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Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/9780471729259.mc02b01s03openalex-snapshot
Transmission Electron Microscopy
inferredcites →https://doi.org/10.1002/humu.20824openalex-snapshot
Molecular and clinical genetics of mitochondrial diseases due to POLG mutations
inferredcites →https://doi.org/10.1007/978-1-4614-3722-2openalex-snapshot
Mitochondrial Disorders Caused by Nuclear Genes
inferredcites →https://doi.org/10.1007/978-1-4614-3722-2_3openalex-snapshot
Mitochondrial Disorders Associated with the Mitochondrial DNA Polymerase g: A Focus on Intersubunit Interactions
inferredcites →https://doi.org/10.1007/978-90-481-3471-7_11openalex-snapshot
The Mitochondrial DNA Polymerase in Health and Disease
inferredcites →https://doi.org/10.1007/s00018-010-0530-4openalex-snapshot
Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations
inferredcites →https://doi.org/10.1007/s00415-010-5565-9openalex-snapshot
Late-onset ptosis and myopathy in a patient with a heterozygous insertion in POLG2
inferredcites →https://doi.org/10.1016/0168-9525(93)90071-oopenalex-snapshot
The atlas of mouse development
inferredcites →https://doi.org/10.1016/j.cell.2007.06.026openalex-snapshot
Mitochondrial Fusion Protects against Neurodegeneration in the Cerebellum
inferredcites →https://doi.org/10.1016/j.cell.2009.07.050openalex-snapshot
Structural Insight into Processive Human Mitochondrial DNA Synthesis and Disease-Related Polymerase Mutations
inferredcites →https://doi.org/10.1016/j.cell.2012.02.035openalex-snapshot
Mitochondria: In Sickness and in Health
inferredcites →https://doi.org/10.1016/j.mito.2011.11.006openalex-snapshot
A p.R369G POLG2 mutation associated with adPEO and multiple mtDNA deletions causes decreased affinity between polymerase γ subunits
inferredcites →https://doi.org/10.1016/j.ymeth.2010.05.008openalex-snapshot
The clinical diagnosis of POLG disease and other mitochondrial DNA depletion disorders
inferredcites →https://doi.org/10.1016/s0021-9258(19)47098-1openalex-snapshot
Cloning and Sequencing of the Nuclear Gene MIP1 Encoding the Catalytic Subunit of the Yeast Mitochondrial DNA Polymerase
inferredcites →https://doi.org/10.1016/s1097-2765(01)00153-8openalex-snapshot
Crystal Structure and Deletion Analysis Show that the Accessory Subunit of Mammalian DNA Polymerase γ, PolγB, Functions as a Homodimer
inferredcites →https://doi.org/10.1016/s1472-6483(10)60409-9openalex-snapshot
Variations in mouse mitochondrial DNA copy number from fertilization to birth are associated with oxidative stress
inferredcites →https://doi.org/10.1021/cr040463dopenalex-snapshot
DNA Polymerase γ in Mitochondrial DNA Replication and Repair
inferredcites →https://doi.org/10.1038/nature09773openalex-snapshot
DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair
inferredcites →https://doi.org/10.1038/ng.2007.63openalex-snapshot
A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes
inferredcites →https://doi.org/10.1038/ng0398-231openalex-snapshot
Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice
inferredcites →https://doi.org/10.1073/pnas.072664899openalex-snapshot
The accessory subunit of DNA polymerase γ is essential for mitochondrial DNA maintenance and development in Drosophila melanogaster
inferredcites →https://doi.org/10.1074/jbc.270.48.28932openalex-snapshot
Subunit Structure of Mitochondrial DNA Polymerase from Drosophila Embryos
inferredcites →https://doi.org/10.1074/jbc.272.21.13640openalex-snapshot
Accessory Subunit of Mitochondrial DNA Polymerase fromDrosophila Embryos
inferredcites →https://doi.org/10.1074/jbc.274.53.38197openalex-snapshot
