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Mendelian randomization: a premature burial?

https://doi.org/10.1101/021386
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.2014.11061openalex-snapshot
Effect of Darapladib on Major Coronary Events After an Acute Coronary Syndrome
inferredcites →https://doi.org/10.1001/jama.2014.13959openalex-snapshot
Association of Low-Density Lipoprotein Cholesterol–Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis
inferredcites →https://doi.org/10.1002/sim.6522openalex-snapshot
Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome
inferredcites →https://doi.org/10.1007/s12263-010-0181-yopenalex-snapshot
Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health
inferredcites →https://doi.org/10.1016/j.atherosclerosis.2015.06.008openalex-snapshot
IMPROVE-IT and genetics reaffirm the causal role of LDL in Cardiovascular Disease
inferredcites →https://doi.org/10.1016/j.earlhumdev.2014.08.023openalex-snapshot
Approaches for drawing causal inferences from epidemiological birth cohorts: A review
inferredcites →https://doi.org/10.1016/j.econlet.2008.09.004openalex-snapshot
Detecting invalid instruments using L1-GMM
inferredcites →https://doi.org/10.1016/j.jacc.2012.09.017openalex-snapshot
Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease
inferredcites →https://doi.org/10.1016/j.jacc.2015.02.049openalex-snapshot
Developing Medicines That Mimic the Natural Successes of the Human Genome
inferredcites →https://doi.org/10.1016/j.jvs.2008.12.036openalex-snapshot
Genetically Elevated C-Reactive Protein and Ischemic Vascular Disease
inferredcites →https://doi.org/10.1016/j.jvs.2015.08.004openalex-snapshot
Efficacy and Safety of Evolocumab in Reducing Lipids and Cardiovascular Events
inferredcites →https://doi.org/10.1016/j.thromres.2010.09.009openalex-snapshot
PLA2G7 gene polymorphisms and coronary heart disease risk: A meta-analysis
inferredcites →https://doi.org/10.1016/s0140-6736(01)06418-2openalex-snapshot
Epidemiological methods for studying genes and environmental factors in complex diseases
inferredcites →https://doi.org/10.1016/s0140-6736(05)67786-0openalex-snapshot
C-reactive protein and its role in metabolic syndrome: mendelian randomisation study
inferredcites →https://doi.org/10.1016/s0140-6736(12)60110-xopenalex-snapshot
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
inferredcites →https://doi.org/10.1016/s0140-6736(12)60312-2openalex-snapshot
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
inferredcites →https://doi.org/10.1016/s0140-6736(14)61183-1openalex-snapshot
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
inferredcites →https://doi.org/10.1016/s0140-6736(86)92972-7openalex-snapshot
APOUPOPROTEIN E ISOFORMS, SERUM CHOLESTEROL, AND CANCER
inferredcites →https://doi.org/10.1016/s0145-4145(08)70160-6openalex-snapshot
Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart Disease
inferredcites →https://doi.org/10.1038/nrd4309openalex-snapshot
Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
inferredcites →https://doi.org/10.1055/s-2002-36768openalex-snapshot
Homocysteine and Coronary Heart Disease
inferredcites →https://doi.org/10.1056/nejmoa054013openalex-snapshot
Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart Disease
inferredcites →https://doi.org/10.1056/nejmoa0707402openalex-snapshot
Genetically Elevated C-Reactive Protein and Ischemic Vascular Disease
inferredcites →https://doi.org/10.1056/nejmoa1315878openalex-snapshot
Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease
inferredcites →https://doi.org/10.1056/nejmoa1410489openalex-snapshot
Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes
inferredcites →https://doi.org/10.1056/nejmoa1501031openalex-snapshot
Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events
inferredcites →https://doi.org/10.1080/01621459.2014.994705openalex-snapshot
Instrumental Variables Estimation With Some Invalid Instruments and its Application to Mendelian Randomization
inferredcites →https://doi.org/10.1080/07350015.2014.978175openalex-snapshot
Identification and Inference With Many Invalid Instruments
inferredcites →https://doi.org/10.1093/aje/kwr323openalex-snapshot
Credible Mendelian Randomization Studies: Approaches for Evaluating the Instrumental Variable Assumptions
inferredcites →https://doi.org/10.1093/aje/kws344openalex-snapshot
Mendelian Randomization and Estimation of Treatment Efficacy for Chronic Diseases
inferredcites →https://doi.org/10.1093/eurheartj/ehu203openalex-snapshot
Anti-inflammatory therapies for cardiovascular disease
inferredcites →https://doi.org/10.1093/ije/dyg070openalex-snapshot
‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*
inferredcites →https://doi.org/10.1093/ije/dyh023openalex-snapshot
Commentary: Mendelian randomization, 18 years on
