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Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

https://doi.org/10.1080/15548627.2016.1208889

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for β-amyloid peptide over-production and localization in Alzheimer’s disease

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Autophagy and Aging

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S6K1 controls autophagosome maturation in autophagy induced by sulforaphane or serum deprivation

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Sulforaphane induces autophagy through ERK activation in neuronal cells

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Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3

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Molecular basis of the Keap1–Nrf2 system

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2015.06.014openalex-snapshot

p62 links autophagy and Nrf2 signaling

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2015.08.002openalex-snapshot

Introduction to Special Issue on ‘Nrf2 Regulated Redox Signaling and Metabolism in Physiology and Medicine

inferredcites →https://doi.org/10.1016/j.mad.2009.12.007openalex-snapshot

Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract

inferredcites →https://doi.org/10.1016/j.molcel.2013.01.024openalex-snapshot

ZKSCAN3 Is a Master Transcriptional Repressor of Autophagy

inferredcites →https://doi.org/10.1016/j.molcel.2013.08.003openalex-snapshot

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

inferredcites →https://doi.org/10.1016/j.neuint.2013.01.014openalex-snapshot

Rapamycin decreases tau phosphorylation at Ser214 through regulation of cAMP-dependent kinase

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2004.09.016openalex-snapshot

Human-like rodent amyloid-β-peptide determines Alzheimer pathology in aged wild-type Octodon degu

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Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment

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Increased Alzheimer's disease–like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy

inferredcites →https://doi.org/10.1016/j.neuroscience.2014.07.072openalex-snapshot

Sulforaphane-induced autophagy flux prevents prion protein-mediated neurotoxicity through AMPK pathway

inferredcites →https://doi.org/10.1016/j.semcdb.2015.03.005openalex-snapshot

Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation

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The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

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NAD(P)H:quinone oxidoreductase activity is increased in hippocampal pyramidal neurons of patients with alzheimer’s disease

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Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies

inferredcites →https://doi.org/10.1038/nature04723openalex-snapshot

Loss of autophagy in the central nervous system causes neurodegeneration in mice

inferredcites →https://doi.org/10.1038/nature04724openalex-snapshot

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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FOXO3A directs a protective autophagy program in haematopoietic stem cells

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Transcriptional regulation of autophagy by an FXR–CREB axis

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Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs

inferredcites →https://doi.org/10.1038/ncomms4496openalex-snapshot

Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52

inferredcites →https://doi.org/10.1038/ncomms7670openalex-snapshot

Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy

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Autophagy modulation as a potential therapeutic target for diverse diseases

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KEAP1–NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity

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Degradation of tau protein by autophagy and proteasomal pathways

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Multivalent DNA Binding Complex Generated by Small Maf and Bach1 as a Possible Biochemical Basis for β-Globin Locus Control Region Complex

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Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

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p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

inferredcites →https://doi.org/10.1074/jbc.m300931200openalex-snapshot

Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression

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Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

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Changed Conformation of Mutant Tau-P301L Underlies the Moribund Tauopathy, Absent in Progressive, Nonlethal Axonopathy of Tau-4R/2N Transgenic Mice

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Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway

inferredcites →https://doi.org/10.1080/15548627.2015.1034410openalex-snapshot

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inferredcites →https://doi.org/10.1089/ars.2012.4754openalex-snapshot

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Neuronal sensitivity to kainic acid is dependent on the Nrf2‐mediated actions of the antioxidant response element

inferredcites →https://doi.org/10.1126/science.1204592openalex-snapshot

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inferredcites →https://doi.org/10.1126/science.290.5497.1717openalex-snapshot

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inferredcites →https://doi.org/10.1128/mcb.24.24.10941-10953.2004openalex-snapshot

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inferredcites →https://doi.org/10.1155/2013/798401openalex-snapshot

