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Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort

https://doi.org/10.1101/063883
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.ajhg.2013.10.004openalex-snapshot
Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements
inferredcites →https://doi.org/10.1016/j.ajhg.2015.09.004openalex-snapshot
Alternative Splicing QTLs in European and African Populations
inferredcites →https://doi.org/10.1016/j.cell.2013.05.039openalex-snapshot
The Hallmarks of Aging
inferredcites →https://doi.org/10.1016/j.cub.2006.04.024openalex-snapshot
Gene expression becomes heterogeneous with age
inferredcites →https://doi.org/10.1016/j.mad.2012.07.005openalex-snapshot
Genotype×age interaction in human transcriptional ageing
inferredcites →https://doi.org/10.1016/j.molcel.2012.10.016openalex-snapshot
Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates
inferredcites →https://doi.org/10.1038/35057062openalex-snapshot
Initial sequencing and analysis of the human genome
inferredcites →https://doi.org/10.1038/ejhg.2008.270openalex-snapshot
Increased expression of the Hutchinson–Gilford progeria syndrome truncated lamin A transcript during cell aging
inferredcites →https://doi.org/10.1038/msb.2012.67openalex-snapshot
Widespread splicing changes in human brain development and aging
inferredcites →https://doi.org/10.1038/nature02661openalex-snapshot
Gene regulation and DNA damage in the ageing human brain
inferredcites →https://doi.org/10.1038/nature04844openalex-snapshot
Increased cell-to-cell variation in gene expression in ageing mouse heart
inferredcites →https://doi.org/10.1038/nature11632openalex-snapshot
An integrated map of genetic variation from 1,092 human genomes
inferredcites →https://doi.org/10.1038/nature12531openalex-snapshot
Transcriptome and genome sequencing uncovers functional variation in humans
inferredcites →https://doi.org/10.1038/ncomms6366openalex-snapshot
Age-related variations in the methylome associated with gene expression in human monocytes and T cells
inferredcites →https://doi.org/10.1038/ncomms9570openalex-snapshot
The transcriptional landscape of age in human peripheral blood
inferredcites →https://doi.org/10.1038/ng.2394openalex-snapshot
Mapping cis- and trans-regulatory effects across multiple tissues in twins
inferredcites →https://doi.org/10.1038/ng.3162openalex-snapshot
Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins
inferredcites →https://doi.org/10.1038/ng1291openalex-snapshot
Comparing genomic expression patterns across species identifies shared transcriptional profile in aging
inferredcites →https://doi.org/10.1038/nm.3909openalex-snapshot
The prognostic landscape of genes and infiltrating immune cells across human cancers
inferredcites →https://doi.org/10.1038/nrg3553openalex-snapshot
Omics technologies and the study of human ageing
inferredcites →https://doi.org/10.1038/srep15145openalex-snapshot
Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases
inferredcites →https://doi.org/10.1080/00949650215733openalex-snapshot
Permutation tests for multi-factorial analysis of variance
inferredcites →https://doi.org/10.1093/bioinformatics/btp073openalex-snapshot
Meta-analysis of age-related gene expression profiles identifies common signatures of aging
inferredcites →https://doi.org/10.1093/bioinformatics/btp324openalex-snapshot
Fast and accurate short read alignment with Burrows–Wheeler transform
inferredcites →https://doi.org/10.1093/bioinformatics/bts680openalex-snapshot
A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data
inferredcites →https://doi.org/10.1093/hmg/ddt582openalex-snapshot
Sex- and age-interacting eQTLs in human complex diseases
inferredcites →https://doi.org/10.1093/toxsci/kfn215openalex-snapshot
Age-Dependent Variability in Gene Expression in Male Fischer 344 Rat Retina
inferredcites →https://doi.org/10.1098/rstb.2010.0259openalex-snapshot
Genetics and genomics of human ageing
inferredcites →https://doi.org/10.1101/010074openalex-snapshot
LargeQvalue: A Program for Calculating FDR Estimates with Large Datasets
inferredcites →https://doi.org/10.1101/014126openalex-snapshot
Alternative splicing QTLs in European and African populations using Altrans, a novel method for splice junction quantification
inferredcites →https://doi.org/10.1101/gr.102160.109openalex-snapshot
Genome-wide gene expression regulation as a function of genotype and age in C. elegans
inferredcites →https://doi.org/10.1101/gr.122226.111openalex-snapshot
Analysis of alternative splicing associated with aging and neurodegeneration in the human brain
inferredcites →https://doi.org/10.1101/gr.135350.111openalex-snapshot
GENCODE: The reference human genome annotation for The ENCODE Project
inferredcites →https://doi.org/10.1111/acel.12039openalex-snapshot
Genome‐wide linkage analysis for human longevity: Genetics of Healthy Aging Study
inferredcites →https://doi.org/10.1111/j.1474-9726.2011.00726.xopenalex-snapshot
Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing
inferredcites →https://doi.org/10.1111/j.1474-9726.2012.00808.xopenalex-snapshot
Human longevity and common variations in the LMNA gene: a meta‐analysis
inferredcites →https://doi.org/10.1111/j.1474-9726.2012.00871.xopenalex-snapshot
Review: a meta‐analysis of GWAS and age‐associated diseases
inferredcites →https://doi.org/10.1126/science.aaa0355openalex-snapshot
The human transcriptome across tissues and individuals
inferredcites →https://doi.org/10.1186/gb-2013-14-10-r115openalex-snapshot
DNA methylation age of human tissues and cell types
inferredcites →https://doi.org/10.1186/gb-2013-14-7-r75openalex-snapshot
Gene expression changes with age in skin, adipose tissue, blood and brain
