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Structure-specific roles for PolG2–DNA complexes in maintenance and replication of mitochondrial DNA

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.cell.2009.07.050openalex-snapshot

Structural Insight into Processive Human Mitochondrial DNA Synthesis and Disease-Related Polymerase Mutations

inferredcites →https://doi.org/10.1016/j.exger.2014.03.027openalex-snapshot

In D-loop: 40years of mitochondrial 7S DNA

inferredcites →https://doi.org/10.1016/j.gde.2016.03.005openalex-snapshot

Human mitochondrial DNA replication machinery and disease

inferredcites →https://doi.org/10.1016/j.jmb.2006.02.073openalex-snapshot

A Novel Processive Mechanism for DNA Synthesis Revealed by Structure, Modeling and Mutagenesis of the Accessory Subunit of Human Mitochondrial DNA Polymerase

inferredcites →https://doi.org/10.1016/j.mito.2011.11.006openalex-snapshot

A p.R369G POLG2 mutation associated with adPEO and multiple mtDNA deletions causes decreased affinity between polymerase γ subunits

inferredcites →https://doi.org/10.1016/j.ymeth.2010.02.015openalex-snapshot

Purification and functional characterization of human mitochondrial DNA polymerase gamma harboring disease mutations

inferredcites →https://doi.org/10.1016/s0076-6879(97)76066-xopenalex-snapshot

[20] Processing of X-ray diffraction data collected in oscillation mode

inferredcites →https://doi.org/10.1016/s1097-2765(01)00153-8openalex-snapshot

Crystal Structure and Deletion Analysis Show that the Accessory Subunit of Mammalian DNA Polymerase γ, PolγB, Functions as a Homodimer

inferredcites →https://doi.org/10.1021/bi980772wopenalex-snapshot

Characterization of the Native and Recombinant Catalytic Subunit of Human DNA Polymerase γ: Identification of Residues Critical for Exonuclease Activity and Dideoxynucleotide Sensitivity

inferredcites →https://doi.org/10.1021/bi992104wopenalex-snapshot

Human Mitochondrial DNA Polymerase Holoenzyme: Reconstitution and Characterization

inferredcites →https://doi.org/10.1021/cr040463dopenalex-snapshot

DNA Polymerase γ in Mitochondrial DNA Replication and Repair

inferredcites →https://doi.org/10.1038/290457a0openalex-snapshot

Sequence and organization of the human mitochondrial genome

inferredcites →https://doi.org/10.1038/ng.2501openalex-snapshot

Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease

inferredcites →https://doi.org/10.1038/nrm.2017.66openalex-snapshot

Mitochondrial diseases: the contribution of organelle stress responses to pathology

inferredcites →https://doi.org/10.1038/s41467-018-03552-xopenalex-snapshot

Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria

inferredcites →https://doi.org/10.1038/s41467-018-04895-1openalex-snapshot

The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions

inferredcites →https://doi.org/10.1038/s41586-020-2308-7openalex-snapshot

The mutational constraint spectrum quantified from variation in 141,456 humans

inferredcites →https://doi.org/10.1038/sj.emboj.7600257openalex-snapshot

Reconstitution of a minimal mtDNA replisome in vitro

inferredcites →https://doi.org/10.1038/srep20513openalex-snapshot

Enhanced electrostatic force microscopy reveals higher-order DNA looping mediated by the telomeric protein TRF2

inferredcites →https://doi.org/10.1073/pnas.68.9.2252openalex-snapshot

A Novel Closed-Circular Mitochondrial DNA with Properties of a Replicating Intermediate

inferredcites →https://doi.org/10.1073/pnas.78.10.6116openalex-snapshot

Elongation of displacement-loop strands in human and mouse mitochondrial DNA is arrested near specific template sequences.

inferredcites →https://doi.org/10.1073/pnas.87.5.1744openalex-snapshot

Application of fluorescence energy transfer and polarization to monitor Escherichia coli cAMP receptor protein and lac promoter interaction.

