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Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1521-4141(199910)29:10<3216::aid-immu3216>3.0.co;2-xopenalex-snapshot
Anti-CD40 antibody enhances responses to polysaccharide without mimicking T cell help
inferredcites →https://doi.org/10.1002/ana.22609openalex-snapshot
Genome‐wide meta‐analysis identifies novel multiple sclerosis susceptibility loci
inferredcites →https://doi.org/10.1002/eji.200425810openalex-snapshot
CD40/CD40L interaction regulates CD4+CD25+ T reg homeostasis through dendritic cell‐produced IL‐2
inferredcites →https://doi.org/10.1007/bf00178582openalex-snapshot
Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86)
inferredcites →https://doi.org/10.1016/1074-7613(94)90095-7openalex-snapshot
The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation
inferredcites →https://doi.org/10.1016/1074-7613(95)90048-9openalex-snapshot
Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by Rapid Up-Regulation of B7-1 and B7-2
inferredcites →https://doi.org/10.1016/b978-0-444-52001-2.00009-1openalex-snapshot
Multiple sclerosis genetics
inferredcites →https://doi.org/10.1016/j.clim.2016.10.001openalex-snapshot
B cells of multiple sclerosis patients induce autoreactive proinflammatory T cell responses
inferredcites →https://doi.org/10.1016/j.molimm.2008.08.280openalex-snapshot
Characterization of natural human antagonistic soluble CD40 isoforms produced through alternative splicing
inferredcites →https://doi.org/10.1016/j.neulet.2009.08.010openalex-snapshot
Memory and naïve B-cell subsets in patients with multiple sclerosis
inferredcites →https://doi.org/10.1016/s1474-4422(14)70041-9openalex-snapshot
Multiple sclerosis genetics
inferredcites →https://doi.org/10.1038/nature10251openalex-snapshot
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
inferredcites →https://doi.org/10.1038/nature11501openalex-snapshot
Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions
inferredcites →https://doi.org/10.1038/nature11582openalex-snapshot
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
inferredcites →https://doi.org/10.1038/ng.2220openalex-snapshot
A genome-wide association study identifies three new risk loci for Kawasaki disease
inferredcites →https://doi.org/10.1038/ng.233openalex-snapshot
Common variants at CD40 and other loci confer risk of rheumatoid arthritis
inferredcites →https://doi.org/10.1038/ng.2770openalex-snapshot
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
inferredcites →https://doi.org/10.1038/ng.3395openalex-snapshot
Class II HLA interactions modulate genetic risk for multiple sclerosis
inferredcites →https://doi.org/10.1038/ng.396openalex-snapshot
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
inferredcites →https://doi.org/10.1038/ni.3371openalex-snapshot
The cellular composition of the human immune system is shaped by age and cohabitation
inferredcites →https://doi.org/10.1038/nm.2482openalex-snapshot
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
inferredcites →https://doi.org/10.1038/nri3193openalex-snapshot
Fine-tuning of dendritic cell biology by the TNF superfamily
inferredcites →https://doi.org/10.1038/nri3871openalex-snapshot
Immunopathology of multiple sclerosis
inferredcites →https://doi.org/10.1056/nejmoa1601277openalex-snapshot
Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis
inferredcites →https://doi.org/10.1056/nejmoa1606468openalex-snapshot
Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis
inferredcites →https://doi.org/10.1073/pnas.93.6.2499openalex-snapshot
CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.
