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Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

https://doi.org/10.1371/journal.pmed.1002179

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Egg, cholesterol and protein intake and incident type 2 diabetes mellitus: Results of repeated measurements from a prospective cohort study

inferred← citeshttps://doi.org/10.1016/j.clnu.2026.106590openalex-snapshot

Serum branched-chain amino acids, dietary factors, and sarcopenia risk in older adults with and without diabetes mellitus

inferred← citeshttps://doi.org/10.1016/j.cmet.2018.04.015openalex-snapshot

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase

inferred← citeshttps://doi.org/10.1016/j.cmet.2018.10.013openalex-snapshot

Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids

inferred← citeshttps://doi.org/10.1016/j.cmet.2021.03.025openalex-snapshot

The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

inferred← citeshttps://doi.org/10.1016/j.coph.2017.03.007openalex-snapshot

Myobolites: muscle-derived metabolites with paracrine and systemic effects

inferred← citeshttps://doi.org/10.1016/j.critrevonc.2022.103796openalex-snapshot

Cellular reprogramming, chemoresistance, and dietary interventions in breast cancer

inferred← citeshttps://doi.org/10.1016/j.diabres.2018.09.014openalex-snapshot

Amino acid profile in women with gestational diabetes mellitus treated with metformin or insulin

inferred← citeshttps://doi.org/10.1016/j.ebiom.2017.12.008openalex-snapshot

Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes

inferred← citeshttps://doi.org/10.1016/j.ebiom.2021.103550openalex-snapshot

Mahalanobis distance, a novel statistical proxy of homeostasis loss is longitudinally associated with risk of type 2 diabetes

inferred← citeshttps://doi.org/10.1016/j.ebiom.2021.103799openalex-snapshot

Changes in metabolomics profiles over ten years and subsequent risk of developing type 2 diabetes: Results from the Nurses' Health Study

inferred← citeshttps://doi.org/10.1016/j.ebiom.2023.104441openalex-snapshot

Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study

inferred← citeshttps://doi.org/10.1016/j.ejca.2017.07.034openalex-snapshot

Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis

inferred← citeshttps://doi.org/10.1016/j.exger.2025.112677openalex-snapshot

Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis

inferred← citeshttps://doi.org/10.1016/j.fshw.2022.04.004openalex-snapshot

Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances

inferred← citeshttps://doi.org/10.1016/j.gde.2023.102112openalex-snapshot

A new era of understanding in vivo metabolic flux in thermogenic adipocytes

inferred← citeshttps://doi.org/10.1016/j.jacc.2021.02.070openalex-snapshot

Molecular Aspects of Lifestyle and Environmental Effects in Patients With Diabetes

inferred← citeshttps://doi.org/10.1016/j.jadohealth.2019.01.030openalex-snapshot

Branched-Chain and Aromatic Amino Acids Are Associated With Insulin Resistance During Pubertal Development in Girls

inferred← citeshttps://doi.org/10.1016/j.jalz.2018.01.003openalex-snapshot

Association of branched‐chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts

inferred← citeshttps://doi.org/10.1016/j.jhepr.2025.101535openalex-snapshot

Mildly elevated liver lipid content is characterised by reduced insulin sensitivity

inferred← citeshttps://doi.org/10.1016/j.jlr.2024.100625openalex-snapshot

The metabolic signature of blood lipids: a causal inference study using twins

inferred← citeshttps://doi.org/10.1016/j.jnutbio.2023.109437openalex-snapshot

Branched-chain amino acids prevent obesity by inhibiting the cell cycle in an NADPH-FTO-m6A coordinated manner

inferred← citeshttps://doi.org/10.1016/j.jpeds.2018.07.056openalex-snapshot

Cord Blood Metabolites Associated with Newborn Adiposity and Hyperinsulinemia

inferred← citeshttps://doi.org/10.1016/j.metabol.2019.04.001openalex-snapshot

Alterations in the metabolism of phospholipids, bile acids and branched-chain amino acids predicts development of type 2 diabetes in black South African women: a prospective cohort study

inferred← citeshttps://doi.org/10.1016/j.metabol.2020.154391openalex-snapshot

Fasting status and metabolic health in relation to plasma branched chain amino acid concentrations in women

inferred← citeshttps://doi.org/10.1016/j.metop.2024.100287openalex-snapshot

Deciphering the complex interplay of risk factors in type 2 diabetes mellitus: A comprehensive review