inferredcites →https://doi.org/10.1073/pnas.96.17.9527openalex-snapshot

The accessory subunit of mtDNA polymerase shares structural homology with aminoacyl-tRNA synthetases: Implications for a dual role as a primer recognition factor and processivity clamp

inferredcites →https://doi.org/10.1074/jbc.274.53.38197openalex-snapshot

The Mitochondrial p55 Accessory Subunit of Human DNA Polymerase γ Enhances DNA Binding, Promotes Processive DNA Synthesis, and Confers N-Ethylmaleimide Resistance

inferredcites →https://doi.org/10.1074/jbc.m109.062752openalex-snapshot

Each Monomer of the Dimeric Accessory Protein for Human Mitochondrial DNA Polymerase Has a Distinct Role in Conferring Processivity

inferredcites →https://doi.org/10.1074/jbc.m116.773341openalex-snapshot

Synergistic Effects of the in cis T251I and P587L Mitochondrial DNA Polymerase γ Disease Mutations

inferredcites →https://doi.org/10.1074/jbc.m117.806406openalex-snapshot

Cohesin SA2 is a sequence-independent DNA-binding protein that recognizes DNA replication and repair intermediates

inferredcites →https://doi.org/10.1074/jbc.m207030200openalex-snapshot

DNA Binding Properties of Human pol γB

inferredcites →https://doi.org/10.1074/jbc.m506348200openalex-snapshot

p53 Monitors Replication Fork Regression by Binding to “Chickenfoot” Intermediates

inferredcites →https://doi.org/10.1074/jbc.ra120.012795openalex-snapshot

Single-molecule level structural dynamics of DNA unwinding by human mitochondrial Twinkle helicase

inferredcites →https://doi.org/10.1074/jbc.ra120.015390openalex-snapshot

Polymerase γ efficiently replicates through many natural template barriers but stalls at the HSP1 quadruplex

inferredcites →https://doi.org/10.1086/504303openalex-snapshot

Mutant POLG2 Disrupts DNA Polymerase γ Subunits and Causes Progressive External Ophthalmoplegia

inferredcites →https://doi.org/10.1093/hmg/ddr209openalex-snapshot

Biochemical analysis of human POLG2 variants associated with mitochondrial disease

inferredcites →https://doi.org/10.1093/hmg/dds506openalex-snapshot

Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance

inferredcites →https://doi.org/10.1093/hmg/ddv240openalex-snapshot

POLG2disease variants: analyses reveal a dominant negative heterodimer, altered mitochondrial localization and impaired respiratory capacity

inferredcites →https://doi.org/10.1093/nar/28.5.1237openalex-snapshot

Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase

inferredcites →https://doi.org/10.1093/nar/gkab282openalex-snapshot

DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion

inferredcites →https://doi.org/10.1093/nar/gkp614openalex-snapshot

The accessory subunit of mitochondrial DNA polymerase γ determines the DNA content of mitochondrial nucleoids in human cultured cells

inferredcites →https://doi.org/10.1093/nar/gkw468openalex-snapshot

MGME1 processes flaps into ligatable nicks in concert with DNA polymerase γ during mtDNA replication

inferredcites →https://doi.org/10.1093/nar/gkx1153openalex-snapshot

ClinVar: improving access to variant interpretations and supporting evidence

inferredcites →https://doi.org/10.1107/s0907444904019158openalex-snapshot

Coot : model-building tools for molecular graphics

inferredcites →https://doi.org/10.1107/s0907444909052925openalex-snapshot

PHENIX : a comprehensive Python-based system for macromolecular structure solution

inferredcites →https://doi.org/10.1126/science.1102077openalex-snapshot

Discovery of a Major D-Loop Replication Origin Reveals Two Modes of Human mtDNA Synthesis

inferredcites →https://doi.org/10.1126/science.aaf5549openalex-snapshot

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

inferredcites →https://doi.org/10.1371/journal.pone.0203198openalex-snapshot

Characterization of the human homozygous R182W POLG2 mutation in mitochondrial DNA depletion syndrome

inferredcites →https://doi.org/10.15252/embj.201591520openalex-snapshot

Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase

inferredcites →https://doi.org/10.21769/bioprotoc.4139openalex-snapshot

Using Atomic Force Microscopy to Study the Real Time Dynamics of DNA Unwinding by Mitochondrial Twinkle Helicase

