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HIV-1 gp120-induced lysosomal stress responses are controlled by TRPML1 redox sensors

https://doi.org/10.64898/2026.03.02.709165
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Perturbation of sphingolipid metabolism and ceramide production in HIV‐dementia
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Requirement for Membrane Lipid Peroxidation in HIV-1 gp120-Induced Neuroblastoma Cell Death
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Glutathione and the intracellular labile heme pool
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Berbamine Hydrochloride inhibits lysosomal acidification by activating Nox2 to potentiate chemotherapy-induced apoptosis via the ROS-MAPK pathway in human lung carcinoma cells
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Lysosomal Stress Response (LSR): Physiological Importance and Pathological Relevance
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HIV-1 gp120-Induced Endolysosome de-Acidification Leads to Efflux of Endolysosome Iron, and Increases in Mitochondrial Iron and Reactive Oxygen Species
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Iron-regulatory genes are associated with Neuroimaging measures in HIV infection
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Endolysosome iron
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Nitrosative Stress Is Associated with Dopaminergic Dysfunction in the HIV-1 Transgenic Rat
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Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage
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HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells
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Dopaminergic neurotoxicity of HIV-1 gp120: Reactive oxygen species as signaling intermediates
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Accumulation of nuclear and mitochondrial DNA damage in the frontal cortex cells of patients with HIV-associated neurocognitive disorders
inferredcites →https://doi.org/10.1016/j.canlet.2022.215752openalex-snapshot
TRPML1-induced autophagy inhibition triggers mitochondrial mediated apoptosis
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Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification
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Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein
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Neuroinflammatory profiles regulated by the redox environment predicted cognitive dysfunction in people living with HIV: A cross-sectional study
inferredcites →https://doi.org/10.1016/j.ecoenv.2023.114942openalex-snapshot
Blunting ROS/TRPML1 pathway protects AFB1-induced porcine intestinal epithelial cells apoptosis by restoring impaired autophagic flux
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Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling
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Hepatic Lysosomal iNOS Activity Impairs Autophagy in Obesity
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Iron accumulation, glutathione depletion, and lipid peroxidation must occur simultaneously during ferroptosis and are mutually amplifying events
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Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate
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The lysosome as a master regulator of iron metabolism
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Targeting Two-Pore Channels: Current Progress and Future Challenges
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HIV gp120- and methamphetamine-mediated oxidative stress induces astrocyte apoptosis via cytochrome P450 2E1
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The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel
inferredcites →https://doi.org/10.1038/ncomms12109openalex-snapshot
MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
inferredcites →https://doi.org/10.1038/s41419-022-04754-4openalex-snapshot
Nogo-B promotes angiogenesis and improves cardiac repair after myocardial infarction via activating Notch1 signaling
inferredcites →https://doi.org/10.1038/s41423-019-0260-yopenalex-snapshot
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology
inferredcites →https://doi.org/10.1038/s41594-025-01581-xopenalex-snapshot
DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation
inferredcites →https://doi.org/10.1038/s41598-018-20271-xopenalex-snapshot
The alpha7-nicotinic receptor contributes to gp120-induced neurotoxicity: implications in HIV-associated neurocognitive disorders
inferredcites →https://doi.org/10.1039/c2mt20156aopenalex-snapshot
Lysosomal metal, redox and proton cycles influencing the CysHis cathepsin reaction
inferredcites →https://doi.org/10.1073/pnas.1419669112openalex-snapshot
Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation
inferredcites →https://doi.org/10.1073/pnas.1707380114openalex-snapshot
TRPM7 senses oxidative stress to release Zn 2+ from unique intracellular vesicles
inferredcites →https://doi.org/10.1073/pnas.2120404119openalex-snapshot
Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin
inferredcites →https://doi.org/10.1073/pnas.2205044120openalex-snapshot
SOD1 is an essential H 2 S detoxifying enzyme
inferredcites →https://doi.org/10.1074/jbc.m115.651380openalex-snapshot
Redox Control of Protein Arginine Methyltransferase 1 (PRMT1) Activity
inferredcites →https://doi.org/10.1074/jbc.m116.772160openalex-snapshot
The lysosomal Ca2+ release channel TRPML1 regulates lysosome size by activating calmodulin
inferredcites →https://doi.org/10.1080/10715769800300121openalex-snapshot
Endogenous ferritin protects cells with iron-laden lysosomes against oxidative stress
inferredcites →https://doi.org/10.1080/13510002.2025.2546496openalex-snapshot
Involvement of endolysosome iron in HIV-1 gp120-, morphine-, and iron supplementation-induced disruption of the reactive species interactome and induction of neurotoxicity
inferredcites →https://doi.org/10.1080/15548627.2021.1911548openalex-snapshot
A NOVEL NOX/PHOX-CD38-NAADP-TFEB AXIS IMPORTANT FOR MACROPHAGE ACTIVATION DURING BACTERIAL PHAGOCYTOSIS
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How Much Gp120 Is There?