inferredcites →https://doi.org/10.1371/journal.pbio.0020427openalex-snapshot
A Transcriptional Profile of Aging in the Human Kidney
inferredcites →https://doi.org/10.1371/journal.pgen.1000529openalex-snapshot
A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies
inferredcites →https://doi.org/10.1371/journal.pgen.1000692openalex-snapshot
Expression Quantitative Trait Loci Are Highly Sensitive to Cellular Differentiation State
inferredcites →https://doi.org/10.1371/journal.pgen.1000730openalex-snapshot
Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis
inferredcites →https://doi.org/10.1371/journal.pgen.1000981openalex-snapshot
On the Use of Variance per Genotype as a Tool to Identify Quantitative Trait Interaction Effects: A Report from the Women's Genome Health Study
inferredcites →https://doi.org/10.1371/journal.pgen.1001236openalex-snapshot
Noisy Splicing Drives mRNA Isoform Diversity in Human Cells
inferredcites →https://doi.org/10.1371/journal.pgen.1002629openalex-snapshot
Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population
inferredcites →https://doi.org/10.1371/journal.pone.0001269openalex-snapshot
The Mutant Form of Lamin A that Causes Hutchinson-Gilford Progeria Is a Biomarker of Cellular Aging in Human Skin
inferredcites →https://doi.org/10.1371/journal.pone.0029848openalex-snapshot
Genetic Signatures of Exceptional Longevity in Humans
inferredcites →https://doi.org/10.1375/1369052042663742openalex-snapshot
The Use of Linear Mixed Models to Estimate Variance Components from Data on Twin Pairs by Maximum Likelihood
inferredcites →https://doi.org/10.1375/183242706779462462openalex-snapshot
The UK Adult Twin Registry (TwinsUK)
inferredcites →https://doi.org/10.1534/g3.114.011411openalex-snapshot
Pathway-Based Factor Analysis of Gene Expression Data Produces Highly Heritable Phenotypes That Associate with Age
inferredcites →https://doi.org/10.2337/db13-1459openalex-snapshot
Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes
inferredcites →https://doi.org/10.3389/fnagi.2016.00183openalex-snapshot
Aging Shapes the Population-Mean and -Dispersion of Gene Expression in Human Brains
inferredcites →https://doi.org/10.7554/elife.01381openalex-snapshot
Genetic interactions affecting human gene expression identified by variance association mapping
inferredcites →https://doi.org/10.7554/elife.01381.039openalex-snapshot
Author response: Genetic interactions affecting human gene expression identified by variance association mapping

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/jso.28151openalex-snapshot
Incidence of Deleterious Genetic Mutations in Newly Diagnosed Breast Cancer Patients Over the Age of 65: Is It Time to Expand Testing Parameters?
inferred← citeshttps://doi.org/10.1007/978-3-030-22009-9_934openalex-snapshot
Genetics: Gene Expression
inferred← citeshttps://doi.org/10.1007/978-3-319-69892-2_934-1openalex-snapshot
Genetics: Gene Expression
inferred← citeshttps://doi.org/10.1007/s11357-025-01834-zopenalex-snapshot
Patterns of transcriptomic aging in the hippocampus of rhesus macaques highlight midlife transitions
inferred← citeshttps://doi.org/10.1016/j.ceb.2018.05.016openalex-snapshot
Tissue aging: the integration of collective and variant responses of cells to entropic forces over time
inferred← citeshttps://doi.org/10.1038/s41467-022-33509-0openalex-snapshot
Tissue-specific impacts of aging and genetics on gene expression patterns in humans
inferred← citeshttps://doi.org/10.1038/s41537-024-00443-7openalex-snapshot
Temporal changes of gene expression in health, schizophrenia, bipolar disorder, and major depressive disorder
inferred← citeshttps://doi.org/10.1038/s41593-024-01624-4openalex-snapshot
Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia
inferred← citeshttps://doi.org/10.1038/s41598-020-60998-0openalex-snapshot
Temporal changes in the gene expression heterogeneity during brain development and aging
inferred← citeshttps://doi.org/10.1038/s41598-020-66052-3openalex-snapshot
Unique age-related transcriptional signature in the nervous system of the long-lived red sea urchin Mesocentrotus franciscanus
inferred← citeshttps://doi.org/10.1073/pnas.1714765115openalex-snapshot
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges
inferred← citeshttps://doi.org/10.1093/bfgp/elad019openalex-snapshot
Quantifying transcriptome diversity: a review
inferred← citeshttps://doi.org/10.1093/hmg/ddw314openalex-snapshot
Epistasis and destabilizing mutations shape gene expression variability in humans via distinct modes of action
inferred← citeshttps://doi.org/10.1101/026393openalex-snapshot
Epistasis and destabilizing mutations shape gene expression variability in humans via distinct modes of action
inferred← citeshttps://doi.org/10.1101/490433openalex-snapshot
Replicative senescense as a consequence of stochastic processes
inferred← citeshttps://doi.org/10.3329/ajmbr.v8i3.61463openalex-snapshot
Expression of lysozyme in diseased shrimp collected from two different coastal areas
inferred← citeshttps://doi.org/10.3390/ani13040698openalex-snapshot
A Comparative Study on the Effect of Euthanasia Methods and Sample Storage Conditions on RNA Yield and Quality in Porcine Tissues
inferred← citeshttps://doi.org/10.3390/genes16030272openalex-snapshot
An Exploratory Genomic and Transcriptomic Analysis Between Choloepus didactylus and Homo sapiens
inferred← citeshttps://doi.org/10.3410/f.732374149.793555978openalex-snapshot
Faculty Opinions recommendation of Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges.
inferred← citeshttps://doi.org/10.3410/f.732374149.793556975openalex-snapshot
Faculty Opinions recommendation of Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges.
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