inferred← citeshttps://doi.org/10.1016/j.mito.2024.101991openalex-snapshot

Mitochondrial DNA abundance and circulating metabolomic profiling: Multivariable-adjusted and Mendelian randomization analyses in UK Biobank

inferred← citeshttps://doi.org/10.1016/j.molmet.2019.06.016openalex-snapshot

Biomarkers for type 2 diabetes

inferred← citeshttps://doi.org/10.1016/j.molmet.2021.101261openalex-snapshot

Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street

inferred← citeshttps://doi.org/10.1016/j.molmet.2022.101611openalex-snapshot

BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice

inferred← citeshttps://doi.org/10.1016/j.molmet.2023.101694openalex-snapshot

Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism

inferred← citeshttps://doi.org/10.1016/j.molmet.2023.101750openalex-snapshot

Amino acid homeostasis is a target of metformin therapy

inferred← citeshttps://doi.org/10.1016/j.molmet.2025.102165openalex-snapshot

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK

inferred← citeshttps://doi.org/10.1016/j.numecd.2020.06.015openalex-snapshot

Branched-chain amino acids, history of gestational diabetes, and breastfeeding: The Bogalusa Heart Study

inferred← citeshttps://doi.org/10.1016/j.numecd.2020.07.030openalex-snapshot

Associations between outdoor temperature and bright sunlight with metabolites in two population-based European cohorts

inferred← citeshttps://doi.org/10.1016/j.nut.2024.112410openalex-snapshot

Branched-chain amino acid supplementation drives dynamic changes in gut microbiota without impairing glucose and lipid homeostasis at the different stages of insulin resistance in mice on a high-fat diet

inferred← citeshttps://doi.org/10.1016/j.phymed.2024.156348openalex-snapshot

Schisandra sphenanthera extract modulates sweet taste receptor pathway, IRS/PI3K, AMPK/mTOR pathway and endogenous metabolites against T2DM

inferred← citeshttps://doi.org/10.1016/j.prmcm.2024.100471openalex-snapshot

WITHDRAWN: Research on Traditional Chinese Medicine Syndrome Animal Models and Multi-omics Biomarkers in Type II Diabetes: A Review

inferred← citeshttps://doi.org/10.1016/j.schres.2024.06.040openalex-snapshot

Multi-omics analysis reveals the impact of gut microbiota on antipsychotic-induced weight gain in schizophrenia

inferred← citeshttps://doi.org/10.1016/j.tem.2021.11.004openalex-snapshot

Amino acid transporters as modulators of glucose homeostasis

inferred← citeshttps://doi.org/10.1016/s0140-6736(18)31132-2openalex-snapshot

Genomic insights into the causes of type 2 diabetes

inferred← citeshttps://doi.org/10.1017/erm.2021.12openalex-snapshot

Role of metabolomics in identifying cardiac hypertrophy: an overview of the past 20 years of development and future perspective

inferred← citeshttps://doi.org/10.1017/jns.2024.66openalex-snapshot

Elevated BCAA catabolism reverses the effect of branched-chain ketoacids on glucose transport in mTORC1-dependent manner in L6 myotubes

inferred← citeshttps://doi.org/10.1017/s0007114518000326openalex-snapshot

Early changes in tissue amino acid metabolism and nutrient routing in rats fed a high-fat diet: evidence from natural isotope abundances of nitrogen and carbon in tissue proteins

inferred← citeshttps://doi.org/10.1017/s0954422425100140openalex-snapshot

The impact of whey protein on plasma branched-chain amino acids and glycaemic control in humans. A narrative review

inferred← citeshttps://doi.org/10.1021/acs.jafc.1c02430openalex-snapshot

Tibet Kefir Milk Regulated Metabolic Changes Induced by High-Fat Diet via Amino Acids, Bile Acids, and Equol Metabolism in Human-Microbiota-Associated Rats

inferred← citeshttps://doi.org/10.1021/acsomega.3c01370openalex-snapshot

The Impact of the Serum Extraction Protocol on Metabolomic Profiling Using UPLC-MS/MS and FTIR Spectroscopy

inferred← citeshttps://doi.org/10.1038/nrcardio.2017.78openalex-snapshot

Mendelian randomization in cardiometabolic disease: challenges in evaluating causality

