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Variation in Antiviral 2′,5′-Oligoadenylate Synthetase (2′5′AS) Enzyme Activity Is Controlled by a Single-Nucleotide Polymorphism at a Splice-Acceptor Site in the OAS1 Gene
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Several different enterovirus serotypes can be associated with prediabetic autoimmune episodes and onset of overt IDDM
inferredcites →https://doi.org/10.1002/hep.510290417openalex-snapshot
Mannose Binding Lectin Gene Mutations Are Associated With Progression of Liver Disease in Chronic Hepatitis B Infection
inferredcites →https://doi.org/10.1006/clim.2000.4874openalex-snapshot
The Antiviral 2′,5′-Oligoadenylate Synthetase Is Persistently Activated in Type 1 Diabetes
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Gene structure and function of the 2′-5′-oligoadenylate synthetase family
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Differential Action of Natural Selection on the N and C-terminal Domains of 2′-5′ Oligoadenylate Synthetases and the Potential Nuclease Function of the C-terminal Domain
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Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin
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Crystal Structure of the 2′-Specific and Double-Stranded RNA-Activated Interferon-Induced Antiviral Protein 2′-5′-Oligoadenylate Synthetase
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The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion
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Implications for RNase L in Prostate Cancer Biology
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RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases
inferredcites →https://doi.org/10.1038/sj.gene.6363984openalex-snapshot
Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR
inferredcites →https://doi.org/10.1046/j.1365-2370.2000.00211.xopenalex-snapshot
Mannose binding lectin (MBL) genotype distributions with relation to serum levels in UK Caucasoids
inferredcites →https://doi.org/10.1046/j.1365-3083.2002.01167.xopenalex-snapshot
Analysis of the Relationship Between Mannose‐Binding Lectin (MBL) Genotype, MBL Levels and Function in an Australian Blood Donor Population
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Infection of mouse neurones by West Nile virus is modulated by the interferon‐inducible 2′‐5′ oligoadenylate synthetase 1b protein
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Positional cloning of the murine flavivirus resistance gene
inferredcites →https://doi.org/10.1073/pnas.172195399openalex-snapshot
A nonsense mutation in the gene encoding 2′-5′-oligoadenylate synthetase/L1 isoform is associated with West Nile virus susceptibility in laboratory mice
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Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays
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Enzymatic Activity of 2′–5′-Oligoadenylate Synthetase Is Impaired by Specific Mutations that Affect Oligomerization of the Protein
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A Specific Isozyme of 2′-5′ Oligoadenylate Synthetase Is a Dual Function Proapoptotic Protein of the Bcl-2 Family
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Islet Cell Antibody Seroconversion in Children Is Temporally Associated with Enterovirus Infections
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Viruses and Interferons
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Association of IDDM and Attenuated Response of 2′,5′-Oligoadenylate Synthetase to Yellow Fever Vaccine
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A Prospective Study of the Role of Coxsackie B and Other Enterovirus Infections in the Pathogenesis of IDDM
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Enterovirus infection as a risk factor for beta-cell autoimmunity in a prospectively observed birth cohort: the Finnish Diabetes Prediction and Prevention Study.
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OAS1 Splice Site Polymorphism Controlling Antiviral Enzyme Activity Influences Susceptibility to Type 1 Diabetes
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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2′-5′-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine
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SARS-CoV-2 5′-UTR stem-loops activate the antiviral protein oligoadenylate synthetase 1 (OAS1)
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Fatal multiorgan failure due to yellow fever vaccine-associated viscerotropic disease
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Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation
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Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation
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Recent insights on pattern recognition receptors and the interplay of innate immune responses against West Nile Virus infection
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Molecular Characterization of the Cytotoxic Mechanism of Multiwall Carbon Nanotubes and Nano-Onions on Human Skin Fibroblast
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Reassessment of the type I diabetes association of the OAS1 locus
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Long-Term Balancing Selection at the Antiviral Gene OAS1 in Central African Chimpanzees
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Biased exon/intron distribution of cryptic and de novo 3' splice sites
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A genetic variant protective against severe COVID-19 is inherited from Neandertals
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Heritability of alternative splicing in the human genome
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Polymorphism of 2′-5′-oligoadenylate synthetase (OAS) genes, associated with predisposition to severe forms of tick-borne encephalitis, in human populations of North Eurasia
inferred← citeshttps://doi.org/10.1134/s0026893317050223openalex-snapshot
Human Genetic Predisposition to Diseases Caused by Viruses from Flaviviridae Family
inferred← citeshttps://doi.org/10.1136/jmg.2005.035212openalex-snapshot
Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype?
