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The Kingdom of the Blind: Disentangling Fundamental Drivers in the Evolution of Eye Loss

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Potential and limitations of X‐Ray micro‐computed tomography in arthropod neuroanatomy: A methodological and comparative survey
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Adaptations for nocturnal and diurnal vision in the hawkmoth lamina
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Cenozoic climate change and diversification on the continental shelf and slope: evolution of gastropod diversity in the family Solariellidae (Trochoidea)
inferredcites →https://doi.org/10.1007/978-0-387-22628-6_16openalex-snapshot
Eye Design and Vision in Deep-Sea Fishes
inferredcites →https://doi.org/10.1007/978-1-4613-1043-3_8openalex-snapshot
Evolution and Genetics of Epigean and Cave Astyanax fasciatus (Characidae, Pisces)
inferredcites →https://doi.org/10.1007/978-1-4684-8094-8_2openalex-snapshot
Cave Ecology and the Evolution of Troglobites
inferredcites →https://doi.org/10.1007/978-3-662-54512-6openalex-snapshot
Evolution in the Dark
inferredcites →https://doi.org/10.1007/978-94-015-9795-1_28openalex-snapshot
Adaptations of cave fishes with some comparisons to deep-sea fishes
inferredcites →https://doi.org/10.1007/b97656openalex-snapshot
Sensory Processing in Aquatic Environments
inferredcites →https://doi.org/10.1007/s00114-015-1329-9openalex-snapshot
Light triggers habitat choice of eyeless subterranean but not of eyed surface amphipods
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Temporal resolution in the eyes of marine decapods from coastal and deep-sea habitats
inferredcites →https://doi.org/10.1007/s13127-013-0165-zopenalex-snapshot
Impact of habitat and life trait on character evolution of pallial eyes in Pectinidae (Mollusca: bivalvia)
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The eyes of trilobites: The oldest preserved visual system
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Regressive Evolution in the Mexican Cave Tetra, Astyanax mexicanus
inferredcites →https://doi.org/10.1016/j.cub.2016.03.038openalex-snapshot
The Dual Function of Orchid Bee Ocelli as Revealed by X-Ray Microtomography
inferredcites →https://doi.org/10.1016/j.visres.2006.01.002openalex-snapshot
Visual summation in night-flying sweat bees: A theoretical study
inferredcites →https://doi.org/10.1016/j.ydbio.2009.03.003openalex-snapshot
Pleiotropic functions of embryonic sonic hedgehog expression link jaw and taste bud amplification with eye loss during cavefish evolution
inferredcites →https://doi.org/10.1016/j.ympev.2014.11.013openalex-snapshot
Phylogenetic and transcriptomic analyses reveal the evolution of bioluminescence and light detection in marine deep-sea shrimps of the family Oplophoridae (Crustacea: Decapoda)
inferredcites →https://doi.org/10.1016/s0042-6989(98)00262-4openalex-snapshot
Seeing better at night: life style, eye design and the optimum strategy of spatial and temporal summation
inferredcites →https://doi.org/10.1016/s0169-5347(00)88957-0openalex-snapshot
Are there physiological and biochemical adaptations of metabolism in deep-sea animals?
