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Cholesterol and Sphingomyelin Drive Ligand-independent T-cell Antigen Receptor Nanoclustering
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/eji.200323884openalex-snapshot
A physical and functional link between cholesterol and tetraspanins
inferredcites →https://doi.org/10.1006/prep.2001.1515openalex-snapshot
One-Step Purification of Recombinant Proteins Using a Nanomolar-Affinity Streptavidin-Binding Peptide, the SBP-Tag
inferredcites →https://doi.org/10.1016/0005-2736(77)90350-9openalex-snapshot
The preferential interactions of cholesterol with different classes of phospholipids
inferredcites →https://doi.org/10.1016/0161-5890(95)00046-hopenalex-snapshot
Evidence for multivalent structure of T-cell antigen receptor complex
inferredcites →https://doi.org/10.1016/j.bbamem.2011.01.009openalex-snapshot
N- and O-methylation of sphingomyelin markedly affects its membrane properties and interactions with cholesterol
inferredcites →https://doi.org/10.1016/j.bbamem.2012.03.007openalex-snapshot
Partitioning, diffusion, and ligand binding of raft lipid analogs in model and cellular plasma membranes
inferredcites →https://doi.org/10.1016/j.cellsig.2005.03.024openalex-snapshot
Revaluation of the role of cholesterol in stabilizing rafts implicated in T cell receptor signaling
inferredcites →https://doi.org/10.1016/j.immuni.2006.10.019openalex-snapshot
Full Activation of the T Cell Receptor Requires Both Clustering and Conformational Changes at CD3
inferredcites →https://doi.org/10.1016/j.immuni.2011.08.010openalex-snapshot
Increased Sensitivity of Antigen-Experienced T Cells through the Enrichment of Oligomeric T Cell Receptor Complexes
inferredcites →https://doi.org/10.1016/j.jim.2007.05.003openalex-snapshot
A native antibody-based mobility-shift technique (NAMOS-assay) to determine the stoichiometry of multiprotein complexes
inferredcites →https://doi.org/10.1016/j.str.2008.05.001openalex-snapshot
A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor
inferredcites →https://doi.org/10.1016/s0092-8674(02)01139-xopenalex-snapshot
Molecular and Functional Profiling of Memory CD8 T Cell Differentiation
inferredcites →https://doi.org/10.1016/s0092-8674(02)01194-7openalex-snapshot
The Organizing Principle in the Formation of the T Cell Receptor-CD3 Complex
inferredcites →https://doi.org/10.1016/s0092-8674(04)00167-9openalex-snapshot
Nanoscale Organization of Multiple GPI-Anchored Proteins in Living Cell Membranes
inferredcites →https://doi.org/10.1016/s1074-7613(09)00099-5openalex-snapshot
Increased TCR Avidity after T Cell Activation A Mechanism for Sensing Low-Density Antigen
inferredcites →https://doi.org/10.1016/s1097-2765(02)00496-3openalex-snapshot
Visualization of Interactions among bZIP and Rel Family Proteins in Living Cells Using Bimolecular Fluorescence Complementation
inferredcites →https://doi.org/10.1021/bi0019803openalex-snapshot
Interaction of Cholesterol with Sphingomyelin in Mixed Membranes Containing Phosphatidylcholine, Studied by Spin-Label ESR and IR Spectroscopies. A Possible Stabilization of Gel-Phase Sphingolipid Domains by Cholesterol
inferredcites →https://doi.org/10.1034/j.1600-065x.2003.00001.xopenalex-snapshot
The roles of membrane microdomains (rafts) in T cell activation
inferredcites →https://doi.org/10.1034/j.1600-065x.2003.00016.xopenalex-snapshot
An evolutionary and structural perspective on T cell antigen receptor function
inferredcites →https://doi.org/10.1038/373353a0openalex-snapshot
CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes
inferredcites →https://doi.org/10.1038/71366openalex-snapshot
Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles
inferredcites →https://doi.org/10.1038/nature09357openalex-snapshot
Oligomeric organization of the B-cell antigen receptor on resting cells
inferredcites →https://doi.org/10.1038/nature10742openalex-snapshot
Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain
inferredcites →https://doi.org/10.1038/ni.1832openalex-snapshot
TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation
inferredcites →https://doi.org/10.1038/ni1272openalex-snapshot
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76
inferredcites →https://doi.org/10.1038/sj.emboj.7600374openalex-snapshot
