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The branched‐chain amino acids valine and leucine have differential effects on hepatic lipid metabolism
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jcb.22688openalex-snapshot
Potential role of branched‐chain amino acids in glucose metabolism through the accelerated induction of the glucose‐sensing apparatus in the liver
inferredcites →https://doi.org/10.1002/mnfr.201600305openalex-snapshot
Importance of propionate for the repression of hepatic lipogenesis and improvement of insulin sensitivity in high‐fat diet‐induced obesity
inferredcites →https://doi.org/10.1007/978-1-4020-8831-5_1openalex-snapshot
Transcriptional Regulation of Hepatic Fatty Acid Metabolism
inferredcites →https://doi.org/10.1007/978-1-59745-019-5_13openalex-snapshot
Isolation and Culture of Adult Mouse Hepatocytes
inferredcites →https://doi.org/10.1007/s00125-014-3176-1openalex-snapshot
Dietary dairy product intake and incident type 2 diabetes: a prospective study using dietary data from a 7-day food diary
inferredcites →https://doi.org/10.1007/s00726-012-1363-2openalex-snapshot
Dietary l-leucine and l-alanine supplementation have similar acute effects in the prevention of high-fat diet-induced obesity
inferredcites →https://doi.org/10.1007/s00726-018-2658-8openalex-snapshot
Does l-leucine supplementation cause any effect on glucose homeostasis in rodent models of glucose intolerance? A systematic review
inferredcites →https://doi.org/10.1007/s11892-005-0067-3openalex-snapshot
PPAR ligands: Potential therapies for metabolic syndrome
inferredcites →https://doi.org/10.1016/0076-6879(75)35136-7openalex-snapshot
[6] Fatty acid synthase from rat liver
inferredcites →https://doi.org/10.1016/j.anifeedsci.2006.06.017openalex-snapshot
Factors affecting odd- and branched-chain fatty acids in milk: A review
inferredcites →https://doi.org/10.1016/j.bbrc.2003.07.012openalex-snapshot
Amino acid signalling and the integration of metabolism
inferredcites →https://doi.org/10.1016/j.biochi.2017.07.003openalex-snapshot
Anti-obesogenic effects of WY14643 (PPAR-alpha agonist): Hepatic mitochondrial enhancement and suppressed lipogenic pathway in diet-induced obese mice
inferredcites →https://doi.org/10.1016/j.cmet.2009.02.002openalex-snapshot
A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance
inferredcites →https://doi.org/10.1016/j.cmet.2012.01.024openalex-snapshot
Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance
inferredcites →https://doi.org/10.1016/j.cmet.2018.08.013openalex-snapshot
Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A
inferredcites →https://doi.org/10.1016/j.diabet.2016.12.008openalex-snapshot
Branched-chain amino acids are associated with odd-chain fatty acids in normoglycaemic individuals
inferredcites →https://doi.org/10.1016/j.jnutbio.2011.10.005openalex-snapshot
Comparison of high-protein diets and leucine supplementation in the prevention of metabolic syndrome and related disorders in mice
inferredcites →https://doi.org/10.1016/j.jnutbio.2015.03.010openalex-snapshot
Effects of dietary inulin on bacterial growth, short-chain fatty acid production and hepatic lipid metabolism in gnotobiotic mice
inferredcites →https://doi.org/10.1016/j.metabol.2014.03.006openalex-snapshot
Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice
inferredcites →https://doi.org/10.1016/j.molmet.2018.10.003openalex-snapshot
Control of hepatic gluconeogenesis by Argonaute2
inferredcites →https://doi.org/10.1016/j.tem.2017.03.003openalex-snapshot
Unraveling the Regulation of Hepatic Metabolism by Insulin
inferredcites →https://doi.org/10.1016/j.trci.2018.10.005openalex-snapshot
Dietary intake of branched‐chain amino acids in a mouse model of Alzheimer's disease: Effects on survival, behavior, and neuropathology
inferredcites →https://doi.org/10.1016/s0006-291x(03)00295-xopenalex-snapshot
Branched-chain amino acids promote albumin synthesis in rat primary hepatocytes through the mTOR signal transduction system
inferredcites →https://doi.org/10.1016/s2213-8587(14)70146-9openalex-snapshot
Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study
inferredcites →https://doi.org/10.1017/s0007114512005934openalex-snapshot
Indices of fatty acid desaturase activity in healthy human subjects: effects of different types of dietary fat
