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Therapeutic targeting of microRNAs: current status and future challenges

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/anie.200801555openalex-snapshot

Small‐Molecule Inhibitors of MicroRNA miR‐21 Function

inferredcites →https://doi.org/10.1002/emmm.201100209openalex-snapshot

MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review

inferredcites →https://doi.org/10.1002/hep.20702openalex-snapshot

Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication†

inferredcites →https://doi.org/10.1002/hep.21663openalex-snapshot

Targeted inhibition of HBV gene expression by single-chain antibody mediated small interfering RNA delivery

inferredcites →https://doi.org/10.1002/path.2806openalex-snapshot

miRNAs in human cancer

inferredcites →https://doi.org/10.1006/dbio.1999.9523openalex-snapshot

The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation

inferredcites →https://doi.org/10.1007/s11095-010-0156-0openalex-snapshot

A Direct Comparison of Anti-microRNA Oligonucleotide Potency

inferredcites →https://doi.org/10.1016/0014-5793(93)81427-2openalex-snapshot

Antisense oligonucleotides made of 2'‐O‐alkylRNA: their properties and applications in RNA biochemistry

inferredcites →https://doi.org/10.1016/0092-8674(93)90529-yopenalex-snapshot

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

inferredcites →https://doi.org/10.1016/0092-8674(93)90530-4openalex-snapshot

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

inferredcites →https://doi.org/10.1016/j.addr.2004.02.014openalex-snapshot

Nanoparticle and targeted systems for cancer therapy

inferredcites →https://doi.org/10.1016/j.addr.2012.09.006openalex-snapshot

Nanoparticles in cancer therapy and diagnosis

inferredcites →https://doi.org/10.1016/j.addr.2012.09.011openalex-snapshot

Delivery of molecular and cellular medicine to solid tumors

inferredcites →https://doi.org/10.1016/j.addr.2012.09.033openalex-snapshot

Nanoparticle and targeted systems for cancer therapy

inferredcites →https://doi.org/10.1016/j.cell.2004.12.035openalex-snapshot

Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets

inferredcites →https://doi.org/10.1016/j.cell.2005.01.014openalex-snapshot

RAS Is Regulated by the let-7 MicroRNA Family

inferredcites →https://doi.org/10.1016/j.cell.2005.07.031openalex-snapshot

Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation

inferredcites →https://doi.org/10.1016/j.cell.2007.10.054openalex-snapshot

let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells

inferredcites →https://doi.org/10.1016/j.cell.2008.02.019openalex-snapshot

Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters

inferredcites →https://doi.org/10.1016/j.cell.2008.06.034openalex-snapshot

T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice

inferredcites →https://doi.org/10.1016/j.cell.2008.10.053openalex-snapshot

Posttranscriptional Crossregulation between Drosha and DGCR8

inferredcites →https://doi.org/10.1016/j.cell.2009.01.002openalex-snapshot

MicroRNAs: Target Recognition and Regulatory Functions

inferredcites →https://doi.org/10.1016/j.cell.2009.06.044openalex-snapshot

Phosphorylation of the Human MicroRNA-Generating Complex Mediates MAPK/Erk Signaling

inferredcites →https://doi.org/10.1016/j.cell.2009.12.023openalex-snapshot

Transcriptional Control of Gene Expression by MicroRNAs

inferredcites →https://doi.org/10.1016/j.cell.2010.01.007openalex-snapshot

miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts

inferredcites →https://doi.org/10.1016/j.cell.2011.09.028openalex-snapshot

A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA

inferredcites →https://doi.org/10.1016/j.cell.2011.09.029openalex-snapshot

Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs

inferredcites →https://doi.org/10.1016/j.cell.2011.09.032openalex-snapshot

In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma

inferredcites →https://doi.org/10.1016/j.cell.2012.05.003openalex-snapshot

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

inferredcites →https://doi.org/10.1016/j.cell.2012.08.002openalex-snapshot

Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression

inferredcites →https://doi.org/10.1016/j.cmet.2006.01.005openalex-snapshot

miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

inferredcites →https://doi.org/10.1016/j.gene.2005.12.031openalex-snapshot

LNA-modified oligonucleotides mediate specific inhibition of microRNA function

inferredcites →https://doi.org/10.1016/j.molcel.2006.01.031openalex-snapshot

Short RNAs Repress Translation after Initiation in Mammalian Cells

inferredcites →https://doi.org/10.1016/j.molcel.2008.09.014openalex-snapshot

Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA

inferredcites →https://doi.org/10.1016/j.molcel.2009.08.020openalex-snapshot

miR-24 Inhibits Cell Proliferation by Targeting E2F2, MYC, and Other Cell-Cycle Genes via Binding to “Seedless” 3′UTR MicroRNA Recognition Elements

