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Cis - and Trans -variations of Stearoyl-CoA Desaturase Provide New Insights into the Mechanisms of Diverged Pattern of Phenotypic Plasticity for Temperature Adaptation in Two Congeneric Oyster Species

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From FastQ Data to High‐Confidence Variant Calls: The Genome Analysis Toolkit Best Practices Pipeline
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Temperature, energy metabolism, and adaptive divergence in two oyster subspecies
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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
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Characterization of Stearoyl-CoA Desaturases from a Psychrophilic Antarctic Copepod, Tigriopus kingsejongensis
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Changes in the physiological parameters, fatty acid metabolism, and SCD activity and expression in juvenile GIFT tilapia (Oreochromis niloticus) reared at three different temperatures
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Temperature-induced homeoviscous adaptation of chinese hamster ovary cells
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Stearoyl-CoA desaturase 5 (SCD5), a Δ-9 fatty acyl desaturase in search of a function
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Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids
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Genetic Assimilation and the Postcolonization Erosion of Phenotypic Plasticity in Island Tiger Snakes
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Direct and heritable effects of natural tidal environments on DNA methylation in Pacific oysters (Crassostrea gigas)
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Physiological responses, desaturase activity, and fatty acid composition in milkfish (Chanos chanos) under cold acclimation
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Cloning, tissue distribution and hormonal regulation of stearoyl-CoA desaturase in tilapia, Oreochromis mossambicus*
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Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes
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Recent advances in the biochemistry and molecular biology of fatty acyl desaturases
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Role of stearoyl-coenzyme A desaturase in lipid metabolism
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Bovine Stearoyl-CoA Desaturase 1 Promotes Adipogenesis by Activating the PPARγ Receptor
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Evolutionary changes in cis and trans gene regulation
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The oyster genome reveals stress adaptation and complexity of shell formation
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Lipid landscapes and pipelines in membrane homeostasis
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Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
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Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease
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The evolutionary significance of cis-regulatory mutations
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SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci
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Environmental influence on the genetic correlations between life-history traits in Caenorhabditis elegans
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Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element
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Anesthesia in Pacific oyster, Crassostrea gigas
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Phenotypic plasticity facilitates recurrent rapid adaptation to introduced predators
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Genomic basis for coral resilience to climate change
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Circadian lipid synthesis in brown fat maintains murine body temperature during chronic cold
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Homeoviscous Adaptation—A Homeostatic Process that Regulates the Viscosity of Membrane Lipids in Escherichia coli
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Evolutionary adaptation of membranes to temperature.
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Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box.
inferredcites →https://doi.org/10.1074/jbc.273.34.22052openalex-snapshot
Transcriptional Activation of the Stearoyl-CoA Desaturase 2 Gene by Sterol Regulatory Element-binding Protein/Adipocyte Determination and Differentiation Factor 1
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Time Course and Magnitude of Synthesis of Heat‐Shock Proteins in Congeneric Marine Snails (GenusTegula) from Different Tidal Heights