inferredcites →https://doi.org/10.1038/s41598-017-06447-xopenalex-snapshot
Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice
inferredcites →https://doi.org/10.1038/s42255-019-0059-2openalex-snapshot
Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control
inferredcites →https://doi.org/10.1046/j.1432-1033.2002.03292.xopenalex-snapshot
Regulation of mammalian translation factors by nutrients
inferredcites →https://doi.org/10.1074/jbc.270.5.2320openalex-snapshot
Phosphorylation of Ribosomal Protein S6 Is Inhibitory for Autophagy in Isolated Rat Hepatocytes
inferredcites →https://doi.org/10.1074/jbc.275.22.16638openalex-snapshot
Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity
inferredcites →https://doi.org/10.1074/jbc.m210577200openalex-snapshot
Regulation of Leucine-stimulated Insulin Secretion and Glutamine Metabolism in Isolated Rat Islets
inferredcites →https://doi.org/10.1080/07315724.2004.10719381openalex-snapshot
The Effects of High Protein Diets on Thermogenesis, Satiety and Weight Loss: A Critical Review
inferredcites →https://doi.org/10.1093/ajcn/68.1.72openalex-snapshot
A molecular model of human branched-chain amino acid metabolism
inferredcites →https://doi.org/10.1093/ajcn/85.4.996openalex-snapshot
Metabolic effects of amino acid mixtures and whey protein in healthy subjects: studies using glucose-equivalent drinks
inferredcites →https://doi.org/10.1093/jn/131.4.1171openalex-snapshot
Oral Administration of Leucine Stimulates Ribosomal Protein mRNA Translation but Not Global Rates of Protein Synthesis in the Liver of Rats
inferredcites →https://doi.org/10.1093/jn/135.8.1854openalex-snapshot
Increasing the Protein:Carbohydrate Ratio in a High-Fat Diet Delays the Development of Adiposity and Improves Glucose Homeostasis in Mice
inferredcites →https://doi.org/10.1093/jn/136.1.319sopenalex-snapshot
Potential Importance of Leucine in Treatment of Obesity and the Metabolic Syndrome
inferredcites →https://doi.org/10.1097/00075197-200501000-00013openalex-snapshot
Update on nutritional supplementation with branched-chain amino acids
inferredcites →https://doi.org/10.1111/j.1753-4887.2010.00282.xopenalex-snapshot
Leucine metabolism in regulation of insulin secretion from pancreatic beta cells
inferredcites →https://doi.org/10.1126/science.1124147openalex-snapshot
Hypothalamic mTOR Signaling Regulates Food Intake
inferredcites →https://doi.org/10.1128/mcb.24.14.6288-6297.2004openalex-snapshot
Protein Profiling of Mouse Livers with Peroxisome Proliferator-Activated Receptor α Activation
inferredcites →https://doi.org/10.1146/annurev-nutr-080508-141056openalex-snapshot
Dietary Protein, Weight Loss, and Weight Maintenance
inferredcites →https://doi.org/10.1152/ajpendo.00198.2012openalex-snapshot
Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice
inferredcites →https://doi.org/10.1161/circ.139.suppl_1.p034openalex-snapshot
Abstract P034: Circulating Odd-Chain Fatty Acids in Relation to Intake of Dairy and Fiber in Post-Myocardial Infarction Patients
inferredcites →https://doi.org/10.1161/circulationaha.115.018410openalex-snapshot
Circulating Biomarkers of Dairy Fat and Risk of Incident Diabetes Mellitus Among Men and Women in the United States in Two Large Prospective Cohorts
inferredcites →https://doi.org/10.1161/jaha.113.000764openalex-snapshot
Plasma Phospholipid Fatty Acid Biomarkers of Dietary Fat Quality and Endogenous Metabolism Predict Coronary Heart Disease Risk: A Nested Case‐Control Study Within the Women's Health Initiative Observational Study
inferredcites →https://doi.org/10.1172/jci6223openalex-snapshot
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
inferredcites →https://doi.org/10.1186/1868-7083-6-27openalex-snapshot
Leucine alters hepatic glucose/lipid homeostasis via the myostatin-AMP-activated protein kinase pathway - potential implications for nonalcoholic fatty liver disease
inferredcites →https://doi.org/10.1186/s12986-019-0407-yopenalex-snapshot
Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients
inferredcites →https://doi.org/10.1194/jlr.m700119-jlr200openalex-snapshot
The acyl-CoA thioesterase I is regulated by PPARα and HNF4α via a distal response element in the promoter
inferredcites →https://doi.org/10.1271/bbb.120737openalex-snapshot
Differential Dose Response of mTOR Signaling to Oral Administration of Leucine in Skeletal Muscle and Liver of Rats
