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Epistasis and destabilizing mutations shape gene expression variability in humans via distinct modes of action
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1 of the 55 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1038/nature13005 (notice 2021-08-11).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1521-1878(200004)22:4<372::aid-bies7>3.0.co;2-jopenalex-snapshot
Canalization in evolutionary genetics: a stabilizing theory?
inferredcites →https://doi.org/10.1016/j.copbio.2013.03.010openalex-snapshot
The details in the distributions: why and how to study phenotypic variability
inferredcites →https://doi.org/10.1016/j.tig.2013.05.010openalex-snapshot
Human housekeeping genes, revisited
inferredcites →https://doi.org/10.1017/s0016672304006640openalex-snapshot
Effects on phenotypic variability of directional selection arising through genetic differences in residual variability
inferredcites →https://doi.org/10.1017/s0016672310000546openalex-snapshot
Genetic analysis of environmental variation
inferredcites →https://doi.org/10.1017/thg.2012.89openalex-snapshot
The UK Adult Twin Registry (TwinsUK Resource)
inferredcites →https://doi.org/10.1038/msb.2009.58openalex-snapshot
Positive selection for elevated gene expression noise in yeast
inferredcites →https://doi.org/10.1038/msb.2013.53openalex-snapshot
Natural sequence variants of yeast environmental sensors confer cell‐to‐cell expression variability
inferredcites →https://doi.org/10.1038/nature04844openalex-snapshot
Increased cell-to-cell variation in gene expression in ageing mouse heart
inferredcites →https://doi.org/10.1038/nature08781openalex-snapshot
Variability in gene expression underlies incomplete penetrance
inferredcites →https://doi.org/10.1038/nature11401openalex-snapshot
FTO genotype is associated with phenotypic variability of body mass index
inferredcites →https://doi.org/10.1038/nature11632openalex-snapshot
An integrated map of genetic variation from 1,092 human genomes
inferredcites →https://doi.org/10.1038/nature12531openalex-snapshot
Transcriptome and genome sequencing uncovers functional variation in humans
inferredcites →https://doi.org/10.1038/nature13005openalex-snapshot
RETRACTED ARTICLE: Detection and replication of epistasis influencing transcription in humans
inferredcites →https://doi.org/10.1038/nature13691openalex-snapshot
Another explanation for apparent epistasis
inferredcites →https://doi.org/10.1038/nature14244openalex-snapshot
Selection on noise constrains variation in a eukaryotic promoter
inferredcites →https://doi.org/10.1038/nature749openalex-snapshot
Hsp90 as a capacitor of phenotypic variation
inferredcites →https://doi.org/10.1038/ng.110openalex-snapshot
Stochastic switching as a survival strategy in fluctuating environments
inferredcites →https://doi.org/10.1038/ng.2394openalex-snapshot
Mapping cis- and trans-regulatory effects across multiple tissues in twins
inferredcites →https://doi.org/10.1038/ng.3162openalex-snapshot
Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins
inferredcites →https://doi.org/10.1038/nrg1615openalex-snapshot
Stochasticity in gene expression: from theories to phenotypes
inferredcites →https://doi.org/10.1038/nrg2502openalex-snapshot
Decanalization and the origin of complex disease
inferredcites →https://doi.org/10.1038/nrg3891openalex-snapshot
The role of regulatory variation in complex traits and disease
inferredcites →https://doi.org/10.1073/pnas.1503830112openalex-snapshot
Behavioral idiosyncrasy reveals genetic control of phenotypic variability
inferredcites →https://doi.org/10.1093/bib/bbs017openalex-snapshot
Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
inferredcites →https://doi.org/10.1093/bioinformatics/btn142openalex-snapshot
Differential variability analysis of gene expression and its application to human diseases
inferredcites →https://doi.org/10.1101/063883openalex-snapshot
Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort
inferredcites →https://doi.org/10.1101/gr.139378.112openalex-snapshot
Noise–mean relationship in mutated promoters
inferredcites →https://doi.org/10.1111/j.1541-0420.2011.01652.xopenalex-snapshot
High‐Dimensional Heteroscedastic Regression with an Application to eQTL Data Analysis
inferredcites →https://doi.org/10.1111/j.2517-6161.1995.tb02031.xopenalex-snapshot
