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MTAG: Multi-Trait Analysis of GWAS

https://doi.org/10.1101/118810
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamapsychiatry.2015.0554openalex-snapshot
Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder
inferredcites →https://doi.org/10.1016/j.ajhg.2010.11.011openalex-snapshot
GCTA: A Tool for Genome-wide Complex Trait Analysis
inferredcites →https://doi.org/10.1016/j.ajhg.2014.11.011openalex-snapshot
Meta-analysis of Correlated Traits via Summary Statistics from GWASs with an Application in Hypertension
inferredcites →https://doi.org/10.1016/j.ajhg.2014.12.006openalex-snapshot
Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder
inferredcites →https://doi.org/10.1016/j.ajhg.2015.09.001openalex-snapshot
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
inferredcites →https://doi.org/10.1016/j.neuron.2012.06.012openalex-snapshot
The Presynaptic Active Zone
inferredcites →https://doi.org/10.1038/ejhg.2011.39openalex-snapshot
Genomic inflation factors under polygenic inheritance
inferredcites →https://doi.org/10.1038/mp.2012.21openalex-snapshot
A mega-analysis of genome-wide association studies for major depressive disorder
inferredcites →https://doi.org/10.1038/mp.2016.49openalex-snapshot
Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci
inferredcites →https://doi.org/10.1038/nature14132openalex-snapshot
New genetic loci link adipose and insulin biology to body fat distribution
inferredcites →https://doi.org/10.1038/nature14177openalex-snapshot
Genetic studies of body mass index yield new insights for obesity biology
inferredcites →https://doi.org/10.1038/nature20566openalex-snapshot
Organization and functions of mGlu and GABAB receptor complexes
inferredcites →https://doi.org/10.1038/ncomms6890openalex-snapshot
Biological interpretation of genome-wide association studies using predicted gene functions
inferredcites →https://doi.org/10.1038/ng.3097openalex-snapshot
Defining the role of common variation in the genomic and biological architecture of adult human height
inferredcites →https://doi.org/10.1038/ng.3211openalex-snapshot
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
inferredcites →https://doi.org/10.1038/ng.3406openalex-snapshot
An atlas of genetic correlations across human diseases and traits
inferredcites →https://doi.org/10.1038/ng.3552openalex-snapshot
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
inferredcites →https://doi.org/10.1038/ng.3623openalex-snapshot
Identification of 15 genetic loci associated with risk of major depression in individuals of European descent
inferredcites →https://doi.org/10.1038/nrg.2016.142openalex-snapshot
Dissecting the genetics of complex traits using summary association statistics
inferredcites →https://doi.org/10.1038/nrg3457openalex-snapshot
Pitfalls of predicting complex traits from SNPs
inferredcites →https://doi.org/10.1038/srep38837openalex-snapshot
Multivariate simulation framework reveals performance of multi-trait GWAS methods
inferredcites →https://doi.org/10.1038/srep42091openalex-snapshot
Using information of relatives in genomic prediction to apply effective stratified medicine
inferredcites →https://doi.org/10.1093/bioinformatics/btw613openalex-snapshot
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis
inferredcites →https://doi.org/10.1093/ije/dyu067openalex-snapshot
Cohort Profile: the Health and Retirement Study (HRS)
inferredcites →https://doi.org/10.1101/115915openalex-snapshot
Multivariate Genome-wide and integrated transcriptome and epigenome-wide analyses of the Well-being spectrum
inferredcites →https://doi.org/10.1124/pr.109.002451openalex-snapshot
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
inferredcites →https://doi.org/10.1126/science.1136800openalex-snapshot
Clustering by Passing Messages Between Data Points
inferredcites →https://doi.org/10.1371/journal.pgen.1003500openalex-snapshot
Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
inferredcites →https://doi.org/10.1371/journal.pgen.1004198openalex-snapshot
A Multi-Trait, Meta-analysis for Detecting Pleiotropic Polymorphisms for Stature, Fatness and Reproduction in Beef Cattle
inferredcites →https://doi.org/10.1371/journal.pgen.1006836openalex-snapshot
Joint modeling of genetically correlated diseases and functional annotations increases accuracy of polygenic risk prediction
inferredcites →https://doi.org/10.1371/journal.pone.0003395openalex-snapshot
Accuracy of Predicting the Genetic Risk of Disease Using a Genome-Wide Approach
inferredcites →https://doi.org/10.1371/journal.pone.0095923openalex-snapshot
A Comparison of Multivariate Genome-Wide Association Methods
inferredcites →https://doi.org/10.1534/genetics.115.183269openalex-snapshot
An Equation to Predict the Accuracy of Genomic Values by Combining Data from Multiple Traits, Populations, or Environments

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s11121-017-0828-7openalex-snapshot
Commentary for Special Issue of Prevention Science “Using Genetics in Prevention: Science Fiction or Science Fact?”
inferred← citeshttps://doi.org/10.1038/mp.2017.163openalex-snapshot
Multi-polygenic score approach to trait prediction
inferred← citeshttps://doi.org/10.1038/nrg.2017.104openalex-snapshot
The new genetics of intelligence
inferred← citeshttps://doi.org/10.1038/s41380-017-0001-5openalex-snapshot
A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence
inferred← citeshttps://doi.org/10.1038/s41380-018-0109-2openalex-snapshot
The contribution of common genetic risk variants for ADHD to a general factor of childhood psychopathology
inferred← citeshttps://doi.org/10.1038/s41467-018-04558-1openalex-snapshot
Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood
inferred← citeshttps://doi.org/10.1038/s41588-018-0269-7openalex-snapshot
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
inferred← citeshttps://doi.org/10.1073/pnas.1802909115openalex-snapshot
Education can reduce health differences related to genetic risk of obesity
inferred← citeshttps://doi.org/10.1093/hmg/ddz121openalex-snapshot
Combined analysis of keratinocyte cancers identifies novel genome-wide loci
inferred← citeshttps://doi.org/10.1098/rsob.170125openalex-snapshot
Statistical methods to detect pleiotropy in human complex traits
inferred← citeshttps://doi.org/10.1101/022269openalex-snapshot
Beyond power: Multivariate discovery, replication, and interpretation of pleiotropic loci using summary association statistics
inferred← citeshttps://doi.org/10.1101/070730openalex-snapshot
Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data
inferred← citeshttps://doi.org/10.1101/196071openalex-snapshot
Genome-wide association study of social relationship satisfaction: significant loci and correlations with psychiatric conditions
inferred← citeshttps://doi.org/10.1101/224774openalex-snapshot
Common risk variants identified in autism spectrum disorder
inferred← citeshttps://doi.org/10.1101/261081openalex-snapshot
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences 1
inferred← citeshttps://doi.org/10.1101/592899openalex-snapshot
Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders
inferred← citeshttps://doi.org/10.1176/appi.ajp.2018.18020149openalex-snapshot
Genetic Markers of ADHD-Related Variations in Intracranial Volume
inferred← citeshttps://doi.org/10.1186/s12864-018-5058-2openalex-snapshot
Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste
inferred← citeshttps://doi.org/10.1186/s13148-026-02202-0openalex-snapshot
Epigenome-wide association study meta-analysis of wellbeing
inferred← citeshttps://doi.org/10.1371/journal.pgen.1007549openalex-snapshot
Heritability informed power optimization (HIPO) leads to enhanced detection of genetic associations across multiple traits
inferred← citeshttps://doi.org/10.3410/f.733499086.793567847openalex-snapshot
Faculty Opinions recommendation of The contribution of common genetic risk variants for ADHD to a general factor of childhood psychopathology.
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