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Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Uniformly modified 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets
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2'-O-alkyl oligoribonucleotides as antisense probes.
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Coaxial stacking of helixes enhances binding of oligoribonucleotides and improves predictions of RNA folding.
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Synthesis and hybridization studies on two complementary nona(2'-O-methyl)ribonucleotides
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inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.0c00060openalex-snapshot
Chemical Synthesis and Biological Application of Modified Oligonucleotides
inferred← citeshttps://doi.org/10.1021/acs.chemrev.1c00386openalex-snapshot
Mass Spectrometry of Nucleic Acid Noncovalent Complexes
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b01839openalex-snapshot
Emerging siRNA Design Principles and Consequences for Biotransformation and Disposition in Drug Development
inferred← citeshttps://doi.org/10.1021/acs.joc.2c02038openalex-snapshot
Synthesis and Properties of Nucleobase-Sugar Dual Modified Nucleic Acids: 2′-OMe-RNA and scpBNA Bearing a 5-Hydroxycytosine Nucleobase
inferred← citeshttps://doi.org/10.1021/acs.joc.5b02375openalex-snapshot
Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′-C-Methyl Pyrimidine-Modified Oligonucleotides
inferred← citeshttps://doi.org/10.1021/acs.joc.6c01145openalex-snapshot
Synthesis of Oligonucleotides Containing 2′-Difluorophosphonylated Thioether Adenosine Derivatives and Study of Their Physicochemical Properties
inferred← citeshttps://doi.org/10.1021/acs.jpclett.0c00929openalex-snapshot
Synthetic Biology: A Solution for Tackling Nanomaterial Challenges
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.0c00954openalex-snapshot
Novel DEK-Targeting Aptamer Delivered by a Hydrogel Microneedle Attenuates Collagen-Induced Arthritis
inferred← citeshttps://doi.org/10.1021/acs.orglett.9b01689openalex-snapshot
Difluorophosphonylated Allylic Ether Moiety as a 2′-Modification of RNA-Type Molecules: Synthesis, Thermal, and Metabolic Studies
inferred← citeshttps://doi.org/10.1021/acsnano.5c17740openalex-snapshot
Phosphorothioate and 2′-Fluoro Ribose Substitution-Mediated Hydrophobic Effect Empowers RNA Probes for Highly Sensitive and Subtype-Selective miRNA Imaging
inferred← citeshttps://doi.org/10.1021/acsomega.9b03042openalex-snapshot
Methoxymethyl Threofuranosyl Thymidine (4′-MOM-TNA-T) at the T7 Position of the Thrombin-Binding Aptamer Boosts Anticoagulation Activity, Thermal Stability, and Nuclease Resistance
inferred← citeshttps://doi.org/10.1021/acssynbio.1c00575openalex-snapshot
Recovery of Information Stored in Modified DNA with an Evolved Polymerase
inferred← citeshttps://doi.org/10.1021/bi026985+openalex-snapshot
Effects of Vinylphosphonate Internucleotide Linkages on the Cleavage Specificity of Exonuclease III and on the Activity of DNA Polymerase I
inferred← citeshttps://doi.org/10.1021/bi050574mopenalex-snapshot
Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2‘-O-Ribonucleic Acid Modifications,
inferred← citeshttps://doi.org/10.1021/bi401677dopenalex-snapshot
Understanding the Effect of Locked Nucleic Acid and 2′-O-Methyl Modification on the Hybridization Thermodynamics of a miRNA–mRNA Pair in the Presence and Absence of AfPiwi Protein
inferred← citeshttps://doi.org/10.1021/cc060142aopenalex-snapshot
Optimizing the Stacking Moiety and Linker of 2‘-Acylamido Caps of DNA Duplexes with 3‘-Terminal Adenine Residues
inferred← citeshttps://doi.org/10.1021/cr5002832openalex-snapshot
Type 2 Diabetes Mellitus: Limitations of Conventional Therapies and Intervention with Nucleic Acid-Based Therapeutics
inferred← citeshttps://doi.org/10.1021/ja304064aopenalex-snapshot
Stabilizing Structure-Switching Signaling RNA Aptamers by Entrapment in Sol–Gel Derived Materials for Solid-Phase Assays
inferred← citeshttps://doi.org/10.1021/ja9533959openalex-snapshot
Oligonucleotide Mimics for Antisense Therapeutics: Solution Phase and Automated Solid-Support Synthesis of MMI Linked Oligomers
inferred← citeshttps://doi.org/10.1021/ja960846wopenalex-snapshot
Modulation of Tetraplex Formation by Chemical Modifications of a G4-Containing Phosphorothioate Oligonucleotide
inferred← citeshttps://doi.org/10.1021/jacs.1c03194openalex-snapshot