Electron crystallography reveals the structure of metarhodopsin I
inferredcites →https://doi.org/10.1038/sj.embor.7400682openalex-snapshot
T‐cell antigen‐receptor stoichiometry: pre‐clustering for sensitivity
inferredcites →https://doi.org/10.1042/bst0330938openalex-snapshot
Specific protein–lipid interactions in membrane proteins
inferredcites →https://doi.org/10.1073/pnas.0607465103openalex-snapshot
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels
inferredcites →https://doi.org/10.1073/pnas.0609009103openalex-snapshot
Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton
inferredcites →https://doi.org/10.1073/pnas.0700411104openalex-snapshot
Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells
inferredcites →https://doi.org/10.1073/pnas.1000925107openalex-snapshot
Evidence for a functional sidedness to the αβTCR
inferredcites →https://doi.org/10.1073/pnas.1105666108openalex-snapshot
Regulation of human EGF receptor by lipids
inferredcites →https://doi.org/10.1073/pnas.95.20.11673openalex-snapshot
Lipid patches in membrane protein oligomers: Crystal structure of the bacteriorhodopsin-lipid complex
inferredcites →https://doi.org/10.1073/pnas.96.4.1547openalex-snapshot
Multivalent structure of an αβT cell receptor
inferredcites →https://doi.org/10.1074/jbc.m111.219212openalex-snapshot
The T Cell Receptor Triggering Apparatus Is Composed of Monovalent or Monomeric Proteins
inferredcites →https://doi.org/10.1084/jem.20042155openalex-snapshot
Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response
inferredcites →https://doi.org/10.1093/emboj/17.18.5334openalex-snapshot
Engagement of T cell receptor triggers its recruitment to low‐density detergent‐insoluble membrane domains
inferredcites →https://doi.org/10.1101/cshperspect.a004705openalex-snapshot
Specificity of Intramembrane Protein-Lipid Interactions
inferredcites →https://doi.org/10.1126/science.1068539openalex-snapshot
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
inferredcites →https://doi.org/10.1126/science.1141727openalex-snapshot
Anatomy and Dynamics of a Supramolecular Membrane Protein Cluster
inferredcites →https://doi.org/10.1126/science.1150577openalex-snapshot
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
inferredcites →https://doi.org/10.1126/stke.3452006pl4openalex-snapshot
Blue Native Polyacrylamide Gel Electrophoresis (BN-PAGE) for the Identification and Analysis of Multiprotein Complexes
inferredcites →https://doi.org/10.1146/annurev.biophys.34.040204.144637openalex-snapshot
Paradigm Shift of the Plasma Membrane Concept from the Two-Dimensional Continuum Fluid to the Partitioned Fluid: High-Speed Single-Molecule Tracking of Membrane Molecules
inferredcites →https://doi.org/10.1146/annurev.immunol.16.1.523openalex-snapshot
LIGAND RECOGNITION BY αβ T CELL RECEPTORS
inferredcites →https://doi.org/10.1186/1478-811x-8-5openalex-snapshot
Stoichiometry and intracellular fate of TRIM-containing TCR complexes
inferredcites →https://doi.org/10.1210/endo.139.12.6390openalex-snapshot
Peripheral-Type Benzodiazepine Receptor Function in Cholesterol Transport. Identification of a Putative Cholesterol Recognition/Interaction Amino Acid Sequence and Consensus Pattern1
inferredcites →https://doi.org/10.4049/jimmunol.157.8.3280openalex-snapshot
Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals
inferredcites →https://doi.org/10.4049/jimmunol.166.12.7009openalex-snapshot
Cutting Edge: Lipid Raft Integrity Affects the Efficiency of MHC Class I Tetramer Binding and Cell Surface TCR Arrangement on CD8+ T Cells
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Cholesterol Metabolism-Mediated Immune Regulation and Cancer Immunotherapy
inferred← citeshttps://doi.org/10.1002/1873-3468.14153openalex-snapshot
Aggregation and mobility of membrane proteins interplay with local lipid order in the plasma membrane of T cells
inferred← citeshttps://doi.org/10.1002/adfm.202307433openalex-snapshot
Bioinspired Materials for Immunoengineering of T Cells and Natural Killer Cells
inferred← citeshttps://doi.org/10.1002/admi.202500806openalex-snapshot
Cholesterol‐DNA Origami Nanostructures for Synthetic Lipid Rafts Induce Early T Cell Activation Signals
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Combined effects of avasimibe immunotherapy, doxorubicin chemotherapy, and metal–organic frameworks nanoparticles on breast cancer