The NRF2 Activation and Antioxidative Response Are Not Impaired Overall during Hyperoxia-Induced Lung Epithelial Cell Death

inferredcites →https://doi.org/10.1159/000373980openalex-snapshot

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

inferredcites →https://doi.org/10.1179/135100099101534701openalex-snapshot

Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer's disease

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Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

inferredcites →https://doi.org/10.1186/2051-5960-2-50openalex-snapshot

Phosphorylation of serine 349 of p62 in Alzheimer’s disease brain

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Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson’s disease – a multicenter study

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Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

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Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice

inferredcites →https://doi.org/10.1523/jneurosci.0800-08.2008openalex-snapshot

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

inferredcites →https://doi.org/10.1523/jneurosci.3049-12.2012openalex-snapshot

Astrocyte-Specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-Synuclein Mutant (A53T) Mouse Model

inferredcites →https://doi.org/10.2353/ajpath.2008.070904openalex-snapshot

Amyloid Activates GSK-3β to Aggravate Neuronal Tauopathy in Bigenic Mice

inferredcites →https://doi.org/10.3109/21678421.2013.839708openalex-snapshot

Association of NFE2L2 and KEAP1 haplotypes with amyotrophic lateral sclerosis

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inferredcites →https://doi.org/10.4161/auto.21861openalex-snapshot

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inferredcites →https://doi.org/10.4161/auto.25803openalex-snapshot

Histone post-translational modifications regulate autophagy flux and outcome

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2019.01.016openalex-snapshot

Redox regulation by NRF2 in aging and disease

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2020.02.010openalex-snapshot

A low glycemic diet protects disease-prone Nrf2-deficient mice against age-related macular degeneration

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2020.02.022openalex-snapshot

Acetyl-11-keto-β-boswellic acid ameliorates cognitive deficits and reduces amyloid-β levels in APPswe/PS1dE9 mice through antioxidant and anti-inflammatory pathways

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2020.06.028openalex-snapshot

Transcription factor NRF2 as a promising therapeutic target for Alzheimer’s disease

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2021.04.003openalex-snapshot

Bach2 regulates autophagy to modulate UVA-induced photoaging in skin fibroblasts

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2022.04.014openalex-snapshot

Hydrogen sulfide alleviates particulate matter-induced emphysema and airway inflammation by suppressing ferroptosis

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2022.10.274openalex-snapshot

Activation of Nrf2 modulates protective immunity against Mycobacterium tuberculosis infection in THP1-derived macrophages

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2022.11.017openalex-snapshot

Targeting NRF2–KEAP1 axis by Omega-3 fatty acids and their derivatives: Emerging opportunities against aging and diseases

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2023.07.008openalex-snapshot

Co-targeting autophagy and NRF2 signaling triggers mitochondrial superoxide to sensitize oral cancer stem cells for cisplatin-induced apoptosis

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2023.09.009openalex-snapshot

Nrf2 depletion in the context of loss-of-function Keap1 leads to mitolysosome accumulation

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2024.09.035openalex-snapshot

Naturally-derived modulators of the Nrf2 pathway and their roles in the intervention of diseases

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2024.11.048openalex-snapshot

NRF2 activation by 6-MSITC increases the generation of neuroprotective, soluble α amyloid precursor protein by inducing the metalloprotease gene ADAM17

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2026.01.023openalex-snapshot

NRF2 at the crossroads of Parkinson’s disease and aging: Mechanistic insights and translational perspectives

inferred← citeshttps://doi.org/10.1016/j.fsi.2022.02.010openalex-snapshot

Silencing of Nrf2 in Litopenaeus vannamei, decreased the antioxidant capacity, and increased apoptosis and autophagy

inferred← citeshttps://doi.org/10.1016/j.gendis.2022.02.012openalex-snapshot

Potential relationship between autophagy and ferroptosis in myocardial ischemia/reperfusion injury

inferred← citeshttps://doi.org/10.1016/j.gendis.2026.102228openalex-snapshot

Rewiring redox defense: Nrf2-driven antioxidant signaling as a gateway to programmed cell death activation in colorectal cancer

inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e18188openalex-snapshot

A bioinformatic investigation of proteasome and autophagy expression in the central nervous system

inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e35869openalex-snapshot

Microglia-induced neuroinflammation in hippocampal neurogenesis following traumatic brain injury

inferred← citeshttps://doi.org/10.1016/j.ibneur.2024.11.005openalex-snapshot

Hyperphosphorylated tau targeting human serum albumin Fusion protein as therapeutics for Alzheimer’s diseases

inferred← citeshttps://doi.org/10.1016/j.immuni.2024.07.004openalex-snapshot

Cancer stem cells release interleukin-33 within large oncosomes to promote immunosuppressive differentiation of macrophage precursors

inferred← citeshttps://doi.org/10.1016/j.intimp.2019.105983openalex-snapshot

Schisandrin A protects against lipopolysaccharide-induced mastitis through activating Nrf2 signaling pathway and inducing autophagy

inferred← citeshttps://doi.org/10.1016/j.intimp.2020.106383openalex-snapshot

HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2

inferred← citeshttps://doi.org/10.1016/j.intimp.2025.115109openalex-snapshot

Inhibition of MMP9 ameliorates neutrophil extracellular traps-mediated necroptosis through regulation of impaired autophagy in severe acute pancreatitis

inferred← citeshttps://doi.org/10.1016/j.intimp.2025.115974openalex-snapshot

Hydrogen alleviates cardiac ferroptosis damage under chronic intermittent hypoxia conditions by targeting Nrf2

inferred← citeshttps://doi.org/10.1016/j.isci.2020.101638openalex-snapshot

Downregulation of Keap1 Confers Features of a Fasted Metabolic State

inferred← citeshttps://doi.org/10.1016/j.jchemneu.2021.101945openalex-snapshot

Amyloid-β (25–35) regulates neuronal damage and memory loss via SIRT1/Nrf2 in the cortex of mice

inferred← citeshttps://doi.org/10.1016/j.jep.2022.115776openalex-snapshot

Crosstalk between autophagy and the Keap1-Nrf2-ARE pathway regulates realgar-induced neurotoxicity

inferred← citeshttps://doi.org/10.1016/j.jlr.2026.101077openalex-snapshot

Ceramide kinase/ceramide 1-phosphate signaling regulates LC3B expression and autophagosome formation

inferred← citeshttps://doi.org/10.1016/j.jmb.2019.06.013openalex-snapshot

Physiological Stress Response by Selective Autophagy

inferred← citeshttps://doi.org/10.1016/j.jphs.2025.04.002openalex-snapshot

Hirsutine attenuated oxidative stress and autophagy in diabetic kidney disease through Keap1/Nrf2 pathway

inferred← citeshttps://doi.org/10.1016/j.lfs.2019.03.032openalex-snapshot

RETRACTED: Cytoprotective effects of euxanthone against ox-LDL-induced endothelial cell injury is mediated via Nrf2

inferred← citeshttps://doi.org/10.1016/j.mcn.2016.08.004openalex-snapshot

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling

inferred← citeshttps://doi.org/10.1016/j.molimm.2021.10.014openalex-snapshot

Inhibitory effects of sulforaphane on NLRP3 inflammasome activation

inferred← citeshttps://doi.org/10.1016/j.neuint.2025.105991openalex-snapshot

Sulforaphane prevents cognitive decline and mitochondrial failure induced by hippocampal expression of caspase-3 cleaved tau

inferred← citeshttps://doi.org/10.1016/j.neuint.2026.106258openalex-snapshot

Neuroinflammation and vascular pathology in Alzheimer's Disease: The NRF2/HO-1 axis as a modulator of microglial phenotypes

inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2017.12.001openalex-snapshot

Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner

inferred← citeshttps://doi.org/10.1016/j.neurom.2026.04.021openalex-snapshot

The Amelioration of Depression-Like Behaviors in Mice by Deep Brain Stimulation of the Ventromedial Prefrontal Cortex Is Associated With Neuroinflammation

inferred← citeshttps://doi.org/10.1016/j.neuron.2022.01.017openalex-snapshot

The different autophagy degradation pathways and neurodegeneration

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2021.06.026openalex-snapshot

The Roles of Oxidative Stress in Regulating Autophagy in Methylmercury-induced Neurotoxicity

inferred← citeshttps://doi.org/10.1016/j.neurot.2025.e00627openalex-snapshot

Intersection of H2S and Nrf2 signaling: Therapeutic opportunities for neurodegenerative diseases

inferred← citeshttps://doi.org/10.1016/j.phrs.2021.106018openalex-snapshot

Posttranscriptional regulation of Nrf2 through miRNAs and their role in Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.phrs.2022.106563openalex-snapshot

Nrf2 and its dependent autophagy activation cooperatively counteract ferroptosis to alleviate acute liver injury

inferred← citeshttps://doi.org/10.1016/j.phymed.2022.154625openalex-snapshot

Neocryptotanshinone protects against myocardial ischemia-reperfusion injury by promoting autolysosome degradation of protein aggregates via the ERK1/2-Nrf2-LAMP2 pathway

inferred← citeshttps://doi.org/10.1016/j.phymed.2023.154746openalex-snapshot

Aescin can alleviate NAFLD through Keap1-Nrf2 by activating antioxidant and autophagy

inferred← citeshttps://doi.org/10.1016/j.phymed.2026.158106openalex-snapshot

Role of traditional Chinese medicine in ferroptosis of liver cancer: Focus on signaling pathways

inferred← citeshttps://doi.org/10.1016/j.phymed.2026.158169openalex-snapshot

Farrerol mitigates fungal keratitis by enhancing fungal clearance and limiting inflammation through autophagy and Nrf2 pathway

inferred← citeshttps://doi.org/10.1016/j.preteyeres.2020.100858openalex-snapshot

Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration

inferred← citeshttps://doi.org/10.1016/j.redox.2017.01.006openalex-snapshot

Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases

inferred← citeshttps://doi.org/10.1016/j.redox.2017.06.010openalex-snapshot

Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus

inferred← citeshttps://doi.org/10.1016/j.redox.2017.07.006openalex-snapshot

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

inferred← citeshttps://doi.org/10.1016/j.redox.2017.10.010openalex-snapshot

Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy

inferred← citeshttps://doi.org/10.1016/j.redox.2018.07.006openalex-snapshot

Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy

inferred← citeshttps://doi.org/10.1016/j.redox.2018.09.004openalex-snapshot

Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival

inferred← citeshttps://doi.org/10.1016/j.redox.2018.09.011openalex-snapshot

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

inferred← citeshttps://doi.org/10.1016/j.redox.2019.101118openalex-snapshot

CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies

inferred← citeshttps://doi.org/10.1016/j.redox.2019.101425openalex-snapshot

Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas

inferred← citeshttps://doi.org/10.1016/j.redox.2020.101664openalex-snapshot

Nrf2/Wnt resilience orchestrates rejuvenation of glia-neuron dialogue in Parkinson's disease

inferred← citeshttps://doi.org/10.1016/j.redox.2020.101679openalex-snapshot

Complex interplay between autophagy and oxidative stress in the development of pulmonary disease

