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Cigarette smoke inhibits the NLRP3 inflammasome and leads to caspase‐1 activation via the TLR4‐TRIF‐caspase‐8 axis in human macrophages

https://doi.org/10.1096/fj.201901239r

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1 of the 47 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-21): 10.1016/j.celrep.2015.05.046 (notice 2023-06-06).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Measuring relative utilization of aerobic glycolysis in breast cancer cells by positional isotopic discrimination

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Impact of tobacco‐smoke on key signaling pathways in the innate immune response in lung macrophages

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A large lung gene expression study identifying IL1B as a novel player in airway inflammation in COPD airway epithelial cells

inferredcites →https://doi.org/10.1007/s10753-018-0780-0openalex-snapshot

NLRP3 Inflammasome Involves in the Acute Exacerbation of Patients with Chronic Obstructive Pulmonary Disease

inferredcites →https://doi.org/10.1016/j.celrep.2015.05.046openalex-snapshot

RETRACTED: mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

inferredcites →https://doi.org/10.1016/j.cmet.2012.04.023openalex-snapshot

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

inferredcites →https://doi.org/10.1016/j.coi.2016.10.007openalex-snapshot

Alternative inflammasome activation enables IL-1β release from living cells

inferredcites →https://doi.org/10.1016/j.exger.2019.01.016openalex-snapshot

Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke

inferredcites →https://doi.org/10.1016/j.jaci.2015.01.046openalex-snapshot

Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

inferredcites →https://doi.org/10.1016/j.jim.2017.03.004openalex-snapshot

A bioluminescent caspase-1 activity assay rapidly monitors inflammasome activation in cells

inferredcites →https://doi.org/10.1016/j.molimm.2017.01.014openalex-snapshot

Inflammasomes in the lung

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Mainstream smoke constituents and in vitro toxicity comparative analysis of 3R4F and 1R6F reference cigarettes

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Metabolic reprogramming in macrophages and dendritic cells in innate immunity

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Caspase signalling controls microglia activation and neurotoxicity

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NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

inferredcites →https://doi.org/10.1038/ncomms13280openalex-snapshot

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

inferredcites →https://doi.org/10.1038/nrd.2018.97openalex-snapshot

Targeting the NLRP3 inflammasome in inflammatory diseases

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Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

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The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages

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17-oxo-DHA displays additive anti-inflammatory effects with fluticasone propionate and inhibits the NLRP3 inflammasome

inferredcites →https://doi.org/10.1073/pnas.1403252111openalex-snapshot

Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling

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Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1β are differentially regulated in human blood mononuclear cells and mouse spleen cells

inferredcites →https://doi.org/10.1074/jbc.272.15.9677openalex-snapshot

Substrate Specificities of Caspase Family Proteases

inferredcites →https://doi.org/10.1074/jbc.m606721200openalex-snapshot

Essential Role for Caspase-8 in Toll-like Receptors and NFκB Signaling

inferredcites →https://doi.org/10.1074/jbc.m708182200openalex-snapshot

The Caspase-1 Digestome Identifies the Glycolysis Pathway as a Target during Infection and Septic Shock

inferredcites →https://doi.org/10.1111/cei.12289openalex-snapshot

Effects of cigarette smoke on Toll-like receptor (TLR) activation of chronic obstructive pulmonary disease (COPD) macrophages

inferredcites →https://doi.org/10.1111/j.1365-2567.2007.02788.xopenalex-snapshot

Cigarette smoke increases Toll‐like receptor 4 and modifies lipopolysaccharide‐mediated responses in airway epithelial cells

inferredcites →https://doi.org/10.1126/science.1156995openalex-snapshot

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

inferredcites →https://doi.org/10.1126/science.aar7607openalex-snapshot

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

inferredcites →https://doi.org/10.1136/thoraxjnl-2012-203062openalex-snapshot

Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD

inferredcites →https://doi.org/10.1136/thoraxjnl-2013-203669openalex-snapshot

Impaired innate immune alveolar macrophage response and the predilection for COPD exacerbations

inferredcites →https://doi.org/10.1165/rcmb.2016-0051ocopenalex-snapshot

The Nucleotide-Binding Oligomerization Domain–Like Receptor Family Pyrin Domain-Containing 3 Inflammasome Regulates Bronchial Epithelial Cell Injury and Proapoptosis after Exposure to Biomass Fuel Smoke

inferredcites →https://doi.org/10.1165/rcmb.2017-0200tropenalex-snapshot

Airway Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease: Role of Cigarette Smoke Exposure

inferredcites →https://doi.org/10.1165/rcmb.2018-0162ocopenalex-snapshot

Cigarette Smoking Impairs the Bioenergetic Immune Response to Mycobacterium tuberculosis Infection

