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Enzymes and Substrates Are Balanced at Minimal Combined Mass Concentration in vivo

https://doi.org/10.1101/128009
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity
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Economics of membrane occupancy and respiro‐fermentation
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Overflow metabolism in Escherichia coli results from efficient proteome allocation
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The quantitative and condition-dependent Escherichia coli proteome
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Escherichia coli achieves faster growth by increasing catalytic and translation rates of proteins
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Intracellular crowding defines the mode and sequence of substrate uptake by Escherichia coli and constrains its metabolic activity
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Calculation of volume fluctuation for globular protein models.
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Extensive Analysis of the Cytoplasmic Proteome of Human Erythrocytes Using the Peptide Ligand Library Technology and Advanced Mass Spectrometry
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Saccharomyces Genome Database: the genomics resource of budding yeast
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The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases
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Pseudoreversion Substitution at Large-Subunit Residue 54 Influences the CO2/O2 Specificity of Chloroplast Ribulose-Bisphosphate Carboxylase/Oxygenase
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Systems Analysis of the Response of Photosynthesis, Metabolism, and Growth to an Increase in Irradiance in the Photosynthetic Model OrganismChlamydomonas reinhardtii
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Systematic Identification of Pathways That Couple Cell Growth and Division in Yeast
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Interdependence of Cell Growth and Gene Expression: Origins and Consequences
inferredcites →https://doi.org/10.1126/science.1216882openalex-snapshot
Multidimensional Optimality of Microbial Metabolism
inferredcites →https://doi.org/10.1172/jci104747openalex-snapshot
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Physiological responses to folate overproduction in Lactobacillus plantarum WCFS1
inferredcites →https://doi.org/10.1186/1742-4682-3-41openalex-snapshot
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sybil – Efficient constraint-based modelling in R
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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Metabolomics-driven understanding of genotype-phenotype relations in model organisms
inferred← citeshttps://doi.org/10.1038/s41467-020-14751-wopenalex-snapshot
An analytical theory of balanced cellular growth
inferred← citeshttps://doi.org/10.1038/s41467-020-18948-xopenalex-snapshot
The protein translation machinery is expressed for maximal efficiency in Escherichia coli
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Nutrient concentrations in food display universal behaviour
inferred← citeshttps://doi.org/10.1042/bst20170242openalex-snapshot
Competitive resource allocation to metabolic pathways contributes to overflow metabolisms and emergent properties in cross-feeding microbial consortia
inferred← citeshttps://doi.org/10.1098/rsfs.2023.0029openalex-snapshot
Optimal enzyme profiles in unbranched metabolic pathways
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Structure of autosynthetic models of balanced cell growth and numerical optimization of their growth rate
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Modeling Cellular Resource Allocation Reveals Low Phenotypic Plasticity of C 4 Plants and Infers Environments of C 4 Photosynthesis Evolution
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An analytical theory of balanced cellular growth
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Environment Constrains Fitness Advantages of Division of Labor in Microbial Consortia Engineered for Metabolite Push or Pull Interactions
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Metabolic enzyme cost explains variable trade-offs between microbial growth rate and yield
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An optimal growth law for RNA composition and its partial implementation through ribosomal and tRNA gene locations in bacterial genomes
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