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Adaptive Phenotypic Plasticity and the Successful Colonization of a Novel Environment
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A Quantitative Survey of Local Adaptation and Fitness Trade‐Offs
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Heterogeneous Selection at Specific Loci in Natural Environments in Arabidopsis thaliana
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Energetic Constraints, Size Gradients, and Size Limits in Benthic Marine Invertebrates
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Assessing the Impacts of Phenotypic Plasticity on Evolution
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Noncoding Variation and Transcriptional Plasticity Promote Thermal Adaptation in Oysters by Altering Energy Metabolism
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Multiple Modes of Adaptation: Regulatory and Structural Evolution in a Small Heat Shock Protein Gene
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Plasticity of Promoter-Core Sequences Allows Bacteria to Compensate for the Loss of a Key Global Regulatory Gene
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Magnetic DNA affinity purification of yeast transcription factor τ—a new purification principle for the ultrarapid isolation of near homogeneous factor
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A genome-wide library of CB4856/N2 introgression lines of Caenorhabditis elegans
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JASPAR 2020: update of the open-access database of transcription factor binding profiles
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The fatty acid desaturation index of blood lipids, as a biomarker of hepatic stearoyl-CoA desaturase expression, is a predictive factor of breast cancer risk
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Evolutionary trade-offs between baseline and plastic gene expression in two congeneric oyster species
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Multivariable regulation of gene expression plasticity in metazoans
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The role of developmental plasticity in evolutionary innovation
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Evolution of growth by genetic accommodation in Icelandic freshwater stickleback
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How important is thermal history? Evidence for lasting effects of developmental temperature on upper thermal limits inDrosophila melanogaster
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DNA methylation and epigenetic inheritance
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Construction of a chromosome‐level genome and variation map for the Pacific oyster Crassostrea gigas
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The contribution of phenotypic plasticity to the evolution of insecticide tolerance in amphibian populations
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PHENOTYPIC PLASTICITY AND EPIGENETIC MARKING: AN ASSESSMENT OF EVIDENCE FOR GENETIC ACCOMMODATION
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Evolutionary and environmental determinants of freshwater fish thermal tolerance and plasticity
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EVOLUTIONARY IMPLICATIONS OF PHENOTYPIC PLASTICITY IN THE HINDLIMB OF THE LIZARD ANOLIS SAGREI
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CHARACTER DISPLACEMENT IN POLYPHENIC TADPOLES
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PERSPECTIVE: GENETIC ASSIMILATION AND A POSSIBLE EVOLUTIONARY PARADOX: CAN MACROEVOLUTION SOMETIMES BE SO FAST AS TO PASS US BY?
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Evolution of phenotypic plasticity: patterns of plasticity and the emergence of ecotypes
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PHENOTYPIC PLASTICITY IN POLYGONUM PERSICARIA. I. DIVERSITY AND UNIFORMITY IN GENOTYPIC NORMS OF REACTION TO LIGHT
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THE BALDWIN EFFECT AND GENETIC ASSIMILATION: REVISITING TWO MECHANISMS OF EVOLUTIONARY CHANGE MEDIATED BY PHENOTYPIC PLASTICITY
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Evidence of genetic change in the flowering phenology of sea beets along a latitudinal cline within two decades
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Genetic accommodation in the wild: evolution of gene expression plasticity during character displacement
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Expression patterns and organization of the hsp70 genes correlate with thermotolerance in two congener endemic amphipod species (Eulimnogammarus cyaneus and E. verrucosus) from Lake Baikal
inferredcites →https://doi.org/10.1111/mec.12390openalex-snapshot
Gene expression under chronic heat stress in populations of the mustard hill coral ( P orites astreoides) from different thermal environments
inferredcites →https://doi.org/10.1111/mec.12887openalex-snapshot