Directed Evolution of 2′-Fluoro-Modified, RNA-Supported Carbohydrate Clusters That Bind Tightly to HIV Antibody 2G12
inferred← citeshttps://doi.org/10.1021/jacs.6c11534openalex-snapshot
Stereoselective C2′-Alkylation of Nucleosides Enabled by Electrochemical Ni-Catalyzed C(sp3)–C(sp3) Cross-Coupling
inferred← citeshttps://doi.org/10.1021/jacs.7b13031openalex-snapshot
Synthesis and Evolution of a Threose Nucleic Acid Aptamer Bearing 7-Deaza-7-Substituted Guanosine Residues
inferred← citeshttps://doi.org/10.1021/jm050822copenalex-snapshot
Improving RNA Interference in Mammalian Cells by 4‘-Thio-Modified Small Interfering RNA (siRNA): Effect on siRNA Activity and Nuclease Stability When Used in Combination with 2‘-O-Alkyl Modifications
inferred← citeshttps://doi.org/10.1021/jm5006594openalex-snapshot
Oligonucleotide Analogues as Modulators of the Expression and Function of Noncoding RNAs (ncRNAs): Emerging Therapeutics Applications
inferred← citeshttps://doi.org/10.1021/jm950937oopenalex-snapshot
2‘-O-Aminopropyl Ribonucleotides: A Zwitterionic Modification That Enhances the Exonuclease Resistance and Biological Activity of Antisense Oligonucleotides
inferred← citeshttps://doi.org/10.1021/jo0103975openalex-snapshot
Synthesis of 2‘-O-[2-[(N,N-Dimethylamino)oxy]ethyl] Modified Nucleosides and Oligonucleotides
inferred← citeshttps://doi.org/10.1021/jo051741ropenalex-snapshot
A General Method for the Synthesis of 2‘-O-Cyanoethylated Oligoribonucleotides Having Promising Hybridization Affinity for DNA and RNA and Enhanced Nuclease Resistance
inferred← citeshttps://doi.org/10.1021/jo100170gopenalex-snapshot
Why Carba-LNA-Modified Oligonucleotides Show Considerably Improved 3′-Exonuclease Stability Compared to That of the LNA Modified or the Native Counterparts: A Michaelis−Menten Kinetic Analysis
inferred← citeshttps://doi.org/10.1021/jo300937kopenalex-snapshot
Oxidation of H-Phosphonates with Iodine by Intramolecular Support of a 2-Pyridyl Thermolabile Protecting Group
inferred← citeshttps://doi.org/10.1021/jo8016742openalex-snapshot
Fine Tuning of Electrostatics around the Internucleotidic Phosphate through Incorporation of Modified 2′,4′-Carbocyclic-LNAs and -ENAs Leads to Significant Modulation of Antisense Properties
inferred← citeshttps://doi.org/10.1021/jo961549copenalex-snapshot
Synthesis of Novel Nucleic Acid Mimics via the Stereoselective Intermolecular Radical Coupling of 3‘-Iodo Nucleosides and Formaldoximes1
inferred← citeshttps://doi.org/10.1021/jo972239copenalex-snapshot
Synthesis of Novel 2‘,3‘-Linked Bicyclic Thymine Ribonucleosides
inferred← citeshttps://doi.org/10.1021/jo9908647openalex-snapshot
Amide-Linked Ribonucleoside Dimers Derived from 5‘-Amino-5‘-deoxy- and 3‘-(Carboxymethyl)-3‘-deoxynucleoside Precursors1
inferred← citeshttps://doi.org/10.1021/jp4016068openalex-snapshot
Structures, Dynamics, and Stabilities of Fully Modified Locked Nucleic Acid (β- d -LNA and α- l -LNA) Duplexes in Comparison to Pure DNA and RNA Duplexes
inferred← citeshttps://doi.org/10.1021/ol006555gopenalex-snapshot
2‘-O-{2-[N,N-(Dialkyl)aminooxy]ethyl}- Modified Antisense Oligonucleotides
inferred← citeshttps://doi.org/10.1021/ol027131kopenalex-snapshot
2‘-O-[2-(Amino)-2-oxoethyl] Oligonucleotides
inferred← citeshttps://doi.org/10.1021/ol0340991openalex-snapshot
2‘-O-[2-[2-(N,N-Dimethylamino)ethoxy]ethyl] Modified Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects
inferred← citeshttps://doi.org/10.1021/ol0348607openalex-snapshot
2‘-Modified-2-thiothymidine Oligonucleotides
inferred← citeshttps://doi.org/10.1021/ol048487uopenalex-snapshot
A Set of Nonpolar Thymidine Nucleoside Analogues with Gradually Increasing Size
inferred← citeshttps://doi.org/10.1021/ol049470eopenalex-snapshot
2‘- O -[2-(Guanidinium)ethyl]-Modified Oligonucleotides: Stabilizing Effect on Duplex and Triplex Structures
inferred← citeshttps://doi.org/10.1021/op020061copenalex-snapshot
Development of 2‘-O-Methoxyethyl Phosphorothioate Oligonucleotides as Antisense Drugs under Stereochemical Control
inferred← citeshttps://doi.org/10.1021/op990100topenalex-snapshot
Efficient Large Scale Synthesis of 2‘-O-Alkyl Pyrimidine Ribonucleosides
inferred← citeshttps://doi.org/10.1023/a:1007657109012openalex-snapshot
Pharmacokinetics and Safety of an Anti-Vascular Endothelial Growth Factor Aptamer (NX1838) Following Injection into the Vitreous Humor of Rhesus Monkeys
inferred← citeshttps://doi.org/10.1038/9304openalex-snapshot
Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.