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αβ and γδ T cell receptors: Similar but different
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Reinvigorating exhausted CD8 + cytotoxic T lymphocytes in the tumor microenvironment and current strategies in cancer immunotherapy
inferred← citeshttps://doi.org/10.1007/978-3-030-80962-1_107-1openalex-snapshot
Hypercholesterolemia Influences the Progression of Cancer by Changing the Biomolecular and Immunological Status of the Tumor Microenvironment
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Targeting CAR T Cells’ Metabolic Pathways to Boost Their Effectiveness Against Tumors
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Hypercholesterolemia Influences the Progression of Cancer by Changing the Biomolecular and Immunological Status of the Tumor Microenvironment
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Targeting CAR T Cells’ Metabolic Pathways to Boost Their Effectiveness Against Tumors
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Activation of the TCR Complex by Peptide-MHC and Superantigens
inferred← citeshttps://doi.org/10.1007/978-3-0348-0726-5_3openalex-snapshot
Activation of the TCR Complex by Small Chemical Compounds
inferred← citeshttps://doi.org/10.1007/978-981-33-6785-2_10openalex-snapshot
Lipid Metabolism in Tumor-Infiltrating T Cells
inferred← citeshttps://doi.org/10.1007/978-981-99-7342-2_6openalex-snapshot
Immune System, Redox Signaling, and Cancer Immunity
inferred← citeshttps://doi.org/10.1007/s10753-023-01961-9openalex-snapshot
Advance in Multi-omics Research Strategies on Cholesterol Metabolism in Psoriasis
inferred← citeshttps://doi.org/10.1007/s11427-021-1999-2openalex-snapshot
Cancer metabolism and tumor microenvironment: fostering each other?
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CRISPR screening reveals NPC1L1 as a key driver of glioblastoma progression via cholesterol metabolic regulation
inferred← citeshttps://doi.org/10.1007/s11882-015-0548-7openalex-snapshot
Regulation of Adaptive Immunity in Health and Disease by Cholesterol Metabolism
inferred← citeshttps://doi.org/10.1007/s11883-023-01125-yopenalex-snapshot
T-cell Cholesterol Accumulation, Aging, and Atherosclerosis
inferred← citeshttps://doi.org/10.1007/s12185-019-02739-2openalex-snapshot
Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation
inferred← citeshttps://doi.org/10.1016/b978-0-12-408143-7.00021-9openalex-snapshot
Visualization of TCR Nanoclusters via Immunogold Labeling, Freeze-Etching, and Surface Replication
inferred← citeshttps://doi.org/10.1016/b978-0-12-821618-7.00202-9openalex-snapshot
T Cell Receptor Triggering
inferred← citeshttps://doi.org/10.1016/b978-0-12-824465-4.00180-0openalex-snapshot
Cellular Metabolism Controls Lymphocyte Activation and Differentiation
inferred← citeshttps://doi.org/10.1016/b978-0-12-824465-4.00275-1openalex-snapshot
Immunometabolism Governs T Cell Immunity
inferred← citeshttps://doi.org/10.1016/bs.ai.2017.12.002openalex-snapshot
Caveolin-1: The Unnoticed Player in TCR and BCR Signaling
inferred← citeshttps://doi.org/10.1016/bs.ai.2019.08.003openalex-snapshot
B cell mechanosensing: A mechanistic overview
inferred← citeshttps://doi.org/10.1016/j.ab.2013.01.026openalex-snapshot
Analysis of interactions between proteins and fatty acids or cholesterol using a fatty acid/cholesterol pull-down assay
inferred← citeshttps://doi.org/10.1016/j.antiviral.2023.105662openalex-snapshot
Avasimibe can cooperate with a DC-targeting and integration-deficient lentivector to induce stronger HBV specific T cytotoxic response by regulating cholesterol metabolism
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2017.10.026openalex-snapshot
Activation-induced FOXP3 isoform profile in peripheral CD4+ T cells is associated with coronary artery disease
inferred← citeshttps://doi.org/10.1016/j.bbalip.2013.12.003openalex-snapshot
The role of sphingomyelin and sphingomyelin synthases in cell death, proliferation and migration—from cell and animal models to human disorders
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2014.10.025openalex-snapshot
Do mechanical forces contribute to nanoscale membrane organisation in T cells?
