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Mutagenic mechanisms of cancer-associated DNA polymerase ϵ alleles

https://doi.org/10.1093/nar/gkab160
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/j.1460-2075.1993.tb05790.xopenalex-snapshot
Pathway correcting DNA replication errors in Saccharomyces cerevisiae.
inferredcites →https://doi.org/10.1007/bf00280418openalex-snapshot
The 3′ → 5′ exonucleases of both DNA polymerases δ and ε participate in correcting errors of DNA replication in Saccharomyces cerevisiae
inferredcites →https://doi.org/10.1016/0092-8674(89)90883-0openalex-snapshot
A conserved 3′→5′ exonuclease active site in prokaryotic and eukaryotic DNA polymerases
inferredcites →https://doi.org/10.1016/j.cell.2017.09.048openalex-snapshot
Comprehensive Analysis of Hypermutation in Human Cancer
inferredcites →https://doi.org/10.1016/j.celrep.2012.12.008openalex-snapshot
Deciphering Signatures of Mutational Processes Operative in Human Cancer
inferredcites →https://doi.org/10.1016/j.molcel.2008.02.022openalex-snapshot
Division of Labor at the Eukaryotic Replication Fork
inferredcites →https://doi.org/10.1016/j.molcel.2020.05.012openalex-snapshot
POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status
inferredcites →https://doi.org/10.1016/s0021-9258(18)68106-2openalex-snapshot
Mutagenesis by transient misalignment.
inferredcites →https://doi.org/10.1016/s0021-9258(19)45781-5openalex-snapshot
Enzymatic Synthesis of Deoxyribonucleic Acid
inferredcites →https://doi.org/10.1016/s0021-9258(19)49692-0openalex-snapshot
Processive proofreading is intrinsic to T4 DNA polymerase.
inferredcites →https://doi.org/10.1021/bi00160a007openalex-snapshot
Kinetic characterization of the polymerase and exonuclease activities of the gene 43 protein of bacteriophage T4
inferredcites →https://doi.org/10.1038/nature12113openalex-snapshot
Integrated genomic characterization of endometrial carcinoma
inferredcites →https://doi.org/10.1038/nature12477openalex-snapshot
Signatures of mutational processes in human cancer
inferredcites →https://doi.org/10.1038/nchembio.424openalex-snapshot
Genome instability due to ribonucleotide incorporation into DNA
inferredcites →https://doi.org/10.1038/ng.2503openalex-snapshot
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
inferredcites →https://doi.org/10.1038/nsmb.2712openalex-snapshot
Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ
inferredcites →https://doi.org/10.1038/s41467-018-04002-4openalex-snapshot
Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair
inferredcites →https://doi.org/10.1038/s41467-018-08114-9openalex-snapshot
Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε
inferredcites →https://doi.org/10.1038/s41467-018-08145-2openalex-snapshot
A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme
inferredcites →https://doi.org/10.1038/s41586-019-1549-9openalex-snapshot
Genome architecture and stability in the Saccharomyces cerevisiae knockout collection
inferredcites →https://doi.org/10.1073/pnas.0803466105openalex-snapshot
A genome-wide view of the spectrum of spontaneous mutations in yeast
inferredcites →https://doi.org/10.1073/pnas.1323011111openalex-snapshot
Precise estimates of mutation rate and spectrum in yeast
inferredcites →https://doi.org/10.1073/pnas.1422948112openalex-snapshot
dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants
inferredcites →https://doi.org/10.1073/pnas.1917624117openalex-snapshot
DNA polymerase δ proofreads errors made by DNA polymerase ε
inferredcites →https://doi.org/10.1073/pnas.88.21.9473openalex-snapshot
Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity.