inferredcites →https://doi.org/10.1073/pnas.98.4.1751openalex-snapshot
Regulation of CD40 function by its isoforms generated through alternative splicing
inferredcites →https://doi.org/10.1084/jem.188.9.1691openalex-snapshot
Identification of Functional Human Splenic Memory B Cells by Expression of CD148 and CD27
inferredcites →https://doi.org/10.1089/105072502321085234openalex-snapshot
A C/T Single-Nucleotide Polymorphism in the Region of the CD40 Gene is Associated with Graves' Disease
inferredcites →https://doi.org/10.1093/hmg/ddv473openalex-snapshot
MRI phenotypes with high neurodegeneration are associated with peripheral blood B-cell changes
inferredcites →https://doi.org/10.1097/mib.0000000000000554openalex-snapshot
Anti–Tumor Necrosis Factor Therapy Restores Peripheral Blood B-cell Subsets and CD40 Expression in Inflammatory Bowel Diseases
inferredcites →https://doi.org/10.1126/science.1222794openalex-snapshot
Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
inferredcites →https://doi.org/10.1126/science.1249547openalex-snapshot
Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes
inferredcites →https://doi.org/10.1136/ard.2010.146530openalex-snapshot
A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis
inferredcites →https://doi.org/10.1159/000377675openalex-snapshot
Update on the Autoimmune Pathology of Multiple Sclerosis: B-Cells as Disease-Drivers and Therapeutic Targets
inferredcites →https://doi.org/10.1172/jci5388openalex-snapshot
Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis
inferredcites →https://doi.org/10.1177/1352458516662727openalex-snapshot
ACCLAIM: A randomized trial of abatacept (CTLA4-Ig) for relapsing-remitting multiple sclerosis
inferredcites →https://doi.org/10.1182/blood-2003-09-3109openalex-snapshot
Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow
inferredcites →https://doi.org/10.1182/blood-2006-10-053793openalex-snapshot
Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse
inferredcites →https://doi.org/10.1210/en.2004-1617openalex-snapshot
A Graves’ Disease-Associated Kozak Sequence Single-Nucleotide Polymorphism Enhances the Efficiency of CD40 Gene Translation: A Case for Translational Pathophysiology
inferredcites →https://doi.org/10.1212/nxi.0000000000000240openalex-snapshot
Immunologic profiles of multiple sclerosis treatments reveal shared early B cell alterations
inferredcites →https://doi.org/10.1371/journal.pone.0127080openalex-snapshot
The MS Risk Allele of CD40 Is Associated with Reduced Cell-Membrane Bound Expression in Antigen Presenting Cells: Implications for Gene Function
inferredcites →https://doi.org/10.2174/138920212803759695openalex-snapshot
Progress in Multiple Sclerosis Genetics
inferredcites →https://doi.org/10.4049/jimmunol.0900270openalex-snapshot
The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals
inferredcites →https://doi.org/10.4049/jimmunol.1402029openalex-snapshot
IFN-β Treatment Requires B Cells for Efficacy in Neuroautoimmunity
inferredcites →https://doi.org/10.4049/jimmunol.167.5.2942openalex-snapshot
Prevention of Experimental Autoimmune Encephalomyelitis in the Common Marmoset ( Callithrix jacchus ) Using a Chimeric Antagonist Monoclonal Antibody Against Human CD40 Is Associated with Altered B Cell Responses
inferredcites →https://doi.org/10.4049/jimmunol.182.2.890openalex-snapshot
Resting Human Memory B Cells Are Intrinsically Programmed for Enhanced Survival and Responsiveness to Diverse Stimuli Compared to Naive B Cells
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4627475openalex-extracted
Single Cell Analysis of Cerebrospinal Fluid Reveals Common Features of Neuroinflammation
inferred← citeshttps://doi.org/10.1002/art.41291openalex-snapshot
Pleiotropy in the Genetic Predisposition to Rheumatoid Arthritis: A Phenome‐Wide Association Study and Inverse Variance–Weighted Meta‐Analysis
inferred← citeshttps://doi.org/10.1007/s11055-026-01942-zopenalex-snapshot
MicroRNA-mediated post-transcriptional regulation in the pathogenesis of multiple sclerosis
inferred← citeshttps://doi.org/10.1007/s11940-024-00818-2openalex-snapshot
Inhibiting CD40 Ligand in Multiple Sclerosis: A Review of Emerging Therapeutic Potential
inferred← citeshttps://doi.org/10.1007/s12035-023-03825-7openalex-snapshot