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2014.12.017openalex-snapshot
Nanoclusters of the resting T cell antigen receptor (TCR) localize to non-raft domains
inferred← citeshttps://doi.org/10.1016/j.bbamem.2013.07.018openalex-snapshot
Interaction of membrane/lipid rafts with the cytoskeleton: Impact on signaling and function
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116441openalex-snapshot
Key links in the physiological regulation of the immune system and disease induction: T cell receptor -CD3 complex
inferred← citeshttps://doi.org/10.1016/j.bcp.2025.116802openalex-snapshot
Cholesterol metabolism in tumor immunity: Mechanisms and therapeutic opportunities for cancer
inferred← citeshttps://doi.org/10.1016/j.biochi.2015.04.005openalex-snapshot
Orchestration of membrane receptor signaling by membrane lipids
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2018.09.029openalex-snapshot
Efficient magnetic enrichment of antigen-specific T cells by engineering particle properties
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2019.119265openalex-snapshot
T cell immunotherapy enhanced by designer biomaterials
inferred← citeshttps://doi.org/10.1016/j.canlet.2020.12.004openalex-snapshot
A metabolic switch to memory CAR T cells: Implications for cancer treatment
inferred← citeshttps://doi.org/10.1016/j.cbpa.2019.05.019openalex-snapshot
Can single molecule localization microscopy detect nanoclusters in T cells?
inferred← citeshttps://doi.org/10.1016/j.chembiol.2024.04.005openalex-snapshot
Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity
inferred← citeshttps://doi.org/10.1016/j.cllc.2022.07.010openalex-snapshot
Circulating Fatty Acid Profile as a Biomarker for Immunotherapy in Advanced Non-Small Cell Lung Cancer
inferred← citeshttps://doi.org/10.1016/j.cmet.2016.05.015openalex-snapshot
Modulating Cholesterol Homeostasis to Build a Better T Cell
inferred← citeshttps://doi.org/10.1016/j.cmet.2017.06.019openalex-snapshot
Ancillary Activity: Beyond Core Metabolism in Immune Cells
inferred← citeshttps://doi.org/10.1016/j.coche.2017.12.007openalex-snapshot
T cell receptor signal transduction: affinity, force and conformational change
inferred← citeshttps://doi.org/10.1016/j.cyto.2018.11.016openalex-snapshot
Metabolic regulation of infection and inflammation
inferred← citeshttps://doi.org/10.1016/j.ejphar.2015.03.091openalex-snapshot
Omega-3 fatty acids, lipid rafts, and T cell signaling
inferred← citeshttps://doi.org/10.1016/j.ejphar.2024.176519openalex-snapshot
Fatostatin promotes anti-tumor immunity by reducing SREBP2 mediated cholesterol metabolism in tumor-infiltrating T lymphocytes
inferred← citeshttps://doi.org/10.1016/j.fsi.2023.108863openalex-snapshot
ATGL-mediated lipophagy balances cholesterol-induced inflammation in pathogen infected Apostichopus japonicus coelomocytes
inferred← citeshttps://doi.org/10.1016/j.immuni.2016.04.011openalex-snapshot
A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation
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Antigen Receptor Nanoclusters: Small Units with Big Functions
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The Intracellular Cholesterol Landscape: Dynamic Integrator of the Immune Response
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Effect of temperature on raft-dependent endocytic cluster formation during activation of Jurkat T cells by concanavalin A
inferred← citeshttps://doi.org/10.1016/j.jmb.2021.167328openalex-snapshot
Cholesterol Binds in a Reversed Orientation to TCRβ-TM in Which Its OH Group is Localized to the Center of the Lipid Bilayer
inferred← citeshttps://doi.org/10.1016/j.jmb.2025.169446openalex-snapshot
Allostery in Biomolecular Condensates
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Enhanced chemo-immunotherapy against melanoma by inhibition of cholesterol esterification in CD8+ T cells
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Atorvastatin pre-exposure in hypercholesterolemia remedies 27HC mediated dendritic cell dysfunctions in triple-negative breast cancer
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Dynamic multiprotein assemblies shape the spatial structure of cell signaling
inferred← citeshttps://doi.org/10.1016/j.pbiomolbio.2015.04.004openalex-snapshot
Lipid in T-cell receptor transmembrane signaling
