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A Phase 1b Clinical Trial to Determine the Safety, Tolerability and Immunogenicity of the Candidate Mycobacterium Avium Complex Subspecies Vaccines ChAdOx2 HAV and MVA HAV in Patients with Active Crohn's Disease

https://doi.org/10.2139/ssrn.4669153
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ibd.21300openalex-extracted
Endoscopic evaluation of Crohnʼs disease activity
inferredcites →https://doi.org/10.1016/j.cgh.2012.09.026openalex-extracted
Trends in Overall and Cause-Specific Mortality Among Patients With Inflammatory Bowel Disease From 1982 to 2010
inferredcites →https://doi.org/10.1016/j.crohns.2013.04.005openalex-extracted
Relationship between levels of angiogenic and lymphangiogenic factors and the endoscopic, histological and clinical activity, and acute-phase reactants in patients with inflammatory bowel disease
inferredcites →https://doi.org/10.1016/j.crohns.2014.02.014openalex-extracted
Serum ficolin-2 correlates worse than fecal calprotectin and CRP with endoscopic Crohn's disease activity
inferredcites →https://doi.org/10.1016/j.prevetmed.2012.08.006openalex-extracted
Herd-level prevalence of Mycobacterium avium subsp. paratuberculosis infection in United States dairy herds in 2007
inferredcites →https://doi.org/10.1016/s0016-5085(76)80163-1openalex-extracted
Development of a Crohn's Disease Activity Index
inferredcites →https://doi.org/10.1016/s0016-5107(04)01878-4openalex-extracted
Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD
inferredcites →https://doi.org/10.1016/s0140-6736(18)31364-3openalex-extracted
Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19)
inferredcites →https://doi.org/10.1016/s0140-6736(20)32661-1openalex-extracted
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
inferredcites →https://doi.org/10.1016/s0378-1135(00)00330-8openalex-extracted
Further studies on the GS element A novel mycobacterial insertion sequence (IS1612), inserted into an acetylase gene (mpa) in Mycobacterium avium subsp. silvaticum but not in Mycobacterium avium subsp. paratuberculosis
inferredcites →https://doi.org/10.1016/s2666-5247(22)00126-4openalex-extracted
Safety and immunogenicity of a simian-adenovirus-vectored rabies vaccine: an open-label, non-randomised, dose-escalation, first-in-human, single-centre, phase 1 clinical trial
inferredcites →https://doi.org/10.1038/nrg.2015.33openalex-extracted
Autoimmune diseases — connecting risk alleles with molecular traits of the immune system
inferredcites →https://doi.org/10.1053/j.gastro.2008.09.012openalex-extracted
Direct Health Care Costs of Crohn's Disease and Ulcerative Colitis in US Children and Adults
inferredcites →https://doi.org/10.1053/j.gastro.2011.10.001openalex-extracted
Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review
inferredcites →https://doi.org/10.1053/j.gastro.2013.08.010openalex-extracted
Validation of Endoscopic Activity Scores in Patients With Crohn's Disease Based on a Post Hoc Analysis of Data From SONIC
inferredcites →https://doi.org/10.1053/j.gastro.2014.08.003openalex-extracted
Converging Goals of Treatment of Inflammatory Bowel Disease From Clinical Trials and Practice
inferredcites →https://doi.org/10.1089/aid.2008.0212openalex-extracted
Safety and Immunogenicity of Adenovirus-Vectored Near-Consensus HIV Type 1 Clade B gag Vaccines in Healthy Adults
inferredcites →https://doi.org/10.1093/cid/ciq015openalex-extracted
Potent CD8+ T-Cell Immunogenicity in Humans of a Novel Heterosubtypic Influenza A Vaccine, MVA-NP+M1
inferredcites →https://doi.org/10.1093/jambio/lxac017openalex-extracted
Culture of Mycobacterium avium subsp. paratuberculosis : challenges, limitations and future prospects
inferredcites →https://doi.org/10.1111/j.1365-2036.2008.03835.xopenalex-extracted
Correlation of faecal calprotectin and lactoferrin with an endoscopic score for Crohn’s disease and histological findings
inferredcites →https://doi.org/10.1128/aem.71.4.2130-2139.2005openalex-extracted
Mycobacterium aviumsubsp.paratuberculosisin the Catchment Area and Water of the River Taff in South Wales, United Kingdom, and Its Potential Relationship to Clustering of Crohn's Disease Cases in the City of Cardiff
inferredcites →https://doi.org/10.1128/aem.72.1.854-859.2006openalex-extracted
