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Genomics implicates adaptive and innate immunity in Alzheimer’s and Parkinson’s

https://doi.org/10.1101/059519
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamaneurol.2016.0150openalex-snapshot
Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease
inferredcites →https://doi.org/10.1007/s00018-008-7440-8openalex-snapshot
The epidermal growth factor receptor family: Biology driving targeted therapeutics
inferredcites →https://doi.org/10.1016/j.ajhg.2013.04.019openalex-snapshot
Network-Based Multiple Sclerosis Pathway Analysis with GWAS Data from 15,000 Cases and 30,000 Controls
inferredcites →https://doi.org/10.1016/j.cell.2015.01.049openalex-snapshot
TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
inferredcites →https://doi.org/10.1016/j.coph.2007.12.002openalex-snapshot
Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
inferredcites →https://doi.org/10.1016/j.jalz.2014.05.1757openalex-snapshot
Convergent genetic and expression data implicate immunity in Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.neuron.2008.01.003openalex-snapshot
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
inferredcites →https://doi.org/10.1016/j.yfrne.2012.08.006openalex-snapshot
The immune system and developmental programming of brain and behavior
inferredcites →https://doi.org/10.1016/s0165-5728(02)00052-8openalex-snapshot
Longitudinal study of antimyelin T-cell reactivity in relapsing–remitting multiple sclerosis: association with clinical and MRI activity
inferredcites →https://doi.org/10.1016/s0891-5849(98)00293-7openalex-snapshot
Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development
inferredcites →https://doi.org/10.1038/nature10251openalex-snapshot
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
inferredcites →https://doi.org/10.1038/nature13185openalex-snapshot
Transcriptional landscape of the prenatal human brain
inferredcites →https://doi.org/10.1038/nature13835openalex-snapshot
Genetic and epigenetic fine mapping of causal autoimmune disease variants
inferredcites →https://doi.org/10.1038/nature14248openalex-snapshot
Integrative analysis of 111 reference human epigenomes
inferredcites →https://doi.org/10.1038/nature14432openalex-snapshot
Structural and functional features of central nervous system lymphatic vessels
inferredcites →https://doi.org/10.1038/ncomms11022openalex-snapshot
Nuclear RNA-seq of single neurons reveals molecular signatures of activation
inferredcites →https://doi.org/10.1038/ng.2653openalex-snapshot
The Genotype-Tissue Expression (GTEx) project
inferredcites →https://doi.org/10.1038/ng.2802openalex-snapshot
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
inferredcites →https://doi.org/10.1038/ng.3043openalex-snapshot
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
inferredcites →https://doi.org/10.1038/ng.3286openalex-snapshot
Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C
inferredcites →https://doi.org/10.1038/ng.3404openalex-snapshot
Partitioning heritability by functional annotation using genome-wide association summary statistics
inferredcites →https://doi.org/10.1038/ng.3406openalex-snapshot
An atlas of genetic correlations across human diseases and traits
inferredcites →https://doi.org/10.1038/ng.3432openalex-snapshot
Large-scale identification of sequence variants influencing human transcription factor occupancy in vivo
inferredcites →https://doi.org/10.1038/ng.642openalex-snapshot
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease
inferredcites →https://doi.org/10.1038/ni0901-762openalex-snapshot
Multiple sclerosis: a two-stage disease
inferredcites →https://doi.org/10.1038/nn.3801openalex-snapshot
Genetic variability in the regulation of gene expression in ten regions of the human brain
inferredcites →https://doi.org/10.1038/nn.4156openalex-snapshot
The PsychENCODE project
inferredcites →https://doi.org/10.1038/nn.4399openalex-snapshot
Gene expression elucidates functional impact of polygenic risk for schizophrenia
inferredcites →https://doi.org/10.1038/nrc3150openalex-snapshot
Parkinson's disease and cancer: two wars, one front
inferredcites →https://doi.org/10.1038/nri3265openalex-snapshot
The anatomical and cellular basis of immune surveillance in the central nervous system
inferredcites →https://doi.org/10.1038/sj.gene.6364324openalex-snapshot
A subtype of multiple sclerosis defined by an activated immune defense program
inferredcites →https://doi.org/10.1056/nejmoa1211103openalex-snapshot
Variant of TREM2 Associated with the Risk of Alzheimer's Disease
inferredcites →https://doi.org/10.1056/nejmoa1211851openalex-snapshot
TREM2 Variants in Alzheimer's Disease
inferredcites →https://doi.org/10.1073/pnas.0701096104openalex-snapshot
Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors
inferredcites →https://doi.org/10.1093/bioinformatics/btt703openalex-snapshot
Causal analysis approaches in Ingenuity Pathway Analysis
inferredcites →https://doi.org/10.1093/hmg/dds492openalex-snapshot
A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease
inferredcites →https://doi.org/10.1093/hmg/ddt587openalex-snapshot
A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1093/nar/gkw377openalex-snapshot
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
inferredcites →https://doi.org/10.1093/schbul/sbw059openalex-snapshot
Genome-Wide Association Studies Suggest Limited Immune Gene Enrichment in Schizophrenia Compared to 5 Autoimmune Diseases
inferredcites →https://doi.org/10.1097/wco.0b013e3280adc943openalex-snapshot
Therapeutic approaches to inflammation in neurodegenerative disease
inferredcites →https://doi.org/10.1101/048991openalex-snapshot
Analysis of Shared Heritability in Common Disorders of the Brain
inferredcites →https://doi.org/10.1101/gr.136127.111openalex-snapshot
Linking disease associations with regulatory information in the human genome
inferredcites →https://doi.org/10.1126/science.1262110openalex-snapshot
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
inferredcites →https://doi.org/10.1155/2012/214714openalex-snapshot
Inflammatory Pathways in Parkinson’s Disease; A BNE Microarray Study
inferredcites →https://doi.org/10.1155/2013/413465openalex-snapshot
Initial Immunopathogenesis of Multiple Sclerosis: Innate Immune Response
inferredcites →https://doi.org/10.1186/1471-2105-14-128openalex-snapshot
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
inferredcites →https://doi.org/10.1186/1750-1326-6-60openalex-snapshot
Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons
inferredcites →https://doi.org/10.1210/er.2011-1049openalex-snapshot
Lipid Metabolism and Neuroinflammation in Alzheimer's Disease: A Role for Liver X Receptors
inferredcites →https://doi.org/10.1371/journal.pgen.1001097openalex-snapshot
Accurately Assessing the Risk of Schizophrenia Conferred by Rare Copy-Number Variation Affecting Genes with Brain Function
inferredcites →https://doi.org/10.1371/journal.pone.0013950openalex-snapshot
Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease
inferredcites →https://doi.org/10.1371/journal.pone.0098122openalex-snapshot
A Bayesian Method to Incorporate Hundreds of Functional Characteristics with Association Evidence to Improve Variant Prioritization
inferredcites →https://doi.org/10.2174/156652411795243450openalex-snapshot
The Role of Immune and Inflammatory Mechanisms in ALS
inferredcites →https://doi.org/10.3233/jpd-130250openalex-snapshot
The Role of Innate and Adaptive Immunity in Parkinson's Disease
inferredcites →https://doi.org/10.4049/jimmunol.1001829openalex-snapshot
The Role of the Transcription Factor CREB in Immune Function

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1038/s41588-018-0081-4openalex-snapshot
Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types
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