inferred← citeshttps://doi.org/10.1016/j.redox.2022.102396openalex-snapshot

An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver

inferred← citeshttps://doi.org/10.1016/j.redox.2022.102522openalex-snapshot

Nrf2: An all-rounder in depression

inferred← citeshttps://doi.org/10.1016/j.redox.2022.102570openalex-snapshot

Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease

inferred← citeshttps://doi.org/10.1016/j.redox.2023.102881openalex-snapshot

Drug repurposing on Alzheimer's disease through modulation of NRF2 neighborhood

inferred← citeshttps://doi.org/10.1016/j.redox.2024.103027openalex-snapshot

Specific targeting of the NRF2/β-TrCP axis promotes beneficial effects in NASH

inferred← citeshttps://doi.org/10.1016/j.redox.2024.103133openalex-snapshot

Αnti-prion effects of anthocyanins

inferred← citeshttps://doi.org/10.1016/j.redox.2025.103569openalex-snapshot

Health position paper and redox perspectives – Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases

inferred← citeshttps://doi.org/10.1016/j.redox.2025.103782openalex-snapshot

Involvement of NRF2 and AMPK signaling in aging and progeria: a digest

inferred← citeshttps://doi.org/10.1016/j.redox.2026.104050openalex-snapshot

NRF2: Master regulator of cellular homeostasis and therapeutic vulnerability in cancer

inferred← citeshttps://doi.org/10.1016/j.redox.2026.104107openalex-snapshot

Hexaraphane as a potential therapeutic strategy for tauopathies

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2019.135624openalex-snapshot

Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2020.139425openalex-snapshot

Long-term arsenite exposure decreases autophagy by increased release of Nrf2 in transformed human keratinocytes

inferred← citeshttps://doi.org/10.1016/j.semcancer.2021.05.016openalex-snapshot

The intricacies of NRF2 regulation in cancer

inferred← citeshttps://doi.org/10.1016/j.taap.2018.03.020openalex-snapshot

Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling

inferred← citeshttps://doi.org/10.1016/j.tibs.2024.12.010openalex-snapshot

Regulating Nrf2 activity: ubiquitin ligases and signaling molecules in redox homeostasis

inferred← citeshttps://doi.org/10.1016/j.tifs.2017.02.002openalex-snapshot

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane

inferred← citeshttps://doi.org/10.1016/j.tiv.2026.106252openalex-snapshot

Bacosine triggers NRF2-TFEB-autophagy axis to attenuate arecoline-induced oxidative stress and inflammasome activation

inferred← citeshttps://doi.org/10.1016/j.tox.2019.04.013openalex-snapshot

Mixture designs to investigate adverse effects upon co-exposure to environmental cyanotoxins

inferred← citeshttps://doi.org/10.1016/j.toxicon.2026.109219openalex-snapshot

Curcumin attenuates AFB1-induced oxidative stress and pyroptosis-associated responses while improving autophagy-related signaling in HD11 macrophages

inferred← citeshttps://doi.org/10.1016/j.yexmp.2025.104989openalex-snapshot

The interplay involving oxidative stress and autophagy: Mechanisms, implications, and therapeutic opportunities

inferred← citeshttps://doi.org/10.1016/j.ymthe.2017.04.022openalex-snapshot

Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity

inferred← citeshttps://doi.org/10.1021/acs.chemrestox.2c00131openalex-snapshot

HIF1, HSF1, and NRF2: Oxidant-Responsive Trio Raising Cellular Defenses and Engaging Immune System

inferred← citeshttps://doi.org/10.1021/acs.jafc.2c01978openalex-snapshot

Sulforaphane Acts Through NFE2L2 to Prevent Hypoxia-Induced Apoptosis in Porcine Granulosa Cells via Activating Antioxidant Defenses and Mitophagy

inferred← citeshttps://doi.org/10.1021/acs.jafc.2c06311openalex-snapshot

Sulforaphane Ameliorates Hepatic Lipid Metabolism via Modulating Lipophagy In Vivo and In Vitro

inferred← citeshttps://doi.org/10.1021/acschemneuro.4c00617openalex-snapshot

Microglial Autophagic Dysregulation in Traumatic Brain Injury: Molecular Insights and Therapeutic Avenues

inferred← citeshttps://doi.org/10.1021/acsomega.6c01122openalex-snapshot

Peptide Design for Targeting BTB Domain Homodimerization of BACH2: Complementary In Silico and In Vitro Approaches