inferredcites →https://doi.org/10.1074/jbc.274.38.26668openalex-snapshot
Biochemical Characterization of the Interaction between the Saccharomyces cerevisiae MSH2-MSH6 Complex and Mispaired Bases in DNA
inferredcites →https://doi.org/10.1074/jbc.m011025200openalex-snapshot
The 3′ → 5′ Exonuclease of T4 DNA Polymerase Removes Premutagenic Alkyl Mispairs and Contributes to Futile Cycling atO 6-Methylguanine Lesions
inferredcites →https://doi.org/10.1093/bioinformatics/btx469openalex-snapshot
ggseqlogo: a versatile R package for drawing sequence logos
inferredcites →https://doi.org/10.1093/hmg/5.supplement_1.1489openalex-snapshot
Mismatch repair defects in human carcinogenesis
inferredcites →https://doi.org/10.1093/hmg/ddt131openalex-snapshot
DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer
inferredcites →https://doi.org/10.1093/nar/gkaa633openalex-snapshot
Mismatch repair and DNA polymerase δ proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ϵ variant
inferredcites →https://doi.org/10.1093/nar/gkn1000openalex-snapshot
DNA damage alters DNA polymerase to a form that exhibits increased discrimination against modified template bases and mismatched primers
inferredcites →https://doi.org/10.1093/nar/gkv023openalex-snapshot
The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ
inferredcites →https://doi.org/10.1093/nar/gky1015openalex-snapshot
COSMIC: the Catalogue Of Somatic Mutations In Cancer
inferredcites →https://doi.org/10.1093/nar/gkz048openalex-snapshot
The absence of the catalytic domains of Saccharomyces cerevisiae DNA polymerase ϵ strongly reduces DNA replication fidelity
inferredcites →https://doi.org/10.1099/00221287-122-2-281openalex-snapshot
Genetic and Biochemical Properties of Thialysine-resistant Mutants of Saccharomyces cerevisiae
inferredcites →https://doi.org/10.1101/gr.178335.114openalex-snapshot
Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition
inferredcites →https://doi.org/10.1101/pdb.prot5492openalex-snapshot
Determination of Gross Chromosomal Rearrangement Rates
inferredcites →https://doi.org/10.1126/science.1144067openalex-snapshot
Yeast DNA Polymerase ε Participates in Leading-Strand DNA Replication
inferredcites →https://doi.org/10.1158/0008-5472.can-13-2892openalex-snapshot
A Common Cancer-Associated DNA Polymerase ϵ Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading
inferredcites →https://doi.org/10.1158/0008-5472.can-20-0624openalex-snapshot
Cancers from Novel Pole -Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
inferredcites →https://doi.org/10.1172/jci.insight.138829openalex-snapshot
A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response
inferredcites →https://doi.org/10.1172/jci122095openalex-snapshot
Polymerase-mediated ultramutagenesis in mice produces diverse cancers with high mutational load
inferredcites →https://doi.org/10.1186/s13073-018-0539-0openalex-snapshot
MutationalPatterns: comprehensive genome-wide analysis of mutational processes
inferredcites →https://doi.org/10.1371/journal.pgen.1001109openalex-snapshot
The Baker's Yeast Diploid Genome Is Remarkably Stable in Vegetative Growth and Meiosis
inferredcites →https://doi.org/10.1371/journal.pgen.1005049openalex-snapshot
Replicative DNA Polymerase δ but Not ε Proofreads Errors in Cis and in Trans
inferredcites →https://doi.org/10.1371/journal.pone.0094835openalex-snapshot
Crystal Structure of Yeast DNA Polymerase ε Catalytic Domain
inferredcites →https://doi.org/10.1534/g3.113.006429openalex-snapshot
Mutation Rates, Spectra, and Genome-Wide Distribution of Spontaneous Mutations in Mismatch Repair Deficient Yeast
inferredcites →https://doi.org/10.1534/g3.116.032342openalex-snapshot
Scan-o-matic: High-Resolution Microbial Phenomics at a Massive Scale
inferredcites →https://doi.org/10.1534/g3.118.200042openalex-snapshot
Functional Analysis of Cancer-Associated DNA Polymerase ε Variants inSaccharomyces cerevisiae
inferredcites →https://doi.org/10.1534/genetics.112.146910openalex-snapshot
Emergence of DNA Polymerase ε Antimutators That Escape Error-Induced Extinction in Yeast