inferred← citeshttps://doi.org/10.1016/j.plipres.2019.101010openalex-snapshot
Galectin-3 modulation of T-cell activation: mechanisms of membrane remodelling
inferred← citeshttps://doi.org/10.1016/j.redox.2020.101759openalex-snapshot
Innate-adaptive immunity interplay and redox regulation in immune response
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Metabolic regulation of T cells in the tumor microenvironment by nutrient availability and diet
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Exploiting T cell signaling to optimize engineered T cell therapies
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NPC1L1 on pancreatic adenocarcinoma cell functions as a two-pronged checkpoint against antitumor activity
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Applying metabolic control strategies to engineered T cell cancer therapies
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Membrane-Based Assembly and Interactions in Immune Receptors
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Biologically Inspired Design of Nanoparticle Artificial Antigen-Presenting Cells for Immunomodulation
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Close Contacts Unlocked: Nanopore-Stabilized Microvilli Bypass T Cell Receptor–Ligand-Dependent T Cell Activation
inferred← citeshttps://doi.org/10.1021/nl4022623openalex-snapshot
Fine Tuning and Efficient T Cell Activation with Stimulatory aCD3 Nanoarrays
inferred← citeshttps://doi.org/10.1038/nature17412openalex-snapshot
Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism
inferred← citeshttps://doi.org/10.1038/ni.3462openalex-snapshot
Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol
inferred← citeshttps://doi.org/10.1038/nri.2016.103openalex-snapshot
Regulation of T cell signalling by membrane lipids
inferred← citeshttps://doi.org/10.1038/s41419-022-04821-wopenalex-snapshot
Impacts and mechanisms of metabolic reprogramming of tumor microenvironment for immunotherapy in gastric cancer
inferred← citeshttps://doi.org/10.1038/s41422-025-01155-yopenalex-snapshot
Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer immunotherapy of glioblastoma
inferred← citeshttps://doi.org/10.1038/s41423-025-01262-1openalex-snapshot
Cholesterol homeostasis and lipid raft dynamics at the basis of tumor-induced immune dysfunction in chronic lymphocytic leukemia
inferred← citeshttps://doi.org/10.1038/s41467-018-05050-6openalex-snapshot
A window of opportunity for cooperativity in the T Cell Receptor
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Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells
inferred← citeshttps://doi.org/10.1038/s41467-021-22967-7openalex-snapshot
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
inferred← citeshttps://doi.org/10.1038/s41467-022-31135-4openalex-snapshot
T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice
inferred← citeshttps://doi.org/10.1038/s41556-018-0217-xopenalex-snapshot
Metabolism as a guiding force for immunity
inferred← citeshttps://doi.org/10.1038/s41577-024-01093-7openalex-snapshot
From TCR fundamental research to innovative chimeric antigen receptor design
inferred← citeshttps://doi.org/10.1038/s41598-017-15546-8openalex-snapshot
Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population
inferred← citeshttps://doi.org/10.1038/s42255-025-01240-xopenalex-snapshot
Disrupting cholesterol homeostasis in T cells boosts antitumour responses
inferred← citeshttps://doi.org/10.1038/s44319-024-00314-3openalex-snapshot
In situ cell-surface conformation of the TCR-CD3 signaling complex
inferred← citeshttps://doi.org/10.1038/srep44320openalex-snapshot
Heterogeneity assessment of functional T cell avidity
inferred← citeshttps://doi.org/10.1042/cs20201394openalex-snapshot
Cholesterol metabolism: a new molecular switch to control inflammation
inferred← citeshttps://doi.org/10.1073/pnas.1611445113openalex-snapshot
A conserved αβ transmembrane interface forms the core of a compact T-cell receptor–CD3 structure within the membrane
inferred← citeshttps://doi.org/10.1073/pnas.2201907119openalex-snapshot
A set point in the selection of the αβTCR T cell repertoire imposed by pre-TCR signaling strength
inferred← citeshttps://doi.org/10.1073/pnas.2208058119openalex-snapshot
T cell and B cell antigen receptors share a conserved core transmembrane structure