inferredcites →https://doi.org/10.1371/journal.pmed.1002179openalex-snapshot
Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis
inferredcites →https://doi.org/10.1371/journal.pone.0021187openalex-snapshot
Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism
inferredcites →https://doi.org/10.1371/journal.pone.0074705openalex-snapshot
Leucine Supplementation Protects from Insulin Resistance by Regulating Adiposity Levels
inferredcites →https://doi.org/10.1371/journal.pone.0145850openalex-snapshot
Catabolism of Branched Chain Amino Acids Contributes Significantly to Synthesis of Odd-Chain and Even-Chain Fatty Acids in 3T3-L1 Adipocytes
inferredcites →https://doi.org/10.1507/endocrj.k10e-221openalex-snapshot
The effects of branched-chain amino acid granules on the accumulation of tissue triglycerides and uncoupling proteins in diet-induced obese mice
inferredcites →https://doi.org/10.2337/db07-0123openalex-snapshot
Increasing Dietary Leucine Intake Reduces Diet-Induced Obesity and Improves Glucose and Cholesterol Metabolism in Mice via Multimechanisms
inferredcites →https://doi.org/10.2337/db10-1246openalex-snapshot
Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways
inferredcites →https://doi.org/10.2337/db12-1397openalex-snapshot
Activation of PPARα Ameliorates Hepatic Insulin Resistance and Steatosis in High Fructose–Fed Mice Despite Increased Endoplasmic Reticulum Stress
inferredcites →https://doi.org/10.2337/db16-1519openalex-snapshot
Acyl-CoA Thioesterase 1 (ACOT1) Regulates PPARα to Couple Fatty Acid Flux With Oxidative Capacity During Fasting
inferredcites →https://doi.org/10.2337/diabetes.50.2.411openalex-snapshot
Peroxisome Proliferator—Activated Receptor (PPAR)-αActivation Lowers Muscle Lipids and Improves Insulin Sensitivity in High Fat—Fed Rats
inferredcites →https://doi.org/10.3390/molecules20022425openalex-snapshot
A Review of Odd-Chain Fatty Acid Metabolism and the Role of Pentadecanoic Acid (C15:0) and Heptadecanoic Acid (C17:0) in Health and Disease
inferredcites →https://doi.org/10.3390/molecules22101718openalex-snapshot
Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid
inferredcites →https://doi.org/10.3945/ajcn.111.021907openalex-snapshot
The amount and type of dairy product intake and incident type 2 diabetes: results from the EPIC-InterAct Study
inferredcites →https://doi.org/10.3945/ajcn.114.092544openalex-snapshot
Serum pentadecanoic acid (15:0), a short-term marker of dairy food intake, is inversely associated with incident type 2 diabetes and its underlying disorders
inferredcites →https://doi.org/10.3945/ajcn.117.152702openalex-snapshot
Odd-chain fatty acids as a biomarker for dietary fiber intake: a novel pathway for endogenous production from propionate ,
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1007/978-3-030-91206-2_12openalex-snapshot
Amino Acid Profile and Bioavailability of Plant-Based Protein-Rich Products
inferred← citeshttps://doi.org/10.1007/s00726-023-03330-0openalex-snapshot
Metabolomic profiling of amino acids study reveals a distinct diagnostic model for diabetic kidney disease
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2023.740384openalex-snapshot
An integrated analysis of transcriptome and metabolome reveals three BCAAs relieve lipid accumulation by inhibiting lipid synthesis and promoting lipid oxidation in the liver of largemouth bass (Micropterus salmoides)
inferred← citeshttps://doi.org/10.1016/j.arr.2026.103313openalex-snapshot
Valine metabolism in cardiovascular disease: Mechanistic insights and translational perspectives
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113390openalex-snapshot
The role of branched chain amino acids metabolic disorders in tumorigenesis and progression
inferred← citeshttps://doi.org/10.1016/j.biortech.2022.127461openalex-snapshot
High-level production of L-valine in Escherichia coli using multi-modular engineering
inferred← citeshttps://doi.org/10.1016/j.cca.2021.11.028openalex-snapshot
An integrated pathological research for precise diagnosis of schizophrenia combining LC-MS/1H NMR metabolomics and transcriptomics
inferred← citeshttps://doi.org/10.1016/j.cell.2023.02.037openalex-snapshot
Large neutral amino acid levels tune perinatal neuronal excitability and survival
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117872openalex-snapshot