inferred← citeshttps://doi.org/10.1038/nbt.3765openalex-snapshot
The chemical evolution of oligonucleotide therapies of clinical utility
inferred← citeshttps://doi.org/10.1038/nrd1955openalex-snapshot
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease
inferred← citeshttps://doi.org/10.1038/nrd4359openalex-snapshot
Therapeutic targeting of microRNAs: current status and future challenges
inferred← citeshttps://doi.org/10.1038/s41467-022-31636-2openalex-snapshot
An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides
inferred← citeshttps://doi.org/10.1038/s41467-023-42174-wopenalex-snapshot
Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A
inferred← citeshttps://doi.org/10.1038/s41551-025-01429-1openalex-snapshot
Extension of replicative lifespan by synthetic engineered telomerase RNA in patient induced pluripotent stem cells
inferred← citeshttps://doi.org/10.1038/s41551-025-01515-4openalex-snapshot
Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics
inferred← citeshttps://doi.org/10.1038/s41557-021-00645-xopenalex-snapshot
A biologically stable DNAzyme that efficiently silences gene expression in cells
inferred← citeshttps://doi.org/10.1038/s41570-017-0076openalex-snapshot
Analysis of aptamer discovery and technology
inferred← citeshttps://doi.org/10.1038/s41594-018-0030-zopenalex-snapshot
2′-O-methylation in mRNA disrupts tRNA decoding during translation elongation
inferred← citeshttps://doi.org/10.1039/9781837674541-00194openalex-snapshot
Oligonucleotide Synthesis and State-of-the-Art Drug Discovery
inferred← citeshttps://doi.org/10.1039/9781847558275-00226openalex-snapshot
Strategies for the Delivery of Oligonucleotides in vivo
inferred← citeshttps://doi.org/10.1039/a801571fopenalex-snapshot
Universality of LNA-mediated high-affinity nucleic acid recognition
inferred← citeshttps://doi.org/10.1039/c1lc20447eopenalex-snapshot
Monitoring mRNA in living cells in a 3D in vitro model using TAT-peptide linked molecular beacons
inferred← citeshttps://doi.org/10.1039/c2ob26871jopenalex-snapshot
Synthesis and properties of 2′-O-neopentyl modified oligonucleotides
inferred← citeshttps://doi.org/10.1039/c3cc43725fopenalex-snapshot
A post-synthetic approach for the synthesis of 2′-O-methyldithiomethyl-modified oligonucleotides responsive to a reducing environment
inferred← citeshttps://doi.org/10.1039/c3ob27005jopenalex-snapshot
The biolabile 2′-O-pivaloyloxymethyl modification in an RNA helix: an NMR solution structure
inferred← citeshttps://doi.org/10.1039/c3ra47841fopenalex-snapshot
Nucleic acid therapeutics: basic concepts and recent developments
inferred← citeshttps://doi.org/10.1039/c4ob02221aopenalex-snapshot
Investigation of end processing and degradation of premature tRNAs and their application to stabilization of in vitro transcripts in wheat germ extract
inferred← citeshttps://doi.org/10.1039/c5ra24756jopenalex-snapshot
Development of a visible nanothermometer with a highly emissive 2′-O-methylated guanosine analogue
inferred← citeshttps://doi.org/10.1039/c6nr06154kopenalex-snapshot
Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles
inferred← citeshttps://doi.org/10.1039/c9ob00668kopenalex-snapshot
Modification of oligonucleotides with weak basic residues via the 2′- O -carbamoylethyl linker for improving nuclease resistance without loss of duplex stability and antisense activity
inferred← citeshttps://doi.org/10.1039/d2cb00100dopenalex-snapshot
Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides
inferred← citeshttps://doi.org/10.1039/d2tb02579eopenalex-snapshot
Aptamers in cancer therapy: problems and new breakthroughs
inferred← citeshttps://doi.org/10.1039/d4cs00799aopenalex-snapshot
Natural, modified and conjugated carbohydrates in nucleic acids
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