inferredcites →https://doi.org/10.1534/genetics.120.303333openalex-snapshot
Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3974793openalex-extracted
inferred← citeshttps://doi.org/10.1002/1878-0261.70255openalex-snapshot
Interpreting the effects of DNA polymerase variants at the structural level
inferred← citeshttps://doi.org/10.1016/b978-0-12-823974-2.00011-5openalex-snapshot
DNA and RNA polymerases
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.113655openalex-snapshot
DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors
inferred← citeshttps://doi.org/10.1016/j.seppur.2024.127241openalex-snapshot
Degradation Strategy and Mechanism of Nitrogenous Disinfection By-products in Three-dimensional Electrochemical System
inferred← citeshttps://doi.org/10.1038/s41588-025-02152-yopenalex-snapshot
A redefined InDel taxonomy provides insights into mutational signatures
inferred← citeshttps://doi.org/10.1038/s41598-022-14602-2openalex-snapshot
Efficient discrimination against RNA-containing primers by human DNA polymerase ε
inferred← citeshttps://doi.org/10.1080/15257770.2024.2428436openalex-snapshot
DNA damage-inducing endogenous and exogenous factors and research progress
inferred← citeshttps://doi.org/10.1093/database/baaf076openalex-snapshot
PolED: a manually curated database of functional studies of POLE and POLD1 variants reported in humans
inferred← citeshttps://doi.org/10.1093/nar/gkac602openalex-snapshot
Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ϵ variants at low dNTP levels
inferred← citeshttps://doi.org/10.1093/narcan/zcac004openalex-snapshot
Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development
inferred← citeshttps://doi.org/10.1101/2021.10.10.463847openalex-snapshot
Mouse model and human patient data suggest critical roles for Pten and p53 in suppressing POLE mutant tumor development
inferred← citeshttps://doi.org/10.1101/2022.01.10.475213openalex-snapshot
A Simple Bypass Assay for DNA Polymerases Shows Hypermutating Variants Associated with Cancer Show Mechanistic Differences In Vitro
inferred← citeshttps://doi.org/10.1101/2025.08.04.653638openalex-snapshot
Interpreting the Effects of DNA Polymerase Variants at the Structural Level Using MAVISp and Molecular Dynamics Simulations
inferred← citeshttps://doi.org/10.1111/febs.16936openalex-snapshot
A simple bypass assay for DNA polymerases shows that cancer‐associated hypermutating variants exhibit differences in vitro
inferred← citeshttps://doi.org/10.1371/journal.pgen.1009526openalex-snapshot
Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication
inferred← citeshttps://doi.org/10.1371/journal.pgen.1011012openalex-snapshot
Genome instability footprint under rapamycin and hydroxyurea treatments
inferred← citeshttps://doi.org/10.1515/medgen-2025-2038openalex-snapshot
The challenge of ultra-rare, overlooked cancer predisposition syndromes : unveiling the role of cancer genome profiling
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1507192/v1openalex-snapshot
The incoming dNTP makes human DNA polymerase ε discriminative against RNA- containing primers
inferred← citeshttps://doi.org/10.3390/cancers12123489openalex-snapshot
DNA Polymerases at the Eukaryotic Replication Fork Thirty Years after: Connection to Cancer
inferred← citeshttps://doi.org/10.3390/cancers14061467openalex-snapshot
Polymerase Epsilon-Associated Ultramutagenesis in Cancer
inferred← citeshttps://doi.org/10.7554/elife.99340openalex-snapshot
The theory of massively repeated evolution and full identifications of cancer-driving nucleotides (CDNs)
inferred← citeshttps://doi.org/10.7554/elife.99340.1openalex-snapshot
The theory of massively repeated evolution and full identifications of Cancer Driving Nucleotides (CDNs)
inferred← citeshttps://doi.org/10.7554/elife.99340.2openalex-snapshot
The theory of massively repeated evolution and full identifications of Cancer Driving Nucleotides (CDNs)
inferred← citeshttps://doi.org/10.7554/elife.99340.3openalex-snapshot
The theory of massively repeated evolution and full identifications of cancer-driving nucleotides (CDNs)
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