Towards a gene regulatory network perspective on phenotypic plasticity, genetic accommodation and genetic assimilation
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Phenotypic plasticity in gene expression contributes to divergence of locally adapted populations of F undulus heteroclitus
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Adaptation to warmer climates by parallel functional evolution of CBF genes in Arabidopsis thaliana
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Molecular investigation of genetic assimilation during the rapid adaptive radiations of East African cichlid fishes
inferredcites →https://doi.org/10.1111/tpj.13027openalex-snapshot
Natural variation in the C‐repeat binding factor cold response pathway correlates with local adaptation of Arabidopsis ecotypes
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Distinct heat shock factors and chromatin modifications mediate the organ‐autonomous transcriptional memory of heat stress
inferredcites →https://doi.org/10.1126/science.1071527openalex-snapshot
Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss
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Cold-Induced Expression of Δ 9 -Desaturase in Carp by Transcriptional and Posttranslational Mechanisms
inferredcites →https://doi.org/10.1134/s0006297911130049openalex-snapshot
Y-box-binding protein 1 (YB-1) and its functions
inferredcites →https://doi.org/10.1146/annurev-marine-120709-142756openalex-snapshot
Local Adaptation in Marine Invertebrates
inferredcites →https://doi.org/10.1146/annurev-micro-091313-103612openalex-snapshot
Temperature Sensing by Membranes
inferredcites →https://doi.org/10.1146/annurev.ecolsys.20.1.249openalex-snapshot
Phenotypic Plasticity And The Origins Of Diversity
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STRUCTURE, FUNCTION, AND DIETARY REGULATION OF Δ6, Δ5, AND Δ9 DESATURASES
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POLYUNSATURATED FATTY ACID REGULATION OF GENES OF LIPID METABOLISM
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Heat acclimation in rats: modulation via lipid polyunsaturation
inferredcites →https://doi.org/10.1155/2013/310948openalex-snapshot
PPARγRegulates Genes Involved in Triacylglycerol Synthesis and Secretion in Mammary Gland Epithelial Cells of Dairy Goats
inferredcites →https://doi.org/10.1186/1471-2148-10-394openalex-snapshot
Unusual conservation of mitochondrial gene order in Crassostreaoysters: evidence for recent speciation in Asia
inferredcites →https://doi.org/10.1186/s12284-019-0270-5openalex-snapshot
Expression Divergence as an Evolutionary Alternative Mechanism Adopted by Two Rice Subspecies Against Rice Blast Infection
inferredcites →https://doi.org/10.1186/s12864-020-06786-6openalex-snapshot
Characterization of the transcriptional divergence between the subspecies of cultivated rice (Oryza sativa)
inferredcites →https://doi.org/10.1194/jlr.m039669openalex-snapshot
Regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase
inferredcites →https://doi.org/10.1194/jlr.m300105-jlr200openalex-snapshot
Low-temperature effect on the sterol-dependent processing of SREBPs and transcription of related genes in HepG2 cells
inferredcites →https://doi.org/10.1194/jlr.m400039-jlr200openalex-snapshot
Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment
inferredcites →https://doi.org/10.1210/jc.2008-0782openalex-snapshot
Stearoyl-Coenzyme A Desaturase 1 Gene Expression Increases after Pioglitazone Treatment and Is Associated with Peroxisomal Proliferator-Activated Receptor-γ Responsiveness
inferredcites →https://doi.org/10.1242/jeb.02070openalex-snapshot
Phenotypic plasticity and evolution by genetic assimilation
inferredcites →https://doi.org/10.1242/jeb.240432openalex-snapshot
Loss of Stearoyl-CoA desaturase 1 leads to cardiac dysfunction and lipotoxicity
inferredcites →https://doi.org/10.1242/jeb.242800openalex-snapshot
Depth- and temperature-specific fatty acid adaptations in ctenophores from extreme habitats
inferredcites →https://doi.org/10.1371/journal.pgen.0020015openalex-snapshot
Genetic and Genomic Analysis of a Fat Mass Trait with Complex Inheritance Reveals Marked Sex Specificity
inferredcites →https://doi.org/10.1371/journal.pgen.1003801openalex-snapshot
PAQR-2 Regulates Fatty Acid Desaturation during Cold Adaptation in C. elegans
inferredcites →https://doi.org/10.1534/g3.116.027946openalex-snapshot
Gene Regulatory Evolution During Speciation in a Songbird
inferredcites →https://doi.org/10.1534/genetics.105.042275openalex-snapshot
Genetic Regulation of Gene Expression During Shoot Development in Arabidopsis
inferredcites →https://doi.org/10.1534/genetics.117.201459openalex-snapshot
Cis- and Trans-regulatory Effects on Gene Expression in a Natural Population of Drosophila melanogaster
inferredcites →https://doi.org/10.1554/02-381openalex-snapshot
PERSPECTIVE: GENETIC ASSIMILATION AND A POSSIBLE EVOLUTIONARY PARADOX: CAN MACROEVOLUTION SOMETIMES BE SO FAST AS TO PASS US BY?
