5openalex-snapshot
Born to run: control of transcription elongation by RNA polymerase II
inferredcites →https://doi.org/10.1038/s41588-020-00772-0openalex-snapshot
Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells
inferredcites →https://doi.org/10.1073/pnas.0730835100openalex-snapshot
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
inferredcites →https://doi.org/10.1073/pnas.1305859110openalex-snapshot
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation
inferredcites →https://doi.org/10.1073/pnas.1420575111openalex-snapshot
Epigenetic targeting of activation-induced cytidine deaminase
inferredcites →https://doi.org/10.1073/pnas.1500788112openalex-snapshot
Overlapping hotspots in CDRs are critical sites for V region diversification
inferredcites →https://doi.org/10.1073/pnas.2001075117openalex-snapshot
DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation
inferredcites →https://doi.org/10.1073/pnas.2104013118openalex-snapshot
Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes
inferredcites →https://doi.org/10.1074/jbc.m113.506550openalex-snapshot
A Mathematical Model for Scanning and Catalysis on Single-stranded DNA, Illustrated with Activation-induced Deoxycytidine Deaminase
inferredcites →https://doi.org/10.1074/jbc.m408135200openalex-snapshot
Biochemical Analysis of Hypermutational Targeting by Wild Type and Mutant Activation-induced Cytidine Deaminase
inferredcites →https://doi.org/10.1084/jem.172.6.1717openalex-snapshot
Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.
inferredcites →https://doi.org/10.1084/jem.20030569openalex-snapshot
H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation
inferredcites →https://doi.org/10.1084/jem.20051604openalex-snapshot
The very 5′ end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions
inferredcites →https://doi.org/10.1084/jem.20062032openalex-snapshot
Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation
inferredcites →https://doi.org/10.1084/jem.20121523openalex-snapshot
Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID
inferredcites →https://doi.org/10.1084/jem.20131512openalex-snapshot
Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo–activated cells
inferredcites →https://doi.org/10.1084/jem.20161649openalex-snapshot
The cell cycle restricts activation-induced cytidine deaminase activity to early G1
inferredcites →https://doi.org/10.1084/jem.20171738openalex-snapshot
A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets
inferredcites →https://doi.org/10.1093/nar/gkz821openalex-snapshot
AID–RNA polymerase II transcription-dependent deamination of IgV DNA
inferredcites →https://doi.org/10.1101/2021.01.28.428713openalex-snapshot
Spatial organization of transcript elongation and splicing kinetics
inferredcites →https://doi.org/10.1101/gad.2057811openalex-snapshot
The diverse functions of Dot1 and H3K79 methylation
inferredcites →https://doi.org/10.1101/gad.316810.118openalex-snapshot
Dynamic turnover of paused Pol II complexes at human promoters
inferredcites →https://doi.org/10.1126/science.aav8912openalex-snapshot
Structural insight into nucleosome transcription by RNA polymerase II with elongation factors
inferredcites →https://doi.org/10.1128/mbio.02315-17openalex-snapshot
Human Immunodeficiency Virus Tat Protein Aids V Region Somatic Hypermutation in Human B Cells
inferredcites →https://doi.org/10.1128/mcb.02076-07openalex-snapshot
DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells
inferredcites →https://doi.org/10.1128/mcb.02375-05openalex-snapshot
The Transcription Elongation Complex Directs Activation-Induced Cytidine Deaminase-Mediated DNA Deamination
inferredcites →https://doi.org/10.1146/annurev.immunol.7.1.537openalex-snapshot
Stable Expression And Somatic Hypermutation Of Antibody V Regions In B-Cell Developmental Pathways
inferredcites →https://doi.org/10.1182/blood-2017-12-818948openalex-snapshot
The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia
inferredcites →https://doi.org/10.1371/journal.pgen.1002518openalex-snapshot
Negative Supercoiling Creates Single-Stranded Patches of DNA That Are Substrates for AID–Mediated Mutagenesis
inferredcites →https://doi.org/10.15252/embj.201693958openalex-snapshot
Histone H3.3 promotes IgV gene diversification by enhancing formation of AID‐accessible single‐stranded DNA
inferredcites →https://doi.org/10.15252/embr.202051184openalex-snapshot
Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation
inferredcites →https://doi.org/10.3389/fimmu.2017.01157openalex-snapshot
Novel Method for High-Throughput Full-Length IGHV-D-J Sequencing of the Immune Repertoire from Bulk B-Cells with Single-Cell Resolution
inferredcites →https://doi.org/10.3389/fimmu.2018.00355openalex-snapshot