inferredcites →https://doi.org/10.1172/jci71747openalex-snapshot

Suppression of NLRX1 in chronic obstructive pulmonary disease

inferredcites →https://doi.org/10.1182/blood-2008-03-146720openalex-snapshot

Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages

inferredcites →https://doi.org/10.1183/23120541.00002-2016openalex-snapshot

The inflammasome pathway in stable COPD and acute exacerbations

inferredcites →https://doi.org/10.1186/s12931-016-0485-6openalex-snapshot

Cigarette smoke destabilizes NLRP3 protein by promoting its ubiquitination

inferredcites →https://doi.org/10.1513/annalsats.201305-123awopenalex-snapshot

Altered Macrophage Function in Chronic Obstructive Pulmonary Disease

inferredcites →https://doi.org/10.4049/jimmunol.1001603openalex-snapshot

Identification of an Autophagy Defect in Smokers’ Alveolar Macrophages

inferredcites →https://doi.org/10.4049/jimmunol.1200312openalex-snapshot

Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1β Production

inferredcites →https://doi.org/10.4049/jimmunol.1201516openalex-snapshot

NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223

inferredcites →https://doi.org/10.4049/jimmunol.1302549openalex-snapshot

Cutting Edge: Endoplasmic Reticulum Stress Licenses Macrophages To Produce Mature IL-1β in Response to TLR4 Stimulation through a Caspase-8– and TRIF-Dependent Pathway

inferredcites →https://doi.org/10.4049/jimmunol.1501612openalex-snapshot

Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication

inferredcites →https://doi.org/10.4049/jimmunol.1700352openalex-snapshot

Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β

inferredcites →https://doi.org/10.4049/jimmunol.180.7.4668openalex-snapshot

Protein Kinase Cα and ζ Differentially Regulate Death-Inducing Signaling Complex Formation in Cigarette Smoke Extract-Induced Apoptosis

inferredcites →https://doi.org/10.5620/eht.e2018012openalex-snapshot

Comparison of volatile organic compounds between cigarette smoke condensate (CSC) and extract (CSE) samples

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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HSP60 Regulates the Cigarette Smoke-Induced Activation of TLR4-NF-κB-MyD88 Signaling Pathway and NLRP3 Inflammasome

inferred← citeshttps://doi.org/10.1002/eji.202451053openalex-snapshot

Release of IL‐1β and IL‐18 in human primary bronchial epithelial cells exposed to cigarette smoke is independent of NLRP3

inferred← citeshttps://doi.org/10.1002/iid3.581openalex-snapshot

Interactions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis

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Repeated intratracheal instillation of whole‐cigarette smoke condensate to assess lung damage in a rat model

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The inflammasomes: crosstalk between innate immunity and hematology

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Inflammasome involvement in CS-induced damage in HaCaT keratinocytes

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Pharmacological Management of Asthma and COPD

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Charnolosome nanotheranostics in metabolic diseases

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The transcriptomic landscape of canonical activation of NLRP3 inflammasome from bone marrow-derived macrophages

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Exposure of cigarette smoke condensate activates NLRP3 inflammasome in THP-1 cells in a stage-specific manner: An underlying role of innate immunity in atherosclerosis.

inferred← citeshttps://doi.org/10.1016/j.intimp.2020.106271openalex-snapshot

Glaucocalyxin A alleviates LPS-mediated septic shock and inflammation via inhibiting NLRP3 inflammasome activation

inferred← citeshttps://doi.org/10.1016/j.intimp.2021.108445openalex-snapshot

HSP60 regulates the cigarette smoke-induced activation of TLR4-NF-κB-MyD88 signalling pathway and NLRP3 inflammasome

inferred← citeshttps://doi.org/10.1016/j.jneuroim.2023.578281openalex-snapshot

Polygalasaponin F ameliorates middle cerebral artery occlusion-induced focal ischemia / reperfusion injury in rats through inhibiting TXNIP/NLRP3 signaling pathway

inferred← citeshttps://doi.org/10.1016/j.lfs.2021.119090openalex-snapshot

Cigarette smoke extract induces pyroptosis in human bronchial epithelial cells through the ROS/NLRP3/caspase-1 pathway

inferred← citeshttps://doi.org/10.1016/j.micinf.2021.104913openalex-snapshot

NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severity

inferred← citeshttps://doi.org/10.1016/j.micpath.2023.106120openalex-snapshot

Toxoplasma gondii profilin induces NLRP3 activation and IL-1β production/secretion in THP-1 cells

inferred← citeshttps://doi.org/10.1016/j.peptides.2025.171381openalex-snapshot

A novel regulator of NLRP3 inflammasome: Peptides

inferred← citeshttps://doi.org/10.1016/j.scr.2023.103039openalex-snapshot

Platelet-Rich stroma from Crohn’s disease patients for treatment of perianal fistula shows a higher myeloid cell profile compared to non-IBD controls