inferred← citeshttps://doi.org/10.1073/pnas.2305245120openalex-snapshot
Tumor cell–derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8 + T cell activation
inferred← citeshttps://doi.org/10.1074/jbc.m113.531632openalex-snapshot
Single Molecule Analysis Reveals Coexistence of Stable Serotonin Transporter Monomers and Oligomers in the Live Cell Plasma Membrane
inferred← citeshttps://doi.org/10.1084/jem.20221839openalex-snapshot
Nutrients: Signal 4 in T cell immunity
inferred← citeshttps://doi.org/10.1088/1367-2630/abeacbopenalex-snapshot
Influence of lipid rafts on pattern formation during T-cell adhesion
inferred← citeshttps://doi.org/10.1088/1478-3975/10/4/045004openalex-snapshot
The spatial structure of cell signaling systems
inferred← citeshttps://doi.org/10.1088/2050-6120/aaed0fopenalex-snapshot
What we talk about when we talk about nanoclusters
inferred← citeshttps://doi.org/10.1093/cei/uxab033openalex-snapshot
The role of lipid metabolism in shaping the expansion and the function of regulatory T cells
inferred← citeshttps://doi.org/10.1093/cvr/cvz166openalex-snapshot
Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology
inferred← citeshttps://doi.org/10.1093/intimm/dxy082openalex-snapshot
Plasma membrane sphingomyelin modulates thymocyte development by inhibiting TCR-induced apoptosis
inferred← citeshttps://doi.org/10.1096/fj.202300515ropenalex-snapshot
Cholesterol metabolism in T‐cell aging: Accomplices or victims
inferred← citeshttps://doi.org/10.1097/cji.0000000000000207openalex-snapshot
Cholesterol Esterification Enzyme Inhibition Enhances Antitumor Effects of Human Chimeric Antigen Receptors Modified T Cells
inferred← citeshttps://doi.org/10.1097/mol.0000000000000540openalex-snapshot
Lipid-driven immunometabolic responses in atherosclerosis
inferred← citeshttps://doi.org/10.1101/2020.05.04.074922openalex-snapshot
Pre-TCR signaling intensity shapes the TCRβ repertoire
inferred← citeshttps://doi.org/10.1101/2023.02.22.529596openalex-snapshot
Synthetic lipid rafts formed by cholesterol nano-patch induce early T cell activation
inferred← citeshttps://doi.org/10.1111/febs.14454openalex-snapshot
Understanding lymphocyte metabolism for use in cancer immunotherapy
inferred← citeshttps://doi.org/10.1111/imr.13200openalex-snapshot
Decoding the crosstalk between mevalonate metabolism and T cell function
inferred← citeshttps://doi.org/10.1111/tra.12718openalex-snapshot
Defining raft domains in the plasma membrane
inferred← citeshttps://doi.org/10.1126/sciadv.adq8114openalex-snapshot
Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells
inferred← citeshttps://doi.org/10.1126/science.adt4169openalex-snapshot
T cell cholesterol transport links intestinal immune responses to dietary lipid absorption
inferred← citeshttps://doi.org/10.1126/scisignal.aau1788openalex-snapshot
Immunometabolism regulates TCR recycling and iNKT cell functions
inferred← citeshttps://doi.org/10.1126/scitranslmed.aaz6667openalex-snapshot
Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy
inferred← citeshttps://doi.org/10.1128/mbio.01680-25openalex-snapshot
PIM1 orchestrates sepsis-associated inflammatory imbalance in CD4 + T cell subsets via cholesterol metabolism
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-16-0427openalex-snapshot
Cancer Immunotherapy: Whence and Whither
inferred← citeshttps://doi.org/10.1158/2326-6066.cir-17-0327openalex-snapshot
Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human Vγ9Vδ2 T Cells
inferred← citeshttps://doi.org/10.1158/2326-6066.cir-21-1118openalex-snapshot
Enhancing the Antitumor Immunity of T Cells by Engineering the Lipid-Regulatory Site of the TCR/CD3 Complex
inferred← citeshttps://doi.org/10.1161/atvbaha.122.318226openalex-snapshot
Specific Loss of ABCA1 (ATP-Binding Cassette Transporter A1) Suppresses TCR (T-Cell Receptor) Signaling and Provides Protection Against Atherosclerosis
inferred← citeshttps://doi.org/10.1161/circresaha.122.320263openalex-snapshot
Animal Models of Atherosclerosis–Supportive Notes and Tricks of the Trade
inferred← citeshttps://doi.org/10.1172/jci97785openalex-snapshot
Hypercholesterolemia induces T cell expansion in humanized immune mice
inferred← citeshttps://doi.org/10.1186/s11658-020-00224-xopenalex-snapshot
Do ABC transporters regulate plasma membrane organization?