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inferred← citeshttps://doi.org/10.1155/2009/631026openalex-snapshot
Murine Pancreatic Beta TC3 Cells Show Greater 2′,5′ -Oligoadenylate Synthetase ( 2′5′ AS) Antiviral Enzyme Activity and Apoptosis Following IFN- α or Poly(I:C) Treatment than Pancreatic Alpha TC3 Cells
inferred← citeshttps://doi.org/10.1172/jci.insight.185739openalex-snapshot
Unbiased cleavage site prediction uncovers viral antagonism of host innate immunity by SARS-CoV-2 3C-like protease
inferred← citeshttps://doi.org/10.1186/1471-2121-15-33openalex-snapshot
Mitochondrial localization of the OAS1 p46 isoform associated with a common single nucleotide polymorphism
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Characterization of the equine 2'-5' oligoadenylate synthetase 1 (OAS1) and ribonuclease L (RNASEL) innate immunity genes
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Genome-wide survey of allele-specific splicing in humans
inferred← citeshttps://doi.org/10.1186/s12575-016-0038-xopenalex-snapshot
A Modified Coupled Spectrophotometric Method to Detect 2-5 Oligoadenylate Synthetase Activity in Prostate Cell Lines
inferred← citeshttps://doi.org/10.1186/s12864-020-06966-4openalex-snapshot
Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines
inferred← citeshttps://doi.org/10.1186/s12890-018-0746-xopenalex-snapshot
2′-5′-Oligoadenylate synthetase 1 polymorphisms are associated with tuberculosis: a case-control study
inferred← citeshttps://doi.org/10.1186/s12957-018-1475-6openalex-snapshot
Prediction of key genes and pathways involved in trastuzumab-resistant gastric cancer
inferred← citeshttps://doi.org/10.1186/s13059-016-1098-6openalex-snapshot
Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans
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Integrating single-cell sQTL mapping with deep-learning splicing prediction identifies causal variants under influenza infection
inferred← citeshttps://doi.org/10.1189/jlb.4mr0617-223ropenalex-snapshot
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inferred← citeshttps://doi.org/10.12122/j.issn.1673-4254.2019.04.01openalex-snapshot
[OAS1 gene polymorphism is associated with central nervous system involvement in children with enterovirus 71 infection].
inferred← citeshttps://doi.org/10.1261/rna.073825.119openalex-snapshot
Alternative splicing coupled with transcript degradation modulates OAS1g antiviral activity
inferred← citeshttps://doi.org/10.1371/journal.pgen.1006820openalex-snapshot
Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons
inferred← citeshttps://doi.org/10.1371/journal.pone.0081123openalex-snapshot
ZODET: Software for the Identification, Analysis and Visualisation of Outlier Genes in Microarray Expression Data
inferred← citeshttps://doi.org/10.1371/journal.ppat.1000321openalex-snapshot
Genetic Variation in OAS1 Is a Risk Factor for Initial Infection with West Nile Virus in Man
inferred← citeshttps://doi.org/10.1371/journal.ppat.1000781openalex-snapshot
Genome-Wide mRNA Expression Correlates of Viral Control in CD4+ T-Cells from HIV-1-Infected Individuals
inferred← citeshttps://doi.org/10.1371/journal.ppat.1010464openalex-snapshot
Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor
inferred← citeshttps://doi.org/10.15252/embj.2019101573openalex-snapshot
Suppressing PARylation by 2′,5′‐oligoadenylate synthetase 1 inhibits DNA damage‐induced cell death
inferred← citeshttps://doi.org/10.17691/stm2016.8.1.13openalex-snapshot
Significance of Polymorphism in 2’,5’-Oligoadenylate Synthetase Genes in HIV Infection
inferred← citeshttps://doi.org/10.18093/978-5-6048754-6-9-2024-2-475-487openalex-snapshot
Genetic factors affecting the course and outcomes of coronavirus disease-associated pneumonia
inferred← citeshttps://doi.org/10.2337/diabetes.54.5.1588openalex-snapshot
OAS1 Splice Site Polymorphism Controlling Antiviral Enzyme Activity Influences Susceptibility to Type 1 Diabetes
inferred← citeshttps://doi.org/10.25772/0hab-cv33openalex-snapshot
Genetic Variations in Interferon-Induced Genes and HCV Recurrence after Liver Transplantation
inferred← citeshttps://doi.org/10.32657/10356/69548openalex-snapshot
Characterization of regulatory mechanisms for BIM exon 3 alternative splicing
inferred← citeshttps://doi.org/10.33442/978-981-14-0914-1_5openalex-snapshot
Chapter 5: TBE in adults
inferred← citeshttps://doi.org/10.3389/fcimb.2024.1322882openalex-snapshot
Single nucleotide variants in the CCL2, OAS1 and DPP9 genes and their association with the severity of COVID-19 in an Ecuadorian population
inferred← citeshttps://doi.org/10.3389/fimmu.2018.02046openalex-snapshot
Variation in the Untranslated Genome and Susceptibility to Infections
