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The hepatocyte nuclear factor 6 (HNF6) and FOXA2 are key regulators in colorectal liver metastases
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/ajmg.c.30023openalex-snapshot
Simple and complex genetics of colorectal cancer susceptibility
inferredcites →https://doi.org/10.1002/hep.20155openalex-snapshot
Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors
inferredcites →https://doi.org/10.1002/hep.21044openalex-snapshot
C/EBPα and HNF6 protein complex formation stimulates HNF6-dependent transcription by CBP coactivator recruitment in HepG2 cells
inferredcites →https://doi.org/10.1016/0092-8674(86)90519-2openalex-snapshot
Tissue-specific in vitro transcription from the mouse albumin promoter
inferredcites →https://doi.org/10.1016/j.gde.2004.08.004openalex-snapshot
Liver development update: new embryo models, cell lineage control, and morphogenesis
inferredcites →https://doi.org/10.1038/nature03649openalex-snapshot
The initiation of liver development is dependent on Foxa transcription factors
inferredcites →https://doi.org/10.1038/ng1175openalex-snapshot
Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis
inferredcites →https://doi.org/10.1053/j.seminoncol.2004.09.034openalex-snapshot
Genetics of hereditary colorectal cancer
inferredcites →https://doi.org/10.1074/jbc.273.22.13552openalex-snapshot
Isoforms of Hepatocyte Nuclear Factor-6 Differ in DNA-binding Properties, Contain a Bifunctional Homeodomain, and Define the New ONECUT Class of Homeodomain Proteins
inferredcites →https://doi.org/10.1074/jbc.m000855200openalex-snapshot
Transcriptional Stimulation by Hepatocyte Nuclear Factor-6
inferredcites →https://doi.org/10.1074/jbc.m009284200openalex-snapshot
Interleukin-6-induced Tethering of STAT3 to the LAP/C/EBPβ Promoter Suggests a New Mechanism of Transcriptional Regulation by STAT3
inferredcites →https://doi.org/10.1074/jbc.m405312200openalex-snapshot
Expression of the α7 Isoform of Hepatocyte Nuclear Factor (HNF) 4 Is Activated by HNF6/OC-2 and HNF1 and Repressed by HNF4α1 in the Liver
inferredcites →https://doi.org/10.1074/jbc.m407472200openalex-snapshot
Stability of the Hepatocyte Nuclear Factor 6 Transcription Factor Requires Acetylation by the CREB-binding Protein Coactivator
inferredcites →https://doi.org/10.1093/annonc/mdi702openalex-snapshot
Treatment of liver metastases of colorectal cancer
inferredcites →https://doi.org/10.1093/emboj/cdf649openalex-snapshot
Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium
inferredcites →https://doi.org/10.1124/pr.54.1.129openalex-snapshot
Liver-Enriched Transcription Factors in Liver Function and Development. Part I: The Hepatocyte Nuclear Factor Network and Liver-Specific Gene Expression
inferredcites →https://doi.org/10.1124/pr.56.2.5openalex-snapshot
Liver-Enriched Transcription Factors in Liver Function and Development. Part II: the C/EBPs and D Site-Binding Protein in Cell Cycle Control, Carcinogenesis, Circadian Gene Regulation, Liver Regeneration, Apoptosis, and Liver-Specific Gene Regulation
inferredcites →https://doi.org/10.1126/science.1089769openalex-snapshot
Control of Pancreas and Liver Gene Expression by HNF Transcription Factors
inferredcites →https://doi.org/10.1128/mcb.20.12.4445-4454.2000openalex-snapshot
Transcription Factor Hepatocyte Nuclear Factor 6 Regulates Pancreatic Endocrine Cell Differentiation and Controls Expression of the Proendocrine Gene ngn3
inferredcites →https://doi.org/10.1128/mcb.23.2.437-449.2003openalex-snapshot
Association between Hepatocyte Nuclear Factor 6 (HNF-6) and FoxA2 DNA Binding Domains Stimulates FoxA2 Transcriptional Activity but Inhibits HNF-6 DNA Binding
inferredcites →https://doi.org/10.1128/mcb.23.23.8429-8439.2003openalex-snapshot
GATA-4 and GATA-5 Transcription Factor Genes and Potential Downstream Antitumor Target Genes Are Epigenetically Silenced in Colorectal and Gastric Cancer
inferredcites →https://doi.org/10.1128/mcb.25.16.7069-7077.2005openalex-snapshot
Transcriptional Networks in the Liver: Hepatocyte Nuclear Factor 6 Function Is Largely Independent of Foxa2
inferredcites →https://doi.org/10.1136/mp.52.1.19openalex-snapshot
Liver enriched transcription factors and differentiation of hepatocellular carcinoma.