inferredcites →https://doi.org/10.1016/j.tips.2009.08.004openalex-snapshot

Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer

inferredcites →https://doi.org/10.1016/j.ymeth.2007.11.001openalex-snapshot

Inhibition of microRNA with antisense oligonucleotides

inferredcites →https://doi.org/10.1016/s0092-8674(04)00045-5openalex-snapshot

MicroRNAs

inferredcites →https://doi.org/10.1016/s0167-4781(99)00138-4openalex-snapshot

2′-Carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation

inferredcites →https://doi.org/10.1016/s0169-409x(02)00044-3openalex-snapshot

Nanoparticles in cancer therapy and diagnosis

inferredcites →https://doi.org/10.1016/s1097-2765(02)00652-4openalex-snapshot

RNAi in Human Cells

inferredcites →https://doi.org/10.1021/ar200253uopenalex-snapshot

Molecular Mechanisms of RNA-Triggered Gene Silencing Machineries

inferredcites →https://doi.org/10.1021/cb7000582openalex-snapshot

Design and Creation of New Nanomaterials for Therapeutic RNAi

inferredcites →https://doi.org/10.1021/ja012288dopenalex-snapshot

Locked Nucleic Acid (LNA) Recognition of RNA: NMR Solution Structures of LNA:RNA Hybrids

inferredcites →https://doi.org/10.1021/ja910275uopenalex-snapshot

Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma

inferredcites →https://doi.org/10.1021/ja9822862openalex-snapshot

LNA (Locked Nucleic Acid): An RNA Mimic Forming Exceedingly Stable LNA:LNA Duplexes

inferredcites →https://doi.org/10.1021/jm00059a007openalex-snapshot

Uniformly modified 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

inferredcites →https://doi.org/10.1038/35002607openalex-snapshot

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

inferredcites →https://doi.org/10.1038/35078107openalex-snapshot

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

inferredcites →https://doi.org/10.1038/35888openalex-snapshot

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

inferredcites →https://doi.org/10.1038/emboj.2011.2openalex-snapshot

Small RNA‐mediated regulation of iPS cell generation

inferredcites →https://doi.org/10.1038/gt.2011.100openalex-snapshot

Chemical modification and design of anti-miRNA oligonucleotides

inferredcites →https://doi.org/10.1038/mt.2008.14openalex-snapshot

Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol

inferredcites →https://doi.org/10.1038/mt.2010.85openalex-snapshot

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

inferredcites →https://doi.org/10.1038/mtna.2013.46openalex-snapshot

Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier

inferredcites →https://doi.org/10.1038/nature02871openalex-snapshot

The functions of animal microRNAs

inferredcites →https://doi.org/10.1038/nature03120openalex-snapshot

The Microprocessor complex mediates the genesis of microRNAs

inferredcites →https://doi.org/10.1038/nature03121openalex-snapshot

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

inferredcites →https://doi.org/10.1038/nature03868openalex-snapshot

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

inferredcites →https://doi.org/10.1038/nature04263openalex-snapshot

An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

inferredcites →https://doi.org/10.1038/nature04303openalex-snapshot

Silencing of microRNAs in vivo with ‘antagomirs’