inferredcites →https://doi.org/10.1089/ars.2009.2461openalex-snapshot
Activation of Membrane NADPH Oxidase Associated with Lysosome-Targeted Acid Sphingomyelinase in Coronary Endothelial Cells
inferredcites →https://doi.org/10.1089/ars.2012.4885openalex-snapshot
Lysosomal Iron, Iron Chelation, and Cell Death
inferredcites →https://doi.org/10.1089/ars.2017.7083openalex-snapshot
The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine
inferredcites →https://doi.org/10.1089/ars.2017.7132openalex-snapshot
Glutathione, Glutaredoxins, and Iron
inferredcites →https://doi.org/10.1089/ars.2020.8238openalex-snapshot
The Reactive Species Interactome in the Brain
inferredcites →https://doi.org/10.1093/hmg/9.17.2471openalex-snapshot
Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel
inferredcites →https://doi.org/10.1093/jnen/61.11.992openalex-snapshot
HIV-1 gp120 Proteins and gp160 Peptides Are Toxic to Brain Endothelial Cells and Neurons: Possible Pathway for HIV Entry into the Brain and HIV-Associated Dementia
inferredcites →https://doi.org/10.1093/toxsci/kfz091openalex-snapshot
Sulfane Sulfur in Toxicology: A Novel Defense System Against Electrophilic Stress
inferredcites →https://doi.org/10.1096/fj.13-236166openalex-snapshot
Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor
inferredcites →https://doi.org/10.1096/fj.202001886ropenalex-snapshot
Lysosomal calcium is modulated by STIM1/TRPML1 interaction which participates to neuronal survival during ischemic preconditioning
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Early Entry and Widespread Cellular Involvement of HIV-1 DNA in Brains of HIV-1 Positive Asymptomatic Individuals
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Antioxidants and Dipyridamole Inhibit HIV-1 gp120-Induced Free Radical-Based Oxidative Damage to Human Monocytoid Cells
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Endo-lysosomal dysfunction in neurodegenerative diseases: opinion on current progress and future direction in the use of exosomes as biomarkers
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Glutathione depletion in hippocampal cells increases levels of H and L ferritin and glutathione S‐transferase mRNAs
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TRP‐ML1 functions as a lysosomal NAADP‐sensitive Ca2+ release channel in coronary arterial myocytes
inferredcites →https://doi.org/10.1111/j.1742-4658.2006.05321.xopenalex-snapshot
Intralysosomal iron chelation protects against oxidative stress‐induced cellular damage
inferredcites →https://doi.org/10.1111/jnc.14640openalex-snapshot
HIV gp120‐induced neuroinflammation potentiates NMDA receptors to overcome basal suppression of inhibitory synapses by p38 MAPK
inferredcites →https://doi.org/10.1111/jnc.15583openalex-snapshot
Heterogeneity of ferrous iron‐containing endolysosomes and effects of endolysosome iron on endolysosome numbers, sizes, and localization patterns
inferredcites →https://doi.org/10.1126/sciadv.abj5716openalex-snapshot
Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca 2+ efflux and disrupted by PSEN1 loss of function
inferredcites →https://doi.org/10.1126/science.aaw9872openalex-snapshot
Cysteine depletion induces pancreatic tumor ferroptosis in mice
inferredcites →https://doi.org/10.1167/iovs.10-5410openalex-snapshot
Intralysosomal Iron Induces Lysosomal Membrane Permeabilization and Cathepsin D–Mediated Cell Death in Trabecular Meshwork Cells Exposed to Oxidative Stress
