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Sulfane Sulfur in Toxicology: A Novel Defense System Against Electrophilic Stress

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology

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A review of mercury concentrations in freshwater fishes of Africa: Patterns and predictors

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The sulfur‐cyanolysis sites of serum albumin: Metabolite competition studies

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Direct and indirect antioxidant properties of α‐lipoic acid and therapeutic potential

inferredcites →https://doi.org/10.1006/abio.1993.1556openalex-snapshot

Determination of Bound Sulfur in Serum by Gas Dialysis/High-Performance Liquid Chromatography

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Analysis of biological thiols: Derivatization with monobromobimane and separation by reverse-phase high-performance liquid chromatography

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Analysis of biological thiols: Quantitative determination of thiols at the picomole level based upon derivatization with monobromobimanes and separation by cation-exchange chromatography

inferredcites →https://doi.org/10.1016/0076-6879(87)43009-7openalex-snapshot

Sulfane sulfur

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[5] Perthiols as antioxidants: Radical-scavenging andprooxidative mechanisms

inferredcites →https://doi.org/10.1016/j.ab.2011.01.044openalex-snapshot

Sulfur signaling: Is the agent sulfide or sulfane?

inferredcites →https://doi.org/10.1016/j.envpol.2017.01.087openalex-snapshot

Cadmium in rice: Transport mechanisms, influencing factors, and minimizing measures

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1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides

inferredcites →https://doi.org/10.1016/j.redox.2017.10.007openalex-snapshot

A novel S-sulfhydrated human serum albumin preparation suppresses melanin synthesis

inferredcites →https://doi.org/10.1016/j.taap.2014.11.015openalex-snapshot

Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice

inferredcites →https://doi.org/10.1016/s0006-291x(75)80193-8openalex-snapshot

Evidence for the formation of a protein bound hydrodisulfide resulting from the microsomal mixed function oxidase catalyzed desulfuration of carbon disulfide

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Cysteinyl‐tRNA formation and prolyl‐tRNA synthetase

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The Oxygen Sensitivity of Spinach Ferredoxin and Other Iron-Sulfur Proteins

inferredcites →https://doi.org/10.1021/ac5044237openalex-snapshot

Near-Infrared Fluorescent Probe for Imaging Mitochondrial Hydrogen Polysulfides in Living Cells and in Vivo

inferredcites →https://doi.org/10.1021/acs.analchem.5b00172openalex-snapshot

Two-Photon Fluorescent Probe for Detection of Exogenous and Endogenous Hydrogen Persulfide and Polysulfide in Living Organisms

inferredcites →https://doi.org/10.1021/acs.chemrestox.5b00101openalex-snapshot

Involvement of Reactive Persulfides in Biological Bismethylmercury Sulfide Formation

inferredcites →https://doi.org/10.1021/acs.chemrestox.5b00245openalex-snapshot

Formation of Sulfur Adducts ofN-Acetyl-p-benzoquinoneimine, an Electrophilic Metabolite of Acetaminophenin Vivo: Participation of Reactive Persulfides

inferredcites →https://doi.org/10.1021/acs.chemrestox.6b00326openalex-snapshot

Environmental Electrophiles: Protein Adducts, Modulation of Redox Signaling, and Interaction with Persulfides/Polysulfides

inferredcites →https://doi.org/10.1021/acs.chemrestox.7b00120openalex-snapshot

Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells

inferredcites →https://doi.org/10.1021/acs.chemrestox.7b00278openalex-snapshot

The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity

inferredcites →https://doi.org/10.1021/cb4001052openalex-snapshot

Persulfide Reactivity in the Detection of Protein S-Sulfhydration

inferredcites →https://doi.org/10.1021/ja00860a005openalex-snapshot

The Factors Determining Nucleophilic Reactivities

inferredcites →https://doi.org/10.1021/ja502968xopenalex-snapshot

Rational Design and Bioimaging Applications of Highly Selective Fluorescence Probes for Hydrogen Polysulfides

inferredcites →https://doi.org/10.1021/tx200394gopenalex-snapshot

Detoxification of Methylmercury by Hydrogen Sulfide-Producing Enzyme in Mammalian Cells

inferredcites →https://doi.org/10.1038/273124a0openalex-snapshot

The covalent and tertiary structure of bovine liver rhodanese

inferredcites →https://doi.org/10.1038/nchembio.1018openalex-snapshot

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

inferredcites →https://doi.org/10.1038/s41467-017-01311-yopenalex-snapshot

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

inferredcites →https://doi.org/10.1038/s41598-017-04590-zopenalex-snapshot

Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts

inferredcites →https://doi.org/10.1039/c3sc50754hopenalex-snapshot

New fluorescent probes for sulfane sulfurs and the application in bioimaging

inferredcites →https://doi.org/10.1039/c6cc08372bopenalex-snapshot

Development of a reversible fluorescent probe for reactive sulfur species, sulfane sulfur, and its biological application