The Mitochondrial p55 Accessory Subunit of Human DNA Polymerase γ Enhances DNA Binding, Promotes Processive DNA Synthesis, and Confers N-Ethylmaleimide Resistance
inferredcites →https://doi.org/10.1074/jbc.m105230200openalex-snapshot
The Fidelity of Human DNA Polymerase γ with and without Exonucleolytic Proofreading and the p55 Accessory Subunit
inferredcites →https://doi.org/10.1074/jbc.m109.062752openalex-snapshot
Each Monomer of the Dimeric Accessory Protein for Human Mitochondrial DNA Polymerase Has a Distinct Role in Conferring Processivity
inferredcites →https://doi.org/10.1074/jbc.m509730200openalex-snapshot
Functional Human Mitochondrial DNA Polymerase γ Forms a Heterotrimer
inferredcites →https://doi.org/10.1080/01926230601052659openalex-snapshot
Detection of Pre-Invasive Lung Cancer: Technical Aspects of the LIFE Project
inferredcites →https://doi.org/10.1086/504303openalex-snapshot
Mutant POLG2 Disrupts DNA Polymerase γ Subunits and Causes Progressive External Ophthalmoplegia
inferredcites →https://doi.org/10.1093/hmg/ddi184openalex-snapshot
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis
inferredcites →https://doi.org/10.1093/hmg/ddr209openalex-snapshot
Biochemical analysis of human POLG2 variants associated with mitochondrial disease
inferredcites →https://doi.org/10.1093/nar/gkp614openalex-snapshot
The accessory subunit of mitochondrial DNA polymerase γ determines the DNA content of mitochondrial nucleoids in human cultured cells
inferredcites →https://doi.org/10.1096/fj.06-6283comopenalex-snapshot
Mammalian dap3 is an essential gene required for mitochondrial homeostasis in vivo and contributing to the extrinsic pathway for apoptosis
inferredcites →https://doi.org/10.1126/science.8016642openalex-snapshot
Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting
inferredcites →https://doi.org/10.1146/annurev.med.59.053006.104646openalex-snapshot
Inherited Mitochondrial Diseases of DNA Replication
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.3155512openalex-extracted
DNA Polymerase Mediates Robust Base Lesion Repair in Mammalian Mitochondria
inferred← citeshttps://doi.org/10.1002/9781118285602.ch11openalex-snapshot
Mitochondrial Differentiation in Early Embryo Cells and Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1002/acn3.361openalex-snapshot
POLG2 deficiency causes adult‐onset syndromic sensory neuropathy, ataxia and parkinsonism
inferred← citeshttps://doi.org/10.1002/ajmg.a.64177openalex-snapshot
A Rare Molecular Diagnosis in a Patient With Hepatocerebral Syndrome Contributes to the Expansion of the Phenotypic Spectrum of POLG2 ‐Related Mitochondrial Disorder
inferred← citeshttps://doi.org/10.1002/bies.201400052openalex-snapshot
Unique features of DNA replication in mitochondria: A functional and evolutionary perspective
inferred← citeshttps://doi.org/10.1002/cptx.75openalex-snapshot
Analysis of Human Mitochondrial DNA Content by Southern Blotting and Nonradioactive Probe Hybridization
inferred← citeshttps://doi.org/10.1002/cpz1.679openalex-snapshot
Generation of Mammalian Cells Devoid of Mitochondrial DNA (ρ0 cells)
inferred← citeshttps://doi.org/10.1002/hep.32759openalex-snapshot
Rapid in vivo multiplexed editing (RIME) of the adult mouse liver
inferred← citeshttps://doi.org/10.1002/jbmr.3624openalex-snapshot
An N-Ethyl-N-Nitrosourea (ENU)-Induced Tyr265Stop Mutation of the DNA Polymerase Accessory Subunit Gamma 2 (Polg2) Is Associated With Renal Calcification in Mice
inferred← citeshttps://doi.org/10.1007/978-3-030-70147-5_10openalex-snapshot
Model Cells and Organisms in Mitochondrial Diseases
inferred← citeshttps://doi.org/10.1007/s00335-026-10278-5openalex-snapshot
The role of impaired mitochondrial function in neurological manifestations of mitochondrial diseases