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Transcriptome sequencing provides evidence of genetic assimilation in a toad-headed lizard at high altitude
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Genetic Assimilation of an Acquired Character
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Classification of a Common Cupped Oyster from Southern China
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Classification of Common Oysters from North China
inferredcites →https://doi.org/10.3103/s0096392516040076openalex-snapshot
Evolutionary role of phenotypic plasticity
inferredcites →https://doi.org/10.3168/jds.2011-5083openalex-snapshot
Transcriptional regulation of lipid synthesis in bovine mammary epithelial cells by sterol regulatory element binding protein-1
inferredcites →https://doi.org/10.3168/jds.2013-7105openalex-snapshot
Peroxisome proliferator-activated receptor-γ stimulates the synthesis of monounsaturated fatty acids in dairy goat mammary epithelial cells via the control of stearoyl-coenzyme A desaturase
inferredcites →https://doi.org/10.3389/fgene.2020.581725openalex-snapshot
Regulation Between HSF1 Isoforms and HSPs Contributes to the Variation in Thermal Tolerance Between Two Oyster Congeners
inferredcites →https://doi.org/10.3389/fmars.2021.744626openalex-snapshot
Integrated Application of Transcriptomics and Metabolomics Reveals the Energy Allocation-Mediated Mechanisms of Growth-Defense Trade-Offs in Crassostrea gigas and Crassostrea angulata
inferredcites →https://doi.org/10.3389/fphys.2019.01137openalex-snapshot
Thermotolerance Divergence Revealed by the Physiological and Molecular Responses in Two Oyster Subspecies of Crassostrea gigas in China
inferredcites →https://doi.org/10.3390/genes10110875openalex-snapshot
The Role of Plasticity and Adaptation in the Incipient Speciation of a Fire Salamander Population
inferredcites →https://doi.org/10.3390/ijms21228619openalex-snapshot
Stearoyl-CoA Desaturase-2 in Murine Development, Metabolism, and Disease
inferredcites →https://doi.org/10.3390/ijms22020948openalex-snapshot
Heat Stress Responses and Thermotolerance in Maize
inferredcites →https://doi.org/10.4254/wjh.v5.i4.220openalex-snapshot
PPARγ agonist-induced alterations in Δ6-desaturase and stearoyl-CoA desaturase 1: Role of MEK/ERK1/2 pathway
inferredcites →https://doi.org/10.7554/elife.43785openalex-snapshot
Predominance of cis-regulatory changes in parallel expression divergence of sticklebacks

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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MAPK/ERK Phosphorylates Conserved PK Ser11 Site in Mollusk Regulates Divergent Thermal Metabolism of Two Congeneric Oyster Species
inferred← citeshttps://doi.org/10.1007/s10126-026-10643-0openalex-snapshot
Stearoyl-CoA Desaturase (SCD) Gene Based Molecular Breeding Enhances Nutritional Quality and Growth Performance in the Oyster (Crassostrea angulata)
inferred← citeshttps://doi.org/10.1007/s10126-026-10658-7openalex-snapshot
Exosome-Secreted Tropomyosin and Gigasin-6 Roles in Biomineralization Divergence Between Estuarine and Coastal Oysters
inferred← citeshttps://doi.org/10.1007/s42995-026-00373-6openalex-snapshot
Cis-variation–trans-variation interactions between Hsp90 promoters shape G × E effects and underlie divergent phenotypic thermal adaptation plasticity in two congeneric oyster species
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2023.740177openalex-snapshot
Comparative chromatin dynamics reveal differential thermal tolerance mechanisms between two congeneric oyster species
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2024.742033openalex-snapshot
Comparative transcriptomic analysis reveals the gut-brain axis regulatory mechanisms in cold-tolerant pufferfish (Takifugu fasciatus) under cold stress