Oligodeoxynucleotide IMT504: Effects on Central Nervous System Repair Following Demyelination
inferred← citeshttps://doi.org/10.1016/j.autrev.2019.05.010openalex-snapshot
Aberrant expression of alternative splicing variants in multiple sclerosis – A systematic review
inferred← citeshttps://doi.org/10.1016/j.gene.2021.146008openalex-snapshot
Multilocus evaluation of genetic predictors of multiple sclerosis
inferred← citeshttps://doi.org/10.1016/j.imlet.2023.07.006openalex-snapshot
Epstein–Barr virus and genetic risk variants as determinants of T-bet+ B cell-driven autoimmune diseases
inferred← citeshttps://doi.org/10.1016/j.jaut.2019.04.006openalex-snapshot
A cell type-specific transcriptomic approach to map B cell and monocyte type I interferon-linked pathogenic signatures in Multiple Sclerosis
inferred← citeshttps://doi.org/10.1016/j.jaut.2024.103279openalex-snapshot
Impact of coding risk variant IFNGR2 on the B cell-intrinsic IFN-γ signaling pathway in multiple sclerosis
inferred← citeshttps://doi.org/10.1016/j.jaut.2026.103533openalex-snapshot
Multiple sclerosis-associated EBNA2 variants influence the response to peginterferon beta-1a therapy
inferred← citeshttps://doi.org/10.1016/j.jneuroim.2018.09.005openalex-snapshot
Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients
inferred← citeshttps://doi.org/10.1016/j.msard.2020.102243openalex-snapshot
Whole transcriptome analysis of multiple Sclerosis patients reveals active inflammatory profile in relapsing patients and downregulation of neurological repair pathways in secondary progressive cases
inferred← citeshttps://doi.org/10.1016/j.msard.2023.105351openalex-snapshot
Gene-environment interactions and risk of pediatric-onset multiple sclerosis associated with time spent outdoors
inferred← citeshttps://doi.org/10.1016/j.neurol.2026.04.001openalex-snapshot
New immunotherapies for multiple sclerosis (MS): A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.xcrm.2024.101733openalex-snapshot
Single-cell analysis of cerebrospinal fluid reveals common features of neuroinflammation
inferred← citeshttps://doi.org/10.1038/s41467-019-09773-yopenalex-snapshot
A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis
inferred← citeshttps://doi.org/10.1038/s41586-022-04419-4openalex-snapshot
Twin study reveals non-heritable immune perturbations in multiple sclerosis
inferred← citeshttps://doi.org/10.1038/s41591-026-04665-3openalex-snapshot
EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse
inferred← citeshttps://doi.org/10.1038/s41598-020-67883-wopenalex-snapshot
Smoking and Epstein–Barr virus infection in multiple sclerosis development
inferred← citeshttps://doi.org/10.1056/nejme2314434openalex-snapshot
Silencing Immune Dialogue in Multiple Sclerosis
inferred← citeshttps://doi.org/10.1056/nejmoa2309439openalex-snapshot
Inhibition of CD40L with Frexalimab in Multiple Sclerosis
inferred← citeshttps://doi.org/10.1073/pnas.2418783122openalex-snapshot
A disease-specific convergence of host and Epstein–Barr virus genetics in multiple sclerosis
inferred← citeshttps://doi.org/10.1093/brain/awad363openalex-snapshot
Impact of multiple sclerosis risk alleles on the plasma proteome
inferred← citeshttps://doi.org/10.1093/brain/awy239openalex-snapshot
Learning from other autoimmunities to understand targeting of B cells to control multiple sclerosis
inferred← citeshttps://doi.org/10.1093/braincomms/fcaa119openalex-snapshot
Summary-data-based Mendelian randomization prioritizes potential druggable targets for multiple sclerosis
inferred← citeshttps://doi.org/10.1093/hmg/ddy324openalex-snapshot
The latitude-dependent autoimmune disease risk genes ZMIZ1 and IRF8 regulate mononuclear phagocytic cell differentiation in response to vitamin D
inferred← citeshttps://doi.org/10.1101/2020.01.20.907451openalex-snapshot
Summary-data-based mendelian randomisation reveals druggable targets for multiple sclerosis
inferred← citeshttps://doi.org/10.1101/2021.06.06.447253openalex-snapshot
Enrichment analysis of GWAS data in autoimmunity delineates the multiple sclerosis-Epstein Barr virus association
inferred← citeshttps://doi.org/10.1101/624049openalex-snapshot