inferred← citeshttps://doi.org/10.1186/s12943-026-02631-8openalex-snapshot
Targeting cholesterol-driven immunometabolism in cancer: from molecular circuits to clinical translation
inferred← citeshttps://doi.org/10.1186/s13045-017-0504-1openalex-snapshot
Metabolism-associated danger signal-induced immune response and reverse immune checkpoint-activated CD40+ monocyte differentiation
inferred← citeshttps://doi.org/10.1242/jcs.146340openalex-snapshot
Nanoclustering as a dominant feature of plasma membrane organization
inferred← citeshttps://doi.org/10.1242/jcs.226423openalex-snapshot
How does T cell receptor clustering impact on signal transduction?
inferred← citeshttps://doi.org/10.1360/nso/20230087openalex-snapshot
T cell receptor signaling and cell immunotherapy
inferred← citeshttps://doi.org/10.1371/journal.pone.0149303openalex-snapshot
A Systems Biology Approach to the Coordination of Defensive and Offensive Molecular Mechanisms in the Innate and Adaptive Host–Pathogen Interaction Networks
inferred← citeshttps://doi.org/10.1515/ntrev-2024-0072openalex-snapshot
Recent process of using nanoparticles in the T cell-based immunometabolic therapy
inferred← citeshttps://doi.org/10.15252/embj.2020104749openalex-snapshot
CCR5 deficiency impairs CD4+ T‐cell memory responses and antigenic sensitivity through increased ceramide synthesis
inferred← citeshttps://doi.org/10.18103/mra.v9i2.2284openalex-snapshot
The role of cholesterol in TCR signalling in autoimmune diseases
inferred← citeshttps://doi.org/10.20900/immunometab20200020openalex-snapshot
T Cell Metabolism in Cancer Immunotherapy
inferred← citeshttps://doi.org/10.2147/ijn.s439828openalex-snapshot
Regulating Cholesterol in Tumorigenesis: A Novel Paradigm for Tumor Nanotherapeutics
inferred← citeshttps://doi.org/10.2147/ott.s315998openalex-snapshot
Cholesterol Metabolism as a Potential Therapeutic Target and a Prognostic Biomarker for Cancer Immunotherapy
inferred← citeshttps://doi.org/10.32604/or.2023.027112openalex-snapshot
A pan-cancer analysis identifies SOAT1 as an immunological and prognostic biomarker
inferred← citeshttps://doi.org/10.33612/diss.241440465openalex-snapshot
Crosstalk between lipoproteins and leukocytes
inferred← citeshttps://doi.org/10.3389/fbioe.2022.1002967openalex-snapshot
Recent advances in engineering nanotopographic substrates for cell studies
inferred← citeshttps://doi.org/10.3389/fcell.2020.615996openalex-snapshot
Direct Regulation of the T Cell Antigen Receptor's Activity by Cholesterol
inferred← citeshttps://doi.org/10.3389/fimmu.2013.00427openalex-snapshot
Pre-Clustering of the B Cell Antigen Receptor Demonstrated by Mathematically Extended Electron Microscopy
inferred← citeshttps://doi.org/10.3389/fimmu.2014.00579openalex-snapshot
Dynamic Aspects of Macrophage Polarization during Atherosclerosis Progression and Regression
inferred← citeshttps://doi.org/10.3389/fimmu.2017.00247openalex-snapshot
Nutrient and Metabolic Sensing in T Cell Responses
inferred← citeshttps://doi.org/10.3389/fimmu.2017.01636openalex-snapshot
Transcriptional Regulation of T-Cell Lipid Metabolism: Implications for Plasma Membrane Lipid Rafts and T-Cell Function
inferred← citeshttps://doi.org/10.3389/fimmu.2017.01664openalex-snapshot
Cholesterol Metabolism in T Cells
inferred← citeshttps://doi.org/10.3389/fimmu.2018.02736openalex-snapshot
Naïve CD8+ T-Cells Engage a Versatile Metabolic Program Upon Activation in Humans and Differ Energetically From Memory CD8+ T-Cells
inferred← citeshttps://doi.org/10.3389/fimmu.2020.584303openalex-snapshot
Liver X Receptors: Regulators of Cholesterol Metabolism, Inflammation, Autoimmunity, and Cancer
inferred← citeshttps://doi.org/10.3389/fimmu.2021.613185openalex-snapshot
Plasma Membrane Integrates Biophysical and Biochemical Regulation to Trigger Immune Receptor Functions
inferred← citeshttps://doi.org/10.3389/fimmu.2021.722320openalex-snapshot
The Chemokine Receptor CCR5 Links Memory CD4+ T Cell Metabolism to T Cell Antigen Receptor Nanoclustering
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1688995openalex-snapshot