inferred← citeshttps://doi.org/10.1007/s00441-019-03164-xopenalex-snapshot
Patient-specific neural progenitor cells derived from induced pluripotent stem cells offer a promise of good models for mitochondrial disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-809633-8.21269-7openalex-snapshot
DNA Recognition/Processing | Eukaryotic DNA Polymerase γ
inferred← citeshttps://doi.org/10.1016/j.ajpath.2022.11.002openalex-snapshot
iPSC-Derived Neurons from Patients with POLG Mutations Exhibit Decreased Mitochondrial Content and Dendrite Simplification
inferred← citeshttps://doi.org/10.1016/j.arr.2016.04.006openalex-snapshot
Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases
inferred← citeshttps://doi.org/10.1016/j.bbabio.2015.05.016openalex-snapshot
Different faces of mitochondrial DNA mutators
inferred← citeshttps://doi.org/10.1016/j.bbabio.2022.148554openalex-snapshot
Mitochondrial DNA replication and repair defects: Clinical phenotypes and therapeutic interventions
inferred← citeshttps://doi.org/10.1016/j.celrep.2014.06.018openalex-snapshot
ATP-Dependent Lon Protease Controls Tumor Bioenergetics by Reprogramming Mitochondrial Activity
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.02.041openalex-snapshot
Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies
inferred← citeshttps://doi.org/10.1016/j.cmet.2013.06.005openalex-snapshot
Mitochondrial Regulation in Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1016/j.dnarep.2017.10.011openalex-snapshot
DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria
inferred← citeshttps://doi.org/10.1016/j.ejmg.2016.08.012openalex-snapshot
Whole exome sequencing identifies a homozygous POLG2 missense variant in an infant with fulminant hepatic failure and mitochondrial DNA depletion
inferred← citeshttps://doi.org/10.1016/j.ejmg.2019.103821openalex-snapshot
Whole exome sequencing identifies a homozygous POLG2 missense variant in an adult patient presenting with optic atrophy, movement disorders, premature ovarian failure and mitochondrial DNA depletion
inferred← citeshttps://doi.org/10.1016/j.fbio.2025.107393openalex-snapshot
Transcriptomics-based exploration of the molecular network of selenium-enriched yeast for improving intramuscular fat in goats
inferred← citeshttps://doi.org/10.1016/j.gde.2016.03.005openalex-snapshot
Human mitochondrial DNA replication machinery and disease
inferred← citeshttps://doi.org/10.1016/j.mito.2015.01.008openalex-snapshot
Mitochondrial Diseases Part II: Mouse models of OXPHOS deficiencies caused by defects in regulatory factors and other components required for mitochondrial function
inferred← citeshttps://doi.org/10.1016/j.mito.2020.05.008openalex-snapshot
The accessory subunit of human DNA polymerase γ is required for mitochondrial DNA maintenance and is able to stabilize the catalytic subunit
inferred← citeshttps://doi.org/10.1016/j.molmet.2020.101027openalex-snapshot
Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus
inferred← citeshttps://doi.org/10.1016/j.nbd.2014.11.014openalex-snapshot
Cumulative mtDNA damage and mutations contribute to the progressive loss of RGCs in a rat model of glaucoma
inferred← citeshttps://doi.org/10.1016/j.theriogenology.2014.08.019openalex-snapshot
Polymerase subunit gamma 2 affects porcine oocyte maturation and subsequent embryonic development
inferred← citeshttps://doi.org/10.1016/j.tox.2017.07.014openalex-snapshot
Inherited mitochondrial genomic instability and chemical exposures
inferred← citeshttps://doi.org/10.1038/ijo.2014.27openalex-snapshot
NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism
inferred← citeshttps://doi.org/10.1038/ncomms9808openalex-snapshot
Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies
inferred← citeshttps://doi.org/10.1038/s41419-024-06622-9openalex-snapshot
Zebrafish polg2 knock-out recapitulates human POLG-disorders; implications for drug treatment
inferred← citeshttps://doi.org/10.1038/s41419-025-07927-zopenalex-snapshot
The ALDH2/PolG2 axis enhances mitochondrial biogenesis via transcriptional regulation of Nrf2 and promotes chemotherapy resistance in acute myeloid leukaemia
inferred← citeshttps://doi.org/10.1038/s41419-025-08366-6openalex-snapshot
Model organisms in POLG-related disorders: insights from yeast to multicellular systems
inferred← citeshttps://doi.org/10.1042/bcj20230262openalex-snapshot
Mechanisms and pathologies of human mitochondrial DNA replication and deletion formation
inferred← citeshttps://doi.org/10.1042/ebc20170100openalex-snapshot
Mitochondrial DNA replication in mammalian cells: overview of the pathway
inferred← citeshttps://doi.org/10.1074/jbc.ra118.007015openalex-snapshot
RNase H1 promotes replication fork progression through oppositely transcribed regions of Drosophila mitochondrial DNA
inferred← citeshttps://doi.org/10.1080/10409238.2020.1818684openalex-snapshot
Mammalian mitochondrial DNA replication and mechanisms of deletion formation
inferred← citeshttps://doi.org/10.1093/hmg/ddv240openalex-snapshot
POLG2disease variants: analyses reveal a dominant negative heterodimer, altered mitochondrial localization and impaired respiratory capacity
inferred← citeshttps://doi.org/10.1093/humrep/dead052openalex-snapshot
A shared pattern of altered gene expression in human embryos affected by mitochondrial diseases
inferred← citeshttps://doi.org/10.1093/humrep/dev228openalex-snapshot
Dynamic comparisons of high-resolution expression profiles highlighting mitochondria-related genes betweenin vivoandin vitrofertilized early mouse embryos
inferred← citeshttps://doi.org/10.1093/nar/gkad679openalex-snapshot
Structure-specific roles for PolG2–DNA complexes in maintenance and replication of mitochondrial DNA
inferred← citeshttps://doi.org/10.1093/nar/gkae539openalex-snapshot
Coordinated DNA polymerization by Polγ and the region of LonP1 regulated proteolysis
inferred← citeshttps://doi.org/10.1093/nar/gkz542openalex-snapshot
Quantitative proteomics revealed C6orf203/MTRES1 as a factor preventing stress-induced transcription deficiency in human mitochondria
inferred← citeshttps://doi.org/10.1111/aji.12651openalex-snapshot
Mitochondrial dysfunction and ovarian aging
inferred← citeshttps://doi.org/10.1126/sciadv.1600963openalex-snapshot
POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA
inferred← citeshttps://doi.org/10.1126/scisignal.abc4436openalex-snapshot
Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase–deficient renal cancer
inferred← citeshttps://doi.org/10.1146/annurev-biochem-060815-014402openalex-snapshot
Maintenance and Expression of Mammalian Mitochondrial DNA
inferred← citeshttps://doi.org/10.1152/ajpendo.00267.2014openalex-snapshot
Impaired cardiac energy metabolism in embryos lacking adrenergic stimulation
inferred← citeshttps://doi.org/10.1161/jaha.119.012731openalex-snapshot
Complex Regulation of Mitochondrial Function During Cardiac Development
inferred← citeshttps://doi.org/10.1177/0883073814537380openalex-snapshot
Defects of Mitochondrial DNA Replication
inferred← citeshttps://doi.org/10.1177/22143602241307198openalex-snapshot
Modelling mitochondrial diseases in neurons In Vitro : A systematic review
inferred← citeshttps://doi.org/10.1186/s12958-024-01254-2openalex-snapshot
Genetic insights into the complexity of premature ovarian insufficiency
inferred← citeshttps://doi.org/10.1186/s12967-024-05633-6openalex-snapshot