inferred← citeshttps://doi.org/10.1038/s41366-020-0603-xopenalex-snapshot

Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome

inferred← citeshttps://doi.org/10.1038/s41366-025-01898-zopenalex-snapshot

Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci

inferred← citeshttps://doi.org/10.1038/s41370-026-00941-zopenalex-snapshot

Metabolome-wide association study identifies metabolites associated with human exposure to perfluoroalkyl substances

inferred← citeshttps://doi.org/10.1038/s41387-022-00200-8openalex-snapshot

Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle

inferred← citeshttps://doi.org/10.1038/s41387-022-00213-3openalex-snapshot

Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes

inferred← citeshttps://doi.org/10.1038/s41392-022-01178-6openalex-snapshot

The evolving view of thermogenic fat and its implications in cancer and metabolic diseases

inferred← citeshttps://doi.org/10.1038/s41467-019-08936-1openalex-snapshot

Assessing the causal association of glycine with risk of cardio-metabolic diseases

inferred← citeshttps://doi.org/10.1038/s41467-020-20750-8openalex-snapshot

An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease

inferred← citeshttps://doi.org/10.1038/s41467-021-21073-yopenalex-snapshot

Genetic predictors of participation in optional components of UK Biobank

inferred← citeshttps://doi.org/10.1038/s41467-023-38148-7openalex-snapshot

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

inferred← citeshttps://doi.org/10.1038/s41467-023-40536-yopenalex-snapshot

Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels

inferred← citeshttps://doi.org/10.1038/s41467-025-58129-2openalex-snapshot

Assessing the potential causal effects of 1099 plasma metabolites on 2099 binary disease endpoints

inferred← citeshttps://doi.org/10.1038/s41467-025-59297-xopenalex-snapshot

DNA damage in proximal tubules triggers systemic metabolic dysfunction through epigenetically altered macrophages

inferred← citeshttps://doi.org/10.1038/s41467-025-60058-zopenalex-snapshot

Pleiotropic and sex-specific genetic mechanisms of circulating metabolic markers

inferred← citeshttps://doi.org/10.1038/s41467-026-70004-2openalex-snapshot

Branched-chain α-keto acids impair glucose-stimulated insulin secretion in pancreatic β-cells under diabetes by reactivating the LDHA-lactate axis

inferred← citeshttps://doi.org/10.1038/s41514-020-00054-3openalex-snapshot

Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan

inferred← citeshttps://doi.org/10.1038/s41574-018-0045-xopenalex-snapshot

The search for predictive metabolic biomarkers for incident T2DM

inferred← citeshttps://doi.org/10.1038/s41574-021-00471-8openalex-snapshot

Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics

inferred← citeshttps://doi.org/10.1038/s41574-023-00898-1openalex-snapshot

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus

inferred← citeshttps://doi.org/10.1038/s41574-025-01100-4openalex-snapshot

Islet hormones at the intersection of glucose and amino acid metabolism

inferred← citeshttps://doi.org/10.1038/s41575-018-0007-8openalex-snapshot

Systems biology in hepatology: approaches and applications

inferred← citeshttps://doi.org/10.1038/s41576-021-00387-zopenalex-snapshot

Advancing the use of genome-wide association studies for drug repurposing

inferred← citeshttps://doi.org/10.1038/s41580-018-0044-8openalex-snapshot

Metabolites as regulators of insulin sensitivity and metabolism

inferred← citeshttps://doi.org/10.1038/s41581-024-00872-8openalex-snapshot

Amino acid metabolism in kidney health and disease

inferred← citeshttps://doi.org/10.1038/s41586-026-10532-5openalex-snapshot

Genetic analysis of circulating metabolic traits in 619,372 individuals

inferred← citeshttps://doi.org/10.1038/s41588-020-00751-5openalex-snapshot

A cross-platform approach identifies genetic regulators of human metabolism and health

inferred← citeshttps://doi.org/10.1038/s41589-026-02293-zopenalex-snapshot

Metabolic reprogramming drives pancreatic β cell neogenesis from α cells

inferred← citeshttps://doi.org/10.1038/s41590-018-0129-8openalex-snapshot

Approaches and advances in the genetic causes of autoimmune disease and their implications

