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Safety and Immunogenicity of Adenovirus-Vectored Near-Consensus HIV Type 1 Clade B gag Vaccines in Healthy Adults

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial
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HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case–cohort analysis
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Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160
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Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity
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HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites
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An HIV Vaccine — Evolving Concepts
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The Challenge of HIV-1 Subtype Diversity
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Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques
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Placebo‐Controlled Phase 3 Trial of a Recombinant Glycoprotein 120 Vaccine to Prevent HIV‐1 Infection
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Cross‐Reactivity of Anti–HIV‐1 T Cell Immune Responses among the Major HIV‐1 Clades in HIV‐1–Positive Individuals from 4 Continents
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HIV Vaccines: New Frontiers in Vaccine Development
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Prevalence of Primary HIV‐1 Drug Resistance among Recently Infected Adolescents: A Multicenter Adolescent Medicine Trials Network for HIV/AIDS Interventions Study
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HIV Epidemiology Update and Transmission Factors: Risks and Risk Contexts--16th International AIDS Conference Epidemiology Plenary
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Safety and Immunogenicity of a Replication‐Incompetent Adenovirus Type 5 HIV‐1 Clade B gag/pol/nef Vaccine in Healthy Adults
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Development of an Adenovirus-Shedding Assay for the Detection of Adenoviral Vector-Based Vaccine and Gene Therapy Products in Clinical Specimens
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Comparative Analysis of the Effects of Packaging Signal, Transgene Orientation, Promoters, Polyadenylation Signals, and E3 Region on Growth Properties of First-Generation Adenoviruses
inferredcites →https://doi.org/10.1089/104303404322886147openalex-snapshot
Quantitative Adenovirus Neutralization Assays Based on the Secreted Alkaline Phosphatase Reporter Gene: Application in Epidemiologic Studies and in the Design of Adenovector Vaccines
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Strong Cytotoxic T Cell and Weak Neutralizing Antibody Responses in a Subset of Persons with Stable Nonprogressing HIV Type 1 Infection
inferredcites →https://doi.org/10.1089/aid.2006.0114openalex-snapshot
Evaluation of Cellular Immune Responses in Subjects Chronically Infected with HIV Type 1
inferredcites →https://doi.org/10.1097/01.aids.0000131310.52526.c7openalex-snapshot
The prevalence of antiretroviral drug resistance in the United States
inferredcites →https://doi.org/10.1097/01.aids.0000252059.85236.afopenalex-snapshot
Routine surveillance for the detection of acute and recent HIV infections and transmission of antiretroviral resistance
inferredcites →https://doi.org/10.1097/qai.0b013e3180377b5bopenalex-snapshot
Detection of HIV Vaccine-Induced Cell-Mediated Immunity in HIV-Seronegative Clinical Trial Participants Using an Optimized and Validated Enzyme-Linked Immunospot Assay
inferredcites →https://doi.org/10.1126/science.283.5403.857openalex-snapshot
Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 + Lymphocytes
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Administration of an Anti-CD8 Monoclonal Antibody Interferes with the Clearance of Chimeric Simian/Human Immunodeficiency Virus during Primary Infections of Rhesus Macaques
inferredcites →https://doi.org/10.1128/jvi.77.11.6305-6313.2003openalex-snapshot
Comparative Immunogenicity in Rhesus Monkeys of DNA Plasmid, Recombinant Vaccinia Virus, and Replication-Defective Adenovirus Vectors Expressing a Human Immunodeficiency Virus Type 1 gag Gene
inferredcites →https://doi.org/10.1128/jvi.77.13.7663-7668.2003openalex-snapshot
Vaccine-Induced Immunity in Baboons by Using DNA and Replication-Incompetent Adenovirus Type 5 Vectors Expressing a Human Immunodeficiency Virus Type 1 gag Gene
inferredcites →https://doi.org/10.1177/135965350100600108openalex-snapshot
Resistance Profiles to Antiretroviral Drugs in HIV-1 Drug-Naive Patients in Argentina
inferredcites →https://doi.org/10.1177/135965350601100208openalex-snapshot
Evolution of Transmitted HIV-1 with Drug-Resistance Mutations in the Absence of Therapy: Effects on Cd4 + T-Cell Count and HIV-1 Rna Load
inferredcites →https://doi.org/10.1177/135965350601100503openalex-snapshot
Drug-Class-Wide Resistance to Antiretrovirals in HIV-Infected Patients Failing Therapy: Prevalence, Risk Factors and Virological Outcome
inferredcites →https://doi.org/10.1191/0962280204sm363raopenalex-snapshot
Use of the false discovery rate for evaluating clinical safety data