inferredcites →https://doi.org/10.1017/s0016756805001421openalex-snapshot
Ontogeny of Drevermannia and the origin of blindness in Late Devonian proetoid trilobites
inferredcites →https://doi.org/10.1017/s0952523813000035openalex-snapshot
Eye evolution and its functional basis
inferredcites →https://doi.org/10.1017/s1464793103006420openalex-snapshot
Vision in the deep sea
inferredcites →https://doi.org/10.1023/a:1011893916855openalex-snapshot
Adaptations of Cave Fishes with some Comparisons to Deep-sea Fishes
inferredcites →https://doi.org/10.1038/217624a0openalex-snapshot
Evolutionary Rate at the Molecular Level
inferredcites →https://doi.org/10.1038/3656openalex-snapshot
Light detection in a 'blind' mammal
inferredcites →https://doi.org/10.1038/nature02864openalex-snapshot
Hedgehog signalling controls eye degeneration in blind cavefish
inferredcites →https://doi.org/10.1038/srep26041openalex-snapshot
Differential investment in visual and olfactory brain areas reflects behavioural choices in hawk moths
inferredcites →https://doi.org/10.1080/00222938400770811openalex-snapshot
A subterranean population ofGarra barreimiae(Teleostei: Cyprinidae) from Oman, with comments on the concept of regressive evolution
inferredcites →https://doi.org/10.1086/419394openalex-snapshot
Adaptation and Natural Selection in Caves: The Evolution of Gammarus minus
inferredcites →https://doi.org/10.1093/icb/38.4.685openalex-snapshot
Evolution of Eye Regression in the CavefishAstyanax: Apoptosis and thePax-6Gene
inferredcites →https://doi.org/10.1093/icb/icy004openalex-snapshot
Regressed but Not Gone: Patterns of Vision Gene Loss and Retention in Subterranean Mammals
inferredcites →https://doi.org/10.1093/icb/icy007openalex-snapshot
Sequence, Structure, and Expression of Opsins in the Monochromatic Stomatopod Squilla empusa
inferredcites →https://doi.org/10.1093/molbev/mst079openalex-snapshot
Evolution of the Eye Transcriptome under Constant Darkness in Sinocyclocheilus Cavefish
inferredcites →https://doi.org/10.1093/oso/9780198546412.001.0001openalex-snapshot
The Comparative Method in Evolutionary Biology
inferredcites →https://doi.org/10.1093/oso/9780198820765.001.0001openalex-snapshot
The Biology of Caves and Other Subterranean Habitats
inferredcites →https://doi.org/10.1093/sysbio/syr085openalex-snapshot
Dispersal between Shallow and Abyssal Seas and Evolutionary Loss and Regain of Compound Eyes in Cylindroleberidid Ostracods: Conflicting Conclusions from Different Comparative Methods
inferredcites →https://doi.org/10.1098/rsbl.2012.1098openalex-snapshot
Rapid evolution of troglomorphic characters suggests selection rather than neutral mutation as a driver of eye reduction in cave crabs
inferredcites →https://doi.org/10.1098/rsos.140386openalex-snapshot
Opsin transcripts of predatory diving beetles: a comparison of surface and subterranean photic niches
inferredcites →https://doi.org/10.1098/rspb.1988.0023openalex-snapshot
Structure and function of the eyes of two species of opilionid from New Zealand glow-worm caves ( Megalopsalis tumida : Palpatores, and Hendea myersi cavernicola : Laniatores)
inferredcites →https://doi.org/10.1098/rspb.2008.1063openalex-snapshot
Multiple origins of deep-sea Asellota (Crustacea: Isopoda) from shallow waters revealed by molecular data
inferredcites →https://doi.org/10.1098/rspb.2017.2743openalex-snapshot
Deep-sea starfish from the Arctic have well-developed eyes in the dark
inferredcites →https://doi.org/10.1111/aen.12264openalex-snapshot
Consequences of evolutionary transitions in changing photic environments
inferredcites →https://doi.org/10.1111/aen.12330openalex-snapshot
How blind are they? Phototactic responses in stygobiont diving beetles (Coleoptera: Dytiscidae) from calcrete aquifers of Western Australia