inferredcites →https://doi.org/10.1042/bj20110841openalex-snapshot

Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide

inferredcites →https://doi.org/10.1042/bj2640625openalex-snapshot

Sulphane sulphur in biological systems: a possible regulatory role

inferredcites →https://doi.org/10.1042/bsr20150147openalex-snapshot

S-sulfhydration as a cellular redox regulation

inferredcites →https://doi.org/10.1073/pnas.1321232111openalex-snapshot

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

inferredcites →https://doi.org/10.1074/jbc.m113.466177openalex-snapshot

Structure and Kinetic Analysis of H2S Production by Human Mercaptopyruvate Sulfurtransferase

inferredcites →https://doi.org/10.1074/jbc.m114.602664openalex-snapshot

Organization of the Human Mitochondrial Hydrogen Sulfide Oxidation Pathway

inferredcites →https://doi.org/10.1074/jbc.m115.672816openalex-snapshot

Reaction of Hydrogen Sulfide with Disulfide and Sulfenic Acid to Form the Strongly Nucleophilic Persulfide

inferredcites →https://doi.org/10.1080/02786820390229471openalex-snapshot

Determination of Four Quinones in Diesel Exhaust Particles, SRM 1649a, and Atmospheric PM2.5Special Issue ofAerosol Science and Technologyon Findings from the Fine Particulate Matter Supersites Program

inferredcites →https://doi.org/10.1080/15216540701206859openalex-snapshot

Common themes and variations in the rhodanese superfamily

inferredcites →https://doi.org/10.1089/ars.2013.5339openalex-snapshot

Enzymology of H 2 S Biogenesis, Decay and Signaling

inferredcites →https://doi.org/10.1093/oxfordjournals.jbchem.a133393openalex-snapshot

The Mechanism of the L-Cystine Cleavage Reaction Catalyzed by Rat Liver γ-Cystathionase1

inferredcites →https://doi.org/10.1093/toxsci/kfw268openalex-snapshot

Cadmium-mediated activation of the HSP90/HSF1 pathway regulated by reactive persulfides/polysulfides

inferredcites →https://doi.org/10.1111/bph.14372openalex-snapshot

The reaction of hydrogen sulfide with disulfides: formation of a stable trisulfide and implications for biological systems

inferredcites →https://doi.org/10.1111/j.1432-1033.1977.tb11219.xopenalex-snapshot

Rhodanese‐Mediated Sulfur Transfer to Succinate Dehydrogenase

inferredcites →https://doi.org/10.1111/j.1476-5381.2010.00704.xopenalex-snapshot

A monobromobimane‐based assay to measure the pharmacokinetic profile of reactive sulphide species in blood

inferredcites →https://doi.org/10.1126/sciadv.1500968openalex-snapshot

A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems

inferredcites →https://doi.org/10.1126/scisignal.2000464openalex-snapshot

H 2 S Signals Through Protein S-Sulfhydration

inferredcites →https://doi.org/10.1126/scisignal.2002329openalex-snapshot

H 2 S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response

inferredcites →https://doi.org/10.1126/scisignal.290re7openalex-snapshot

Transduction of Redox Signaling by Electrophile-Protein Reactions

inferredcites →https://doi.org/10.1289/ehp.834959openalex-snapshot

The Role of Glutathione in Detoxication

inferredcites →https://doi.org/10.3109/10715762.2015.1094184openalex-snapshot

Reactions of electrophiles with nucleophilic thiolate sites: relevance to pathophysiological mechanisms and remediation

inferredcites →https://doi.org/10.3164/jcbn.15-111openalex-snapshot

Redox signaling regulated by electrophiles and reactive sulfur species

inferredcites →https://doi.org/10.3390/molecules190812789openalex-snapshot

Thiosulfoxide (Sulfane) Sulfur: New Chemistry and New Regulatory Roles in Biology

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1007/s11756-023-01500-9openalex-snapshot

Correlation between the level of sulfane sulfur and the expression/activity of sulfurtransferases in chicken tissues – a possible ways of cyanide detoxification

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A persulfide shield

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Nutrition and sulfur

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The chemistry of hydropersulfides (RSSH) as related to possible physiological functions

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Gut microbiota reinforce host antioxidant capacity via the generation of reactive sulfur species

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Concentrations of nucleophilic sulfur species in small Indian mongoose (Herpestes auropunctatus) in Okinawa, Japan

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Potentiation of Methylmercury Toxicity by Combined Metal Exposure: In Vitro and in Vivo Models of a Restricted Metal Exposome

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Comparative electrochemical study of N-(4-aminophenyl) and N-(4-hydroxyphenyl)benzenesulfonamide derivatives

inferred← citeshttps://doi.org/10.1016/j.fm.2022.104124openalex-snapshot

Characterization of polysulfides in Saccharomyces cerevisiae cells and finished wine from a cysteine-supplemented model grape medium

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2019.12.027openalex-snapshot