inferredcites →https://doi.org/10.2307/2530666openalex-snapshot
Testing the Statistical Certainty of a Response to Increasing Doses of a Drug

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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A Phase 1b Clinical Trial to Determine the Safety, Tolerability and Immunogenicity of the Candidate Mycobacterium Avium Complex Subspecies Vaccines ChAdOx2 HAV and MVA HAV in Patients with Active Crohn's Disease
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Adenovirus 5‐ and 35‐based immunotherapy enhances the strength but not breadth or quality of immunity during chronic SIV infection
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The influence of innate and pre‐existing immunity on adenovirus therapy
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Seroprevalence of neutralizing antibodies to human adenovirus type 5 in healthy adults in China
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HIV‐1 vaccine clinical trials: the Brazilian experience
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The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China
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Advances in human clinical trials of vaccines to prevent HIV/AIDS and other HIV prevention interventions
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Antibodies against Adenoviruses
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Adenoviral Vector Vaccines Antigen Transgene
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Development of Gene-Based Vectors for Immunization
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The development of gene-based vectors for immunization
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T Lymphocytes as Measurable Targets of Protection and Vaccination Against Viral Disorders
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Unmasking the potential of secretory IgA and its pivotal role in protection from respiratory viruses
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Immunologic Basis of Vaccine Vectors
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Comparative performance of a licensed anthrax vaccine versus electroporation based delivery of a PA encoding DNA vaccine in rhesus macaques
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International epidemiology of human pre-existing adenovirus (Ad) type-5, type-6, type-26 and type-36 neutralizing antibodies: Correlates of high Ad5 titers and implications for potential HIV vaccine trials
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Vaccination with a modified vaccinia virus Ankara (MVA)-vectored HIV-1 immunogen induces modest vector-specific T cell responses in human subjects
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Comparison of T cell immune responses induced by vectored HIV vaccines in non-human primates and humans
inferred← citeshttps://doi.org/10.1016/j.vaccine.2010.12.058openalex-snapshot
The PEDVAC trial: Preliminary data from the first therapeutic DNA vaccination in HIV-infected children
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Human immunodeficiency virus (HIV) immunopathogenesis and vaccine development: A review
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Evaluation of adenovirus 19a as a novel vector for mucosal vaccination against influenza A viruses
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Protection of non-human primates against rabies with an adenovirus recombinant vaccine
inferred← citeshttps://doi.org/10.1016/j.virusres.2015.09.010openalex-snapshot
Immunogenicity and efficacy in mice of an adenovirus-based bicistronic rotavirus vaccine expressing NSP4 and VP7
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Recombinant adenovirus type 5 HIV gag/pol/nef vaccine in South Africa: unblinded, long-term follow-up of the phase 2b HVTN 503/Phambili study
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IRO-203: a novel intranasal COVID-19 vaccine showing immunogenicity and viral suppression in African green monkey challenge study
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Approaches and issues towards development of efficient mucosal vaccines against pneumonia
inferred← citeshttps://doi.org/10.1086/648591openalex-snapshot
Comparative Cell‐Mediated Immunogenicity of DNA/DNA, DNA/Adenovirus Type 5 (Ad5), or Ad5/Ad5 HIV‐1 Clade BgagVaccine Prime‐Boost Regimens
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AIDS Clinical Trials Group 5197: A Placebo‐Controlled Trial of Immunization of HIV‐1–Infected Persons with a Replication‐Deficient Adenovirus Type 5 Vaccine Expressing the HIV‐1 Core Protein
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Safety and Immunogenicity of the MRKAd5 gag HIV Type 1 Vaccine in a Worldwide Phase 1 Study of Healthy Adults
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First-in-Human Evaluation of the Safety and Immunogenicity of a Recombinant Adenovirus Serotype 26 HIV-1 Env Vaccine (IPCAVD 001)
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Human Immunodeficiency Virus Vaccine Trials
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mRNA vaccines against HIV : Hopes and challenges
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DNA vaccines: an historical perspective and view to the future