inferredcites →https://doi.org/10.1186/1472-6890-12-26openalex-snapshot
Iron status in HIV-1 infection: implications in disease pathology
inferredcites →https://doi.org/10.1194/jlr.m055152openalex-snapshot
Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity
inferredcites →https://doi.org/10.1212/01.wnl.0000042048.85204.3dopenalex-snapshot
Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants
inferredcites →https://doi.org/10.1212/01.wnl.0000134662.19883.06openalex-snapshot
Dysregulation of sphingolipid and sterol metabolism by ApoE4 in HIV dementia
inferredcites →https://doi.org/10.1212/nxi.0000000000000902openalex-snapshot
Nucleic acid oxidation is associated with biomarkers of neurodegeneration in CSF in people with HIV
inferredcites →https://doi.org/10.1371/journal.pone.0248309openalex-snapshot
Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism
inferredcites →https://doi.org/10.1515/nipt-2022-0013openalex-snapshot
Mu opioid receptor-mediated release of endolysosome iron increases levels of mitochondrial iron, reactive oxygen species, and cell death
inferredcites →https://doi.org/10.1515/nipt-2023-0021openalex-snapshot
Weak base drug-induced endolysosome iron dyshomeostasis controls the generation of reactive oxygen species, mitochondrial depolarization, and cytotoxicity
inferredcites →https://doi.org/10.1523/jneurosci.0826-23.2024openalex-snapshot
HERV-K (HML-2) Envelope Protein Induces Mitochondrial Depolarization and Neurotoxicity via Endolysosome Iron Dyshomeostasis
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gp120-Induced Neurotoxicity in Hippocampal Pyramidal Neuron Cultures: Protective Action of TGF-β1
inferredcites →https://doi.org/10.1523/jneurosci.3085-04.2004openalex-snapshot
Human Immunodeficiency Virus Type 1 gp120 Induces Apoptosis in Human Primary Neurons through Redox-Regulated Activation of Neutral Sphingomyelinase
inferredcites →https://doi.org/10.3109/10715769709065788openalex-snapshot
On the Cytoprotective Role of Ferritin in Macrophages and its Ability to Enhance Lysosomal Stability
inferredcites →https://doi.org/10.3109/13550280903296346openalex-snapshot
Preferential sensitivity of human dopaminergic neurons to gp120-induced oxidative damage
inferredcites →https://doi.org/10.3389/fmicb.2015.00614openalex-snapshot
HIV-1 gp120 and morphine induced oxidative stress: role in cell cycle regulation
inferredcites →https://doi.org/10.3389/fneur.2020.00840openalex-snapshot
N-Acetylcysteine Reverses Antiretroviral-Mediated Microglial Activation by Attenuating Autophagy-Lysosomal Dysfunction
inferredcites →https://doi.org/10.3389/fphys.2020.00251openalex-snapshot
Pathophysiological Role of Transient Receptor Potential Mucolipin Channel 1 in Calcium-Mediated Stress-Induced Neurodegenerative Diseases
inferredcites →https://doi.org/10.3390/biom10050761openalex-snapshot
High Levels of ROS Impair Lysosomal Acidity and Autophagy Flux in Glucose-Deprived Fibroblasts by Activating ATM and Erk Pathways
inferredcites →https://doi.org/10.3390/cells11111811openalex-snapshot
Endolysosome Iron Chelation Inhibits HIV-1 Protein-Induced Endolysosome De-Acidification-Induced Increases in Mitochondrial Fragmentation, Mitophagy, and Cell Death
inferredcites →https://doi.org/10.7554/elife.51031openalex-snapshot
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo
inferredcites →https://doi.org/10.7554/elife.68487openalex-snapshot
Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis
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