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2025.742331openalex-snapshot
The improved heat tolerance and underlying mechanism for the selected backcross population from the Crassostrea gigas with Crassostrea angulata
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2025.742855openalex-snapshot
MAPK/ERK-driven transcriptional regulation mediates divergent thermal tolerance in two congeneric oyster species
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2025.742906openalex-snapshot
Impacts of acidification and warming on carbon sequestration capacity in Pacific oysters: Roles of biosynthesis and biodeposition
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2025.742933openalex-snapshot
Functional characterization of CSAD and its genomic variations modulating taurine synthesis and heat adaptation between two congeneric oyster species
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2025.743464openalex-snapshot
Cardiac transcriptomic analysis of thermal stress and recovery reveals dynamic metabolic regulation in the Zhikong scallop (Chlamys farreri)
inferred← citeshttps://doi.org/10.1016/j.cbd.2025.101588openalex-snapshot
Genomic identification and functional characterization of the ACTIN gene family in relation to gonadal development and gametogenesis in the Pacific oyster (Crassostrea gigas)
inferred← citeshttps://doi.org/10.1016/j.cbd.2026.102020openalex-snapshot
Expression regulation of Fad and Mboat gene families to cold stress in the noble scallop Chlamys nobilis: A comparative analysis across bivalves
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2025.118210openalex-snapshot
Comparative transcriptomic analysis reveals a differential acid response mechanism between estuarine oyster (Crassostrea ariakensis) and Pacific oyster (Crassostrea gigas)
inferred← citeshttps://doi.org/10.1016/j.envpol.2025.126411openalex-snapshot
Biomineralization mechanisms in the estuarine oyster (Crassostrea ariakensis): Unveiling the adaptive potential of mollusks in response to rapid climate change
inferred← citeshttps://doi.org/10.1016/j.envres.2026.125571openalex-snapshot
Temperature sensitivity of pyrrhotite-driven metavanadate bioreduction in groundwater
inferred← citeshttps://doi.org/10.1016/j.fsi.2026.111388openalex-snapshot
The function of stearoyl-CoA desaturase in unsaturated fatty acid biosynthesis and cold tolerance in Haliotis discus hannai
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.139483openalex-snapshot
Ascorbic acid transporter MmSLC23A2 functions to inhibit apoptosis via ROS scavenging in hard clam (Mercenaria mercenaria) under acute hypo-salinity stress
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.143183openalex-snapshot
Ctnnb1 and Keap1-Nrf2 mediating divergent heat resistance in two congeneric oysters
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.145808openalex-snapshot
Unravelling the regulatory network underlying divergent expression of the key lipid metabolism transcription factor SREBP in two congeneric oyster species
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2026.151530openalex-snapshot
Heterologous expression, purification and characteristics of a high molecular weight manganese oxidase McoA from Pseudomonas sp. AN-1
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2026.153160openalex-snapshot
Identifying the regulatory network of the key lipid metabolism transcription factor peroxisome proliferator-activated receptor in oysters
inferred← citeshttps://doi.org/10.1016/j.isci.2024.110321openalex-snapshot
MAPK/ERK-PK(Ser11) pathway regulates divergent thermal metabolism of two congeneric oyster species
inferred← citeshttps://doi.org/10.1016/j.marpolbul.2025.118659openalex-snapshot
Combined effects of marine heatwaves and nano-titanium dioxide (nano-TiO₂) on the physiological fitness in the mussel Mytilus coruscus