inferredcites →https://doi.org/10.1111/azo.12061openalex-snapshot
The eye of the caecilian Rhinatrema bivittatum (Amphibia: Gymnophiona: Rhinatrematidae)
inferredcites →https://doi.org/10.1111/evo.13022openalex-snapshot
Repeated eye reduction events reveal multiple pathways to degeneration in a family of marine snails
inferredcites →https://doi.org/10.1111/j.1095-8312.2003.00230.xopenalex-snapshot
Convergent evolution of the cavefish Astyanax (Characidae, Teleostei): genetic evidence from reduced eye-size and pigmentation
inferredcites →https://doi.org/10.1111/j.1365-294x.2010.04759.xopenalex-snapshot
Evolution in caves: Darwin’s ‘wrecks of ancient life’ in the molecular era
inferredcites →https://doi.org/10.1111/j.1439-0469.1997.tb00400.xopenalex-snapshot
Studies in cave life evolution: a rationale for future theoretical developments using phylogenetic inference
inferredcites →https://doi.org/10.1111/j.1525-142x.2006.05071.xopenalex-snapshot
Conservation of retinal circadian rhythms during cavefish eye degeneration
inferredcites →https://doi.org/10.1111/j.1525-142x.2006.05078.xopenalex-snapshot
Modularity and sense organs in the blind cavefish,Astyanax mexicanus
inferredcites →https://doi.org/10.1111/j.1525-142x.2008.00227.xopenalex-snapshot
Multi‐trait evolution in a cave fish, Astyanax mexicanus
inferredcites →https://doi.org/10.1111/j.1558-5646.1961.tb03156.xopenalex-snapshot
CONVERGENCE AND PARALLELISM IN CAVE ENTOMOBRYINAE
inferredcites →https://doi.org/10.1111/j.1558-5646.1967.tb03410.xopenalex-snapshot
THE SELECTIVE VALUE OF EYE AND PIGMENT LOSS IN MEXICAN CAVE FISH
inferredcites →https://doi.org/10.1111/j.1558-5646.1989.tb04267.xopenalex-snapshot
EVIDENCE FOR SELECTION ON SENSORY STRUCTURES IN A CAVE POPULATION OF GAMMARUS MINUS (AMPHIPODA)
inferredcites →https://doi.org/10.1111/j.1558-5646.2012.01822.xopenalex-snapshot
EVIDENCE FOR REPEATED LOSS OF SELECTIVE CONSTRAINT IN RHODOPSIN OF AMBLYOPSID CAVEFISHES (TELEOSTEI: AMBLYOPSIDAE)
inferredcites →https://doi.org/10.1111/mec.13036openalex-snapshot
High‐stakes species delimitation in eyeless cave spiders ( Cicurina, Dictynidae, Araneae) from central Texas
inferredcites →https://doi.org/10.1111/zsc.12258openalex-snapshot
Anophthalmia and elongation of body appendages in cave scale worms (Annelida: Aphroditiformia)
inferredcites →https://doi.org/10.1126/sciadv.1500363openalex-snapshot
The energetic cost of vision and the evolution of eyeless Mexican cavefish
inferredcites →https://doi.org/10.1146/annurev-cellbio-100616-060432openalex-snapshot
Unconventional Roles of Opsins
inferredcites →https://doi.org/10.1146/annurev-genet-102108-134216openalex-snapshot
Regressive Evolution in Astyanax Cavefish
inferredcites →https://doi.org/10.1146/annurev.ecolsys.23.1.263openalex-snapshot
The Nearly Neutral Theory of Molecular Evolution
inferredcites →https://doi.org/10.1163/20021975-99990136openalex-snapshot
Anatomical Comparisons of Neural Systems in Sighted Epigean and Troglobitic Crayfish Species
inferredcites →https://doi.org/10.1186/1471-2148-13-89openalex-snapshot
Parallel reduction in expression, but no loss of functional constraint, in two opsin paralogs within cave populations of Gammarus minus (Crustacea: Amphipoda)
inferredcites →https://doi.org/10.1186/1741-7007-10-108openalex-snapshot
Evolution of an adaptive behavior and its sensory receptors promotes eye regression in blind cavefish
inferredcites →https://doi.org/10.1186/1741-7007-11-81openalex-snapshot
Eye regression in blind Astyanax cavefish may facilitate the evolution of an adaptive behavior and its sensory receptors
inferredcites →https://doi.org/10.1186/2041-9139-4-26openalex-snapshot
Evolution of eye development in the darkness of caves: adaptation, drift, or both?