inferredcites →https://doi.org/10.1242/dev.129.8.1819openalex-snapshot
The onecut transcription factor HNF6 is required for normal development of the biliary tract
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4781335openalex-extracted
The Abl1 Tyrosine Kinase and p53 are Key Players in Doxorubicin-Induced Cardiomyopathy and Their Cell Death Signaling Differs in Atrial and Ventricular Cardiomyocytes
inferred← citeshttps://doi.org/10.1002/jcp.27140openalex-snapshot
HNF6 promotes tumor growth in colorectal cancer and enhances liver metastasis in mouse model
inferred← citeshttps://doi.org/10.1007/978-3-540-71123-0_22openalex-snapshot
Leberspezifische Transkriptionsfaktoren und deren Bedeutung in kolorektalen Lebermetastasen
inferred← citeshttps://doi.org/10.1007/s00432-016-2121-8openalex-snapshot
Hepatocyte nuclear factor 6 inhibits the growth and metastasis of cholangiocarcinoma cells by regulating miR-122
inferred← citeshttps://doi.org/10.1007/s10555-013-9445-5openalex-snapshot
Epithelial cancers in the post-genomic era: should we reconsider our lifestyle?
inferred← citeshttps://doi.org/10.1016/j.bbrc.2011.04.001openalex-snapshot
Epigenetic regulation of the transcription factor Foxa2 directs differential elafin expression in melanocytes and melanoma cells
inferred← citeshttps://doi.org/10.1016/j.canlet.2015.03.008openalex-snapshot
FOXA2 attenuates the epithelial to mesenchymal transition by regulating the transcription of E-cadherin and ZEB2 in human breast cancer
inferred← citeshttps://doi.org/10.1016/j.cellsig.2011.08.009openalex-snapshot
Pathophysiologic role of hepatocyte nuclear factor 6
inferred← citeshttps://doi.org/10.1016/j.gene.2014.07.038openalex-snapshot
Whole transcriptome RNA-seq analysis: tumorigenesis and metastasis of melanoma
inferred← citeshttps://doi.org/10.1016/j.intimp.2023.110713openalex-snapshot
The role and mechanism of action of microRNA-122 in cancer: Focusing on the liver
inferred← citeshttps://doi.org/10.1016/j.molcel.2011.11.018openalex-snapshot
IKKα Activation of NOTCH Links Tumorigenesis via FOXA2 Suppression
inferred← citeshttps://doi.org/10.1016/j.pathol.2024.03.010openalex-snapshot
HNF6 and HNF4α expression in adenocarcinomas of the liver, pancreaticobiliary tract, and gastrointestinal tract: an immunohistochemical study of 480 adenocarcinomas of the digestive system
inferred← citeshttps://doi.org/10.1016/j.semcancer.2020.05.013openalex-snapshot
Genomic profiling of sporadic liver metastatic colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.yexcr.2024.114035openalex-snapshot
Role of ONECUT family transcription factors in cancer and other diseases
inferred← citeshttps://doi.org/10.1038/cr.2010.126openalex-snapshot
FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers
inferred← citeshttps://doi.org/10.1074/jbc.m111.225680openalex-snapshot
Tripartite Motif 24 (Trim24/Tif1α) Tumor Suppressor Protein Is a Novel Negative Regulator of Interferon (IFN)/Signal Transducers and Activators of Transcription (STAT) Signaling Pathway Acting through Retinoic Acid Receptor α (Rarα) Inhibition
inferred← citeshttps://doi.org/10.1074/jbc.m113.480285openalex-snapshot
Hepatocyte Nuclear Factor 6 Suppresses the Migration and Invasive Growth of Lung Cancer Cells through p53 and the Inhibition of Epithelial-Mesenchymal Transition
inferred← citeshttps://doi.org/10.1093/hmg/ddab042openalex-snapshot
Integrative analyses of scRNA-seq and scATAC-seq reveal CXCL14 as a key regulator of lymph node metastasis in breast cancer