inferredcites →https://doi.org/10.1093/ije/dyh132openalex-snapshot
Mendelian randomization: prospects, potentials, and limitations
inferredcites →https://doi.org/10.1093/ije/dyh312openalex-snapshot
Apolipoprotein E isoforms, serum cholesterol, and cancer
inferredcites →https://doi.org/10.1093/ije/dyt110openalex-snapshot
Power and sample size calculations for Mendelian randomization studies using one genetic instrument
inferredcites →https://doi.org/10.1093/ije/dyv071openalex-snapshot
Mendelian randomization studies: a review of the approaches used and the quality of reporting
inferredcites →https://doi.org/10.1093/ije/dyv080openalex-snapshot
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
inferredcites →https://doi.org/10.1097/ede.0000000000000081openalex-snapshot
Methodological Challenges in Mendelian Randomization
inferredcites →https://doi.org/10.1101/018150openalex-snapshot
Fulfilling the promise of Mendelian randomization
inferredcites →https://doi.org/10.1101/019885openalex-snapshot
Detection and interpretation of shared genetic influences on 40 human traits
inferredcites →https://doi.org/10.1111/j.1742-7843.2007.246_2.xopenalex-snapshot
Errata
inferredcites →https://doi.org/10.1136/bmj.b1665openalex-snapshot
Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies
inferredcites →https://doi.org/10.1136/bmj.d548openalex-snapshot
Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data
inferredcites →https://doi.org/10.1136/jmedgenet-2014-102438openalex-snapshot
Mendelian randomisation applied to drug development in cardiovascular disease: a review
inferredcites →https://doi.org/10.1146/annurev.nu.12.070192.002135openalex-snapshot
Serum Cholesterol and Cancer Risk: An Epidemiologic Perspective
inferredcites →https://doi.org/10.1161/01.atv.8.1.1openalex-snapshot
Apolipoprotein E polymorphism and atherosclerosis.
inferredcites →https://doi.org/10.1161/hy1101.093424openalex-snapshot
Effects of Alcohol Reduction on Blood Pressure
inferredcites →https://doi.org/10.1161/hypertensionaha.109.130005openalex-snapshot
Does Greater Adiposity Increase Blood Pressure and Hypertension Risk?
inferredcites →https://doi.org/10.1177/014107680710000923openalex-snapshot
Capitalizing on Mendelian randomization to assess the effects of treatments
inferredcites →https://doi.org/10.1371/journal.pone.0003011openalex-snapshot
The Association of C-Reactive Protein and CRP Genotype with Coronary Heart Disease: Findings from Five Studies with 4,610 Cases amongst 18,637 Participants
inferredcites →https://doi.org/10.2165/00019053-200220070-00001openalex-snapshot
Homocyst(e)ine and Coronary Heart Disease
inferredcites →https://doi.org/10.4324/9780203470855openalex-snapshot
Inference to the Best Explanation
inferredcites →https://doi.org/10.7326/m14-2957openalex-snapshot
Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Antibodies in Adults With Hypercholesterolemia

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/path.5421openalex-snapshot
The use of Mendelian randomisation to identify causal cancer risk factors: promise and limitations
inferred← citeshttps://doi.org/10.1007/s40273-016-0432-xopenalex-snapshot
Estimating Marginal Healthcare Costs Using Genetic Variants as Instrumental Variables: Mendelian Randomization in Economic Evaluation
inferred← citeshttps://doi.org/10.1007/s40484-020-0216-3openalex-snapshot
Mendelian randomization and pleiotropy analysis
inferred← citeshttps://doi.org/10.1038/s41588-018-0099-7openalex-snapshot
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
inferred← citeshttps://doi.org/10.1073/pnas.1707388115openalex-snapshot
Genetic instrumental variable regression: Explaining socioeconomic and health outcomes in nonexperimental data
inferred← citeshttps://doi.org/10.1093/bioinformatics/btaa985openalex-snapshot
An iterative approach to detect pleiotropy and perform Mendelian Randomization analysis using GWAS summary statistics
inferred← citeshttps://doi.org/10.1093/ije/dyx002openalex-snapshot
Pleiotropy-robust Mendelian randomization
inferred← citeshttps://doi.org/10.1101/2022.03.25.22272928openalex-snapshot
A comparison of the genes and genesets identified by EWAS and GWAS of fourteen complex traits
inferred← citeshttps://doi.org/10.1101/630426openalex-snapshot
Why are education, socioeconomic position and intelligence genetically correlated?
inferred← citeshttps://doi.org/10.14264/uql.2019.880openalex-snapshot
On the use of genetic information in causal inference for human complex diseases: a collection of studies on cancers
inferred← citeshttps://doi.org/10.22541/au.149652750.03402000openalex-snapshot
Mendelian Randomisation: A Minireview
inferred← citeshttps://doi.org/10.3410/f.733091753.793549148openalex-snapshot
Faculty Opinions recommendation of Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases.
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