inferred← citeshttps://doi.org/10.1038/s41597-025-05822-yopenalex-snapshot
Genetic Resources for Research on the Regulatory Mechanism of ω-3 Fatty Acids in Oysters
inferred← citeshttps://doi.org/10.1038/s42003-024-07184-4openalex-snapshot
PI3K-AKT-mediated phosphorylation of Thr260 in CgCaspase-3/6/7 regulates heat-induced activation in oysters
inferred← citeshttps://doi.org/10.1038/s42003-026-10054-wopenalex-snapshot
A naturally synonymous mutation modulates an ERK-centered regulatory network to mediate thermotolerance divergence in Crassostrea oysters
inferred← citeshttps://doi.org/10.1073/pnas.2533429123openalex-snapshot
The KAT2/HDACⅡa–PGK–ALDO axis constitutes a dual degradation inhibition cascade links energy stress to glycolytic amplification
inferred← citeshttps://doi.org/10.1093/gigascience/giad077openalex-snapshot
Construction and analysis of the chromosome-level haplotype-resolved genomes of two Crassostrea oyster congeners: Crassostrea angulata and Crassostrea gigas
inferred← citeshttps://doi.org/10.1101/2024.03.11.584362openalex-snapshot
Novel Ser74 of NF-κB/ Cg IκBα Phosphorylated by MAPK/ERK Regulates Temperature Adaptation in Oysters
inferred← citeshttps://doi.org/10.1111/eva.70156openalex-snapshot
Membrane Lipid Remodeling Strategies Regulate Fluidity for Acute Temperature Adaptation in Oysters
inferred← citeshttps://doi.org/10.1111/mec.17623openalex-snapshot
Genotype‐by‐Environment Effects of Cis ‐Variations in the Atgl Promoter Mediate the Divergent Pattern of Phenotypic Plasticity for Temperature Adaptation in Two Congeneric Oyster Species
inferred← citeshttps://doi.org/10.1111/mec.17634openalex-snapshot
A Genetic Variant of Delta‐9 Desaturase Is Associated With Latitudinal Adaptation in a Coral from the Great Barrier Reef
inferred← citeshttps://doi.org/10.1111/pce.70810openalex-snapshot
Frequent Tandem Gene Duplications Enhance Stress Resistance and Environmental Adaptation in Extremophilic Apocynum Species
inferred← citeshttps://doi.org/10.1186/s12964-024-01923-0openalex-snapshot
Novel Ser74 of NF-κB/IκBα phosphorylated by MAPK/ERK regulates temperature adaptation in oysters
inferred← citeshttps://doi.org/10.1186/s12983-026-00622-5openalex-snapshot
Response mechanism to heat and hypoxia stress in hard clam: insights from antioxidation and lipid metabolism
inferred← citeshttps://doi.org/10.1186/s13059-025-03885-zopenalex-snapshot
Multi-omics dissection of the genetic regulation underlying fatty acid composition in cattle
inferred← citeshttps://doi.org/10.2139/ssrn.5132244openalex-snapshot
Biomineralization Mechanisms in the Estuarine Oyster (Crassostrea Ariakensis): Unveiling the Adaptive Potential of Molluscs in Response to Rapid Climate Change
inferred← citeshttps://doi.org/10.2139/ssrn.6891372openalex-snapshot
Enzyme activity and gene expression reflect adaptive divergence in response to thermal stress in two congeneric oyster species
inferred← citeshttps://doi.org/10.2983/035.044.0309openalex-snapshot
Fish Oil Supplementation of Diets for the Mangrove Oyster Crassostrea gasar to Enhance Broodstock Reproductive Conditioning
inferred← citeshttps://doi.org/10.3390/cimb46010012openalex-snapshot
Comparative Transcriptome Analyses Provide New Insights into the Evolution of Divergent Thermal Resistance in Two Eel Gobies
inferred← citeshttps://doi.org/10.3390/ijms25010125openalex-snapshot
Genome-Wide Association Analysis of Heat Tolerance in F2 Progeny from the Hybridization between Two Congeneric Oyster Species
inferred← citeshttps://doi.org/10.3390/ijms26104523openalex-snapshot
LncRNA-Mediated Tissue-Specific Plastic Responses to Salinity Changes in Oysters
inferred← citeshttps://doi.org/10.5713/ab.24.0389openalex-snapshot
Intermittent cold stimulation acclimates broilers to acute cold stress by affecting cardiac lipid metabolism
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