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Beyond power: Multivariate discovery, replication, and interpretation of pleiotropic loci using summary association statistics

https://doi.org/10.1101/022269
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/gepi.20607openalex-snapshot
Bias due to two-stage residual-outcome regression analysis in genetic association studies
inferredcites →https://doi.org/10.1002/gepi.22046openalex-snapshot
Conditional analysis of multiple quantitative traits based on marginal GWAS summary statistics
inferredcites →https://doi.org/10.1016/j.ajhg.2011.10.004openalex-snapshot
Abundant Pleiotropy in Human Complex Diseases and Traits
inferredcites →https://doi.org/10.1016/j.ajhg.2014.03.016openalex-snapshot
Maximizing the Power of Principal-Component Analysis of Correlated Phenotypes in Genome-wide Association Studies
inferredcites →https://doi.org/10.1016/j.ajhg.2014.11.011openalex-snapshot
Meta-analysis of Correlated Traits via Summary Statistics from GWASs with an Application in Hypertension
inferredcites →https://doi.org/10.1016/j.ajhg.2017.06.005openalex-snapshot
10 Years of GWAS Discovery: Biology, Function, and Translation
inferredcites →https://doi.org/10.1038/nature14132openalex-snapshot
New genetic loci link adipose and insulin biology to body fat distribution
inferredcites →https://doi.org/10.1038/nature14177openalex-snapshot
Genetic studies of body mass index yield new insights for obesity biology
inferredcites →https://doi.org/10.1038/nature15393openalex-snapshot
A global reference for human genetic variation
inferredcites →https://doi.org/10.1038/ng.2213openalex-snapshot
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
inferredcites →https://doi.org/10.1038/ng.3097openalex-snapshot
Defining the role of common variation in the genomic and biological architecture of adult human height
inferredcites →https://doi.org/10.1038/s41467-017-00453-3openalex-snapshot
Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation
inferredcites →https://doi.org/10.1038/s41467-017-02317-2openalex-snapshot
Causal associations between risk factors and common diseases inferred from GWAS summary data
inferredcites →https://doi.org/10.1038/s41588-019-0469-9openalex-snapshot
Author Correction: Multi-trait analysis of genome-wide association summary statistics using MTAG
inferredcites →https://doi.org/10.1038/srep38837openalex-snapshot
Multivariate simulation framework reveals performance of multi-trait GWAS methods
inferredcites →https://doi.org/10.1093/bioinformatics/btn563openalex-snapshot
A multivariate test of association
inferredcites →https://doi.org/10.1093/bioinformatics/btw052openalex-snapshot
metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis
inferredcites →https://doi.org/10.1093/bioinformatics/btw373openalex-snapshot
PhenoScanner: a database of human genotype–phenotype associations
inferredcites →https://doi.org/10.1093/gigascience/giy137openalex-snapshot
A network-based conditional genetic association analysis of the human metabolome
inferredcites →https://doi.org/10.1101/118810openalex-snapshot
MTAG: Multi-Trait Analysis of GWAS
inferredcites →https://doi.org/10.1371/journal.pgen.1003500openalex-snapshot
Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
inferredcites →https://doi.org/10.1371/journal.pone.0034861openalex-snapshot
MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS
inferredcites →https://doi.org/10.1371/journal.pone.0065245openalex-snapshot
A Unified Framework for Association Analysis with Multiple Related Phenotypes
inferredcites →https://doi.org/10.1371/journal.pone.0163912openalex-snapshot
Multivariate Analysis of Anthropometric Traits Using Summary Statistics of Genome-Wide Association Studies from GIANT Consortium

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1038/ng.3698openalex-snapshot
Genome-wide analysis identifies 12 loci influencing human reproductive behavior
inferred← citeshttps://doi.org/10.1038/s42003-020-1051-9openalex-snapshot
Analysis of genetically independent phenotypes identifies shared genetic factors associated with chronic musculoskeletal pain conditions
inferred← citeshttps://doi.org/10.1038/s43587-021-00159-8openalex-snapshot
Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging
inferred← citeshttps://doi.org/10.1038/s43856-021-00033-zopenalex-snapshot
Genetic and phenotypic analysis of the causal relationship between aging and COVID-19
inferred← citeshttps://doi.org/10.1093/hmg/ddab072openalex-snapshot
Multivariate genome-wide analysis of immunoglobulin G N-glycosylation identifies new loci pleiotropic with immune function
inferred← citeshttps://doi.org/10.1101/2020.08.06.20169854openalex-snapshot
Genetic and Phenotypic Evidence for the Causal Relationship Between Aging and COVID-19
inferred← citeshttps://doi.org/10.1101/2021.01.22.427837openalex-snapshot
Genetically independent phenotype analysis identifies LPA and VCAM1 as drug targets for human ageing
inferred← citeshttps://doi.org/10.7554/elife.39856openalex-snapshot
Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances
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