inferred← citeshttps://doi.org/10.1016/j.snb.2024.136676openalex-snapshot

Simultaneously monitoring ATP and neutrophil elastase to assess inflammation progression

inferred← citeshttps://doi.org/10.1016/j.tiv.2021.105249openalex-snapshot

Cigarette smoke extracts induce apoptosis in Raw264.7 cells via endoplasmic reticulum stress and the intracellular Ca2+/P38/STAT1 pathway

inferred← citeshttps://doi.org/10.1016/j.tox.2021.152751openalex-snapshot

Cigarette smoke extract reduces FOXO3a promoting tumor progression and cell migration in lung cancer

inferred← citeshttps://doi.org/10.1016/j.toxlet.2021.11.002openalex-snapshot

Cigarette smoke upregulates Notch-1 signaling pathway and promotes lung adenocarcinoma progression

inferred← citeshttps://doi.org/10.1016/j.yjmcc.2022.04.014openalex-snapshot

E-cigarette exposure with or without heating the e-liquid induces differential remodeling in the lungs and right heart of mice

inferred← citeshttps://doi.org/10.1038/s41392-023-01687-yopenalex-snapshot

The role of inflammasomes in human diseases and their potential as therapeutic targets

inferred← citeshttps://doi.org/10.1038/s41419-023-06318-6openalex-snapshot

Caspase-8 activation by cigarette smoke induces pro-inflammatory cell death of human macrophages exposed to lipopolysaccharide

inferred← citeshttps://doi.org/10.1080/02713683.2024.2409885openalex-snapshot

TLR4/TRIF/Caspase-8/Caspase-1 Pathway in Choroidal Endothelial Cells Promotes Choroidal Neovascularization

inferred← citeshttps://doi.org/10.1080/08923973.2020.1850761openalex-snapshot

Etidronate down-regulates Toll-like receptor 2 ligand-induced chemokine production by inhibiting MyD88 expression and NF-κB activation

inferred← citeshttps://doi.org/10.1089/ars.2022.0087openalex-snapshot

Cigarette Smoke Modulates Inflammation and Immunity via Reactive Oxygen Species-Regulated Trained Immunity and Trained Tolerance Mechanisms

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Cigarette smoke promotes inflammasome‐independent activation of caspase‐1 and ‐4 leading to gasdermin D cleavage in human macrophages

inferred← citeshttps://doi.org/10.1097/prs.0000000000007617openalex-snapshot

Inflammasome Activation in Pollution-Induced Skin Conditions

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Differences in the Inflammatory Response and Corticoid Responsiveness of Human Lung Macrophages and Parenchymal Explants Exposed to Cigarette Smoke Extracts

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Caspase inhibition restores collagen Iα1 and fibronectin release in cigarette smoke extract-exposed human lung fibroblasts

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The NLRP3 Genetic Variant (rs10754555) Reduces the Risk of Adverse Outcome in Middle-Aged Patients with Chronic Coronary Syndrome

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Expression of Key Inflammatory Proteins Is Increased in Immune Cells From Tobacco Cigarette Smokers But Not Electronic Cigarette Vapers: Implications for Atherosclerosis

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Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD

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Salvianolic acid A inhibits PRRSV replication via binding to Keap1 to activate the MKRN1–Nrf2–NQO1 pathway

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Lipopolysaccharide upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1)

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Inflammasome as an early pathophysiological phenomenon of inflammation in skin diseases and other pathologies

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Double Targeting Inflammasome Activation and Accelerated Cellular Senescence in Alveolar Macrophages Exposed to Cigarette Smoke and COPD

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Double Targeting Inflammasome Activation and Accelerated Cellular Senescence in Alveolar Macrophages Exposed to Cigarette Smoke and COPD

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Polygalasaponin F ameliorates middle cerebral artery occlusion-induced focal ischemia in rats through inhibiting TXNIP/NLRP3 signaling pathway

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Changes in the Oropharyngeal Microbiome in Moderate-to-Severe Tobacco Dependence Before and After 30 Days of Smoking Cessation

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Host Immune-Metabolic Adaptations Upon Mycobacterial Infections and Associated Co-Morbidities

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Cigarette smoke-induced gasdermin D activation in bronchoalveolar macrophages and bronchial epithelial cells dependently on NLRP3

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Multiple TLRs elicit alternative NLRP3 inflammasome activation in primary human monocytes independent of RIPK1 kinase activity

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Role of Caspase Family in Intervertebral Disc Degeneration and Its Therapeutic Prospects

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The Relationship between Smoking and Susceptibility to HIV Infection: A Two-Sample Mendelian Randomization Analysis

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An Emerging Syndemic of Smoking and Cardiopulmonary Diseases in People Living with HIV in Africa

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