inferred← citeshttps://doi.org/10.1038/s41591-025-04105-8openalex-snapshot

Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes

inferred← citeshttps://doi.org/10.1038/s41598-017-12931-1openalex-snapshot

Branched-chain amino acids and Alzheimer’s disease: a Mendelian randomization analysis

inferred← citeshttps://doi.org/10.1038/s41598-018-19388-wopenalex-snapshot

Association between plasma concentrations of branched-chain amino acids and adipokines in Japanese adults without diabetes

inferred← citeshttps://doi.org/10.1038/s41598-018-26320-9openalex-snapshot

Serum metabolite profile associated with incident type 2 diabetes in Koreans: findings from the Korean Genome and Epidemiology Study

inferred← citeshttps://doi.org/10.1038/s41598-019-46478-0openalex-snapshot

Acute and short-term administrations of delta-9-tetrahydrocannabinol modulate major gut metabolomic regulatory pathways in C57BL/6 mice

inferred← citeshttps://doi.org/10.1038/s41598-020-58430-8openalex-snapshot

Associations between adipose tissue volume and small molecules in plasma and urine among asymptomatic subjects from the general population

inferred← citeshttps://doi.org/10.1038/s41598-020-67010-9openalex-snapshot

Serum branched-chain amino acids are associated with leukocyte telomere length and frailty based on residents from Guangxi longevity county

inferred← citeshttps://doi.org/10.1038/s41598-021-85684-7openalex-snapshot

Triangulating evidence from longitudinal and Mendelian randomization studies of metabolomic biomarkers for type 2 diabetes

inferred← citeshttps://doi.org/10.1038/s41598-021-92163-6openalex-snapshot

Association between alterations in plasma metabolome profiles and laminitis in intensively finished Holstein bulls in a randomized controlled study

inferred← citeshttps://doi.org/10.1038/s41598-022-19159-8openalex-snapshot

The role of NMR-based circulating metabolic biomarkers in development and risk prediction of new onset type 2 diabetes

inferred← citeshttps://doi.org/10.1038/s41598-025-98992-zopenalex-snapshot

Genome-wide association study of plasma amino acids and Mendelian randomization for cardiometabolic traits

inferred← citeshttps://doi.org/10.1038/s42255-019-0112-1openalex-snapshot

A new branch connecting thermogenesis and diabetes

inferred← citeshttps://doi.org/10.1038/s42255-023-00794-yopenalex-snapshot

Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance

inferred← citeshttps://doi.org/10.1038/s42255-023-00961-1openalex-snapshot

Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes

inferred← citeshttps://doi.org/10.1038/s42255-025-01253-6openalex-snapshot

Haem biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue

inferred← citeshttps://doi.org/10.1038/s43856-023-00382-xopenalex-snapshot

Branched chain amino acids harbor distinct and often opposing effects on health and disease

inferred← citeshttps://doi.org/10.1039/d3fo03899hopenalex-snapshot

Branched-chain amino acid modulation of lipid metabolism, gluconeogenesis, and inflammation in a finishing pig model: targeting leucine and valine

inferred← citeshttps://doi.org/10.1039/d5mo00074bopenalex-snapshot

The omics revolution in obesity: from molecularsignatures to clinical solutions

inferred← citeshttps://doi.org/10.1042/bcj20190182openalex-snapshot

Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform

inferred← citeshttps://doi.org/10.1042/bcj20200686openalex-snapshot

Whole-body metabolic fate of branched-chain amino acids

inferred← citeshttps://doi.org/10.1042/bsr20204201openalex-snapshot

The SARS-CoV-2 induced targeted amino acid profiling in patients at hospitalized and convalescent stage

inferred← citeshttps://doi.org/10.1055/a-1081-2036openalex-snapshot

Exploration of the Relationship Between Gut Microbiota and Polycystic Ovary Syndrome (PCOS): a Review

inferred← citeshttps://doi.org/10.1073/pnas.2104650118openalex-snapshot

Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A

inferred← citeshttps://doi.org/10.1073/pnas.2206083119openalex-snapshot

Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer’s disease

inferred← citeshttps://doi.org/10.1080/07853890.2021.1965204openalex-snapshot

Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease

inferred← citeshttps://doi.org/10.1080/10408398.2023.2198605openalex-snapshot

Omics biomarkers and an approach for their practical implementation to delineate health status for personalized nutrition strategies