inferredcites →https://doi.org/10.1186/s12862-018-1156-7openalex-snapshot
Evidence for late Pleistocene origin of Astyanax mexicanus cavefish
inferredcites →https://doi.org/10.1186/s12862-018-1263-5openalex-snapshot
Developmental studies provide new insights into the evolution of sense organs in Sabellariidae (Annelida)
inferredcites →https://doi.org/10.1242/jeb.012864openalex-snapshot
Shadow response in the blind cavefishAstyanaxreveals conservation of a functional pineal eye
inferredcites →https://doi.org/10.1242/jeb.017574openalex-snapshot
Energy limitation as a selective pressure on the evolution of sensory systems
inferredcites →https://doi.org/10.1242/jeb.045914openalex-snapshot
Identification and characterization of visual pigments in caecilians (Amphibia: Gymnophiona), an order of limbless vertebrates with rudimentary eyes
inferredcites →https://doi.org/10.1242/jeb.058883openalex-snapshot
Spectral and duration sensitivity to light-at-night in ‘blind’ and sighted rodent species
inferredcites →https://doi.org/10.1242/jeb.060368openalex-snapshot
Phototransduction and clock gene expression in the troglobiont beetlePtomaphagus hirtusof Mammoth cave
inferredcites →https://doi.org/10.1242/jeb.072009openalex-snapshot
Light and vision in the deep-sea benthos: I. Bioluminescence at 500–1000 m depth in the Bahamian Islands
inferredcites →https://doi.org/10.1371/journal.pone.0053553openalex-snapshot
De Novo Sequencing of Astyanax mexicanus Surface Fish and Pachón Cavefish Transcriptomes Reveals Enrichment of Mutations in Cavefish Putative Eye Genes
inferredcites →https://doi.org/10.1371/journal.pone.0055659openalex-snapshot
An Integrated Transcriptome-Wide Analysis of Cave and Surface Dwelling Astyanax mexicanus
inferredcites →https://doi.org/10.1371/journal.pone.0140484openalex-snapshot
A Transcriptomic Analysis of Cave, Surface, and Hybrid Isopod Crustaceans of the Species Asellus aquaticus
inferredcites →https://doi.org/10.1371/journal.pone.0170424openalex-snapshot
First Insights into the Subterranean Crustacean Bathynellacea Transcriptome: Transcriptionally Reduced Opsin Repertoire and Evidence of Conserved Homeostasis Regulatory Mechanisms
inferredcites →https://doi.org/10.1371/journal.pone.0186173openalex-snapshot
The transcriptomes of cave and surface populations of Gammarus minus (Crustacea: Amphipoda) provide evidence for positive selection on cave downregulated transcripts
inferredcites →https://doi.org/10.1525/bio.2013.63.4.7openalex-snapshot
Sensory Adaptations of Fishes to Subterranean Environments
inferredcites →https://doi.org/10.15298/invertzool.14.1.11openalex-snapshot
Lazarus in the museum: resurrecting historic specimens through new technology
inferredcites →https://doi.org/10.1636/k13-84.1openalex-snapshot
Discovery of two new species of eyeless spiders within a single Hispaniola cave
inferredcites →https://doi.org/10.2307/2423056openalex-snapshot
Cave Adaptation in Amblyopsid Fishes
inferredcites →https://doi.org/10.4159/harvard.9780674419070openalex-snapshot
Adaptation and Natural Selection in Caves
inferredcites →https://doi.org/10.5860/choice.29-5104openalex-snapshot
The comparative method in evolutionary biology
inferredcites →https://doi.org/10.5860/choice.47-1398openalex-snapshot
The biology of caves and other subterranean habitats

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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A new species of an unusual polychaete genus Ctenophoricola (Phyllodocida, Phyllodocidae, Alciopini) from the Indian Ocean
inferred← citeshttps://doi.org/10.1002/ece3.71584openalex-snapshot
Light in the Darkness: Responses to Light and Diel Activity Rhythm in an Eyeless Cave Flatworm ( Dendrocoelum italicum )
inferred← citeshttps://doi.org/10.1002/lno.12584openalex-snapshot
Sight and blindness: The relationship between ostracod eyes, water depth, and light availability in the Arctic Ocean
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Ophthalmology of Myodonta: Mice, Rats, Hamsters, Gerbils, and Relatives
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Das Sehen
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Unveiling the microhabitat puzzle: how spatial heterogeneity shapes cave invertebrate biodiversity across scales
inferred← citeshttps://doi.org/10.1007/s10071-023-01818-6openalex-snapshot
Photobehaviours guided by simple photoreceptor systems
inferred← citeshttps://doi.org/10.1016/j.cub.2024.06.020openalex-snapshot
Allometry and ecology shape eye size evolution in spiders
inferred← citeshttps://doi.org/10.1016/j.jbc.2025.110291openalex-snapshot
A repertoire of visible light–sensitive opsins in the deep-sea hydrothermal vent shrimp Rimicaris hybisae