inferredcites →https://doi.org/10.1038/nature04688openalex-snapshot

RNAi-mediated gene silencing in non-human primates

inferredcites →https://doi.org/10.1038/nature06765openalex-snapshot

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

inferredcites →https://doi.org/10.1038/nature06783openalex-snapshot

LNA-mediated microRNA silencing in non-human primates

inferredcites →https://doi.org/10.1038/nature07511openalex-snapshot

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

inferredcites →https://doi.org/10.1038/nature08956openalex-snapshot

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

inferredcites →https://doi.org/10.1038/nature09267openalex-snapshot

Mammalian microRNAs predominantly act to decrease target mRNA levels

inferredcites →https://doi.org/10.1038/nature10112openalex-snapshot

MicroRNAs 103 and 107 regulate insulin sensitivity

inferredcites →https://doi.org/10.1038/nature11134openalex-snapshot

Autoregulation of microRNA biogenesis by let-7 and Argonaute

inferredcites →https://doi.org/10.1038/nbt.1564openalex-snapshot

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

inferredcites →https://doi.org/10.1038/nbt.1618openalex-snapshot

Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model

inferredcites →https://doi.org/10.1038/nbt.2612openalex-snapshot

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

inferredcites →https://doi.org/10.1038/nbt0713-577openalex-snapshot

First microRNA mimic enters clinic

inferredcites →https://doi.org/10.1038/nbt1081openalex-snapshot

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

inferredcites →https://doi.org/10.1038/nbt1101openalex-snapshot

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

inferredcites →https://doi.org/10.1038/nbt1122openalex-snapshot

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

inferredcites →https://doi.org/10.1038/nbt1339openalex-snapshot

Mechanisms and optimization of in vivo delivery of lipophilic siRNAs

inferredcites →https://doi.org/10.1038/nbt1402openalex-snapshot

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

inferredcites →https://doi.org/10.1038/ncb1333openalex-snapshot

A role for the P-body component GW182 in microRNA function

inferredcites →https://doi.org/10.1038/ncb2024openalex-snapshot

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

inferredcites →https://doi.org/10.1038/nchembio.939openalex-snapshot

Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing

inferredcites →https://doi.org/10.1038/nchembio839openalex-snapshot

RNAi therapeutics: a potential new class of pharmaceutical drugs

inferredcites →https://doi.org/10.1038/ng.317openalex-snapshot

A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function

inferredcites →https://doi.org/10.1038/ng.786openalex-snapshot

Silencing of microRNA families by seed-targeting tiny LNAs

inferredcites →https://doi.org/10.1038/ni.1863openalex-snapshot

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

inferredcites →https://doi.org/10.1038/ni.2648openalex-snapshot

MicroRNAs of the miR-17∼92 family are critical regulators of TFH differentiation

inferredcites →https://doi.org/10.1038/nm1191openalex-snapshot

Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7

inferredcites →https://doi.org/10.1038/nmeth1079openalex-snapshot

MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells

inferredcites →https://doi.org/10.1038/nnano.2012.73openalex-snapshot

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

inferredcites →https://doi.org/10.1038/nrd2614openalex-snapshot

Nanoparticle therapeutics: an emerging treatment modality for cancer

inferredcites →https://doi.org/10.1038/nrd3179openalex-snapshot

Targeting microRNAs in cancer: rationale, strategies and challenges

inferredcites →https://doi.org/10.1038/nrd3864openalex-snapshot

MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles

inferredcites →https://doi.org/10.1038/nrg2634openalex-snapshot

Causes and consequences of microRNA dysregulation in cancer

inferredcites →https://doi.org/10.1038/nrg2843openalex-snapshot

The widespread regulation of microRNA biogenesis, function and decay

inferredcites →https://doi.org/10.1038/nri2708openalex-snapshot

Physiological and pathological roles for microRNAs in the immune system

inferredcites →https://doi.org/10.1038/nsmb.1405openalex-snapshot

GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay

inferredcites →https://doi.org/10.1038/nsmb.2580openalex-snapshot

From pseudo-ceRNAs to circ-ceRNAs: a tale of cross-talk and competition

inferredcites →https://doi.org/10.1038/onc.2008.178openalex-snapshot

MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma

inferredcites →https://doi.org/10.1038/onc.2011.193openalex-snapshot

microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer

inferredcites →https://doi.org/10.1038/sj.onc.1210425openalex-snapshot

Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92

inferredcites →https://doi.org/10.1038/sj.onc.1210856openalex-snapshot

MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer

inferredcites →https://doi.org/10.1039/a708608copenalex-snapshot

LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

inferredcites →https://doi.org/10.1042/bj20080599openalex-snapshot

Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies

inferredcites →https://doi.org/10.1053/j.gastro.2007.05.022openalex-snapshot

MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer

inferredcites →https://doi.org/10.1056/nejmoa073108openalex-snapshot

Local Dystrophin Restoration with Antisense Oligonucleotide PRO051

inferredcites →https://doi.org/10.1073/pnas.0307323101openalex-snapshot

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

inferredcites →https://doi.org/10.1073/pnas.0404432101openalex-snapshot

MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias

inferredcites →https://doi.org/10.1073/pnas.0510565103openalex-snapshot

A microRNA expression signature of human solid tumors defines cancer gene targets

inferredcites →https://doi.org/10.1073/pnas.0701458104openalex-snapshot

Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA

inferredcites →https://doi.org/10.1073/pnas.0703820104openalex-snapshot

Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR

inferredcites →https://doi.org/10.1073/pnas.0712321105openalex-snapshot

Suppression of non-small cell lung tumor development by the let-7 microRNA family

inferredcites →https://doi.org/10.1073/pnas.0907904107openalex-snapshot

miR-221 overexpression contributes to liver tumorigenesis

inferredcites →https://doi.org/10.1073/pnas.1016152108openalex-snapshot

Delivery of siRNA and other macromolecules into skin and cells using a peptide enhancer