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
inferredcites →https://doi.org/10.1126/science.1070919openalex-snapshot
Stochastic Gene Expression in a Single Cell
inferredcites →https://doi.org/10.1126/science.1098641openalex-snapshot
Control of Stochasticity in Eukaryotic Gene Expression
inferredcites →https://doi.org/10.1158/0008-5472.can-04-0496openalex-snapshot
Normalization of Real-Time Quantitative Reverse Transcription-PCR Data: A Model-Based Variance Estimation Approach to Identify Genes Suited for Normalization, Applied to Bladder and Colon Cancer Data Sets
inferredcites →https://doi.org/10.1186/1471-2156-11-92openalex-snapshot
Variance heterogeneity analysis for detection of potentially interacting genetic loci: method and its limitations
inferredcites →https://doi.org/10.1186/1471-2156-13-4openalex-snapshot
An R package "VariABEL" for genome-wide searching of potentially interacting loci by testing genotypic variance heterogeneity
inferredcites →https://doi.org/10.1186/1755-8794-6-34openalex-snapshot
Pathway-based outlier method reveals heterogeneous genomic structure of autism in blood transcriptome
inferredcites →https://doi.org/10.1186/gb-2002-3-7-research0034openalex-snapshot
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
inferredcites →https://doi.org/10.1186/s13073-014-0125-zopenalex-snapshot
Higher gene expression variability in the more aggressive subtype of chronic lymphocytic leukemia
inferredcites →https://doi.org/10.1371/journal.pcbi.1000770openalex-snapshot
A Bayesian Framework to Account for Complex Non-Genetic Factors in Gene Expression Levels Greatly Increases Power in eQTL Studies
inferredcites →https://doi.org/10.1371/journal.pgen.0010078openalex-snapshot
Genome-Wide Associations of Gene Expression Variation in Humans
inferredcites →https://doi.org/10.1371/journal.pgen.1000049openalex-snapshot
Cell-to-Cell Stochastic Variation in Gene Expression Is a Complex Genetic Trait
inferredcites →https://doi.org/10.1371/journal.pgen.1000981openalex-snapshot
On the Use of Variance per Genotype as a Tool to Identify Quantitative Trait Interaction Effects: A Report from the Women's Genome Health Study
inferredcites →https://doi.org/10.1371/journal.pgen.1002207openalex-snapshot
Variance of Gene Expression Identifies Altered Network Constraints in Neurological Disease
inferredcites →https://doi.org/10.1371/journal.pgen.1002295openalex-snapshot
Genomic Analysis of QTLs and Genes Altering Natural Variation in Stochastic Noise
inferredcites →https://doi.org/10.1371/journal.pgen.1002839openalex-snapshot
Inheritance Beyond Plain Heritability: Variance-Controlling Genes in Arabidopsis thaliana
inferredcites →https://doi.org/10.1371/journal.pgen.1004942openalex-snapshot
Aberrant Gene Expression in Humans
inferredcites →https://doi.org/10.1371/journal.pgen.1006213openalex-snapshot
Exploiting Single-Cell Quantitative Data to Map Genetic Variants Having Probabilistic Effects
inferredcites →https://doi.org/10.15252/msb.20145704openalex-snapshot
Orthogonal control of expression mean and variance by epigenetic features at different genomic loci
inferredcites →https://doi.org/10.1534/genetics.111.127068openalex-snapshot
Detecting Major Genetic Loci Controlling Phenotypic Variability in Experimental Crosses
inferredcites →https://doi.org/10.1534/genetics.112.146779openalex-snapshot
Genetic Variants Contribute to Gene Expression Variability in Humans
inferredcites →https://doi.org/10.1534/genetics.113.157503openalex-snapshot
Additive, Epistatic, and Environmental Effects Through the Lens of Expression Variability QTL in a Twin Cohort
inferredcites →https://doi.org/10.3389/fnagi.2016.00183openalex-snapshot
Aging Shapes the Population-Mean and -Dispersion of Gene Expression in Human Brains
inferredcites →https://doi.org/10.7554/elife.01381openalex-snapshot
Genetic interactions affecting human gene expression identified by variance association mapping
inferredcites →https://doi.org/10.7554/elife.05856openalex-snapshot
Expression noise facilitates the evolution of gene regulation
What points at this work
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inferred← citeshttps://doi.org/10.3389/fnagi.2016.00183openalex-snapshot
Aging Shapes the Population-Mean and -Dispersion of Gene Expression in Human Brains
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