Epigenomic Modifications Mediating Antibody Maturation
inferredcites →https://doi.org/10.3389/fimmu.2019.00438openalex-snapshot
Mutating for Good: DNA Damage Responses During Somatic Hypermutation
inferredcites →https://doi.org/10.4049/jimmunol.1400433openalex-snapshot
Binding of AID to DNA Does Not Correlate with Mutator Activity
inferredcites →https://doi.org/10.4049/jimmunol.1401849openalex-snapshot
IgH Chain Class Switch Recombination: Mechanism and Regulation
inferredcites →https://doi.org/10.4049/jimmunol.171.9.4639openalex-snapshot
Estimating Hypermutation Rates from Clonal Tree Data
inferredcites →https://doi.org/10.4049/jimmunol.172.6.3382openalex-snapshot
Cutting Edge: DGYW/WRCH Is a Better Predictor of Mutability at G:C Bases in Ig Hypermutation Than the Widely Accepted RGYW/WRCY Motif and Probably Reflects a Two-Step Activation-Induced Cytidine Deaminase-Triggered Process
inferredcites →https://doi.org/10.4161/trns.24556openalex-snapshot
Transcriptional stalling in B-lymphocytes

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4137693openalex-extracted
Somatic Hypermutation Spectra Are Independent of the Local Transcriptional and Epigenetic Landscape
inferred← citeshttps://doi.org/10.1016/b978-0-128-24465-4.00124-1openalex-snapshot
Error-Prone DNA Mismatch and Base Excision Repair in the Somatic Hypermutation of Antibody Variable Regions
inferred← citeshttps://doi.org/10.1016/j.actatropica.2024.107352openalex-snapshot
Interplay between DOT1L and HDAC1 regulates Leishmania donovani infection in human THP-1 cells
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.114211openalex-snapshot
Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma
inferred← citeshttps://doi.org/10.1016/j.gde.2024.102165openalex-snapshot
Somatic hypermutation mechanisms during lymphomagenesis and transformation
inferred← citeshttps://doi.org/10.1016/j.it.2025.10.007openalex-snapshot
Epigenetically programmed identity crisis to combat diffuse large B cell lymphoma
inferred← citeshttps://doi.org/10.1016/j.molcel.2025.02.007openalex-snapshot
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination
inferred← citeshttps://doi.org/10.1038/s41467-026-68332-4openalex-snapshot
DOT1L activity limits transcription elongation velocity and favors RNAPII pausing to facilitate mutagenesis by AID
inferred← citeshttps://doi.org/10.1038/s41586-026-11087-1openalex-snapshot
Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity
inferred← citeshttps://doi.org/10.1038/s41586-026-11092-4openalex-snapshot
Transcription pause and elongation regulators mediate somatic hypermutation
inferred← citeshttps://doi.org/10.1038/s44318-025-00640-9openalex-snapshot
Somatic hypermutation patterns are shaped by both motif position and sequence grammar
inferred← citeshttps://doi.org/10.1073/pnas.2114743118openalex-snapshot
The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions
inferred← citeshttps://doi.org/10.1080/16078454.2023.2255800openalex-snapshot
The significance of autologous hematopoietic stem cell transplantation on immunoglobulin reconstitution and prognosis in elderly patients with multiple myeloma
inferred← citeshttps://doi.org/10.1093/jimmun/vkaf243openalex-snapshot
DOT1L-mediated H3K79me2 directs B-cell repertoire establishment, marginal zone development, and germinal center function
inferred← citeshttps://doi.org/10.1101/2022.05.21.492925openalex-snapshot
Somatic hypermutation patterns in immunoglobulin variable regions are established independently of the local transcriptional landscape
inferred← citeshttps://doi.org/10.1101/2022.09.08.507190openalex-snapshot
Locus-specific proteomics identifies new aspects of the chromatin context involved in V region somatic hypermutation
inferred← citeshttps://doi.org/10.2174/0109298665342261240912105111openalex-snapshot
Immunoproteomics: Approach to Diagnostic and Vaccine Development
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1385319openalex-snapshot
An emerging maestro of immune regulation: how DOT1L orchestrates the harmonies of the immune system
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1407470openalex-snapshot
Interpretable deep learning reveals the role of an E-box motif in suppressing somatic hypermutation of AGCT motifs within human immunoglobulin variable regions
inferred← citeshttps://doi.org/10.7554/elife.106566openalex-snapshot
Somatic hypermutation patterns in immunoglobulin variable regions are established independently of the local transcriptional landscape
inferred← citeshttps://doi.org/10.7554/elife.106566.1openalex-snapshot
Somatic hypermutation patterns in immunoglobulin variable regions are established independently of the local transcriptional landscape
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