Adipose GGPPS stabilizes BCAT2 to orchestrate BCAA catabolism and lipid mobilization in fasting-induced liver remodeling
inferred← citeshttps://doi.org/10.1016/j.cplett.2024.141364openalex-snapshot
Employing molecular dynamics simulations and DFT calculations to elucidate the energetic, structural, and spectroscopic attributes of (poly)valines in water solution
inferred← citeshttps://doi.org/10.1016/j.foodres.2022.111499openalex-snapshot
Molecular composition of lipid and protein fraction of almond, beef and lesser mealworm after in vitro simulated gastrointestinal digestion and correlation with the hormone-stimulating properties of the digesta
inferred← citeshttps://doi.org/10.1016/j.medmic.2023.100078openalex-snapshot
BCAA dysmetabolism in the host and gut microbiome, a key player in the development of obesity and T2DM
inferred← citeshttps://doi.org/10.1016/j.microc.2025.114194openalex-snapshot
Amino acid, fatty acid, and metabolomic profiling of Mi pigs and crossbred pigs: Implications for meat quality
inferred← citeshttps://doi.org/10.1016/j.molcel.2022.01.021openalex-snapshot
Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination
inferred← citeshttps://doi.org/10.1016/j.redox.2024.103385openalex-snapshot
Branched-chain amino acids alleviate NAFLD via inhibiting de novo lipogenesis and activating fatty acid β-oxidation in laying hens
inferred← citeshttps://doi.org/10.1016/j.theriogenology.2023.11.020openalex-snapshot
l-valine supplementation disturbs vital molecular pathways and induces apoptosis in mouse testes
inferred← citeshttps://doi.org/10.1016/j.ymben.2025.09.005openalex-snapshot
Multi-layered transcriptional and post-translational fine-tuning of metabolic pathways for overproduction of L-valine
inferred← citeshttps://doi.org/10.1021/acs.jafc.1c02301openalex-snapshot
Bioaccumulation, Metabolism and the Toxic Effects of Chlorfenapyr in Zebrafish (Danio rerio)
inferred← citeshttps://doi.org/10.1038/s41387-022-00200-8openalex-snapshot
Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle
inferred← citeshttps://doi.org/10.1038/s41419-024-06893-2openalex-snapshot
Targeting valine catabolism to inhibit metabolic reprogramming in prostate cancer
inferred← citeshttps://doi.org/10.1038/s41598-021-02591-7openalex-snapshot
Branched-chain amino acids govern the high learning ability phenotype in Tokai high avoider (THA) rats
inferred← citeshttps://doi.org/10.1038/s41598-022-12021-xopenalex-snapshot
Large-scale genetic correlation scanning and causal association between deep vein thrombosis and human blood metabolites
inferred← citeshttps://doi.org/10.1039/d6an00497kopenalex-snapshot
Metabolic profiling reveals subtype-specific responses to jerantinine A acetate in breast cancer cells
inferred← citeshttps://doi.org/10.1080/00439339.2025.2507168openalex-snapshot
Understanding the functional roles of branched-chain amino acids and their interactions in broiler nutrition and health: a review
inferred← citeshttps://doi.org/10.1080/1745039x.2024.2438420openalex-snapshot
BCAA interactions: how do they influence broiler performance, intestinal morphometry, lipid profile, and liver health?
inferred← citeshttps://doi.org/10.1093/bbb/zbad169openalex-snapshot
Valine improves mitochondrial function and protects against oxidative stress
inferred← citeshttps://doi.org/10.1093/mam/ozaf099openalex-snapshot
Plant Protein-based Diet Fortified With Isoleucine, Leucine, and Valine Mitigates the Carbon Tetrachloride-induced Damage on Caspase-3 Gene Expression and Tissue Architecture: Histomorphological and Immunohistochemical Approaches
inferred← citeshttps://doi.org/10.1093/tas/txac017openalex-snapshot
A review of branched-chain amino acids in lactation diets on sow and litter growth performance
inferred← citeshttps://doi.org/10.1096/fj.202200111ropenalex-snapshot
Intervention with isoleucine or valine corrects hyperinsulinemia and reduces intrahepatic diacylglycerols, liver steatosis, and inflammation in Ldlr−/−.Leiden mice with manifest obesity‐associated NASH
inferred← citeshttps://doi.org/10.1097/mpa.0000000000002281openalex-snapshot
Reduced Branched-Chain Amino Acid Intake Improved High-Fat Diet-Induced Nonalcoholic Fatty Pancreas Disease in Mice
inferred← citeshttps://doi.org/10.1101/2024.01.01.573829openalex-snapshot
Valine Catabolism Drives Bioenergetic and Lipogenic Fuel Plasticity in Prostate Cancer