inferred← citeshttps://doi.org/10.1038/s41388-019-0956-6openalex-snapshot

Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma

inferred← citeshttps://doi.org/10.1038/s41392-026-02577-9openalex-snapshot

The consensus molecular subtypes of esophageal squamous cell carcinoma

inferred← citeshttps://doi.org/10.1038/s41398-018-0231-6openalex-snapshot

A role for APP in Wnt signalling links synapse loss with β-amyloid production

inferred← citeshttps://doi.org/10.1038/s41419-018-0642-6openalex-snapshot

The proton pump inhibitor pantoprazole disrupts protein degradation systems and sensitizes cancer cells to death under various stresses

inferred← citeshttps://doi.org/10.1038/s41419-021-03507-zopenalex-snapshot

Targeted de-repression of neuronal Nrf2 inhibits α-synuclein accumulation

inferred← citeshttps://doi.org/10.1038/s41419-021-03599-7openalex-snapshot

Autophagy-dependent survival is controlled with a unique regulatory network upon various cellular stress events

inferred← citeshttps://doi.org/10.1038/s41420-022-01191-2openalex-snapshot

ACE2 deficiency exacerbates obesity-related glomerulopathy through its role in regulating lipid metabolism

inferred← citeshttps://doi.org/10.1038/s41467-018-05861-7openalex-snapshot

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

inferred← citeshttps://doi.org/10.1038/s41467-023-35899-1openalex-snapshot

The metabolite alpha-ketobutyrate extends lifespan by promoting peroxisomal function in C. elegans

inferred← citeshttps://doi.org/10.1038/s41573-018-0008-xopenalex-snapshot

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

inferred← citeshttps://doi.org/10.1038/s41573-025-01145-0openalex-snapshot

Thirty years of NRF2: advances and therapeutic challenges

inferred← citeshttps://doi.org/10.1038/s41586-023-06984-8openalex-snapshot

An epigenetic barrier sets the timing of human neuronal maturation

inferred← citeshttps://doi.org/10.1038/s41598-017-00456-6openalex-snapshot

Role of p62 in the suppression of inflammatory cytokine production by adiponectin in macrophages: Involvement of autophagy and p21/Nrf2 axis

inferred← citeshttps://doi.org/10.1038/s41598-017-01174-9openalex-snapshot

Glucocorticoids Suppress Antimicrobial Autophagy and Nitric Oxide Production and Facilitate Mycobacterial Survival in Macrophages

inferred← citeshttps://doi.org/10.1038/s41598-017-05687-1openalex-snapshot

Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis

inferred← citeshttps://doi.org/10.1038/s41598-017-11262-5openalex-snapshot

Transcription factors NRF2 and HSF1 have opposing functions in autophagy

inferred← citeshttps://doi.org/10.1038/s41598-019-50356-0openalex-snapshot

NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling

inferred← citeshttps://doi.org/10.1038/s41598-019-50877-8openalex-snapshot

TFEB activates Nrf2 by repressing its E3 ubiquitin ligase DCAF11 and promoting phosphorylation of p62

inferred← citeshttps://doi.org/10.1038/s41598-020-59930-3openalex-snapshot

Nrf2 positively regulates autophagy antioxidant response in human bronchial epithelial cells exposed to diesel exhaust particles

inferred← citeshttps://doi.org/10.1038/s41598-023-41492-9openalex-snapshot

The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis

inferred← citeshttps://doi.org/10.1038/s41598-025-22873-8openalex-snapshot

The role of thrombospondin-1 in trehalose-induced autophagy and ocular hypertension in mice

inferred← citeshttps://doi.org/10.1038/s44319-025-00483-9openalex-snapshot

KEAP1 retention in phase-separated p62 bodies drives liver damage under autophagy-deficient conditions