inferredcites →https://doi.org/10.1073/pnas.1208863110openalex-snapshot

Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family

inferredcites →https://doi.org/10.1074/jbc.m611393200openalex-snapshot

MicroRNA-21 Targets the Tumor Suppressor Gene Tropomyosin 1 (TPM1)

inferredcites →https://doi.org/10.1074/jbc.m707224200openalex-snapshot

Programmed Cell Death 4 (PDCD4) Is an Important Functional Target of the MicroRNA miR-21 in Breast Cancer Cells

inferredcites →https://doi.org/10.1083/jcb.201208082openalex-snapshot

Discovering the first microRNA-targeted drug

inferredcites →https://doi.org/10.1089/ard.1994.4.201openalex-snapshot

Complement Activation and Hemodynamic Changes Following Intravenous Administration of Phosphorothioate Oligonucleotides in the Monkey

inferredcites →https://doi.org/10.1089/nat.2011.0298openalex-snapshot

Immunostimulatory Potential of Silencing RNAs Can Be Mediated by a Non-Uridine-Rich Toll-Like Receptor 7 Motif

inferredcites →https://doi.org/10.1089/nat.2011.0332openalex-snapshot

A Locked Nucleic Acid Oligonucleotide Targeting MicroRNA 122 Is Well-Tolerated in Cynomolgus Monkeys

inferredcites →https://doi.org/10.1089/nat.2012.0366openalex-snapshot

Chemical Modification Study of Antisense Gapmers

inferredcites →https://doi.org/10.1089/oli.1.1997.7.503openalex-snapshot

Inhibition of Coagulation by a Phosphorothioate Oligonucleotide

inferredcites →https://doi.org/10.1093/nar/23.11.2019openalex-snapshot

Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity

inferredcites →https://doi.org/10.1093/nar/26.9.2224openalex-snapshot

Advantages of 2'-O-methyl oligoribonucleotide probes for detecting RNA targets

inferredcites →https://doi.org/10.1093/nar/gkg707openalex-snapshot

Developmental defects by antisense-mediated inactivation of micro-RNAs 2 and 13 in Drosophila and the identification of putative target genes

inferredcites →https://doi.org/10.1093/nar/gkl1071openalex-snapshot

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

inferredcites →https://doi.org/10.1093/nar/gkl183openalex-snapshot

Improved targeting of miRNA with antisense oligonucleotides

inferredcites →https://doi.org/10.1093/nar/gkm1113openalex-snapshot

Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver

inferredcites →https://doi.org/10.1093/nar/gkq1307openalex-snapshot

Silencing microRNA by interfering nanoparticles in mice

inferredcites →https://doi.org/10.1093/nar/gnh140openalex-snapshot

Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

inferredcites →https://doi.org/10.1093/toxsci/kft278openalex-snapshot

Comparison of Hepatic Transcription Profiles of Locked Ribonucleic Acid Antisense Oligonucleotides: Evidence of Distinct Pathways Contributing to Non-target Mediated Toxicity in Mice

inferredcites →https://doi.org/10.1101/gad.1424106openalex-snapshot

mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

inferredcites →https://doi.org/10.1126/science.1093616openalex-snapshot

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

inferredcites →https://doi.org/10.1126/science.1093620openalex-snapshot

Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

inferredcites →https://doi.org/10.1126/science.1113329openalex-snapshot

Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA

inferredcites →https://doi.org/10.1126/science.1115079openalex-snapshot

Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

inferredcites →https://doi.org/10.1126/science.1137999openalex-snapshot

Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation

inferredcites →https://doi.org/10.1126/science.1139089openalex-snapshot

Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA

inferredcites →https://doi.org/10.1126/science.1149859openalex-snapshot

Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target

inferredcites →https://doi.org/10.1126/science.1157396openalex-snapshot

Endogenous siRNAs Derived from Transposons and mRNAs in Drosophila Somatic Cells

inferredcites →https://doi.org/10.1126/science.1178178openalex-snapshot

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

inferredcites →https://doi.org/10.1126/scitranslmed.3003205openalex-snapshot

MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways

inferredcites →https://doi.org/10.1126/scitranslmed.3003601openalex-snapshot

Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2 + Breast Cancer Growth and Metastasis

inferredcites →https://doi.org/10.1128/mcb.05776-11openalex-snapshot

Hypoxia Potentiates MicroRNA-Mediated Gene Silencing through Posttranslational Modification of Argonaute2

inferredcites →https://doi.org/10.1146/annurev.biochem.67.1.99openalex-snapshot

MODIFIED OLIGONUCLEOTIDES: Synthesis and Strategy for Users

inferredcites →https://doi.org/10.1146/annurev.pharmtox.010909.105654openalex-snapshot