inferred← citeshttps://doi.org/10.1093/neuonc/noz137openalex-snapshot
Patient-derived xenografts of central nervous system metastasis reveal expansion of aggressive minor clones
inferred← citeshttps://doi.org/10.1096/fj.202101506rrropenalex-snapshot
FOXA1 /2 depletion drives global reprogramming of differentiation state and metabolism in a human liver cell line and inhibits differentiation of human stem cell‐derived hepatic progenitor cells
inferred← citeshttps://doi.org/10.1097/pai.0000000000000638openalex-snapshot
Reduced Immunohistochemical Expression of Hnf1β and FoxA2 in Liver Tissue Can Discriminate Between Biliary Atresia and Other Causes of Neonatal Cholestasis
inferred← citeshttps://doi.org/10.1111/j.1440-1746.2012.07137.xopenalex-snapshot
Therapeutic potential of mesenchymal stem cells overexpressing human forkhead box A2 gene in the regeneration of damaged liver tissues
inferred← citeshttps://doi.org/10.1152/ajpgi.00035.2016openalex-snapshot
Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer
inferred← citeshttps://doi.org/10.1186/1471-2407-12-521openalex-snapshot
Overexpression of Snail is associated with lymph node metastasis and poor prognosis in patients with gastric cancer
inferred← citeshttps://doi.org/10.1186/s10020-025-01105-9openalex-snapshot
Role of HNF6 in liver homeostasis and pathophysiology
inferred← citeshttps://doi.org/10.1186/s12863-017-0581-8openalex-snapshot
Upregulation of NETO2 gene in colorectal cancer
inferred← citeshttps://doi.org/10.1186/s12967-024-05623-8openalex-snapshot
The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes
inferred← citeshttps://doi.org/10.1371/journal.pgen.1007766openalex-snapshot
Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity
inferred← citeshttps://doi.org/10.1371/journal.pone.0013344openalex-snapshot
Inhibition of the Liver Enriched Protein FOXA2 Recovers HNF6 Activity in Human Colon Carcinoma and Liver Hepatoma Cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0013752openalex-snapshot
Mapping of Genetic Abnormalities of Primary Tumours from Metastatic CRC by High-Resolution SNP Arrays
inferred← citeshttps://doi.org/10.1371/journal.pone.0079359openalex-snapshot
Distinct Expression Patterns of ICK/MAK/MOK Protein Kinases in the Intestine Implicate Functional Diversity
inferred← citeshttps://doi.org/10.14201/gredos.122975openalex-snapshot
Desarrollo de algoritmos bioinformáticos para estudios de genómica funcional: aplicaciones en cáncer
inferred← citeshttps://doi.org/10.14201/gredos.76408openalex-snapshot
Estudio de las metástasis hepáticas de cáncer colorrectal con rescate quirúrgico en un hospital de tercer nivel: identificación de marcadores biológicos pronósticos
inferred← citeshttps://doi.org/10.21203/rs.3.rs-4360926/v1openalex-snapshot
Mapping Heterogeneity of Hepatocellular Carcinoma by Investigating Hepatocyte-Specific Genes/TFs/Pathways Across Cellular and Tumor Landscapes
inferred← citeshttps://doi.org/10.3390/ijms17050598openalex-snapshot
Identification of 42 Genes Linked to Stage II Colorectal Cancer Metastatic Relapse
inferred← citeshttps://doi.org/10.3390/ijms26136072openalex-snapshot
Epigenetic Remodeling of Regulatory Regions by Indicaxanthin Suggests a Shift in Cell Identity Programs in Colorectal Cancer Cells
inferred← citeshttps://doi.org/10.3748/wjg.v16.i31.3919openalex-snapshot
Mapping of liver-enriched transcription factors in the human intestine
inferred← citeshttps://doi.org/10.5580/2755openalex-snapshot
Oncogenomics: The Future Of Cancer Therapy
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