inferred← citeshttps://doi.org/10.3389/fimmu.2020.605024openalex-snapshot
All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1287940openalex-snapshot
Innate immune responses to RNA: sensing and signaling
inferred← citeshttps://doi.org/10.3389/fmed.2022.654395openalex-snapshot
Human Genetic Host Factors and Its Role in the Pathogenesis of Chikungunya Virus Infection
inferred← citeshttps://doi.org/10.3389/fmed.2023.1215246openalex-snapshot
Occurrence of SARS-CoV-2 viremia is associated with genetic variants of genes related to COVID-19 pathogenesis
inferred← citeshttps://doi.org/10.3390/cancers12113119openalex-snapshot
The Effects of Single Nucleotide Polymorphisms in Cancer RNAi Therapies
inferred← citeshttps://doi.org/10.3390/genes14020527openalex-snapshot
Genetic Ethnic Differences in Human 2′-5′-Oligoadenylate Synthetase and Disease Associations: A Systematic Review
inferred← citeshttps://doi.org/10.3390/ijms26020524openalex-snapshot
OAS1: A Protective Mechanism for Alzheimer’s Disease? An Exploration of Data and Possible Mechanisms
inferred← citeshttps://doi.org/10.3390/ijms27072965openalex-snapshot
The Functional OAS1 rs10774671A>G Variant Is Associated with COVID-19 Susceptibility in Mexican Patients
inferred← citeshttps://doi.org/10.3390/jpm12030386openalex-snapshot
Nucleic Acid-Based COVID-19 Therapy Targeting Cytokine Storms: Strategies to Quell the Storm
inferred← citeshttps://doi.org/10.3390/jpm15040156openalex-snapshot
Genetic Predictors of Paxlovid Treatment Response: The Role of IFNAR2, OAS1, OAS3, and ACE2 in COVID-19 Clinical Course
inferred← citeshttps://doi.org/10.3390/v11121122openalex-snapshot
The Cellular Localization of the p42 and p46 Oligoadenylate Synthetase 1 Isoforms and Their Impact on Mitochondrial Respiration
inferred← citeshttps://doi.org/10.3390/v12020152openalex-snapshot
Characteristics of Human OAS1 Isoform Proteins
inferred← citeshttps://doi.org/10.3410/f.2369956.1999054openalex-snapshot
Faculty Opinions recommendation of Genome-wide mRNA expression correlates of viral control in CD4+ T-cells from HIV-1-infected individuals.
inferred← citeshttps://doi.org/10.3410/f.735004774.793556115openalex-snapshot
Faculty Opinions recommendation of Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates.
inferred← citeshttps://doi.org/10.3410/f.739272461.793581617openalex-snapshot
Faculty Opinions recommendation of All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes.
inferred← citeshttps://doi.org/10.3748/wjg.v22.i41.9186openalex-snapshot
Impact of IL28B and OAS gene family polymorphisms on interferon treatment response in Caucasian children chronically infected with hepatitis B virus
inferred← citeshttps://doi.org/10.3892/wasj.2024.287openalex-snapshot
Association of OAS1 gene polymorphism with the severity of COVID‑19 infection
inferred← citeshttps://doi.org/10.3958/059.048.0211openalex-snapshot
Oligoadenylate Synthetase Single-Nucleotide Polymorphisms Associated With Infection by Chikungunya Virus
inferred← citeshttps://doi.org/10.4049/jimmunol.0902728openalex-snapshot
Distinct Antiviral Roles for Human 2′,5′-Oligoadenylate Synthetase Family Members against Dengue Virus Infection
inferred← citeshttps://doi.org/10.4049/jimmunol.176.5.2976openalex-snapshot
Molecular Genetic Analysis of the Idd4 Locus Implicates the IFN Response in Type 1 Diabetes Susceptibility in Nonobese Diabetic Mice
inferred← citeshttps://doi.org/10.4161/rna.7.4.12301openalex-snapshot
Alternative splicing in multiple sclerosis and other autoimmune diseases
inferred← citeshttps://doi.org/10.54817/ic.v65n2a04openalex-snapshot
Genetic association study of the rs10774671 variant of the OAS1 gene with the severity of COVID-19 in an Ecuadorian population.
inferred← citeshttps://doi.org/10.57709/1959830openalex-snapshot
Study of Innate Immune Response Components in West Nile Virus Infected Cells
inferred← citeshttps://doi.org/10.57709/2435185openalex-snapshot
Regulation of Interferon Stimulated Genes in West Nile Virus Infected Mouse Embryofibroblasts
inferred← citeshttps://doi.org/10.57709/8519788openalex-snapshot
Characterization of Simian Hemorrhagic Fever Virus Subgenomic RNAs and Proteins
inferred← citeshttps://doi.org/10.7554/elife.71047openalex-snapshot
Endomembrane targeting of human OAS1 p46 augments antiviral activity
inferred← citeshttps://doi.org/10.7868/s0026898418020039openalex-snapshot
ГЕНЕТИЧЕСКАЯ ПРЕДРАСПОЛОЖЕННОСТЬ ЧЕЛОВЕКА К?ЗАБОЛЕВАНИЯМ, ВЫЗЫВАЕМЫМ ВИРУСАМИ СЕМЕЙСТВА FLAVIVIRIDAE, "Молекулярная биология"
Editorial review for independent work. ICSAC — the Institute for Complexity
Science and Advanced Computing — runs a structured editorial panel for researchers
publishing outside journals, and publishes on CiteStamp rails. Submission is free
and goes through ORCID: icsacinstitute.org/submit.