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

inferredcites →https://doi.org/10.1158/0008-5472.can-04-0637openalex-snapshot

Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

inferredcites →https://doi.org/10.1158/0008-5472.can-05-0137openalex-snapshot

MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells

inferredcites →https://doi.org/10.1158/0008-5472.can-05-0565openalex-snapshot

Sequence-Specific Knockdown of EWS-FLI1 by Targeted, Nonviral Delivery of Small Interfering RNA Inhibits Tumor Growth in a Murine Model of Metastatic Ewing's Sarcoma

inferredcites →https://doi.org/10.1158/0008-5472.can-07-1083openalex-snapshot

The let-7 MicroRNA Represses Cell Proliferation Pathways in Human Cells

inferredcites →https://doi.org/10.1158/0008-5472.can-08-1305openalex-snapshot

MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells

inferredcites →https://doi.org/10.1158/0008-5472.can-11-1144openalex-snapshot

miR-221 Silencing Blocks Hepatocellular Carcinoma and Promotes Survival

inferredcites →https://doi.org/10.1158/1078-0432.ccr-09-0092openalex-snapshot

MicroRNA-221 Targets Bmf in Hepatocellular Carcinoma and Correlates with Tumor Multifocality

inferredcites →https://doi.org/10.1161/circresaha.111.244442openalex-snapshot

Inhibition of miR-15 Protects Against Cardiac Ischemic Injury

inferredcites →https://doi.org/10.1161/circresaha.111.248880openalex-snapshot

miR-15 Family Regulates Postnatal Mitotic Arrest of Cardiomyocytes

inferredcites →https://doi.org/10.1161/circulationaha.111.030932openalex-snapshot

Therapeutic Inhibition of miR-208a Improves Cardiac Function and Survival During Heart Failure

inferredcites →https://doi.org/10.1186/1471-2105-8-69openalex-snapshot

Inference of miRNA targets using evolutionary conservation and pathway analysis

inferredcites →https://doi.org/10.1242/dev.006486openalex-snapshot

Biogenesis and germline functions of piRNAs

inferredcites →https://doi.org/10.1261/rna.1591709openalex-snapshot

Post-transcriptional control of DGCR8 expression by the Microprocessor

inferredcites →https://doi.org/10.1261/rna.2414110openalex-snapshot

MicroRNA sponges: Progress and possibilities

inferredcites →https://doi.org/10.1261/rna.5103703openalex-snapshot

siRNA function in RNAi: A chemical modification analysis

inferredcites →https://doi.org/10.1261/rna.5235104openalex-snapshot

Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing

inferredcites →https://doi.org/10.1371/journal.pbio.0000060openalex-snapshot

Identification of Drosophila MicroRNA Targets

inferredcites →https://doi.org/10.1371/journal.pbio.0020098openalex-snapshot

Sequence-Specific Inhibition of Small RNA Function

inferredcites →https://doi.org/10.1371/journal.pbio.0040210openalex-snapshot

Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54

inferredcites →https://doi.org/10.1371/journal.pbio.0050203openalex-snapshot

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Glycogen Synthase Kinase 3 Beta (GSK3β) Phosphorylates the RNAase III Enzyme Drosha at S300 and S302

inferredcites →https://doi.org/10.1517/17425250902877680openalex-snapshot

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inferredcites →https://doi.org/10.4049/jimmunol.172.11.6545openalex-snapshot

Small Interfering RNAs Mediate Sequence-Independent Gene Suppression and Induce Immune Activation by Signaling through Toll-Like Receptor 3

inferredcites →https://doi.org/10.4161/cc.7.6.5834openalex-snapshot

The let-7 microRNA reduces tumor growth in mouse models of lung cancer

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1007/s00439-019-02046-0openalex-snapshot

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inferred← citeshttps://doi.org/10.1007/s00774-023-01433-yopenalex-snapshot

Mir-4699 promotes the osteogenic differentiation of mesenchymal stem cells

inferred← citeshttps://doi.org/10.1007/s10456-017-9545-xopenalex-snapshot

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inferred← citeshttps://doi.org/10.1007/s10456-021-09778-6openalex-snapshot

Hydrogel-mediated delivery of microRNA-92a inhibitor polyplex nanoparticles induces localized angiogenesis

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inferred← citeshttps://doi.org/10.1007/s10544-018-0298-0openalex-snapshot