inferred← citeshttps://doi.org/10.1111/aos.16614openalex-snapshot
Protein profiling of conjunctival impression cytology samples of aniridia subjects
inferred← citeshttps://doi.org/10.1111/dom.70809openalex-snapshot
Sexually Dimorphic Impacts of Early Life BCAAs Supplementation on Metabolic Dysfunctions in Adult Mice
inferred← citeshttps://doi.org/10.1111/ijfs.16249openalex-snapshot
Nutritional composition of Sacha inchi (Plukenetia volubilis) according to cooking method and its application as an elder‐friendly drink
inferred← citeshttps://doi.org/10.1155/2024/5568337openalex-snapshot
Metabolomics of Mice with Type 2 Diabetes and Nonalcoholic Fatty Liver Treated by Acupuncture
inferred← citeshttps://doi.org/10.1161/circresaha.125.327192openalex-snapshot
Methylmalonate Overload Despite Glycemic Control Drives Diabetic Heart Damage
inferred← citeshttps://doi.org/10.1161/jaha.122.025310openalex-snapshot
Age‐Independent Cardiac Protection by Pharmacological Activation of Beclin‐1 During Endotoxemia and Its Association With Energy Metabolic Reprograming in Myocardium—A Targeted Metabolomics Study
inferred← citeshttps://doi.org/10.18174/534842openalex-snapshot
A matter of fat : Epidemiological studies of dietary and plasma fatty acids in coronary heart disease
inferred← citeshttps://doi.org/10.21037/tcr-24-1142openalex-snapshot
Association of branched-chain amino acids and risk of three urologic cancers: a Mendelian randomization study
inferred← citeshttps://doi.org/10.26641/2307-0404.2024.2.307572openalex-snapshot
Conections between platelets amino acids profile and known cardiometabolic risk factors in patients with coronary artery disease and atrial fibrillation
inferred← citeshttps://doi.org/10.26724/2079-8334-2023-4-86-110-114openalex-snapshot
PLATELETS AMINO ACIDS PROFILE AND CARDIOMETABOLIC RISK FACTORS IN PATIENTS WITH CORONARY ARTERY DISEASE AND ATRIAL FIBRILLATION
inferred← citeshttps://doi.org/10.3389/fendo.2021.786952openalex-snapshot
Metabolite Changes After Metabolic Surgery – Associations to Parameters Reflecting Glucose Homeostasis and Lipid Levels
inferred← citeshttps://doi.org/10.3389/fendo.2023.1237934openalex-snapshot
Metabolite profiles of diabetes mellitus and response to intervention in anti-hyperglycemic drugs
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1626973openalex-snapshot
Regulation of dendritic cell biology by amino acids and their transporters
inferred← citeshttps://doi.org/10.3389/fmed.2021.765873openalex-snapshot
Metabolomic Profiling of Amino Acids in Human Plasma Distinguishes Diabetic Kidney Disease From Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.3389/fnut.2024.1379390openalex-snapshot
Valine induces inflammation and enhanced adipogenesis in lean mice by multi-omics analysis
inferred← citeshttps://doi.org/10.3389/fphys.2021.783498openalex-snapshot
Metabolic Profiling Analysis of Liver in Landes Geese During the Formation of Fatty Liver via GC-TOF/MS
inferred← citeshttps://doi.org/10.3390/ani13040680openalex-snapshot
The Duck RXRA Gene Promotes Adipogenesis and Correlates with Feed Efficiency
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Serum Metabolomics and Ionomics Analysis of Hoof-Deformed Cows Based on LC-MS/MS and ICP-OES/MS
inferred← citeshttps://doi.org/10.3390/biology12010071openalex-snapshot
A Novel Method to Screen Strong Constitutive Promoters in Escherichia coli and Serratia marcescens for Industrial Applications
inferred← citeshttps://doi.org/10.3390/nu13051546openalex-snapshot
Effect of Microbial Status on Hepatic Odd-Chain Fatty Acids Is Diet-Dependent
inferred← citeshttps://doi.org/10.3390/nu15092052openalex-snapshot
Heptadecanoic Acid Is Not a Key Mediator in the Prevention of Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice
inferred← citeshttps://doi.org/10.3920/jiff2021.0017openalex-snapshot
Characterisation of black soldier fly larva protein before and after conjugation by the Maillard reaction
inferred← citeshttps://doi.org/10.5204/thesis.eprints.248849openalex-snapshot
Investigating the role of mitochondrial energy rewiring throughout prostate cancer progression
inferred← citeshttps://doi.org/10.5713/ab.21.0174openalex-snapshot
Glutamic-oxaloacetic transaminase 1 regulates adipocyte differentiation by altering nicotinamide adenine dinucleotide phosphate content
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