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.5281/zenodo.23300190zenodo-depositor-declared

inferred← citeshttps://doi.org/10.1002/ajmg.a.64177openalex-snapshot

A Rare Molecular Diagnosis in a Patient With Hepatocerebral Syndrome Contributes to the Expansion of the Phenotypic Spectrum of POLG2 ‐Related Mitochondrial Disorder

inferred← citeshttps://doi.org/10.1007/s10646-026-03081-0openalex-snapshot

Silver nanoparticles induce binding of mitochondrial DNA polymerase gamma subunit Polg2 and mitochondrial dysfunction in HeLa cells

inferred← citeshttps://doi.org/10.1007/s44272-026-00071-5openalex-snapshot

Exploring mitochondrial central dogma in cancer from a metabolic perspective

inferred← citeshttps://doi.org/10.1016/j.bpj.2025.06.027openalex-snapshot

Multiplexed stamp-transfer AFM deposition improves resolution of protein-DNA conformational states

inferred← citeshttps://doi.org/10.1016/j.omtn.2024.102257openalex-snapshot

Discovery of novel disease-causing mutation in SSBP1 and its correction using adenine base editor to improve mitochondrial function

inferred← citeshttps://doi.org/10.1021/acs.jproteome.6c00156openalex-snapshot

Mapping the Interactome of c-Myc/Max Heterodimer by Micro-affinity Purification Coupling Mass Spectrometry

inferred← citeshttps://doi.org/10.1038/s41419-024-06622-9openalex-snapshot

Zebrafish polg2 knock-out recapitulates human POLG-disorders; implications for drug treatment

inferred← citeshttps://doi.org/10.1038/s41419-025-07927-zopenalex-snapshot

The ALDH2/PolG2 axis enhances mitochondrial biogenesis via transcriptional regulation of Nrf2 and promotes chemotherapy resistance in acute myeloid leukaemia

inferred← citeshttps://doi.org/10.1038/s41419-025-08366-6openalex-snapshot

Model organisms in POLG-related disorders: insights from yeast to multicellular systems

inferred← citeshttps://doi.org/10.1038/s41598-024-82423-6openalex-snapshot

Transcriptomic comparison of corneal endothelial cells in young versus old corneas

inferred← citeshttps://doi.org/10.1093/nar/gkae539openalex-snapshot

Coordinated DNA polymerization by Polγ and the region of LonP1 regulated proteolysis

inferred← citeshttps://doi.org/10.1101/2023.11.02.23297943openalex-snapshot

Adenine base editing corrects point mutation in mitochondrial single-stranded binding protein ( SSBP1 ) to improve mitochondrial function

inferred← citeshttps://doi.org/10.1101/2025.03.26.645540openalex-snapshot

Structural Basis for DNA Replication and Uracil Repair in Phage A-Family DNA Polymerases

inferred← citeshttps://doi.org/10.18632/aging.206406openalex-snapshot

Investigating POLG-driven modulation of cancer stemness: a pilot study in breast cancer cells

inferred← citeshttps://doi.org/10.21203/rs.3.rs-9241346/v1openalex-snapshot

Topology-Resolved Imaging of Mitochondrial Nucleoid Condensates Uncovers Dynamic G-Quadruplex Remodeling

inferred← citeshttps://doi.org/10.3389/fonc.2025.1485006openalex-snapshot

Developing a prognostic model of glutamine metabolism-related genes associated with clinical features and immune status in melanoma

inferred← citeshttps://doi.org/10.3390/ijms262110275openalex-snapshot

Mitochondrial DNA Replication and Disease: A Historical Perspective on Molecular Insights and Therapeutic Advances

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