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MiR-137-3p Inhibits Colorectal Cancer Cell Migration by Regulating a KDM1A-Dependent Epithelial–Mesenchymal Transition

inferred← citeshttps://doi.org/10.1007/s10735-020-09950-0openalex-snapshot

Exosomes with high level of miR-181c from bone marrow-derived mesenchymal stem cells inhibit inflammation and apoptosis to alleviate spinal cord injury

inferred← citeshttps://doi.org/10.1007/s10928-015-9406-4openalex-snapshot

A PBPK workflow for first-in-human dose selection of a subcutaneously administered pegylated peptide

inferred← citeshttps://doi.org/10.1007/s11010-024-05164-0openalex-snapshot

The neuroinflammatory role of microRNAs in Alzheimer’s disease: pathological insights to therapeutic potential

inferred← citeshttps://doi.org/10.1007/s11011-019-00485-2openalex-snapshot

The role of non-coding RNAs in neuroprotection and angiogenesis following ischemic stroke

inferred← citeshttps://doi.org/10.1007/s11033-018-4352-zopenalex-snapshot

Increased expression of microRNAs, miR-20a and miR-326 in PBMCs of patients with type 1 diabetes

inferred← citeshttps://doi.org/10.1007/s11033-018-4358-6openalex-snapshot

Molecular pathways involved in microRNA-mediated regulation of multidrug resistance

inferred← citeshttps://doi.org/10.1007/s11033-018-4511-2openalex-snapshot

Regulation mechanism of microRNA in plant response to abiotic stress and breeding

inferred← citeshttps://doi.org/10.1007/s11033-022-07620-wopenalex-snapshot

Recent findings on the role of microRNAs in genetic kidney diseases

inferred← citeshttps://doi.org/10.1007/s11033-025-11406-1openalex-snapshot

MicroRNA-mediated regulation of hepatic metabolism in pregnancy: current understanding and future perspectives

inferred← citeshttps://doi.org/10.1007/s11154-023-09866-6openalex-snapshot

Pulling the trigger: Noncoding RNAs in white adipose tissue browning

inferred← citeshttps://doi.org/10.1007/s11523-017-0476-7openalex-snapshot

Exploiting microRNAs As Cancer Therapeutics

inferred← citeshttps://doi.org/10.1007/s11523-017-0478-5openalex-snapshot

miRNAs as Biomarkers and Therapeutic Targets in Non-Small Cell Lung Cancer: Current Perspectives

inferred← citeshttps://doi.org/10.1007/s11523-020-00717-xopenalex-snapshot

MicroRNAs (miRNAs) and Long Non-Coding RNAs (lncRNAs) as New Tools for Cancer Therapy: First Steps from Bench to Bedside

inferred← citeshttps://doi.org/10.1007/s11626-019-00417-5openalex-snapshot

MicroRNA302-367-PI3K-PTEN-AKT-mTORC1 pathway promotes the development of cardiac hypertrophy through controlling autophagy

inferred← citeshttps://doi.org/10.1007/s11883-017-0699-1openalex-snapshot

Novel Approaches for HDL-Directed Therapies

inferred← citeshttps://doi.org/10.1007/s11883-022-01007-9openalex-snapshot

RNA Therapeutics: the Next Generation of Drugs for Cardiovascular Diseases

inferred← citeshttps://doi.org/10.1007/s11892-020-01325-9openalex-snapshot

miRNA Regulation of T Cells in Islet Autoimmunity and Type 1 Diabetes

inferred← citeshttps://doi.org/10.1007/s11926-016-0604-xopenalex-snapshot

The Role of MicroRNAs and Their Targets in Osteoarthritis

inferred← citeshttps://doi.org/10.1007/s12016-016-8589-9openalex-snapshot

Diagnostic Potential of Extracellular MicroRNA in Respiratory Diseases

inferred← citeshttps://doi.org/10.1007/s12031-020-01600-0openalex-snapshot

MicroRNA-107 Ameliorates Damage in a Cell Model of Alzheimer’s Disease by Mediating the FGF7/FGFR2/PI3K/Akt Pathway

inferred← citeshttps://doi.org/10.1007/s12032-023-02212-5openalex-snapshot

Prospects of microRNAs as therapeutic biomarkers in non-small cell lung cancer

inferred← citeshttps://doi.org/10.1007/s12033-017-0034-7openalex-snapshot

A Concise Review of MicroRNA Exploring the Insights of MicroRNA Regulations in Bacterial, Viral and Metabolic Diseases

inferred← citeshttps://doi.org/10.1007/s12035-016-9940-0openalex-snapshot

Amikacin Inhibits miR-497 Maturation and Exerts Post-ischemic Neuroprotection

inferred← citeshttps://doi.org/10.1007/s12035-018-0951-xopenalex-snapshot

miRNA Editing: New Insights into the Fast Control of Gene Expression in Health and Disease

inferred← citeshttps://doi.org/10.1007/s12038-022-00288-1openalex-snapshot

Involvement of host microRNAs in flavivirus-induced neuropathology: An update

inferred← citeshttps://doi.org/10.1007/s12223-026-01574-3openalex-snapshot

The gut microbiota–miRNA axis in multiple sclerosis: Mechanisms and therapeutic potentials