inferred← citeshttps://doi.org/10.1080/10408398.2025.2524472openalex-snapshot

Yogurt and health: a focus on its matrix

inferred← citeshttps://doi.org/10.1080/15622975.2018.1487077openalex-snapshot

Branched-chain amino acids are associated with metabolic parameters in bipolar disorder

inferred← citeshttps://doi.org/10.1080/17446651.2017.1323631openalex-snapshot

Using genetics to inform new therapeutics for diabetes

inferred← citeshttps://doi.org/10.1089/met.2016.0145openalex-snapshot

Branched Chain Amino Acids Are Associated with Insulin Resistance Independent of Leptin and Adiponectin in Subjects with Varying Degrees of Glucose Tolerance

inferred← citeshttps://doi.org/10.1089/met.2024.0038openalex-snapshot

Metabolomics Characterization of Disease Markers in Diabetes and Its Associated Pathologies

inferred← citeshttps://doi.org/10.1093/advances/nmy110openalex-snapshot

Animal and Plant Protein Sources and Cardiometabolic Health

inferred← citeshttps://doi.org/10.1093/ajcn/nqab392openalex-snapshot

Adiposity, metabolomic biomarkers, and risk of nonalcoholic fatty liver disease: a case-cohort study

inferred← citeshttps://doi.org/10.1093/ajcn/nqy100openalex-snapshot

Rate of appearance of amino acids after a meal regulates insulin and glucagon secretion in patients with type 2 diabetes: a randomized clinical trial

inferred← citeshttps://doi.org/10.1093/aje/kwae167openalex-snapshot

A large study of metabolomics reveals common and distinct metabolic biomarkers for type 2 diabetes, coronary heart disease, and stroke

inferred← citeshttps://doi.org/10.1093/aje/kwy017openalex-snapshot

Serum Metabolomic Profiling of All-Cause Mortality: A Prospective Analysis in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study Cohort

inferred← citeshttps://doi.org/10.1093/aje/kwy096openalex-snapshot

The Roles of 27 Genera of Human Gut Microbiota in Ischemic Heart Disease, Type 2 Diabetes Mellitus, and Their Risk Factors: A Mendelian Randomization Study

inferred← citeshttps://doi.org/10.1093/hmg/ddaa162openalex-snapshot

Insights into genetic variants associated with NASH-fibrosis from metabolite profiling

inferred← citeshttps://doi.org/10.1093/ije/dyad093openalex-snapshot

Association of iron homeostasis biomarkers in type 2 diabetes and glycaemic traits: a bidirectional two-sample Mendelian randomization study

inferred← citeshttps://doi.org/10.1093/jn/nxac056openalex-snapshot

Association of Modifiable Lifestyle Factors with Plasma Branched-Chain Amino Acid Metabolites in Women

inferred← citeshttps://doi.org/10.1093/jn/nxz263openalex-snapshot

A Combination of Metabolites Predicts Adherence to the Mediterranean Diet Pattern and Its Associations with Insulin Sensitivity and Lipid Homeostasis in the General Population: The Fenland Study, United Kingdom

inferred← citeshttps://doi.org/10.1093/jnci/djy081openalex-snapshot

Circulating Selenium and Prostate Cancer Risk: A Mendelian Randomization Analysis

inferred← citeshttps://doi.org/10.1093/jncics/pkab059openalex-snapshot

Branched-Chain Amino Acids and Risk of Breast Cancer

inferred← citeshttps://doi.org/10.1093/nargab/lqae046openalex-snapshot

Unravelling genetic architecture of circulatory amino acid levels, and their effect on risk of complex disorders

inferred← citeshttps://doi.org/10.1096/fj.201802842rropenalex-snapshot

Role of branched‐chain amino acid–catabolizing enzymes in intertissue signaling, metabolic remodeling, and energy homeostasis

inferred← citeshttps://doi.org/10.1096/fj.202000195ropenalex-snapshot

The branched‐chain amino acids valine and leucine have differential effects on hepatic lipid metabolism

inferred← citeshttps://doi.org/10.1096/fj.202501757ropenalex-snapshot

Metabolome‐Wide Mendelian Randomization Identifies Valine as a Potential Mediator of the Effect of Obesity on Pancreatic Cancer Risk

inferred← citeshttps://doi.org/10.1097/hco.0000000000000552openalex-snapshot

Altered branched chain amino acid metabolism

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