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Pathways analyses of schizophrenia GWAS focusing on known and novel drug targets

https://doi.org/10.1101/091264
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin
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Cytochrome P450 genotypes are not associated with refractoriness to antipsychotic treatment
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Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study
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Antiepileptic drugs in schizophrenia: a review
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Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach
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Mining for Bioactive Scaffolds with Scaffold Networks: Improved Compound Set Enrichment from Primary Screening Data
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The human serotonin transporter gene explains why some populations are more optimistic?
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Targeting the schizophrenia genome: a fast track strategy from GWAS to clinic
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Biological insights from 108 schizophrenia-associated genetic loci
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Chromosome conformation elucidates regulatory relationships in developing human brain
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Use of genome-wide association studies for drug repositioning
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Rational drug repositioning by medical genetics
inferredcites →https://doi.org/10.1038/ng.2742openalex-snapshot
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
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LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
inferredcites →https://doi.org/10.1038/ng.3314openalex-snapshot
The support of human genetic evidence for approved drug indications
inferredcites →https://doi.org/10.1038/ng.940openalex-snapshot
Genome-wide association study identifies five new schizophrenia loci
inferredcites →https://doi.org/10.1038/nn.4411openalex-snapshot
Translating genome-wide association findings into new therapeutics for psychiatry
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Genetic Relationship between Schizophrenia and Nicotine Dependence
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Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
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Ensembl 2016
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DGIdb 2.0: mining clinically relevant drug–gene interactions
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Open Targets: a platform for therapeutic target identification and validation
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Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
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Anxiolytic- and Antidepressant-Like Profile of ATC0065 and ATC0175: Nonpeptidic and Orally Active Melanin-Concentrating Hormone Receptor 1 Antagonists
inferredcites →https://doi.org/10.1162/089976698300017953openalex-snapshot
GTM: The Generative Topographic Mapping
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Galantamine for the Treatment of Cognitive Impairments in People With Schizophrenia
inferredcites →https://doi.org/10.1177/0269881105053284openalex-snapshot
Cinnarizine has an atypical antipsychotic profile in animal models of psychosis
inferredcites →https://doi.org/10.1177/0269881116653109openalex-snapshot
Gene-set analysis based on the pharmacological profiles of drugs to identify repurposing opportunities in schizophrenia
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The Multiplicity of Serotonin Receptors: Uselessly Diverse Molecules or an Embarrassment of Riches?
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The control of the false discovery rate in multiple testing under dependency
inferredcites →https://doi.org/10.1371/journal.pcbi.1004219openalex-snapshot
MAGMA: Generalized Gene-Set Analysis of GWAS Data
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The Role of Calcium Channel Blockers in the Treatment of Psychiatric Disorders
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Individual Comparisons by Ranking Methods
inferredcites →https://doi.org/10.2337/db13-0430openalex-snapshot
Antipsychotic-Induced Insulin Resistance and Postprandial Hormonal Dysregulation Independent of Weight Gain or Psychiatric Disease
inferredcites →https://doi.org/10.3389/fgene.2013.00076openalex-snapshot
Major channels involved in neuropsychiatric disorders and therapeutic perspectives
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Design of integrated system for heterogeneous network query terminal

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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The Psychiatric Genomics Consortium: History, development, and the future
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Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways
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Conference Report: Psychiatric Genomics Consortium Meeting: Pathways to Drugs, London, March 2017
inferred← citeshttps://doi.org/10.1016/j.celrep.2017.11.028openalex-snapshot
Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets
inferred← citeshttps://doi.org/10.1016/j.jpsychires.2018.12.015openalex-snapshot
Implications of de novo mutations in guiding drug discovery: A study of four neuropsychiatric disorders
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Interactome Analyses implicated CAMK2A in the genetic predisposition and pharmacological mechanism of Bipolar Disorder
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Genetics of Eating Disorders
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Comparative genomic evidence for the involvement of schizophrenia risk genes in antipsychotic effects
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Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry
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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
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Genome-wide association study identifies 30 loci associated with bipolar disorder
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The international postpartum depression: action towards causes and treatment (PACT) consortium
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Translating GWAS Findings Into Therapies For Depression And Anxiety Disorders: Drug Repositioning Using Gene-Set Analyses Reveals Enrichment Of Psychiatric Drug Classes
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Evaluation of Chromatin Accessibility in Prefrontal Cortex of Schizophrenia Cases and Controls
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Psychiatric Genomics: An Update and an Agenda
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Wellcome Sanger Institute and Wellcome Genome Campus Landscape Review
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.