Replication and Long-Term Persistence of Bovine and Human Strains of Mycobacterium avium subsp. paratuberculosis within Acanthamoeba polyphaga
inferredcites →https://doi.org/10.1128/iai.68.2.801-808.2000openalex-extracted
Alkyl Hydroperoxide Reductases C and D Are Major Antigens Constitutively Expressed by Mycobacterium avium subsp. paratuberculosis
inferredcites →https://doi.org/10.1128/jcm.24.3.357-363.1986openalex-extracted
Spheroplastic phase of mycobacteria isolated from patients with Crohn's disease
inferredcites →https://doi.org/10.1136/gut.49.6.755openalex-extracted
Mycobacterium avium subspecies paratuberculosis is a cause of Crohn's disease
inferredcites →https://doi.org/10.1136/gutjnl-2013-304984openalex-extracted
Clinical disease activity, C-reactive protein normalisation and mucosal healing in Crohn's disease in the SONIC trial
inferredcites →https://doi.org/10.1136/gutjnl-2015-309903openalex-extracted
IOIBD technical review on endoscopic indices for Crohn's disease clinical trials
inferredcites →https://doi.org/10.1186/1471-2180-10-268openalex-extracted
Iron-sparing Response of Mycobacterium avium subsp. paratuberculosis is strain dependent
inferredcites →https://doi.org/10.1186/1757-4749-1-25openalex-extracted
A rhodanine agent active against non-replicating intracellular Mycobacterium avium subspecies paratuberculosis
inferredcites →https://doi.org/10.1186/preaccept-3233046541320296openalex-extracted
Immunity, safety and protection of an Adenovirus 5 prime - Modified Vaccinia virus Ankara boost subunit vaccine against Mycobacterium avium subspecies paratuberculosis infection in calves
inferredcites →https://doi.org/10.1186/s12964-016-0152-zopenalex-extracted
The role of IL-10 in Mycobacterium avium subsp. paratuberculosis infection
inferredcites →https://doi.org/10.1186/s13099-016-0115-3openalex-extracted
RHB-104 triple antibiotics combination in culture is bactericidal and should be effective for treatment of Crohn’s disease associated with Mycobacterium paratuberculosis
inferredcites →https://doi.org/10.1186/s13567-014-0112-9openalex-extracted
Immunity, safety and protection of an Adenovirus 5 prime - Modified Vaccinia virus Ankara boost subunit vaccine against Mycobacterium avium subspecies paratuberculosis infection in calves
inferredcites →https://doi.org/10.1371/journal.pone.0048322openalex-extracted
A T Cell-Inducing Influenza Vaccine for the Elderly: Safety and Immunogenicity of MVA-NP+M1 in Adults Aged over 50 Years
inferredcites →https://doi.org/10.1371/journal.pone.0167951openalex-extracted
Safety, Immunogenicity and Efficacy of Prime-Boost Vaccination with ChAd63 and MVA Encoding ME-TRAP against Plasmodium falciparum Infection in Adults in Senegal
inferredcites →https://doi.org/10.1371/journal.pone.0208328openalex-extracted
First field efficacy trial of the ChAd63 MVA ME-TRAP vectored malaria vaccine candidate in 5-17 months old infants and children
inferredcites →https://doi.org/10.15252/embr.201540241openalex-extracted
Attacking the system
inferredcites →https://doi.org/10.1586/17474124.2015.1093931openalex-extracted
Mycobacterium paratuberculosis as a cause of Crohn’s disease
inferredcites →https://doi.org/10.2217/fvl-2016-0070openalex-extracted
Simian Adenoviruses As Vaccine Vectors
inferredcites →https://doi.org/10.3390/biomedicines11020544openalex-extracted
Defining the Failure of Medical Therapy for Inflammatory Bowel Disease in the Era of Advanced Therapies: A Systematic Review
inferredcites →https://doi.org/10.3390/v15010204openalex-extracted
The Adenovirus Vector Platform: Novel Insights into Rational Vector Design and Lessons Learned from the COVID-19 Vaccine
inferredcites →https://doi.org/10.3748/wjg.v18.i29.3828openalex-extracted
Surgery for Crohn’s disease in the era of biologicals: A reduced need or delayed verdict?
inferredcites →https://doi.org/10.3748/wjg.v24.i25.2741openalex-extracted
Current global trends in the incidence of pediatric-onset inflammatory bowel disease
inferredcites →https://doi.org/10.4314/ovj.v8i2.10openalex-extracted
Mycobacterium avium subspecies paratuberculosis: A possible causative agent in human morbidity and risk to public health safety
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