inferred← citeshttps://doi.org/10.1038/srep46763openalex-snapshot

Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways

inferred← citeshttps://doi.org/10.1039/d4fo03490bopenalex-snapshot

Astaxanthin promotes the longevity of Caenorhabditis elegans via modulation of the intracellular redox status and PHA-4-mediated autophagy

inferred← citeshttps://doi.org/10.1042/bst20210370openalex-snapshot

Extracellular Hsp90 and protection of neuronal cells through Nrf2

inferred← citeshttps://doi.org/10.1073/pnas.1819541116openalex-snapshot

NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models

inferred← citeshttps://doi.org/10.1073/pnas.2217128120openalex-snapshot

Slingshot homolog-1–mediated Nrf2 sequestration tips the balance from neuroprotection to neurodegeneration in Alzheimer’s disease

inferred← citeshttps://doi.org/10.1073/pnas.2310740121openalex-snapshot

Interplay between autophagy and CncC regulates dendrite pruning in Drosophila

inferred← citeshttps://doi.org/10.1080/00207454.2023.2210409openalex-snapshot

The interplay between tauopathy and aging through interruption of UPR/Nrf2/autophagy crosstalk in the Alzheimer’s disease transgenic experimental models

inferred← citeshttps://doi.org/10.1080/10715762.2024.2386075openalex-snapshot

Ferroptosis: a new target for hepatic ischemia-reperfusion injury?

inferred← citeshttps://doi.org/10.1080/1354750x.2021.1999503openalex-snapshot

The level of S-glutathionylated protein is a predictor for metastasis in colorectal cancer and correlated with those of Nrf2/Keap1 pathway

inferred← citeshttps://doi.org/10.1080/14728222.2019.1601703openalex-snapshot

Sequestosome 1/p62-related pathways as therapeutic targets in hepatocellular carcinoma

inferred← citeshttps://doi.org/10.1080/15548627.2017.1390636openalex-snapshot

Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models

inferred← citeshttps://doi.org/10.1080/15548627.2018.1474992openalex-snapshot

Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A

inferred← citeshttps://doi.org/10.1080/15548627.2019.1589257openalex-snapshot

Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation

inferred← citeshttps://doi.org/10.1080/15548627.2020.1797280openalex-snapshot

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

inferred← citeshttps://doi.org/10.1080/17460441.2020.1773429openalex-snapshot

Targeting Autophagy In Disease: Recent Advances In Drug Discovery

inferred← citeshttps://doi.org/10.1080/19490976.2023.2206504openalex-snapshot

Interlink between the gut microbiota and inflammation in the context of oxidative stress in Alzheimer’s disease progression

inferred← citeshttps://doi.org/10.1080/27694127.2026.2698350openalex-snapshot

Autophagy in the liver

inferred← citeshttps://doi.org/10.1084/jem.20180783openalex-snapshot

N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1

inferred← citeshttps://doi.org/10.1089/ars.2017.7084openalex-snapshot

Oxidative Stress Induces an Interactive Decline in Wnt and Nrf2 Signaling in Degenerating Retinal Pigment Epithelium

inferred← citeshttps://doi.org/10.1089/ars.2017.7223openalex-snapshot

Reactive Oxygen Species-Mediated Autophagy Defines the Fate of Cancer Stem Cells

inferred← citeshttps://doi.org/10.1089/ars.2020.8148openalex-snapshot

NRF2 and Hypoxia-Inducible Factors: Key Players in the Redox Control of Systemic Iron Homeostasis

inferred← citeshttps://doi.org/10.1089/ars.2022.0200openalex-snapshot

NRF2 and the Moirai: Life and Death Decisions on Cell Fates

inferred← citeshttps://doi.org/10.1089/ars.2023.0455openalex-snapshot

Adenosine A2A Receptor Antagonist Sch58261 Improves the Cognitive Function in Alzheimer’s Disease Model Mice Through Activation of Nrf2 via an Autophagy-Dependent Pathway

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