inferred← citeshttps://doi.org/10.1007/s12519-019-00265-zopenalex-snapshot

MicroRNA-125b regulates Th17/Treg cell differentiation and is associated with juvenile idiopathic arthritis

inferred← citeshttps://doi.org/10.1007/s12640-020-00236-7openalex-snapshot

Non-coding RNAs in Ischemic Stroke: Roles in the Neuroinflammation and Cell Death

inferred← citeshttps://doi.org/10.1007/s12975-022-01071-yopenalex-snapshot

MicroRNA-193a-5p Rescues Ischemic Cerebral Injury by Restoring N2-Like Neutrophil Subsets

inferred← citeshttps://doi.org/10.1007/s13204-022-02701-5openalex-snapshot

Prospects in the use of gold nanoparticles as cancer theranostics and targeted drug delivery agents

inferred← citeshttps://doi.org/10.1007/s13273-024-00468-0openalex-snapshot

The therapeutic potential of Laggera alata in alleviating inflammation and oxidative stress: insights into the miR-150-5p/TRIM8 axis

inferred← citeshttps://doi.org/10.1007/s13277-016-4960-yopenalex-snapshot

The interplay between microRNAs and Twist1 transcription factor: a systematic review

inferred← citeshttps://doi.org/10.1007/s13277-016-5405-3openalex-snapshot

Involvement of microRNAs in HER2 signaling and trastuzumab treatment

inferred← citeshttps://doi.org/10.1007/s13346-017-0440-1openalex-snapshot

Therapeutic prospects of microRNAs in cancer treatment through nanotechnology

inferred← citeshttps://doi.org/10.1007/s13346-020-00721-8openalex-snapshot

Technological challenges in the preclinical development of an HIV nanovaccine candidate

inferred← citeshttps://doi.org/10.1007/s13346-020-00779-4openalex-snapshot

Simultaneous delivery of anti-miRNA and docetaxel with supramolecular self-assembled “chitosome” for improving chemosensitivity of triple negative breast cancer cells

inferred← citeshttps://doi.org/10.1007/s40495-014-0009-3openalex-snapshot

MicroRNA Regulating Glutathione S-Transferase P1 in Prostate Cancer

inferred← citeshttps://doi.org/10.1007/s40618-023-02059-7openalex-snapshot

The role of miR-139-5p in radioiodine-resistant thyroid cancer

inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.12423-0openalex-snapshot

Manufacturing of Oligonucleotides

inferred← citeshttps://doi.org/10.1016/b978-0-12-420135-4.00018-8openalex-snapshot

Cardiovascular Diseases and Personalized Epigenetics

inferred← citeshttps://doi.org/10.1016/b978-0-12-799961-6.00002-0openalex-snapshot

Modern Transcriptomics and Small RNA Diversity

inferred← citeshttps://doi.org/10.1016/b978-0-12-800553-8.00007-xopenalex-snapshot

MicroRNAs in Idiopathic Pulmonary Fibrosis

inferred← citeshttps://doi.org/10.1016/b978-0-12-802175-0.00012-7openalex-snapshot

Stress Reactions Orchestrate Parasympathetic Functioning and Inflammation Under Diverse Cholinergic Manipulations

inferred← citeshttps://doi.org/10.1016/b978-0-12-802389-1.00021-6openalex-snapshot

Pharmacological and Therapeutic Targeting of Epigenetic Regulators

inferred← citeshttps://doi.org/10.1016/b978-0-12-811060-7.00020-6openalex-snapshot

Healthy Aging and Epigenetic Drugs for Diabetes and Obesity

inferred← citeshttps://doi.org/10.1016/b978-0-12-811785-9.00035-1openalex-snapshot

Molecular Assessment of Ovarian Cancer and Translation to Clinical Management

inferred← citeshttps://doi.org/10.1016/b978-0-12-814470-1.00001-0openalex-snapshot

Therapeutic Oligonucleotides Against Cancer: Recent Approaches and New Perspectives

inferred← citeshttps://doi.org/10.1016/b978-0-12-814513-5.00006-4openalex-snapshot

Computational Tools for microRNA Target Prediction

inferred← citeshttps://doi.org/10.1016/b978-0-12-814835-8.00009-1openalex-snapshot

Innovation in nanomedicine and engineered nanomaterials for therapeutic purposes

inferred← citeshttps://doi.org/10.1016/b978-0-12-819178-1.00020-4openalex-snapshot

Non-coding RNA therapy in cancer

inferred← citeshttps://doi.org/10.1016/b978-0-12-819612-0.00009-2openalex-snapshot