inferred← citeshttps://doi.org/10.1017/jpa.2020.104openalex-snapshot
A new, giant ricinuleid (Arachnida, Ricinulei), from the Pennsylvanian of Illinois, and the identification of a new, ontogenetically stable, diagnostic character
inferred← citeshttps://doi.org/10.1038/s41467-024-54478-6openalex-snapshot
Reduced adult stem cell fate specification led to eye reduction in cave planarians
inferred← citeshttps://doi.org/10.1038/s41598-019-51909-zopenalex-snapshot
The utility of micro-computed tomography for the non-destructive study of eye microstructure in snails
inferred← citeshttps://doi.org/10.1086/712114openalex-snapshot
Continuous and Regular Expansion of a Distributed Visual System in the Eyed ChitonTonicia lebruni
inferred← citeshttps://doi.org/10.1086/719721openalex-snapshot
Dark Degenerations: Life, Light, and Transformation beneath the Earth, 1840–circa 1900
inferred← citeshttps://doi.org/10.1093/icb/icy082openalex-snapshot
Evolution in the Dark: Unifying our Understanding of Eye Loss
inferred← citeshttps://doi.org/10.1098/rspb.2023.2847openalex-snapshot
Gene loss and relaxed selection of plaat1 in vertebrates adapted to low-light environments
inferred← citeshttps://doi.org/10.1098/rspb.2024.2069openalex-snapshot
Development and patterning of a highly versatile visual system in spiders
inferred← citeshttps://doi.org/10.1101/2023.12.28.573503openalex-snapshot
Complex allometric relationships and ecological factors shape the development and evolution of eye size in the modular visual system of spiders
inferred← citeshttps://doi.org/10.1101/2024.01.21.576511openalex-snapshot
Investments in photoreceptors compete with investments in optics to determine eye design
inferred← citeshttps://doi.org/10.1111/1365-2435.13527openalex-snapshot
Environmental filtering and convergent evolution determine the ecological specialization of subterranean spiders
inferred← citeshttps://doi.org/10.1111/1365-2435.70107openalex-snapshot
At the edge of darkness: A framework for the evolution of visual systems in dim light
inferred← citeshttps://doi.org/10.1111/1365-2435.70140openalex-snapshot
In good form: Morphological adaptations to burrowing lifestyles in cockroaches (Dictyoptera: Blattodea)
inferred← citeshttps://doi.org/10.1111/evo.14050openalex-snapshot
Hard to get, easy to lose: Evolution of mantle photoreceptor organs in bivalves (Bivalvia, Pteriomorphia)
inferred← citeshttps://doi.org/10.1111/evo.14541openalex-snapshot
Variation in eye abundance among scallops reveals ontogenetic and evolutionary convergence associated with life habits
inferred← citeshttps://doi.org/10.1111/evo.14647openalex-snapshot
Evolutionary loss of shell pigmentation, pattern, and eye structure in deep‐sea snails in the dysphotic zone
inferred← citeshttps://doi.org/10.3390/biology14070887openalex-snapshot
Romanian Dendrocoelidae Hallez, 1892 (Platyhelminthes, Tricladida, Dendrocoelidae) Revisited: A Tribute to Radu Codreanu and Doina Balcesco
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Little Fish, Big Questions: A Collection of Modern Techniques for Mexican Tetra Research
inferred← citeshttps://doi.org/10.64898/2026.05.08.723754openalex-snapshot
Differential evolutionary and ecological patterns in eye loss between parallel visual systems in spiders
inferred← citeshttps://doi.org/10.7554/elife.96517openalex-snapshot
Investments in photoreceptors compete with investments in optics to determine eye design
inferred← citeshttps://doi.org/10.7554/elife.96517.1openalex-snapshot
Investments in photoreceptors compete with investments in optics to determine eye design
inferred← citeshttps://doi.org/10.7554/elife.96517.1.sa0openalex-snapshot
Reviewer #3 (Public Review): Investments in photoreceptors compete with investments in optics to determine eye design
inferred← citeshttps://doi.org/10.7554/elife.96517.1.sa1openalex-snapshot
Reviewer #2 (Public Review): Investments in photoreceptors compete with investments in optics to determine eye design
inferred← citeshttps://doi.org/10.7554/elife.96517.1.sa2openalex-snapshot
Reviewer #1 (Public Review): Investments in photoreceptors compete with investments in optics to determine eye design
inferred← citeshttps://doi.org/10.7554/elife.96517.1.sa3openalex-snapshot
eLife Assessment: Investments in photoreceptors compete with investments in optics to determine eye design
inferred← citeshttps://doi.org/10.7554/elife.96517.2openalex-snapshot
Investments in photoreceptors compete with investments in optics to determine eye design
inferred← citeshttps://doi.org/10.7554/elife.96517.3openalex-snapshot
Investments in photoreceptors compete with investments in optics to determine eye design
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