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A Human Type 5 Adenovirus–Based Tuberculosis Vaccine Induces Robust T Cell Responses in Humans Despite Preexisting Anti-Adenovirus Immunity
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Safety and Immunogenicity of the Merck Adenovirus Serotype 5 (MRKAd5) and MRKAd6 Human Immunodeficiency Virus Type 1 Trigene Vaccines Alone and in Combination in Healthy Adults
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DNA/NYVAC Vaccine Regimen Induces HIV-Specific CD4 and CD8 T-Cell Responses in Intestinal Mucosa
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A Multiagent Alphavirus DNA Vaccine Delivered by Intramuscular Electroporation Elicits Robust and Durable Virus-Specific Immune Responses in Mice and Rabbits and Completely Protects Mice against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenges
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The Novel Tuberculosis Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4+ and CD8+ T Cells in Adults
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The effect of adenovirus-specific antibodies on adenoviral vector–induced, transgene product–specific T cell responses
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Novel Vaccines to Human Rabies
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Preferential Amplification of CD8 Effector-T Cells after Transcutaneous Application of an Inactivated Influenza Vaccine: A Randomized Phase I Trial
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Safety and Immunogenicity of a Replication-Defective Adenovirus Type 5 HIV Vaccine in Ad5-Seronegative Persons: A Randomized Clinical Trial (HVTN 054)
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Vaccination with Ad5 Vectors Expands Ad5-Specific CD8+ T Cells without Altering Memory Phenotype or Functionality
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Adenovirus 5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part A: Safety and Immunogenicity in Seronegative Adults
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Adenovirus-5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part B: Safety, Immunogenicity and Protective Efficacy of the CSP Component
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Consensus HIV-1 FSU-A Integrase Gene Variants Electroporated into Mice Induce Polyfunctional Antigen-Specific CD4+ and CD8+ T Cells
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Sterile Immunity to Malaria after DNA Prime/Adenovirus Boost Immunization Is Associated with Effector Memory CD8+T Cells Targeting AMA1 Class I Epitopes
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Effect of rAd5-Vector HIV-1 Preventive Vaccines on HIV-1 Acquisition: A Participant-Level Meta-Analysis of Randomized Trials
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Continued Follow-Up of Phambili Phase 2b Randomized HIV-1 Vaccine Trial Participants Supports Increased HIV-1 Acquisition among Vaccinated Men
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Prime–boost immunization with poxvirus or adenovirus vectors as a strategy to develop a protective vaccine for HIV-1
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Optimizing vaccine-induced CD8+T-cell immunity: focus on recombinant adenovirus vectors
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Seroprevalence of Neutralizing Antibodies against Human Adenovirus Type-5 and Chimpanzee Adenovirus Type-68 in Cancer Patients
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HIV-1 Protease as DNA Immunogen against Drug Resistance in HIV-1 Infection: DNA Immunization with Drug Resistant HIV-1 Protease Protects Mice from Challenge with Protease-Expressing Cells
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Understanding Post Entry Sorting of Adenovirus Capsids; A Chance to Change Vaccine Vector Properties
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Immunogenicity Differences of the ChAdOx1 nCoV-19 Vaccine According to Pre-Existing Adenovirus Immunity
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Safety and Immunogenicity of a Novel Recombinant Simian Adenovirus ChAdOx2 as a Vectored Vaccine
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Adaptation of a previously validated vaccination report card for use in adult vaccine clinical trials to align with the 2007 FDA Toxicity Grading Scale Guidance
inferred← citeshttps://doi.org/10.4161/hv.24941openalex-snapshot
Human adenovirus 5-vectoredPlasmodium falciparumNMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against controlled human malaria infection
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Is Prime Boost Strategy a Promising Approach in HIV Vaccine Development?
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Élaboration d'Intrabodies ciblant l'organisation conformationnelle du complexe de reverse transcription de VIH-1
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Conception de nouveaux vaccins anti-VIH basés sur des épitopes conformationels cross clade de gp41 issus d'anticorps muqueux protecteurs de sujets exposés au VIH mais restant séronégatifs (ESN)
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