Regulation of RKIP expression in breast cancer cells by miRNAs

inferred← citeshttps://doi.org/10.1016/b978-0-12-819621-2.00005-xopenalex-snapshot

Mitochondrial dysfunction in kidney diseases

inferred← citeshttps://doi.org/10.1016/b978-0-12-821595-1.00012-9openalex-snapshot

CMC and regulatory aspects of oligonucleotide therapeutics

inferred← citeshttps://doi.org/10.1016/b978-0-12-822287-4.00005-0openalex-snapshot

MicroRNA involvement in invasion and metastasis

inferred← citeshttps://doi.org/10.1016/b978-0-323-47347-7.00029-xopenalex-snapshot

Nanotherapeutic Platforms for Cancer Treatment: From Preclinical Development to Clinical Application

inferred← citeshttps://doi.org/10.1016/b978-0-323-47927-1.00006-2openalex-snapshot

Epigenetics of Lupus

inferred← citeshttps://doi.org/10.1016/b978-0-323-89774-7.00008-xopenalex-snapshot

MicroRNAs and other noncoding RNAs in human pathology

inferred← citeshttps://doi.org/10.1016/b978-0-323-89774-7.00013-3openalex-snapshot

Clinical applications of microRNAs

inferred← citeshttps://doi.org/10.1016/b978-0-323-90406-3.00006-3openalex-snapshot

Therapeutic targeting non-coding RNAs

inferred← citeshttps://doi.org/10.1016/b978-0-323-91305-8.00003-xopenalex-snapshot

Post-transcriptional gene regulation in metabolic syndrome

inferred← citeshttps://doi.org/10.1016/b978-0-323-91305-8.00009-0openalex-snapshot

Post-transcriptional regulation of inflammatory disorder

inferred← citeshttps://doi.org/10.1016/b978-0-443-29808-0.00012-1openalex-snapshot

Manufacturing of oligonucleotides

inferred← citeshttps://doi.org/10.1016/b978-0-443-44185-1.00032-xopenalex-snapshot

Clinical status of anticancer drug delivery systems

inferred← citeshttps://doi.org/10.1016/b978-0-444-63667-6.00005-5openalex-snapshot

Functional Genomics of MicroRNAs

inferred← citeshttps://doi.org/10.1016/bs.acc.2017.06.003openalex-snapshot

miRNAs: Nanomachines That Micromanage the Pathophysiology of Diabetes Mellitus

inferred← citeshttps://doi.org/10.1016/bs.acr.2015.04.005openalex-snapshot

Unravelling the Complexity and Functions of MTA Coregulators in Human Cancer

inferred← citeshttps://doi.org/10.1016/bs.ircmb.2017.03.005openalex-snapshot

MicroRNA Dysregulation in Aging and Pathologies of the Skeletal Muscle

inferred← citeshttps://doi.org/10.1016/bs.ircmb.2017.03.007openalex-snapshot

A Macro View of MicroRNAs: The Discovery of MicroRNAs and Their Role in Hematopoiesis and Hematologic Disease

inferred← citeshttps://doi.org/10.1016/bs.pmbts.2014.11.015openalex-snapshot

MicroRNA Biology and Pain

inferred← citeshttps://doi.org/10.1016/bs.pmbts.2023.12.010openalex-snapshot

Advances in liposome-based delivery of RNA therapeutics for cancer treatment

inferred← citeshttps://doi.org/10.1016/j.ab.2017.09.007openalex-snapshot

Ultrasensitive microRNA-21 detection based on DNA hybridization chain reaction and SYBR Green dye

inferred← citeshttps://doi.org/10.1016/j.abb.2022.109139openalex-snapshot

miR9 inhibits 6-mer HA-induced cytokine production and apoptosis in human chondrocytes by reducing NF-kB activation

inferred← citeshttps://doi.org/10.1016/j.actbio.2018.05.049openalex-snapshot

A dual-targeting reconstituted high density lipoprotein leveraging the synergy of sorafenib and antimiRNA21 for enhanced hepatocellular carcinoma therapy

inferred← citeshttps://doi.org/10.1016/j.actbio.2021.07.027openalex-snapshot

Targeted extracellular vesicle delivery systems employing superparamagnetic iron oxide nanoparticles

inferred← citeshttps://doi.org/10.1016/j.actbio.2021.08.041openalex-snapshot

Precise in-situ release of microRNA from an injectable hydrogel induces bone regeneration

inferred← citeshttps://doi.org/10.1016/j.addr.2014.09.003openalex-snapshot

Target-responsive DNA/RNA nanomaterials for microRNA sensing and inhibition: The jack-of-all-trades in cancer nanotheranostics?

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