Non-redox cycling mechanisms of oxidative stress induced by PM metals

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Potential of graphene as an adsorbent for HSSS· radical – A DFT investigation

inferred← citeshttps://doi.org/10.1016/j.redox.2023.102625openalex-snapshot

Hydropersulfides (RSSH) attenuate doxorubicin-induced cardiotoxicity while boosting its anticancer action

inferred← citeshttps://doi.org/10.1016/j.redox.2026.104123openalex-snapshot

Formation of a reducing microenvironment and regulation of protein supersulfidation by gut microbial supersulfides

inferred← citeshttps://doi.org/10.1016/j.talanta.2024.126515openalex-snapshot

Sulfur-based fluorescent probes for biological analysis: A review

inferred← citeshttps://doi.org/10.1016/j.tox.2021.152685openalex-snapshot

Acute acrylonitrile exposure inhibits endogenous H2S biosynthesis in rat brain and liver: The role of CBS/3-MPST-H2S pathway in its astrocytic toxicity

inferred← citeshttps://doi.org/10.1021/acs.analchem.9b02875openalex-snapshot

Sensitive Method for Reliable Quantification of Sulfane Sulfur in Biological Samples

inferred← citeshttps://doi.org/10.1021/acs.chemrestox.2c00223openalex-snapshot

Capture of Electrophilic Quinones in the Extracellular Space: Evidence for a Phase Zero Reaction

inferred← citeshttps://doi.org/10.1021/acs.chemrestox.9b00494openalex-snapshot

Cysteine Trisulfide Protects E. coli from Electrophile-Induced Death through the Generation of Cysteine Hydropersulfide

inferred← citeshttps://doi.org/10.1021/acs.inorgchem.6c04125openalex-snapshot

Bioinspired Persulfidation of a Mononuclear Ni(II)-ONO Compound: Evidence for Sulfur/Nitrogen “Crosstalk”

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c01575openalex-snapshot

Light-Controlled Anticancer Activity and Cellular Uptake of a Photoswitchable Cisplatin Analogue

inferred← citeshttps://doi.org/10.1021/jacs.4c17661openalex-snapshot

Arylsulfonothioates: Thiol-Activated Donors of Hydropersulfides which are Excreted to Maintain Cellular Redox Homeostasis or Retained to Counter Oxidative Stress

inferred← citeshttps://doi.org/10.1021/jacs.9b12180openalex-snapshot

Alkylamine-Substituted Perthiocarbamates: Dual Precursors to Hydropersulfide and Carbonyl Sulfide with Cardioprotective Actions

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A new disulfide Schiff base as a versatile “OFF–ON–OFF” fluorescent–colorimetric chemosensor for sequential detection of CN − and Fe 3+ ions: combined experimental and theoretical studies

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Hydrogen sulfide increases copper-dependent neurotoxicityviaintracellular copper accumulation

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Reactive sulfur species and their significance in health and disease

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Extracellularly secreted cysteine derived from cystine regulates oxidative and electrophilic stress in HepG2 cells

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HIV-1 gp120-induced lysosomal stress responses are controlled by TRPML1 redox sensors

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SG1002 and Catenated Divalent Organic Sulfur Compounds as Promising Hydrogen Sulfide Prodrugs

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Predicting the Possible Physiological/Biological Utility of the Hydropersulfide Functional Group Based on Its Chemistry: Similarities Between Hydropersulfides and Selenols

inferred← citeshttps://doi.org/10.1093/toxres/tfac011openalex-snapshot

Differential effects of subchronic acrylonitrile exposure on hydrogen sulfide levels in rat blood, brain, and liver

inferred← citeshttps://doi.org/10.1093/toxsci/kfae132openalex-snapshot

Multi-defense pathways against electrophiles through adduct formation by low molecular weight substances with sulfur atoms

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Modulation of Human Hydrogen Sulfide Metabolism by Micronutrients, Preliminary Data

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Fibroblast Growth Factor-2 Upregulates Reactive Sulfur Species Production via ERK1/2 Signal-Mediated Cystathionine γ-Lyase Induction in Cultured Bovine Aortic Endothelial Cells

inferred← citeshttps://doi.org/10.2131/fts.7.161openalex-snapshot

Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide

inferred← citeshttps://doi.org/10.2478/ahem-2025-0021openalex-snapshot

A tendency to maintain a stable level of sulfane sulfur under various environmental or culture conditions

inferred← citeshttps://doi.org/10.32802/asmscj.2022.1242openalex-snapshot

Sulphide Donor Exhibits Cytoprotective and Antioxidative Activity in UV-induced HaCaT Cell Lines

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Is Hydrogen Sulfide a Concern During Treatment of Lung Adenocarcinoma With Ammonium Tetrathiomolybdate?

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Multidirectional Changes in Parameters Related to Sulfur Metabolism in Frog Tissues Exposed to Heavy Metal-Related Stress

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H2S, Polysulfides, and Enzymes: Physiological and Pathological Aspects

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N-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells

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Nrf2 Activation and Its Coordination with the Protective Defense Systems in Response to Electrophilic Stress

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Effect of S-Allyl –L-Cysteine on MCF-7 Cell Line 3-Mercaptopyruvate Sulfurtransferase/Sulfane Sulfur System, Viability and Apoptosis

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Research Progress of Small-Molecular Hydropersulfide Donors

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HIV-1 gp120-induced lysosomal stress responses are controlled by TRPML1 redox sensors

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