Fetal and obstetrics manifestations of mitochondrial diseases
inferred← citeshttps://doi.org/10.1242/dev.188714openalex-snapshot
Nuclear encoded mitochondrial ribosomal proteins are required to initiate gastrulation
inferred← citeshttps://doi.org/10.1262/jrd.2016-168openalex-snapshot
High-resolution profiles of gene expression and DNA methylation highlight mitochondrial modifications during early embryonic development
inferred← citeshttps://doi.org/10.13172/2052-0069-2-2-571openalex-snapshot
Development of aerobic metabolism in utero: Requirement for mitochondrial function during embryonic and fetal periods
inferred← citeshttps://doi.org/10.1371/journal.pgen.1008085openalex-snapshot
Mitochondrial fusion is required for regulation of mitochondrial DNA replication
inferred← citeshttps://doi.org/10.1371/journal.pone.0203198openalex-snapshot
Characterization of the human homozygous R182W POLG2 mutation in mitochondrial DNA depletion syndrome
inferred← citeshttps://doi.org/10.18632/aging.206406openalex-snapshot
Investigating POLG-driven modulation of cancer stemness: a pilot study in breast cancer cells
inferred← citeshttps://doi.org/10.21926/obm.genet.1901070openalex-snapshot
The Role of Mitochondria in Oocyte and Early Embryo Health
inferred← citeshttps://doi.org/10.2741/4510openalex-snapshot
DNA polymerases in the mitochondria A critical review of the evidence
inferred← citeshttps://doi.org/10.3233/jnd-140041openalex-snapshot
Adult-onset Mendelian PEO Associated with Mitochondrial Disease
inferred← citeshttps://doi.org/10.3389/fcvm.2021.795747openalex-snapshot
p53 SUMOylation Mediates AOPP-Induced Endothelial Senescence and Apoptosis Evasion
inferred← citeshttps://doi.org/10.3389/fmolb.2017.00074openalex-snapshot
Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance
inferred← citeshttps://doi.org/10.3389/fonc.2024.1394699openalex-snapshot
Our current understanding of the biological impact of endometrial cancer mtDNA genome mutations and their potential use as a biomarker
inferred← citeshttps://doi.org/10.3390/cells11142168openalex-snapshot
A Method for In Situ Reverse Genetic Analysis of Proteins Involved mtDNA Replication
inferred← citeshttps://doi.org/10.3390/cells15080714openalex-snapshot
Maternal Inflammation Alters Nuclear and Mitochondrial DNA Methylation Patterns in Neonatal Brain Monocytes
inferred← citeshttps://doi.org/10.3390/dna4030013openalex-snapshot
Efficient Elimination of mtDNA from Mammalian Cells with 2′,3′-Dideoxycytidine
inferred← citeshttps://doi.org/10.3390/genes12010092openalex-snapshot
Contribution of Mitochondrial DNA Heteroplasmy to the Congenital Cardiac and Palatal Phenotypic Variability in Maternally Transmitted 22q11.2 Deletion Syndrome
inferred← citeshttps://doi.org/10.3390/genes12101461openalex-snapshot
Transcriptome Analysis of In Vitro Fertilization and Parthenogenesis Activation during Early Embryonic Development in Pigs
inferred← citeshttps://doi.org/10.3390/ijms20133245openalex-snapshot
Analysis of Mitochondrial DNA Polymorphisms in the Human Cell Lines HepaRG and SJCRH30
inferred← citeshttps://doi.org/10.3390/ijms262110275openalex-snapshot
Mitochondrial DNA Replication and Disease: A Historical Perspective on Molecular Insights and Therapeutic Advances
inferred← citeshttps://doi.org/10.64898/2026.05.27.728277openalex-snapshot
Beyond copy number: The regulatory architecture of mitochondrial DNA gene expression
inferred← citeshttps://doi.org/10.70675/bd5b2b41za47dz43e0z98e2z0199f1adcad7openalex-snapshot
Le co-activateur transcriptionnel CREB-binding protein (CBP) : un nouvel acteur de la fonction mitochondriale
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