Significant enrichment of Herpesvirus interactors in GWAS data suggests causal inferences for the association between Epstein Barr virus and multiple sclerosis
inferred← citeshttps://doi.org/10.1134/s0006297918120118openalex-snapshot
Potential Markers of Autoimmune Diseases, Alleles rs115662534(T) and rs548231435(C), Disrupt the Binding of Transcription Factors STAT1 and EBF1 to the Regulatory Elements of Human CD40 Gene
inferred← citeshttps://doi.org/10.1155/2024/5383099openalex-snapshot
The Plasticity of Immune Cell Response Complicates Dissecting the Underlying Pathology of Multiple Sclerosis
inferred← citeshttps://doi.org/10.1172/jci156254openalex-snapshot
Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis
inferred← citeshttps://doi.org/10.1177/11795735211050712openalex-snapshot
Elevated sCD40L in Secondary Progressive Multiple Sclerosis in Comparison to Non-progressive Benign and Relapsing Remitting Multiple Sclerosis
inferred← citeshttps://doi.org/10.1177/13524585211069926openalex-snapshot
Gene–environment interactions increase the risk of pediatric-onset multiple sclerosis associated with ozone pollution
inferred← citeshttps://doi.org/10.1186/s12865-020-00343-2openalex-snapshot
A combination of the activation marker CD86 and the immune checkpoint marker B and T lymphocyte attenuator (BTLA) indicates a putative permissive activation state of B cell subtypes in healthy blood donors independent of age and sex
inferred← citeshttps://doi.org/10.1186/s12964-023-01289-9openalex-snapshot
Advances in immune checkpoint-based immunotherapies for multiple sclerosis: rationale and practice
inferred← citeshttps://doi.org/10.1186/s12974-025-03472-wopenalex-snapshot
NEK2 regulates B cell function and the severity of experimental autoimmune encephalomyelitis
inferred← citeshttps://doi.org/10.1212/nxi.0000000000200553openalex-snapshot
Integrin β1 Demarks Precursors of Brain-Residing Antibody-Secreting Cells in Multiple Sclerosis
inferred← citeshttps://doi.org/10.14412/2074-2711-2021-1s-31-38openalex-snapshot
Genome-wide polygenic analysis of multiple sclerosis markers
inferred← citeshttps://doi.org/10.26481/dis.20201015gmdopenalex-snapshot
Immune regulation by mimethyl fumarate (DMF) in relapsing-remitting multiple sclerosis patients
inferred← citeshttps://doi.org/10.29245/2578-3009/2021/1.1202openalex-snapshot
The Role of TET Proteins in B Cell Biology
inferred← citeshttps://doi.org/10.3389/fimmu.2018.01590openalex-snapshot
Higher Serum Immunoglobulin G3 Levels May Predict the Development of Multiple Sclerosis in Individuals With Clinically Isolated Syndrome
inferred← citeshttps://doi.org/10.3389/fimmu.2020.00760openalex-snapshot
B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers
inferred← citeshttps://doi.org/10.3389/fimmu.2021.676619openalex-snapshot
Treatment-Induced BAFF Expression and B Cell Biology in Multiple Sclerosis
inferred← citeshttps://doi.org/10.3389/fimmu.2022.1010605openalex-snapshot
Analysis of herpesvirus infection and genome single nucleotide polymorphism risk factors in multiple sclerosis, Volga federal district, Russia
inferred← citeshttps://doi.org/10.3389/fimmu.2022.867693openalex-snapshot
The Effect of Peripheral Immune Cell Counts on the Risk of Multiple Sclerosis: A Mendelian Randomization Study
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1172993openalex-snapshot
Understanding humoral immunity and multiple sclerosis severity in Black, and Latinx patients
inferred← citeshttps://doi.org/10.3389/fneur.2019.00095openalex-snapshot
Genome-Wide Multiple Sclerosis Association Data and Coagulation
inferred← citeshttps://doi.org/10.3389/fnins.2021.639527openalex-snapshot
Cell-Type-Specific Gene Modules Related to the Regional Homogeneity of Spontaneous Brain Activity and Their Associations With Common Brain Disorders
inferred← citeshttps://doi.org/10.3410/f.735802950.793560642openalex-snapshot
Faculty Opinions recommendation of A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis.
inferred← citeshttps://doi.org/10.4103/1673-5374.245462openalex-snapshot
The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging
inferred← citeshttps://doi.org/10.70675/65ea40a7zbe2dz4f33z969bz1fa9a07e0174openalex-snapshot
Investigation of regulatory plasma cells in health and disease
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