Metabolic reprogramming of CAR T cells: a new frontier in cancer immunotherapy
inferred← citeshttps://doi.org/10.3389/fonc.2023.1107484openalex-snapshot
Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model
inferred← citeshttps://doi.org/10.3389/fphar.2022.1002915openalex-snapshot
How sphingolipids affect T cells in the resolution of inflammation
inferred← citeshttps://doi.org/10.3389/fphar.2022.840440openalex-snapshot
Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity
inferred← citeshttps://doi.org/10.3389/fphar.2023.1191692openalex-snapshot
HECT, UBA and WWE domain containing 1 represses cholesterol efflux during CD4+ T cell activation in Sjögren’s syndrome
inferred← citeshttps://doi.org/10.3389/fphar.2024.1324140openalex-snapshot
Statin therapy: a potential adjuvant to immunotherapies in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.3390/biomedicines13081895openalex-snapshot
Lipid Metabolism Reprogramming in Cancer: Insights into Tumor Cells and Immune Cells Within the Tumor Microenvironment
inferred← citeshttps://doi.org/10.3390/cells13060555openalex-snapshot
Modulating Cholesterol Metabolism via ACAT1 Knockdown Enhances Anti-B-Cell Lymphoma Activities of CD19-Specific Chimeric Antigen Receptor T Cells by Improving the Cell Activation and Proliferation
inferred← citeshttps://doi.org/10.3390/ijms22179186openalex-snapshot
ABC Transporters in T Cell-Mediated Physiological and Pathological Immune Responses
inferred← citeshttps://doi.org/10.3390/ijms26167942openalex-snapshot
Epidermal and Dermal T Cells Exhibit Distinct Proteomic Signatures
inferred← citeshttps://doi.org/10.3390/molecules28186598openalex-snapshot
Rafting on the Evidence for Lipid Raft-like Domains as Hubs Triggering Environmental Toxicants’ Cellular Effects
inferred← citeshttps://doi.org/10.3390/pharmaceutics14040734openalex-snapshot
Biomimetic and Materials-Potentiated Cell Engineering for Cancer Immunotherapy
inferred← citeshttps://doi.org/10.3410/f.736033315.793563766openalex-snapshot
Faculty Opinions recommendation of Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology.
inferred← citeshttps://doi.org/10.3892/ol.2019.10427openalex-snapshot
Effect of inhibiting ACAT‑1 expression on the growth and metastasis of Lewis lung carcinoma
inferred← citeshttps://doi.org/10.4049/jimmunol.1601661openalex-snapshot
The Allostery Model of TCR Regulation
inferred← citeshttps://doi.org/10.4110/in.2023.23.e29openalex-snapshot
The Immunosuppressive Potential of Cholesterol Sulfate Through T Cell Microvilli Disruption
inferred← citeshttps://doi.org/10.4110/in.2023.23.e3openalex-snapshot
T Cell Microvilli: Finger-Shaped External Structures Linked to the Fate of T Cells
inferred← citeshttps://doi.org/10.4172/2155-9929.1000413openalex-snapshot
Immune Modulatory Effects of Hypercholesterolemia: Can Atorvastatin Convert the Detrimental Effect of Hypercholesterolemia on the Immune System?
inferred← citeshttps://doi.org/10.4251/wjgo.v15.i4.617openalex-snapshot
Lipid metabolism of hepatocellular carcinoma impacts targeted therapy and immunotherapy
inferred← citeshttps://doi.org/10.5821/dissertation-2117-95842openalex-snapshot
Membrane protein nanoclustering as a functional unit of immune cells : from nanoscopy to single molecule dynamics
inferred← citeshttps://doi.org/10.64898/2026.08.16.745088openalex-snapshot
Spatial cholesterol homeostasis gatekeeps T-cell development and activation by orchestrating signaling and fitness
inferred← citeshttps://doi.org/10.70675/0582ddaaze61dz4707z9cb1zdb8fe1d82653openalex-snapshot
Targeting the metabolic environment to modulate T cell effector function
inferred← citeshttps://doi.org/10.70675/f95a22e2z510fz40c8z89b3z948cac8a09c8openalex-snapshot
Immune synapse : T cell receptor clustering is associated with a liquid-disordered plasma membrane
inferred← citeshttps://doi.org/10.7150/thno.82189openalex-snapshot
Perturbing plasma membrane lipid: a new paradigm for tumor nanotherapeutics
inferred← citeshttps://doi.org/10.7554/elife.70055openalex-snapshot
Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes
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